The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms and the gravity of unmet need, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology: Leading companies in cancer monoclonal antibody therapy. Buy the report here.

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According to GlobalData’s Technology Foresights, which uses over 756,000 patents to analyse innovation intensity for the pharmaceutical industry, there are 110 innovation areas that will shape the future of the industry.

Cancer monoclonal antibody therapy is a key innovation area in immuno-oncology

Monoclonal antibodies are synthetic proteins that target cancer cells directly (targeted therapies) or help improve the immune system’s response to cancer cells (passive immunotherapy). New generation of monoclonal antibodies (bi-specific antibodies) are considered active immunotherapies because they link immune cells and cancer cells to activate anti-cancer immune response. Due to their cancer-targeting properties, many different antibody therapies are currently being evaluated and several antibody-based immunotherapies have been approved.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies.  According to GlobalData, there are 130+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of cancer monoclonal antibody therapy.

Key players in cancer monoclonal antibody therapy – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to cancer monoclonal antibody therapy

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
Immatics 529 Unlock Company Profile
F. Hoffmann-La Roche 520 Unlock Company Profile
Amgen 410 Unlock Company Profile
Johnson & Johnson 266 Unlock Company Profile
AbbVie 231 Unlock Company Profile
Bristol-Myers Squibb 219 Unlock Company Profile
Iovance Biotherapeutics 206 Unlock Company Profile
OncoTherapy Science 203 Unlock Company Profile
Regeneron Pharmaceuticals 144 Unlock Company Profile
Sanofi 142 Unlock Company Profile
Memorial Sloan Kettering Cancer Center 130 Unlock Company Profile
Takeda Pharmaceutical 129 Unlock Company Profile
GSK 124 Unlock Company Profile
UCB 123 Unlock Company Profile
Merck & Co 119 Unlock Company Profile
Kirin Holdings 107 Unlock Company Profile
Eisai 95 Unlock Company Profile
Abbott Laboratories 84 Unlock Company Profile
Gilead Sciences 83 Unlock Company Profile
Daiichi Sankyo 83 Unlock Company Profile
Lundbeck Foundation 81 Unlock Company Profile
E. Merck 73 Unlock Company Profile
AstraZeneca 72 Unlock Company Profile
Esbatech Alcon Biomed Research Unit 62 Unlock Company Profile
Innovative Cellular Therapeutics 61 Unlock Company Profile
Eli Lilly and 60 Unlock Company Profile
XOMA 60 Unlock Company Profile
Grifols 59 Unlock Company Profile
Zoetis 58 Unlock Company Profile
bluebird bio 57 Unlock Company Profile
Autolus 56 Unlock Company Profile
C. H. Boehringer Sohn 55 Unlock Company Profile
Pfizer 55 Unlock Company Profile
UK Research and Innovation 54 Unlock Company Profile
XBiotech 53 Unlock Company Profile
Acorda Therapeutics 50 Unlock Company Profile
Jiangsu Hengrui Medicine 46 Unlock Company Profile
Xencor 45 Unlock Company Profile
Abbott Biotechnology 44 Unlock Company Profile
Miltenyi Biotec 40 Unlock Company Profile
Pierre Fabre Foundation 38 Unlock Company Profile
CRISPR Therapeutics 37 Unlock Company Profile
Biocad 35 Unlock Company Profile
Light Chain Bioscience 35 Unlock Company Profile
Fred Hutchinson Cancer Research Center 34 Unlock Company Profile
Gracell Biotechnologies 31 Unlock Company Profile
Hanmi Science 31 Unlock Company Profile
MacroGenics 28 Unlock Company Profile
Lykera biomed 28 Unlock Company Profile
Vaccinex 28 Unlock Company Profile

Source: GlobalData Patent Analytics

Immatics is one of the most important players concerning innovation surrounding cancer monoclonal antibody therapy. The company is largely involved in immuno-oncology. Immatics undertakes the discovery of targets for cancer immunotherapies with the development of the right T-cell receptors. It has undertaken the development of adoptive cell therapies and TCR bispecifics.

In terms of application diversity, Immatics is the top company, followed by Regeneron Pharmaceuticals and Acorda Therapeutics. By means of geographic reach, Grifols holds the top position, while Acorda Therapeutics and Lykera Biomed are in the second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Immuno-Oncology – Thematic Research.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.