The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. ” The Ideal Bacteria.

Bacteria 52

Bacteria Engineer Drugs Research 52

BioTech 365

MAY 7, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study describes new mechanism for terminating transcription of DNA into RNA in bacteria.A bacterial protein helps to stop transcription—the process of making RNA copies of DNA to … Continue reading →

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RNA DNA Bacteria Protein 40

Medical Xpress

FEBRUARY 13, 2023

The gut microbiota contains trillions of bacteria that can promote health or cause disease under different conditions. The collective DNA sequences that make up the bacteria flora, is called the microbiome.

Bacteria 74

Bacteria DNA Containment Research 74

Pharmaceutical Technology

DECEMBER 14, 2022

Bacteria naturally develop resistance to antibiotics over time, through genetic mutation, horizontal gene transfer between bacteria, or because of selective pressure. Virus versus bacteria. Phages are viruses of bacteria. Secondly, the relationships between phages and bacteria are very specific.

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Bacteria DNA Clinical Trials Clinical Trials 130

Scienmag

FEBRUARY 5, 2021

An international research group led by the University of Bologna achieved this result by extracting and analysing ancient DNA from 50,000-year-old faecal sediments sampled at the archaeological site of El Salt, near Alicante (Spain). Published […].

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Bacteria DNA Research 63

Scienmag

JUNE 21, 2022

The last two decades have seen the development of sophisticated computational tools that explore the DNA of bacteria. These tools are on the lookout for interesting metabolites (metabolism-related molecules) that illicit a strong biological reaction.

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Bacteria Gene DNA Development 86

XTalks

NOVEMBER 28, 2023

Following passive diffusion into the organism, metronidazole is activated in the cytoplasm of susceptible anaerobic bacteria through reduction. The reduced form of metronidazole, along with free radicals, interacts with DNA, inhibiting DNA synthesis and causing DNA degradation, ultimately leading to the demise of the bacteria.

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FDA Approval Bacteria DNA Drugs 103

Scienmag

JULY 1, 2022

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].

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Regulation Gene DNA Bacteria 63

Scienmag

JANUARY 22, 2021

coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].

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RNA Production Regulation Bacteria 85

Scienmag

MAY 7, 2021

Study describes new mechanism for terminating transcription of DNA into RNA in bacteria Credit: Babitzke Laboratory and Dani Zemba, Penn State The protein, known as NusG, pauses the transcription machinery at specific DNA sequences to facilitate what is called “intrinsic termination” and prevent unwanted transcription that could disrupt (..)

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Genetics DNA Bacteria RNA 53

Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

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In-Vivo Genome Genomics Gene Editing 162

pharmaphorum

OCTOBER 7, 2020

Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. million) Nobel Prize award.

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Gene Editing Bacteria DNA Gene 103

Camargo

JULY 27, 2021

It is a comprehensive term which encompasses a large variety of therapy products including viral and bacterial vectors, plasmid DNA, human gene editing technology, and patient-specific cellular gene therapy. Formulation Considerations.

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Gene Therapy Gene Gene Editing Genetics 238

pharmaphorum

JANUARY 20, 2021

This sticky mucus gets trapped and breeds infections from bacteria I inhale,” says Ella, who adds she was “terrified” of doctors as a child. The bacteria become more resistant to antibiotics and that makes them harder to clear. I would spend two or three weeks at a time in hospital on antibiotics.”. I was really sick.

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Bacteria Bacterium DNA Doctors 108

Roots Analysis

FEBRUARY 27, 2024

How many of the ADCs in development have pyrrolobenzodiazepine (PBD) as warhead: Pyrrolobenzodiazepines are a class of compounds that kill cells by binding their DNA and interfering with replication. In nature, they are made by a group of bacteria known as actinomycetes.

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Antibody Licensing Licensing Contract Manufacturing 52

Drug Discovery World

FEBRUARY 8, 2024

This is largely due to their highly stable Inverted Terminal Repeat (ITR) regions, as this secondary structure is prone to deletions during propagation in bacteria and cannot be read by standard Sanger sequencing. Dr O’Hara also provided an AAV plasmid preparation case study. Why are those important?

Gene Therapy 59

Gene Therapy Gene Bioinformatics Life Science 59

Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

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Vaccination Vaccine Containment Immune Response 130

pharmaphorum

APRIL 23, 2021

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of gene editing technology and has refined its technology to the point where it can be used to accurately edit someone’s DNA to correct genetic conditions.

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Gene Editing Gene DNA Bacteria 64

Drug Discovery World

NOVEMBER 17, 2022

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. The Rockefeller University 2 recently reported the development of a synthetic antibiotic that could potentially work against drug-resistant bacteria.

Bacteria 52

Bacteria Engineer Gene Genetics 52

XTalks

DECEMBER 14, 2022

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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Gene Editing DNA Gene Gene Sequencing 98

Delveinsight

JULY 26, 2021

Often the bacteria develop antibiotic resistance to certain drugs, leaving it non-effective for the usage the second time in the case of recurrence of the infection that occurs in approximately 30-35% of the uUTI cases, therefore, leaving a serious dearth of the new antibiotics. coli bacteria called FimH.

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Marketing Bacteria Vaccination Vaccine 93

pharmaphorum

MAY 7, 2021

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of the gene editing technology and has refined it to the point where it can be used to accurately edit DNA to correct genetic conditions or modify cells to fight disease.

Gene Editing 52

Gene Editing Gene Genetic Engineering DNA 52

Drug Discovery World

OCTOBER 3, 2023

This is largely due to their highly stable Inverted Terminal Repeat (ITR) regions, as this secondary structure is prone to deletions during propagation in bacteria and cannot be read by standard Sanger sequencing. Dr O’Hara also provided an AAV plasmid preparation case study. Why are those important?

Gene Therapy 52

Gene Therapy Gene Life Science Bioinformatics 52

Roots Analysis

OCTOBER 16, 2023

DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.

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DNA Gene Protein In-Vitro 40

The Pharma Data

JANUARY 4, 2021

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. “Essentially, what Justin did was to create a series of DNA instructions you can give to cells that will enable them to survive when fluoride is around,” said O’Malley.

Bacteria 52

Bacteria Engineer Genetics Genetic Engineering 52

Roots Analysis

JANUARY 14, 2024

Different types of expression system for the production of biologics have been mentioned in the following sections: Insect Expression Systems: Baculovirus is a double stranded DNA (dsDNA) lytic virus that can be effectively amplified in insect cells belonging to the Lepidoptera family.

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Contract Manufacturing Manufacturing Protein Bacteria 40

XTalks

NOVEMBER 19, 2021

No one enjoys cold food, but once it drops below 140 degrees F, bacteria can form on the surface. InnerPlant, a startup that edits the DNA of plants to enable them to glow a certain color when the plant is under attack from pests or fungal infection or is stressed from lack of water. Upside Foods, a maker of cultured chicken.

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Bacteria Packaging Packaging DNA 97

Drug Discovery World

FEBRUARY 6, 2024

The company has created a novel AI platform to develop enzymes from bacteria-killing viruses (bacteriophages) as a new way to tackle bacterial infections, and has secured €4 million investment to support its development. Obulytix is not alone.

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Marketing Medicine Genome Genomics 69

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

Drug Discovery World

OCTOBER 11, 2023

Alexander Fleming, the discoverer of penicillin, warned, as early as 1945, against the overuse of antibiotics, suggesting it would select for resistant bacterial species 3 – in fact, penicillin-resistant bacteria were identified before penicillin was approved for use 1,4.

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Bacteria Development Scientist Protein 59

XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

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Genetics DNA Genome Genomics 119

Roots Analysis

MARCH 1, 2023

Disruption of the integrity and function of DNA at the gene or chromosomal level can lead to heritable mutations, resulting in genetic disorders, birth abnormalities, or cancer. Mechanism of Genotoxicity / Mutagenicity The interaction of genotoxins / mutagens with the structure of DNA causes damage to the genetic material.

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Genotoxicity DNA Genetics Bacteria 52

XTalks

FEBRUARY 11, 2021

The drugmaker is targeting various steps in the manufacturing process, beginning right at the DNA stage, which is required as the template from which the mRNA for the SARS-CoV-2 spike protein in the vaccine is made. DNA Templates: The vaccine development process first begins with raw ingredients coming together at the Chesterfield plant.

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Manufacturing Vaccination Vaccine DNA 52

Roots Analysis

AUGUST 31, 2023

coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium. Gene switches can be regulatory proteins or specific DNA sequences that act to either switch on or off the expression of a gene.

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Gene Gene Therapy Gene Expression Regulation 40

Drug Discovery World

MAY 2, 2023

Steve Wowk , VP, Business Unit and General Management of Integrated DNA Technologies, shared with DDW the value of CRISPR-Cas9 in drug discovery. In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome.

Genome 52

Genome Genomics Gene DNA 52

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g., Herpesviridae, Polyomaviridae, and Papillomaviridae), bacteria (e.g.,

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DNA Genome Genomics RNA 98

Drug Discovery World

JULY 26, 2023

This requires the identification and categorisation of massive sets of genomic sequences corresponding to a huge diversity of bacteria and other microorganisms – a challenge quite distinct from studying the human genome (e.g., Cell-free microbial DNA (cf-mbDNA)’s orthogonal position to the human genome offers several advantages.

Medicine 52

Medicine Genome Genomics Bioinformatics 52