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Salt stress alters legume responses to symbiotic rhizobacteria by modulating gene expression

Scienmag

Legumes engage in a unique and beneficial interaction with a group of soil bacteria, collectively called rhizobia. Crop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations.

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Scientists discover small RNA that regulates bacterial infection

The Pharma Data

But the bacteria can sometimes change their behavior and enter the bloodstream, causing chronic localized infections to become acute and potentially fatal. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch.

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Gene Therapy and Pharmacokinetics

Camargo

The technology of gene therapy is possible due to extensive DNA research and our resulting understanding of many diseases on the genetic level, and it encompasses several mechanisms such as introducing new genes (gene addition) and inactivating or replacing mutated genes (gene editing).

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Biologics – The Next Step in Revolutionary Medication

Roots Analysis

Usually, the desired gene, such as human insulin gene, when inserted into the plasmid of the host cell uses transcriptional and translational machinery of the host to express itself. It is worth mentioning that in vitro gene expression requires a suitable host for the production of a specific gene product.

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Artificial intelligence could be new blueprint for precision drug discovery

The Pharma Data

The AI approach helps model a disease using a map of successive changes in gene expression at the onset and during the progression of the disease. The underlying algorithms ensure that the identified gene expression patterns are ‘invariant’ regardless of different disease cohorts.

Drugs 52
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Anti-tumor agent from the intestine

The Pharma Data

We are talking about the microbiome – the vast collection of bacteria in the human gut. The microbiome has been the focus of research for 20 years – ever since a new technique made it possible to analyse these bacteria quickly and precisely: high-throughput sequencing. In doing so, they induce epigenetic changes.

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Vtama (tapinarof) Cream Gains FDA Approval for the Treatment of Plaque Psoriasis in Adults

XTalks

Tapinarof was discovered as an outcome of investigations into the secondary metabolites of Photorhabdus luminescens, a bioluminescent, Gram-negative bacteria. There is 10 mg of tapinarof per gram of Vtama cream. XTALKS WEBINAR: All Means All: The Road to Inclusivity in Clinical Trials. Clinical Trials of Vtama.