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Radical Vaccine Strategy Could Help Quash Parasite Afflicting Millions

AuroBlog - Aurous Healthcare Clinical Trials blog

Using viruses that infect bacteria to detect proteins sprouted by a notorious parasite, scientists have honed in on possible vaccine targets for schistosomiasis, a neglected tropical disease that currently affects an estimated 600 million people worldwide, causing 280,000 deaths per year.

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RNA holds the reins in bacteria: U-M researchers observe RNA controlling protein synthesis

Scienmag

Credit: Surajit Chatterjee To better understand how RNA in bacteria gives rise to protein–and along the way, target these processes in the design of new antibiotics–researchers are turning their attention to the unique way this process happens in bacteria.

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How bacteria cope with stress

Scienmag

When exposed to stress, bacteria allow their metabolism to take a break during which they suppress, for example, the incorporation of proteins into membranes. Scientists from Marburg, Freiburg and Munich have discovered this by biochemically investigating the stress response of microorganisms.

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Protein structure offers clues to drug-resistance mechanism

Scienmag

CAMBRIDGE, MA — MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.

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Louisville researchers reveal how oral bacteria suppress protection against viral growth

Scienmag

. – Researchers from the University of Louisville School of Dentistry and their colleagues have discovered details of how proteins produced by oral epithelial cells protect humans against viruses entering the body through the mouth. Credit: University […].

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Excitement over new antibiotics that can kill drug-resistant bacteria

Drug Discovery World

New antibiotics directed against the world’s highest priority bacteria, like Acinetobacter baumannii , require novel development paths. It inhibits the LptB2FGC complex, the machinery that assembles the outer membrane of gram-negative bacteria. One of the molecules, called zosurabalpin, killed multiple resistant strains of A.

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Dual brake on transport protein prevents cells from exploding

Scienmag

To counter this, bacteria can increase their internal solute concentration. Scientists from the University of Groningen elucidated the structure of a transport protein OpuA, that imports glycine betaine to counter […].

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