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US researchers decipher how one gut bacterium influences immunity

Drug Discovery World

A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. You can change the bacterium and apply the same set of tests,” said Clardy. Such knowledge is essential for learning how to manipulate gut bacteria to treat or prevent illness.

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Pathogenic genetic variations found to boost the risk of H. pylori–related stomach cancer

Medical Xpress

A large case-control study by international researchers at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan has found that people who carry certain genetic risk factors for gastric (stomach) cancer have a much greater risk if they have also been infected by the bacterium Helicobacter pylori.

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Comeback of drug-resistant neglected tropical disease tracked through genomic surveillance

Scienmag

Study will influence the global elimination strategy for yaws Genome sequencing has shed light on the re-emergence of the bacterium that causes yaws, a neglected tropical disease of the skin, bones and joints. The re-emergence followed a mass drug administration (MDA) campaign that aimed to eliminate the disease in Papua New Guinea.

Genome 40
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Researchers peer inside deadly pathogen’s burglary kit

Scienmag

Structural insights about a deadly bacterium’s toolbox point to ways to block it Credit: Maria Schumacher Lab, Duke Biochemistry DURHAM, N.C. – The bacterium that causes the tick-borne disease tularemia is a lean, mean infecting machine.

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Cause of 1990s Argentina cholera epidemic uncovered

Scienmag

Work allows genomic monitoring for epidemic strains of Vibrio cholerae bacteria The evolution of epidemic and endemic strains of the cholera-causing bacterium Vibrio cholerae in Argentina has been mapped in detail by researchers at the Wellcome Sanger Institute, the London School of Hygiene and Tropical Medicine, the University of Cambridge and the (..)

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Anti-tumor agent from the intestine

The Pharma Data

Since then, there has been an increasing body of findings that the microbiome, which is sometimes also referred to as the second human genome, is not only of central importance for digestion, but also influences, if not controls, at least a large number of body functions. The immune system is mentioned particularly frequently.

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Stanford researchers construct the most complete synthetic microbiome

Drug Discovery World

The researchers decided to build their colony from the most prevalent bacteria and turned to the Human Microbiome Project (HMP), a National Institutes of Health initiative to sequence the full microbial genomes of over 300 adults. “We