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Evaluating methods targeting Protein-Protein Interactions

pharmaphorum

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins. These regions are critical for optimal interactions between proteins.

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Can artificial intelligence help craft new medicines?

Drug Discovery World

The drug target for Penicillin is a protein that helps bacteria to synthesise its cell wall. One of the first and most basic requirements for a protein to be characterised as a drug target is to show that inhibiting its function prevents the disease. Salvarsan was soon overtaken by the Penicillin antibiotics.

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Reimagining cell engineering with picodroplet microfluidic technology

Drug Discovery World

However, standard technologies used to ensure the highest value cells are progressed require multistep operations and instruments, extensive hands-on time, and lengthy liquid handling processes, as well as complex, low throughput bioassays for functional validation and verification.