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Using analytics and bioassays to de-risk your mRNA LNP drug development programme

Pharmaceutical Technology

Another area where we tend to see problems is in encapsulation efficiency,” says Andrew Kondratowicz, Bioassay Team Lead, Precision NanoSystems. The bioassays are the canary in the coal mine of how well your process development is going. Outlook The era of mRNA-based genomic medicines is on the horizon. Where is your payload?

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RNA-based immunotherapy eradicates melanoma tumours

Drug Discovery World

This is because tumours have a tendency to evolve in different ways to switch off each stage of the cancer-immunity cycle,” said Yizhou Dong, corresponding author of the study, Professor of Oncological Sciences, and a member of the Icahn Genomics Institute and the Marc and Jennifer Lipschultz Precision Immunology Institute at Icahn Mount Sinai.

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4th Gene Therapy Analytical Development Summit 2022

pharmaphorum

This year’s summit returns in-person to Boston to reunite 300+ analytical experts in innovative biotech, pharma and academia to continue to develop resilient, long-lasting and robust analytical tools to enhance the safety, quality, and efficacy of gene therapy products.

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Evaluating methods targeting Protein-Protein Interactions

pharmaphorum

It is a popular method in systems biology, requiring fewer compounds to be screened in bioassays, reducing time and cost. According to a 2021 publication “…recent advancements have made it possible to generate and analyse genome-wide PP I networks en masse by coupling Y2H with next-generation sequencing technology (NGS)”. .

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Reimagining cell engineering with picodroplet microfluidic technology

Drug Discovery World

However, standard technologies used to ensure the highest value cells are progressed require multistep operations and instruments, extensive hands-on time, and lengthy liquid handling processes, as well as complex, low throughput bioassays for functional validation and verification.

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Can artificial intelligence help craft new medicines?

Drug Discovery World

Here, new bioassay technologies helped testing, but more definite answers were required. Expression patterns, proteomic profiles, bioassay results, and structures could now be captured en masse in normal and disease conditions. Thus, there was a dire need for new and effective drug targets.