Drug Discovery World

OCTOBER 3, 2023

Earlier this year, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

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Gene Therapy Gene Life Science Bioinformatics 52

Scienmag

AUGUST 4, 2020

Led by Boyce Thompson Institute’s Andrew Nelson, four partners will identify RNA modifications and develop resources that may lead to hardier crops Credit: Photo credit: Anna Nelson Dittrich ITHACA, NY, August 4, 2020 — RNA perform a variety of functions in cells, helping with everything from regulating genes to building proteins.

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RNA Bioinformatics Protein Regulation 74

Scienmag

JUNE 9, 2021

Researchers from CRAG and IRTA find the gene that determines Japanese plum skin colour due to the presence or absence of anthocyanins, a group of plant antioxidant pigments with health-promoting effects Credit: CRAG-IRTA The presence and accumulation of the antioxidant pigment anthocyanin dictates fruit hue in plums, and the synthesis of this compound (..)

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Gene Research Bioinformatics Production 89

Scienmag

SEPTEMBER 17, 2020

Bioinformatics platform simplifies data analysis to help biologists glean scientific insights into the novel coronavirus as body of data surges Scientists at Sanford Burnham Prebys Medical Discovery Institute today announced they have released Coronascape (coronascape.org), a customized version of the Metascape bioinformatics platform that removes (..)

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Big Data Bioinformatics Scientist Gene 90

Drug Discovery World

MAY 16, 2023

New South African company NewBiologix has launched with the aim of developing a proprietary and breakthrough platform for the advanced engineering of cell lines used to manufacture gene and cell therapies. NewBiologix is currently focused on recombinant adeno-associated virus (rAAV) vectors, the preferred delivery vehicle for gene therapies.

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Production Gene Therapy Gene Bioinformatics 52

Scienmag

SEPTEMBER 28, 2020

NIH-funded study points to genes that control the establishment of neural circuits during early development Credit: Courtesy of Dreamstime | ©Jarenwicklund.

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Gene Genetics Development Research 74

Scienmag

DECEMBER 18, 2020

A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down […]. . ¬- When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval.

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Gene Production Development Research 52

Scienmag

OCTOBER 5, 2020

Road trips result in the first shattering gene found in a wild population ST. LOUIS, MO — For years, Elizabeth (Toby) Kellogg, PhD, member and Robert E.

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Gene Research Bioinformatics Production 70

pharmaphorum

AUGUST 10, 2021

The three-year project – led by respiratory medicine expert Dr Timothy Hinks from the Oxford University Respiratory Medicine Unit – will use whole-genome sequencing of around 500 patients with severe asthma, comparing their gene sequences with control subjects who don’t have asthma.

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Gene Sequencing Bioinformatics Gene Genome 116

Scienmag

FEBRUARY 4, 2021

Study has big implications for management of bat populations Credit: Sarah Gignoux-Wolfsohn Scientists have found genetic differences between bats killed by white-nose syndrome and bats that survived, suggesting that survivors rapidly evolve to resist the fungal disease, according to a Rutgers-led study with big implications for deciding how to safeguard (..)

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Gene Genetics Scientist Bioinformatics 91

Scienmag

APRIL 27, 2021

Credit: Nigel Michki Neurons result from a highly complex and unique series of cell divisions. For example, in fruit flies, the process starts with stem cells that divide into mother cells (progenitor cells), that then divide into precursor cells that eventually become neurons.

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RNA Scientist Gene Development 98

Scienmag

JANUARY 29, 2021

In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the “wake-sleep” cycle.

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Gene Scientist Medicine Research 69

Drug Discovery World

NOVEMBER 17, 2022

Researchers have identified 35 genes associated with long-term Lyme disease that could potentially be used as biomarkers to diagnose patients with the condition. . The researchers also identified a subset of genes that were highly expressed but have not been previously established for this Lyme-associated inflammatory response. .

Genetics 52

Genetics RNA Immune Response Bioinformatics 52

XTalks

JULY 19, 2021

Phosphorus developed innovations in chemistry, bioinformatics and workflow to design a vertically integrated operating system for clinical genomics within their state-of-the-art CLIA and CAP certified clinical laboratory.

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Genetics Genome Genomics Gene 98

Drug Discovery World

OCTOBER 20, 2023

GenomeFrontier will use their virus-free cell and gene engineering platforms and Quantum Engine cell-engineering system to manufacture the CAR-T therapy for use in a Phase I clinical trial. Anders Grøn, CEO at Clinical Microbiomics, said: “We are a company made up of scientists – Innovation is at the heart of our DNA.

Drugs 52

Drugs Antibody DNA Gene Therapy 52

pharmaphorum

JULY 20, 2022

The two organisations have previously collaborated on the creation of three cancer therapeutics companies, including bacterial delivery system developer Neobe therapeutics, oncolytic virus therapy company Stratosvir, and bioinformatics specialist Enedra.

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Research Bioinformatics Gene Therapy Medicine 84

pharmaphorum

JULY 5, 2022

The new partnership will apply Mogrify’s cellular reprogramming and bioinformatics expertise to try to identify transcription factors – proteins which can turn specific genes on or off – that can be used to generate new cochlear hair cells. An estimated 1.57

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In-Vivo Bioinformatics Genetics Licensing 98

XTalks

SEPTEMBER 28, 2020

The test is based on the detection of actionable genes – genes with known driver mutations that can be targeted by an approved therapy (or investigational therapies in clinical trials). The panel of genes in the test only include known NSCLC-associated genes, making the test specific to the disease. Personalized Approach.

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Scienmag

JUNE 14, 2021

HOUSTON – (June 14, 2021) – In the two decades since the Human Genome Project mapped the entire human genome, improvements in technology have helped in developing updated reference genomes used for sequencing.

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Genome Genomics Genome Project Gene 40

pharmaphorum

JANUARY 19, 2022

The process enables researchers to examine the transcriptome – the sum total of all the messenger RNA molecules expressed from the genes of an organism – of individual cells, which gives them information that might otherwise escape scrutiny. Developments in the sector have already led to significant scientific breakthroughs.

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RNA Research Life Science Bioinformatics 72

Drug Discovery World

NOVEMBER 30, 2023

Cell and gene therapy developer eXmoor pharma has hired Matthew Paterson as the company’s first Chief Commercial Officer, moving on from 18 years at Quotient Sciences. She is currently Professor of Structural Bioinformatics at the University of Oxford and Chief AI Officer at Exscientia.

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Drugs Genome Genomics Bioinformatics 52

Scienmag

DECEMBER 16, 2020

Comparative analysis of human and animal coronaviruses strains implicates miR1307 PHOENIX, Ariz. — Dec. 15, 2020 — The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has identified a specific genetic target that could help explain the tremendous variation in how sick those infected with COVID-19 become.

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Drug Discovery World

OCTOBER 7, 2022

To investigate the immune environment that surrounds these chemotherapy-resistant tumours, the researchers employed multiple and novel complementary technologies looking at proteins and genes on both pre-treatment and post-treatment breast cancer tissue. Developing immunotherapies for high-risk breast cancer patients.

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Research Immune Response Gene Bioinformatics 52

Drug Discovery World

APRIL 18, 2023

Among individuals who consented to whole-exome sequencing and were identified as carriers of predisposition genes for hereditary breast and ovarian cancer (HBOC) or Lynch syndrome, 39.2% Read more here. Read more about AACR award winners here.

Genetics 52

Genetics DNA Research Bioinformatics 52

Scienmag

MAY 27, 2021

Capturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function.

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Gene Expression RNA DNA Protein 41

Scienmag

JULY 1, 2021

Almost twenty years ago, the process of RNA silencing was discovered in plants, whereby small fragments of RNA inactivate a portion of a gene during protein synthesis.

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RNA Protein Research Gene 60

Drug Discovery World

OCTOBER 26, 2023

The technologies cover the whole range of biomolecules from genes to protein to metabolites. All statistical algorithms in PanHunter are peer-reviewed, ensuring that the results are trustworthy and reproducible by users with all levels of bioinformatic skills.

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Drugs Protein Genome Genomics 52

Scienmag

DECEMBER 1, 2020

– A team of biomedical engineers at Duke University has created a new way to turn stem cells into a desired cell type by mastering the language of gene regulatory networks. Tagging produces detailed catalog of transcription factors key to making each cell type Credit: Gersbach Lab, Duke University DURHAM, N.C.

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Engineer Gene Bioinformatics 52

The Pharma Data

SEPTEMBER 11, 2021

This precise and rational approach to library fabrication combined with sophisticated bioinformatics and software expertise expedites antibody discovery by decreasing risk, increasing speed, and lowering the failure rate for antibody therapeutic development. About Twist Bioscience Corporation.

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Drug Discovery World

JULY 29, 2022

Scientists modelling the cancer-suppressing p53 gene identify how the 20 different molecules unique to elephants get activated for increased sensitivity and response against carcinogenic conditions – with implications for cancer treatments in humans. The post Could elephant genes hold the key to avoiding cancers?

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Gene DNA Protein Genetics 52

Drug Discovery World

JUNE 7, 2023

That’s why at Macomics we have developed the ENIGMAC discovery platform, which allows stringent bioinformatic analysis coupled with macrophage gene editing technology; our platform enables strong target validation and drug screening using biologically relevant functional assays.

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In-Vivo Gene Editing Engineer Bioinformatics 52

Drug Discovery World

OCTOBER 25, 2023

I started my career in a molecular genetics diagnostics laboratory in the NHS and I remember NGS just starting to be evaluated for routine use for every sample that came into the lab, rather than us having to examine single mutations in single genes. The post The use-case for NGS appeared first on Drug Discovery World (DDW).

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Bioinformatics Genetics RNA Drugs 115

Drug Discovery World

JULY 26, 2023

With 100-fold the number of genes in the human genome 1 , this microbial collection is a rich genetic signature of clinical significance that we have only recently gained the tools to explore. Collectively, these systems biology bioinformatic puzzles often require partnerships to solve.

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Medicine Genome Genomics Bioinformatics 52

Drug Discovery World

FEBRUARY 6, 2023

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care.

Big Data 52

Big Data RNA Bioinformatics Vaccination 52

pharmaphorum

APRIL 15, 2021

We have a pipeline of novel therapeutics and technological approaches, advancing a diverse array of candidates, including small molecules, biologics and cell and gene therapies, so a lot of the time we are working where there’s little, or no precedent.”. In principle, this goes beyond medicines.

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Development Manufacturing Production Bioinformatics 61

Drug Discovery World

APRIL 14, 2023

He is being recognised for his revolutionary contributions to developing the first gene-edited cell-based therapy for cancer that involves the genetic re-engineering of a patient’s own T cells to combat their disease, and for demonstrating that adoptive T-cell therapy can induce remission and in some cases cure patients with advanced cancer.

Genetics 52

Genetics Research Medicine Clinical Research 52

Scienmag

MAY 14, 2021

The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including […].

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Gene Expression Bioinformatics Gene Research 63