Scienmag

MARCH 25, 2021

Decade-long search uncovers genes responsible for lacunar strokes, a major cause of vascular dementia Scientists have identified new genetic clues in people who’ve had small and often apparently ‘silent’ strokes that are difficult to treat and a major cause of vascular dementia, according to research funded by the British Heart Foundation (..)

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Genetics Gene Scientist Research 75

Medical Xpress

NOVEMBER 14, 2022

Ten months after transplanting the first genetically-modified pig heart into a human patient, University of Maryland School of Medicine (UMSOM) researchers continue to report on new findings from the landmark transplant.

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Genetics Medicine Research Cardiology 65

Scienmag

JULY 13, 2021

Circulation: Genomic and Precision Medicine Journal Report DALLAS, July 13, 2021 — Sharing the results of genetic testing for cardiomyopathy in adolescents ages 13-18 does not appear to cause emotional harm to families or adversely impact family function or dynamics, according to new research published today in Circulation: Genomic and Precision (..)

Genetics 75

Genetics Genome Genomics Medicine 75

Medical Xpress

MAY 1, 2023

To get an inside look at the heart, cardiologists often use electrocardiograms (ECGs) to trace its electrical activity and magnetic resonance images (MRIs) to map its structure. Because the two types of data reveal different details about the heart, physicians typically study them separately to diagnose heart conditions.

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Scienmag

MAY 5, 2021

Study published in JAMA Cardiology Credit: UIC/Jenny Fontaine A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.

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Cardiology Genetics Gene Research 53

Scienmag

APRIL 28, 2021

In a world first study of 390,435 people, University of South Australia researchers found causal genetic evidence that cardio health […].

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Genetics Research Cardiology Gene 52

Pharmaceutical Technology

SEPTEMBER 21, 2022

Renovacor focuses on offering precision treatments for genetic cardiovascular and mechanistically-related ailments. Building on our success in Danon Disease to date, I am particularly excited to expand our cardiology focus and capabilities and address a clear unmet medical need in BAG3-associated dilated cardiomyopathy. “By

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Gene Therapy Gene Cardiology Genetics 147

Scienmag

AUGUST 20, 2020

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can […]. (..)

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Genetics Gene Genome Genomics 41

Scienmag

NOVEMBER 18, 2020

— Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. ROCHESTER, Minn. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease ?

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Genetics RNA Protein Research 40

STAT News

AUGUST 4, 2022

When coronary arteries are blocked, starving the heart of blood, there are good medications and treatments to deploy, from statins to stents. Not so for heart failure, the leading factor involved in heart disease, the top cause of death worldwide. “It’s what’s on death certificates,” said cardiologist Christine Seidman.

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Drug Discovery World

AUGUST 7, 2023

Together, Evox and Icahn Mount Sinai are focused on tackling a long-standing challenge in cardiovascular medicine, namely the safe and effective delivery of genetic medicines to cardiomyocytes.

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Gene Therapy Gene Research In-Vivo 52

Scienmag

MARCH 31, 2021

Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure Credit: In-Hyuk Jung, PhD, Stitziel Lab High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke.

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Scientist Genetics Gene Medicine 62

Medical Xpress

NOVEMBER 21, 2022

Hypertrophic obstructive cardiomyopathy (HOCM) is a common genetic condition that can cause fatigue, shortness of breath, fainting and chest pain, according to the American Heart Association.

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Genetics Cardiology 98

Medical Xpress

JANUARY 26, 2023

Research in a mouse model of diet-induced obesity has found greater disruption to genes involved in heart function when coupled with vitamin A deficiency using a combined dietary and genetic approach. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.

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Genetics Gene Research Cardiology 105

Medical Xpress

MAY 8, 2023

Asian Americans have significant differences in genetics, socioeconomic factors, culture, diet, lifestyle, health interventions and acculturation levels based on the Asian region of their ancestry that likely have unique effects on their risk for heart disease and Type 2 diabetes, according to a new American Heart Association scientific statement published (..)

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Genetics Cardiology 85

Scienmag

AUGUST 31, 2020

Sophia Antipolis, France – 31 Aug 2020: Losing weight could prevent or even reverse diabetes, according to late breaking research presented today at ESC Congress 2020.1 In 2019, approximately 463 million people worldwide had diabetes, of which the vast majority (around 90%) was type 2 diabetes.2

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Genetics Research Cardiology Medicine 72

The Pharma Data

OCTOBER 27, 2021

Appointment further strengthens Board scientific capabilities, including in genetics which is central to GSK’s R&D approach. Dietz MD, Professor of Genetic Medicine at The Johns Hopkins University School of Medicine in the United States, will join the Board of the Company as a Non-Executive Director. Dr Hal Dietz is Victor A.

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Genetics Medicine Cardiology Scientist 52

Medical Xpress

FEBRUARY 6, 2023

A genetic score may be able to identify higher stroke risk—but only for people living in the most privileged neighborhoods, according to new research that highlights inequities related to wealth and health.

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Gene Genetics Research Cardiology 75

Scienmag

JUNE 3, 2021

Conducted in partnership with the University of Reading, the world-first study used a genetic-approach to investigate causal […].

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Scienmag

FEBRUARY 24, 2021

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. Credit: UEF/Raija Törrönen.

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Scienmag

DECEMBER 10, 2020

Jefferson researchers find that the genetic underpinnings of a skin disorder at birth indicate future heart problems PHILADELPHIA – Our skin tells us when we’ve spent too much time in the sun or when the dry air of winter has sucked away too much moisture.

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Genetics Research Dermatology Cardiology 75

Scienmag

FEBRUARY 17, 2021

In a world first genetic study, researchers from the Australian Centre for Precision Health at the University of South Australia found that that long-term, […].

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Genetics Research Cardiology Medicine 65

Scienmag

APRIL 20, 2021

Researchers at Penn Medicine uncover more genetic mutations that predispose women to peripartum cardiomyopathy, with implications for the future of increased genetic testing PHILADELPHIA– Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), (..)

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Scienmag

MAY 17, 2021

Patients’ genetic profile strongly influences size of effect in early-phase trial People with extremely high levels of triglycerides (a type of fat in the blood) and a specific genetic profile saw a substantial reduction in triglycerides after taking the human monoclonal antibody evinacumab compared with those taking a placebo, in a study presented (..)

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Scienmag

DECEMBER 3, 2020

In a randomized, controlled clinical trial, researchers found that patients who received genetic test results about the side effects of cholesterol-lowering medications did not have worse outcomes after one year A person’s genetic make-up can influence whether they might experience side effects from certain medications.

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Clinical Trials Clinical Trials Trials Genetics 44

The Pharma Data

OCTOBER 22, 2020

Pre-pregnancy care for a woman with known aortic disease would include evaluation of maternal and fetal risk, counseling and possible genetic testing, followed by ongoing monitoring and testing, study co-author Dr. Melinda Davis, a cardio-obstetrics expert at University of Michigan Medicine, said in a university news release. Source link.

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Cardiology Hormones Genetics Research 52

Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome. In recent years, the mix of these resident bacteria, and the […].

Bacteria 74

Bacteria Genetics Scientist Cardiology 74

Scienmag

OCTOBER 15, 2020

Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease Credit: Photo: Gladstone Institutes SAN FRANCISCO, CA–October 15, 2020–The National Institutes of Health (NIH) has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, (..)

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DNA Genetics Scientist Research 54

Scienmag

DECEMBER 3, 2020

are entering into a collaboration to sequence the complete human genomes of thousands of consenting patients, in order to identify genetic alterations driving […].

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Genome Genomics Medicine Genetics 52

Scienmag

FEBRUARY 17, 2021

A leading cause of SCD in young athletes is arrhythmogenic cardiomyopathy (ACM), a genetic disease in which healthy heart muscle is replaced over time […]. Credit: Mark Bauer/FSU College of Medicine Nearly a half-million people a year die from sudden cardiac death (SCD) in the U.S.

Medicine 55

Medicine Genetic Disease Development Genetics 55

Scienmag

JANUARY 14, 2021

14, 2021 — Adults who smoke or who are genetically predisposed to smoking behaviors are more likely to experience a serious type of stroke called subarachnoid hemorrhage (SAH), according to new research published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association. […].

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Genetics Research Cardiology Medicine 46

XTalks

FEBRUARY 19, 2024

Aging, unhealthy lifestyles and genetics increase the risk of heart-related conditions. Related: Top 15 Cardiovascular Disease Drugs in 2023 by 2022 Sales Data Understanding Cardiovascular Disease Trends The US faces a worrying trend in cardiovascular disease, affecting a large part of the population.

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pharmaphorum

AUGUST 13, 2020

Adding in Regeneron’s antibody resulted in a 49% drop in cholesterol levels from the start of the study compared to patients sticking with their current therapy alone, according to results presented earlier this year at the American College of Cardiology’ congress in March.

Drugs 52

Drugs Antibody Sales Cardiology 52

Scienmag

DECEMBER 3, 2020

Using a new variant to repair DNA will improve both safety and effectiveness of the much-touted CRISPR-Cas9 tool in genetic research, Michigan Medicine researchers say. Eugene Chen, M.D., […].

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Gene Editing Gene DNA Genetics 41

The Pharma Data

AUGUST 30, 2021

Wilson disease is a rare and progressive genetic condition in which the body’s pathway for removing excess copper is compromised. Wilson disease is a rare and progressive genetic condition in which the body’s pathway for removing excess copper is compromised. Wilson disease. 1 It affects one in 30,000 live births in the US.

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Trials Genetics Cardiology Medicine 52

The Pharma Data

JANUARY 5, 2021

.” “They are frequently hospitalized and often undergo multiple invasive procedures or surgeries early in childhood and throughout their lifetime,” said Dr. Vincent Gonzalez, a pediatric cardiology fellow at Baylor College of Medicine/Texas Children’s Hospital in Houston.

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Cardiology Doctors Doctor Genetics 52

Delveinsight

DECEMBER 29, 2020

X-linked myotubular myopathy (XLMTM) is a rare genetic neuromuscular disorder and leads to muscle weakness, respiratory failure, and early death. The ASPIRO trial is a two-part, open-label ascending dose study, and is examining the safety and preliminary efficacy of AT132 in children with XLMTM younger than five years old.

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Trials Drugs Hormones Radiology 52