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Taking a new approach to tackle neurodegenerative diseases

Drug Discovery World

New York-based Oligomerix is an emerging clinical-stage biotechnology company focused on developing disease-modifying therapeutics for neurodegenerative diseases characterised by aberrant tau protein ranging from rare tauopathies such as progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) to Alzheimer’s disease (AD).

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Informatics helps virtual biotech bring compound to clinical trial

Drug Discovery World

With no in-house laboratory space, the company works closely with multiple international contract research organisations (CROs), including Axxam, which carry out all of the Libra R&D, from compound screening assays, to in vivo pharmacokinetic/pharmacodynamic and ADME work, as well as in vitro and in vivo pre-clinical safety assessments.

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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

We suggest a new generation of screening assays, that better recapitulate the electrophysiology of the whole human heart, may allow better decisions across research and development. A more recent analysis has illustrated how both assay validity and reproducibility correlate across a population of simulated screening and disease models 2.

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