Evaluating methods targeting Protein-Protein Interactions

Pharma Phorum

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins.

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) Drugs In Development, 2021 Research Report – ResearchAndMarkets.com

BioTech 365

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) Drugs In Development, 2021 Research Report – ResearchAndMarkets.com Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) Drugs In Development, 2021 Research Report – ResearchAndMarkets.com DUBLIN–(BUSINESS WIRE)–The “Bromodomain Containing Protein 4 (Protein HUNK1 … Continue reading → Business Wire

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Could High-Protein Iced Tea Be the Next Big Beverage Trend?

XTalks

One such fusion beverage is high-protein iced tea – a functional, refreshing beverage that has the potential to be the next big beverage trend. Alone, iced tea contains antioxidant properties, making it a popular choice for those seeking a healthy drink.

Protein fingerprinting in minutes

Scienmag

New technology enables ultrafast identification of COVID-19 biomarkers Credit: Photo: Arne Sattler/Charité Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes.

Latest Data from Novavax COVID-19 Vaccine Trial Involving B.1.351 Variant Shared by Protein Vaccine Maker

XTalks

As Novavax awaits emergency use authorization (EUA) from the US Food and Drug Administration (FDA) for its protein-based COVID-19 vaccine NVX-CoV2373, the company shared new data this week on the vaccine’s efficacy against the South African B.1.351 variant.

Are Animal-Free Dairy Products Considered Vegan?

XTalks

Renegade Creamery makes plant-based cheese but adds milk proteins produced in strains of yeast and bacteria and uses an “artisan fermentation process.” Brave Robot uses Perfect Day’s non-animal whey protein to make their ice cream.

Why Plant-Based Meat Safety Differs From That of Animal Protein

XTalks

But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. For example, the Allergen Bureau indicated a possible connection between pea protein and peanut allergies.

Radioligand therapy pipeline with in-license for compounds targeting Fibroblast Activation Protein (FAP)

The Pharma Data

Basel, March 30, 2021 — Novartis has obtained exclusive worldwide rights to develop and commercialize therapeutic applications for a library of Fibroblast Activation Protein (FAP) targeting agents including FAPI-46 and FAPI-74, through an assignment agreement with iTheranostics, Inc.,

WORLD’S LARGEST BROWSABLE RESOURCE LINKING RARE PROTEIN-CODING GENETIC VARIANTS TO HUMAN HEALTH AND DISEASE

The Pharma Data

Today, access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie (NYSE: ABBV), Biogen Inc.

Evotec Achieves Key Milestones in Its Collaboration with Bristol Myers Squibb On Targeted Protein Degradation

The Pharma Data

HAMBURG, GERMANY / ACCESSWIRE / December 17, 2020 / Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) today announced that the Company has achieved key milestones in its partnership with Bristol Myers Squibb in the field of targeted protein degradation with the first two targets transitioning into drug discovery after completing a comprehensive target validation process.

Company Spotlight: Cue Biopharma Innovates in the Immunotherapy Space with its Immuno-STAT Platform

XTalks

protein-based biologics) and vaccine treatments. protein-based biologics) : are those which bind to specific components (i.e. The Immuno-STAT Platform: Cell-Independent Protein Design.

Will People Eat Nuggets for Breakfast? Jimmy Dean Thinks So

XTalks

However, Jimmy Dean has introduced a nugget with the same shape as ones found in your favorite fast-food restaurants but contain different ingredients and flavors. Each serving has around 11 grams of protein.

Collaboration between AbbVie, Biogen and Pfizer creates world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease

The Pharma Data

The access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie (NYSE: ABBV), Biogen Inc.

Novavax Announces Agreement with Government of New Zealand for 10.7 Million Doses of COVID-19 VaccineAdvance purchase agreement signed for NVX-CoV2373, Novavax’ adjuvanted protein vaccine candidate

The Pharma Data

Currently in Phase 3 clinical testing in the United Kingdom for the prevention of COVID-19, NVX-CoV2373 is a recombinant protein vaccine adjuvanted with Novavax’ proprietary Matrix-M to enhance the immune response. GAITHERSBURG, Md., 16, 2020 (GLOBE NEWSWIRE) — Novavax , Inc.

Artelo Biosciences Files Patent on Use of Fatty Acid Binding Protein 5 Inhibitors for Treating Psychological DisordersReports positive preclinical data in animal models

The Pharma Data

Patent and Trademark Office covering the use of Fatty Acid Binding Protein 5 (FABP5) inhibitors for the treatment of psychological disorders such as anxiety and post-traumatic stress disorder (PTSD). LA JOLLA, Calif., 21, 2020 (GLOBE NEWSWIRE) — Artelo Biosciences , Inc.

A better tool for the job: Laser-based technique to elucidate the mysteries of exosomes

Scienmag

Undergraduate students explore a more efficient way to measure protein-containing vessels released by cells Credit: DGIST Despite our great progress in understanding various cellular mechanisms over the last decades, many of them remain unclear.

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New research will allow convenient investigation of human innate immune response to viral infections

Scienmag

(Boston)–Researchers from Boston University School of Medicine (BUSM) report the formation of human cells containing a green fluorescent protein or GFP (one of the most important proteins in biology and fluorescence imaging) genetically fused with two interferon stimulated genes (ISGs), namely Viperin and ISG15.

Precise acousto-electric sorting of submicron cell-secreted extracellular vesicles

Scienmag

They contain biological information such as ribonucleic acid and proteins which can be transferred to not only local cells, but also to remote cells since they circulate through most of the body fluids such as blood and […].

The structure of DNA is found to be actively involved in genome regulation

Scienmag

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […].

Folding of SARS-CoV2 genome reveals drug targets — and preparation for ‘SARS-CoV3’

Scienmag

It contains the information for the production of 27 proteins. This is not much compared to the possible 40,000 kinds of protein that a […]. Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. Medicine & Health Infectious/Emerging Diseases Medicine/Health Molecular Biology Virology

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World Egg Day 2021: What’s New in Egg Innovation?

XTalks

Held each year on the second Friday in October, World Egg Day is meant to celebrate the significance of eggs as one of the world’s oldest sources of protein. The product contains soy protein and omega-3 fatty acids and is part of Nestlé’s wider aim to focus on health and sustainability.

DNA-peptide interactions create complex behaviours which may have helped shape biology

Scienmag

Credit: Tommaso P Fraccia Deoxyribonucleic acid (DNA)-protein interactions are extremely important in biology. For example, each human cell contains about 2 meters worth of DNA, but this is […].

Superfoods, Super You!

Riverside Clinical Research

Whole grains contain tons of minerals, vitamin B and phytonutrients which are known to lower cholesterol and protect against heart disease and diabetes. Legumes can be a great source of fiber, folate and protein which can reduce the risk of heart disease.

Using PK Modeling and Simulation to Plan Studies for Pediatric Patient Populations

Camargo

If the model does not contain covariates relevant for young patients, they are added to the model based on the known information.

Parkinson’s and Melanoma Share an Amyloid Link, Says New Research

XTalks

synuclein, a protein involved in the formation of amyloid deposits in the brain characteristic of Parkinson’s disease and other neurodegenerative disorders, is also implicated in melanoma. What’s more, the protein involved in Parkinson’s disease, ?-synuclein,

Nestlé Set To Launch Low-Sugar Cereal Amid Healthy Cereal Craze

XTalks

Nestlé Cereals, a UK division of the international food giant, recently announced the launch of Cheerios Vanilla O’s, a low-sugar cereal that contains no artificial colors or flavors. Each of its six, nostalgia-inducing flavors is low in carbs, high in protein, keto-friendly and sugar-free. .

Say Hello to Hilo Life: PepsiCo’s New Keto Snack

XTalks

Food and beverage giant PepsiCo recently launched Hilo Life , a keto snack that looks like a Dorito but contains more protein and fewer carbohydrates. Hilo Life also contains only three grams of net carbohydrates and zero grams of added sugar per one-ounce bag. “We

WunderEggs: The World’s First Plant-Based Hard-Boiled Eggs

XTalks

Nutritionally, they contain around the same amount of saturated fat as real eggs, minus the cholesterol. However, WunderEggs contain slightly more calories and less protein than real eggs, which Crafty Counter is hoping to improve upon for the second version of the product.

Nature’s Fynd: The Billionaire-Backed Alt Meat Derived from a Volcanic Microbe

XTalks

Along with a team of scientists, Kozubel fermented the microbe into a protein-rich substance and dubbed it “Fy.” While many faux meats tend to use soy, pea and other plant-based proteins, Fy is the foundation of Nature’s Fynd products.

Greenwich LifeSciences to Participate in Multiple Virtual Investor Conferences During 2021 JP Morgan Healthcare Week

The Pharma Data

HER2/ neu (human epidermal growth factor receptor 2) protein is a cell surface receptor protein that is expressed in a variety of common cancers, including in 75% of breast cancers at low (1+), intermediate (2+), and high (3+ or over-expressor) levels. 8, 2021 11:00 UTC.

Egg Without the Chicken: How Clara Foods is Cracking Animal-Free Eggs

XTalks

While Clara Foods, a leader in animal-free proteins, worked for years to replicate the taste, function and proteins of eggs without the chickens, scaling the product has been difficult — until now.

Halo Top is Adding Low-Calorie Frozen Fruit Pops to its Lineup

XTalks

The frozen treats are made with real fruit and fruit juice and contain up to 65 percent less sugar than other frozen fruit desserts. Coconut: Made with coconut cream, dehydrated coconut, skim milk and stevia, the coconut flavor contains 90 calories and 9 grams of sugar.

Is Electrolyte Beer the Next Big Beverage Trend?

XTalks

There is no shortage of post-workout drinks on the market, including innovative new additions to the category, like high-protein chocolate milk to sports drinks made with upcycled dairy byproducts.

Mmmly: The Newest Plant-Based, Functional Cookie Brand

XTalks

Each serving contains five to six grams of prebiotic fiber, 4 grams of net carbohydrates and only 2 grams of added sugar. In October, 2020, Deux Foods released a line of functional cookie dough called DEUX, enhanced with vitamins, collagens and protein.

EFSA Finds Mealworms Safe for Human Consumption, But Will Consumers Agree?

XTalks

The EFSA’s decision is the first step in heralding in EU-wide approval of snacks and other foods containing the insect as an ingredient. A source of protein, fat and fiber, mealworms also show promise as a sustainable source of food for generations to come.

The Silent Mutations That Gave Coronavirus a Selective Advantage

XTalks

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. Previous research found fingerprints of positive selection within a gene that encodes the spike proteins.

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Arvinas, Inc. Announces Pricing of $400 Million Public Offering of Common Stock

The Pharma Data

Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation using its PROTAC ® Discovery Engine, today announced the pricing of an underwritten public offering of 5,714,286 shares of its common stock at a price of $70.00

Brochure: Dynabeads manual and automated SARS-CoV-2 enrichment

The Pharma Data

Cell culture for virus isolation also remains a useful method for growing and studying viruses in research settings especially in the characterization of novel pathogenic viruses like SARS-CoV-2 although this requires more advanced containment facilities such as biosafety level 3 (BSL-3).

WunderEggs Plant-Based Hard-Boiled Eggs + Animal-Free Dairy Products – Xtalks Food Podcast Ep. 26

XTalks

She introduces the team Renegade Creamery, Perfect Day and Brave Robot, three companies that have developed dairy products that contain the same proteins as animal milk without raising livestock and collecting their milk. Are WunderEggs the world’s first plant-based hard-boiled eggs?

What Is Chronic Kidney Disease and What Are Some Conditions Commonly Associated with It?

Riverside Clinical Research

The diagnosis of chronic kidney disease typically includes kidney function and flow tests, hormone testing, urine tests for blood or protein, an ultrasound to look for obstructions and possibly a kidney biopsy. Nutrition management includes a low salt, low potassium, low protein diet.

Cinnabon and Nestlé Launch Cinnamon-Flavored Nutritional Drink

XTalks

This nutritional beverage is 240 calories, contains 10 grams of protein and includes 21 vitamins and minerals while providing users with the famous flavors of Cinnabon’s cinnamon rolls.

New CRISPR-Based Rapid COVID-19 Test Can Detect SARS-CoV-2 Variants

XTalks

Moreover, studies show that saliva samples can contain a marginally higher SARS-CoV-2 viral load compared with nasopharyngeal samples (shown in a study involving hospitalized patients), and that the virus can be detected in saliva for a greater number of days post-infection.

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Novavax’s COVID-19 Vaccine is Over 90 Percent Effective Overall, Including Against Variants

XTalks

The company’s candidate recombinant nanoparticle protein-based COVID-19 vaccine, NVX-CoV2373, is being evaluated in the PREVENT-19 (the PRE-fusion protein subunit Vaccine Efficacy Novavax Trial COVID-19) Phase III trial, which has close to 30,000 participants across 119 states in the US and Mexico.