Development and Vaccination - Clinical Research Informer

Moderna leads the development of mRNA vaccines in infectious diseases

Pharmaceutical Technology

JANUARY 29, 2024

The rapid sequencing of the SARS-CoV-2 and the subsequent development of mRNA vaccines led to the authorisation of the first of these vaccines in late 2020.

Vaccination

Vaccination Vaccine Development

Sanofi signs mRNA vaccine development deal with IDT Australia

Pharmaceutical Technology

APRIL 16, 2024

Sanofi has signed an agreement with IDT Australia for preclinical formulation development of its messenger RNA (mRNA) vaccines.

Vaccination

Vaccination Vaccine Development RNA

BioNTech targets infectious diseases for vaccine development

Pharmaceutical Technology

MARCH 28, 2023

Following on from its Covid-19 vaccine programmes, BioNTech has set its sights on a range of infectious diseases for vaccine development. The company saw major successes with its Covid-19 vaccine, developed in collaboration with Pfizer. In response to the lower vaccine sales forecasts, BioNTech shares opened at 3.9%

Vaccination

Vaccination Vaccine Development Clinical Trials

Intravacc, Primrose to advance conjugate vaccine development

Pharmaceutical Technology

MARCH 29, 2024

Intravacc and Primrose Bio have announced a strategic collaboration aimed at bolstering the conjugate vaccine development and supply.

Vaccination

Vaccination Vaccine Development

US launches $5bn effort for new Covid-19 vaccines development

Pharmaceutical Technology

APRIL 11, 2023

The US government is reportedly investing more than $5bn in a programme to accelerate the development of new Covid-19 vaccines and treatments. Health experts have lent their support to the new programme as the existing vaccines may not be as effective against future virus threats.

Vaccination

Vaccination Vaccine Development Antibody

Evaxion Biotech to develop new vaccines for cancer

Pharmaceutical Technology

JANUARY 25, 2024

Evaxion Biotech has announced plans to develop customised cancer vaccines by targeting a category of AI-discovered tumour antigens.

Vaccination

Vaccination Vaccine Development

Oragenics secures CQDM funding for Covid-19 vaccine antigen development

Pharmaceutical Technology

JUNE 6, 2023

Oragenics has secured funding from the Canadian bioresearch consortium CQDM to develop a variant-agnostic protein antigen for use in its Covid-19 intranasal vaccine. In March 2023, Oragenics and Inspirevax entered an exclusive global licence deal to develop the former’s lead intranasal Covid-19 vaccine candidate, NT-CoV2-1.

Vaccination

Vaccination Vaccine Development Manufacturing

LimmaTech secures funding for vaccine technology development

Pharmaceutical Technology

FEBRUARY 2, 2024

LimmaTech announced the closing of a second round of its Series A financing, securing $3m from Tenmile for vaccine technology development.

Vaccination

Vaccination Vaccine Development

RVAC and University of Pennsylvania to develop mRNA vaccines

Pharmaceutical Technology

MARCH 20, 2023

RVAC Medicines has announced a research collaboration with the University of Pennsylvania (Penn) for the discovery and development of mRNA vaccines. The mRNA vaccine candidates will help reduce the chances of autoimmune responses that might lead to allergic conditions or serious autoimmune diseases.

Vaccination

Vaccination Vaccine Development Allergies

Merck and Moderna partner to develop and sell cancer vaccine

Pharmaceutical Technology

OCTOBER 14, 2022

German pharmaceutical firm Merck has extended its partnership with Moderna to jointly develop and sell mRNA-4157/V940, an investigational personalised cancer vaccine (PCV). In 2016, the companies entered a strategic partnership to develop novel messenger RNA (mRNA) based PCVs.

Vaccination

Vaccination Vaccine Development Immune Response

Breaking barriers: Advances and challenges in therapeutic cancer vaccines

Bio Pharma Dive

APRIL 1, 2024

The development of cancer vaccines has provided some hope in the battle against cancer worldwide; however, there are still many challenges to overcome when developing these life-saving treatments.

Vaccination

Vaccination Vaccine Development

Seattle institute lands $18m funding to develop RNA vaccine for chikungunya

Pharmaceutical Technology

AUGUST 3, 2023

AAHI is developing a novel RNA vaccine that overcomes manufacturing and storage limitations to increase accessibility.

RNA

RNA Vaccination Vaccine Development

Merck stops coronavirus vaccine development in surprise setback

Bio Pharma Dive

JANUARY 25, 2021

The drugmaker, one of the largest vaccine developers globally, won't move forward with either of two candidates it's been testing after disappointing data in early trials.

Vaccination

Vaccination Vaccine Development Trials

XtalPi and CK Life Sciences to develop AI-driven tumour vaccine R&D platform

Pharmaceutical Technology

NOVEMBER 25, 2022

XtalPi has entered a strategic partnership with CK Life Sciences for artificial intelligence (AI)-driven tumour vaccine research and development (R&D). Under the collaboration, the companies will utilise their capabilities to co-develop a new AI tumour vaccine R&D platform.

Life Science

Life Science Vaccination Vaccine Development

CureVac and MD Anderson Cancer Center partner to develop new cancer vaccines

Pharma Times

APRIL 19, 2024

Both will develop cancer vaccine candidates in selected haematological and solid tumour indications

Vaccination

Vaccination Vaccine Development

GreenLight and US NIH partner to develop Covid-19 vaccine for variants

Pharmaceutical Technology

AUGUST 1, 2022

GreenLight Biosciences has entered a partnership with the US National Institutes of Health (NIH) for the development of Covid-19 vaccines, which offer broader protection against new variants and with durable effects. They intend to develop vaccines that provide lasting immune responses compared to existing vaccines.

Vaccination

Vaccination Vaccine Development RNA

SK bioscience and Hilleman to develop Ebola-Zaire virus vaccine

Pharmaceutical Technology

NOVEMBER 23, 2023

SK bioscience has signed an agreement with Hilleman Laboratories Singapore for the co-development of a vaccine against the Zaire Ebola virus.

Vaccination

Vaccination Vaccine Development

BioNTech and CEPI partner to develop Mpox vaccine

Pharmaceutical Technology

SEPTEMBER 19, 2023

BioNTech has entered a strategic collaboration with the CEPI to develop mRNA-based vaccine candidates for monkeypox (Mpox ) prevention.

Vaccination

Vaccination Vaccine Development

Cancer Research UK and CRIS fund lung cancer vaccine research

Pharmaceutical Technology

MARCH 25, 2024

Cancer Research UK and the CRIS Cancer Foundation have awarded a £1.7m ($2.1m) grant for developing the lung cancer vaccine LungVax.

Vaccination

Vaccination Vaccine Research Development

Evaxion partners with Afrigen Biologics to develop mRNA gonorrhea vaccine

Pharmaceutical Technology

SEPTEMBER 21, 2023

The collaboration will use Evaxion’s EDEN platform to bring an AI-designed gonorrhea mRNA vaccine to the market.

Vaccination

Vaccination Vaccine Development Marketing

IAVI and Biofabri sign deal for TB vaccine candidate development

Pharmaceutical Technology

MAY 18, 2023

International non-profit research organisation IAVI and Zendal Group’s subsidiary Biofabri have signed an expanded deal to develop MTBVAC, a tuberculosis (TB) vaccine candidate. The organisation and the company initially collaborated in 2021 to advance the vaccine candidate into efficacy trials.

Vaccination

Vaccination Vaccine Development Trials

Human infection model drives forward TB vaccine development

Drug Discovery World

APRIL 18, 2024

For the first time, a controlled human infection model for tuberculosis (TB) has been developed and could help with the future development of TB vaccines. The team states that it’s the first step towards establishing a challenge model that can be used to test new vaccines for TB.

Vaccination

Vaccination Vaccine Development Bacterium

Naobios and Sumagen partner to develop HIV vaccine

Drug Discovery World

APRIL 15, 2024

Naobios has signed a partnership agreement with Sumagen, a Korean-Canadian biotechnology company developing an HIV-1 vaccine candidate, to manage the manufacturing process during its Phase II clinical trials. At the end of 2022, the World Health Organization (WHO) reported that approximately 39 million people were living with HIV.

Vaccination

Vaccination Vaccine Development Clinical Trials

IISc develops heat-tolerant vaccine for protection against different strains of SARS-CoV-2 & future variants

AuroBlog - Aurous Healthcare Clinical Trials blog

JANUARY 22, 2024

The Indian Institute of Science (IISc) is now developing a heat-tolerant vaccine that can offer protection against different strains of SARS-CoV-2 – both current and future variants. The research […]

Vaccination

Vaccination Vaccine Development Research

Intravacc gets NIAID contract for intranasal gonorrhoea vaccine development

Pharmaceutical Technology

OCTOBER 6, 2022

from the US National Institutes of Health (NIH) unit National Institute of Allergy and Infectious Diseases (NIAID) to develop a prophylactic intranasal vaccine against Neisseria gonorrhoeae (NG). Leveraging its outer membrane vesicles (OMV) platform technology, Intravacc will develop the vaccine.

Vaccination

Vaccination Vaccine Development Bacterium

US HHS grants $1.4bn for Covid-19 vaccines development

Pharmaceutical Technology

AUGUST 23, 2023

The US HHS has granted over $1.4bn for Project NextGen to facilitate the development of new vaccines and therapeutics for Covid-19.

Vaccination

Vaccination Vaccine Development

SK Bioscience and Vaxxas partner to develop needle-free typhoid vaccine patch

Pharmaceutical Technology

AUGUST 24, 2023

The companies received a $3.67m grant to develop a low-cost, temperature-stable vaccine to improve market access in developing countries.

Vaccination

Vaccination Vaccine Development Marketing

Indonesia grants EUA for US-developed Covid-19 vaccine

Pharmaceutical Technology

OCTOBER 3, 2022

Indonesia has granted Emergency Use Authorization (EUA) for the patent-free Covid-19 vaccine, IndoVac, developed by the Texas Children’s Hospital Center for Vaccine Development (CVD) and Baylor College of Medicine, US. PT Bio Farma will manufacture 20 million doses of the vaccine this year.

Vaccination

Vaccination Vaccine Development Production

UTMB and HDT Bio receive US funding for vaccine development

Pharmaceutical Technology

NOVEMBER 30, 2022

in a project agreement from the US government for developing self-amplifying RNA (saRNA) vaccine technology against advanced and emergent viral threats. Development of vaccines to Phase I trials under the five-year $59m prototype project comprises additional $28.4m in milestone payments.

Vaccination

Vaccination Vaccine Development Gene Therapy

Biovac and IVI enter deal to develop oral cholera vaccine

Pharmaceutical Technology

NOVEMBER 24, 2022

South African bio-pharmaceutical firm Biovac and the International Vaccine Institute (IVI) in South Korea have signed a licencing and technology transfer agreement for developing and manufacturing an oral cholera vaccine (OCV).

Vaccination

Vaccination Vaccine Development Manufacturing

Evaxion and ExpreS²ion partner to develop new CMV vaccine

Pharmaceutical Technology

DECEMBER 6, 2022

Evaxion Biotech and ExpreS 2 ion Biotechnologies have entered a vaccine discovery collaboration agreement to co-develop a new cytomegalovirus (CMV) vaccine candidate. Additionally, this project will be part of the development pipeline of Evaxion under EVX-V1. A herpesvirus family member, CMV is spread through body fluids.

Vaccination

Vaccination Vaccine Development Immune Response

AstriVax awarded €3m to develop therapeutic vaccine for hepatitis B

Pharma Times

DECEMBER 15, 2023

The funding builds on AstriVax’s €30m in seed funding for its vaccine platform AstriVax has announced that it has been awarded a total of €3m in funding from Flanders Innovation & Entrepreneurship (VLAIO) for its therapeutic vaccine targeting chronic hepatitis B. in May to advance the company’s innovative vaccine platform.

Vaccination

Vaccination Vaccine Development Clinical Development

SK bioscience and CEPI enter mRNA vaccine development deal

Pharmaceutical Technology

OCTOBER 26, 2022

SK bioscience has signed a new collaboration agreement with the Coalition for Epidemic Preparedness Innovations (CEPI) to develop messenger ribonucleic acid (mRNA) vaccines for infectious diseases. The company has obtained the newest vaccine platform technologies such as bacterial culture, cell culture and genetic recombination.

Vaccination

Vaccination Vaccine Development Gene Therapy

UKRI awards three projects £25m for vaccine development

Pharma Times

OCTOBER 13, 2023

The projects will support the development of new and longer-lasting vaccines - News - PharmaTimes

Vaccination

Vaccination Vaccine Development

HIV vaccine being developed by Johnson & Johnson fails clinical trial

STAT News

JANUARY 18, 2023

Yet another experimental HIV vaccine has failed. The National Institute of Allergy and Infectious Diseases reported Wednesday that a Phase 3 clinical trial of a vaccine was stopped because the vaccine was ineffective at preventing HIV infection. Read the rest…

Clinical Trials

Clinical Trials Clinical Trials Vaccination Vaccine

‘Project NextGen’ picks new mRNA, intranasal COVID vaccines for funding

Bio Pharma Dive

OCTOBER 13, 2023

The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.

Vaccination

Vaccination Vaccine Development

BioNTech’s RNA vaccine sparks potential in pancreatic cancer

Pharmaceutical Technology

MAY 11, 2023

Results published in Nature for a personalised pancreatic cancer vaccine that uses neoantigens from patients’ tumours have lent further support to early positive signals. The vaccine, developed by BioNTech, led to half of the patients with pancreatic cancer in the Phase I trial remaining cancer-free 18 months later.

RNA

RNA Vaccination Vaccine Trials

Vaxess raises $9m to accelerate mRNA vaccine patch development

Pharmaceutical Technology

SEPTEMBER 13, 2023

The patch allows for vaccine storage and transport at room temperature along with at-home administration.

Vaccination

Vaccination Vaccine Development

Novo Nordisk Foundation sets up airborne infection vaccine initiative

Pharmaceutical Technology

DECEMBER 18, 2023

The Novo Nordisk Foundation has invested Dkr1.8bn in the initiative to develop vaccines for various airborne infection diseases.

Vaccination

Vaccination Vaccine Development

UK launches vaccine development hubs in $43 million project

BioPharma Reporter

NOVEMBER 6, 2023

million) in funding for four hubs dedicated to the development of vaccines for diseases with epidemic potential in low- and middle-income countries (LMICs). The UK has unveiled Â34.5 million ($42.8

Vaccination

Vaccination Vaccine Development Regulation

SK Bioscience gains UK authorisation for SKYCovion Covid-19 vaccine

Pharmaceutical Technology

MAY 30, 2023

SK Bioscience has received marketing authorisation from the UK’s medicines and healthcare products regulatory agency (MHRA) for its Covid-19 vaccine, SKYCovion. The authorisation allows the distribution of the vaccine in Scotland, Wales and England.

Vaccination

Vaccination Vaccine Protein Medicine

Ghana becomes first country to approve Oxford’s malaria vaccine

Pharmaceutical Technology

APRIL 14, 2023

Ghana’s Food and Drug Authority (FDA) has approved R21/Matrix-M malaria vaccine in children aged 5 to 36 months, marking the first regulatory clearance for the University of Oxford-developed vaccine in any country in the world. Children between the ages of five and 36 months are at highest risk of death from malaria.

Vaccination

Vaccination Vaccine Manufacturing Containment