Drug Discovery World

NOVEMBER 7, 2022

They subsequently applied additional bioinformatic approaches, using advanced computer technologies to identify genetic alterations in a patients’ DNA which may be causing disease but had been overlooked during routine testing. . This personalised approach increased the diagnostic rate from 16.7% of patients. . Official comments .

Genome 52

Genome Genomics Genetics Genetic Disease 52

Drug Discovery World

NOVEMBER 7, 2022

One might argue that this all started getting exciting with the launch of the Human Genome Project, which the National Human Genome Research Institute consider to be one of the greatest scientific feats in history 1. DDW’s Megan Thomas observes developments of accessibility in this sector and the potential impact. .

Genome 98

Genome Genomics Development Genetics 98

Drug Discovery World

SEPTEMBER 20, 2022

The key difference between the two technologies is that long-read sequences are more effective at unambiguously determining how all the pieces of a sequenced genome fit together. This study is also part of our broader efforts to demonstrate the use case of long read sequencing in identifying rare diseases.

Gene Therapy 52

Gene Therapy Gene Genome Genomics 52

XTalks

APRIL 5, 2021

The Human Genome Project could not have succeeded without the use of bioinformatics. Since the conclusion of the project in 2003, bioinformatics tools have been used to identify genes and elucidate their function with the aim of developing gene-based strategies for disease prevention, diagnosis and treatment.

Bioinformatics 59

Bioinformatics Engineer Scientist Genome 59

pharmaphorum

SEPTEMBER 13, 2022

2012 – The 100,000 Genomics Project begins. Unlocking the secrets of the human genome has intrigued investigators for centuries. However, the technology needed to analyse genomic and long-term clinical data is a relatively recent development. This was an entirely new approach to DNA research.

Genome Project 94

Genome Project Genome Genomics DNA 94

Drug Discovery World

JULY 15, 2022

The first complete, gapless sequence of a human genome was published 1 April 2022 in a special issue of the journal Science 1. While The Human Genome Project mapped about 92% of the human genome two decades ago, sequencing the last 8% of the genome proved highly challenging.

Genome 52

Genome Genomics DNA Containment 52

XTalks

FEBRUARY 11, 2021

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.

Genetics 119

Genetics DNA Genome Genomics 119

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Nutrigenomics is the science studying the relationship between human genome, nutrition and health.

Genome 40

Genome Genomics Genetics Gene 40

Drug Discovery World

OCTOBER 16, 2023

The country’s pioneering genomics research, crucial for future drug discovery, is demonstrated by institutes like the Wellcome Sanger Institute and projects like the 100,000 Genomes Project. It has a vibrant community of life-science companies, from global pharma to smaller start-ups.

Drugs 75

Drugs Life Science Gene Therapy Genome 75

pharmaphorum

APRIL 20, 2022

In 2012, Jennifer Doudna and Emmanuelle Charpentier published a paper in Science where they outlined isolating the components of the CRISPR-Cas9 system and demonstrated how it could be used to cut specific sites in isolated DNA. The publication and their work eventually led to the pair being awarded the Nobel Prize in Chemistry in 2020.

Gene Editing 52

Gene Editing DNA Gene Genetics 52

Roots Analysis

AUGUST 28, 2022

As a result, industry and non-industry stakeholders, are on the lookout for advanced platforms that can simultaneously capture the arrangement of multiple biomolecules (DNA, RNA, proteins and others) with single-cell or subcellular resolution. The trend is unlikely to change in the foreseen future. Concluding Remarks.

Genome 52

Genome Genomics RNA Genome Project 52

pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. Currently, the most common way of looking at genomes in these settings is by using ‘short-read’ technology. This allows for much lengthier reads.

Genome 115

Genome Genomics Medicine Gene 115

Drug Discovery World

MARCH 6, 2024

Guiding neurological drug discovery and development to success The 20 years since the Human Genome Project has seen transformational advances in the molecular understanding of cancers and rare genetic diseases, leading to genetically informed, personalised selection of therapies and massively improved outcomes for many patients.

Genome 64

Genome Genomics Clinical Trials Clinical Trials 64

Drug Discovery World

OCTOBER 6, 2022

Both the binary and quantitative have relied on measurement of protein, DNA, and more recently, RNA. For example, only 37% of patients are found to have an actionable mutation for those undergoing DNA mutation testing using some of the most comprehensive and common testing panels in our industry.

Medicine 52

Medicine Clinical Trials Clinical Trials Genome 52