Tue.Nov 23, 2021

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AstraZeneca, after years of delays, opens UK hub meant to recharge drug research

Bio Pharma Dive

Formally unveiled five years after originally planned, the $1 billion headquarters will become the British drugmaker's second-largest R&D center by headcount.

Research 278
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Insulin costs ignore the root cause of diabetes

World of DTC Marketing

OPENING: As the NY Times recently reported , obesity is the leading cause of mortality in the United States. Obesity costs the nation $1.72 trillion every year. Although not everyone with type 2 diabetes is overweight, obesity and an inactive lifestyle are two of the most common causes of type 2 diabetes. These things are responsible for about 90% to 95% of diabetes cases in the United States.

Insulin 231
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GSK dives into NASH, RNA interference with Arrowhead deal

Bio Pharma Dive

GSK has secured rights to a genetic medicine in early-stage human testing for NASH, a disease thought to affect millions of people and which has proven to be a tough target for drugmakers.

RNA 183
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AI in Pharma and Biotech Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2020 – 2030

Pharma Mirror

AI in Pharma and Biotech Market: Introduction Artificial Intelligence (AI) in pharma refers to the system of interconnected and automated technologies in the biotech industry that can function autonomously, with little or no human intervention. AI is an emerging technology that is being applied in numerous facets of the pharma sector, ranging from drug development to diagnosis and even patient care.

Marketing 130
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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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UK-wide whole genome sequencing for newborns is feasible – but there are some key questions to answer first

pharmaphorum

Genomics England, the Department of Health and Social Care’s genome-sequencing hub, has this year announced that support for whole genome sequencing (WGS) has reached a level at which its national rollout on the NHS may someday become a reality. The timing of this announcement is particularly opportune, as increasing knowledge and advances in WGS amongst scientists has resulted in the technology becoming increasingly affordable and effective, making its incorporation into the existing standardis

Genome 116
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NICE recommends risdiplam for spinal muscular atrophy

Pharma Times

NICE has published draft guidance recommending risdiplam (Evrysdi) as part of a managed access agreement (MAA) for the treatment of the rare genetic disorder spinal muscular atrophy (SMA).

Genetics 120

More Trending

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Bonus BioGroup’s MesenCure Shows Promise Against COVID-19 Pneumonia

BioSpace

Bonus BioGroup’s product is back in the news again as its cell therapy promises to treat late-stage COVID-19.

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Chinese tech giant Baidu licenses mRNA algorithm to Sanofi

pharmaphorum

Sanofi has bolstered its push into mRNA-based therapies with a new licensing deal – but not as might be expected with some up-and-coming biotech company. The French drugmaker has been enticed by an artificial intelligence (AI) algorithm developed by Chinese tech giant Baidu, which controls most of China’s search engine traffic and is sometimes referred to as the country’s Google.

Licensing 105
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Pfizer-licensed Cardiovascular Drug Reduces Triglycerides in Phase II

BioSpace

A cardiovascular drug Pfizer licensed from Akcea Therapeutics in 2019 hit the mark in a Phase IIb dose-ranging study in patients with elevated non-HDL-C and triglycerides.

Licensing 106
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Buoyed by new data, Santhera preps filing for DMD drug vamorolone

pharmaphorum

A year ago, Swiss biotech Santhera was slashing staff to cut costs after it abandoned lead Duchenne muscular dystrophy (DMD) therapy idebenone. Now, it’s ready to file replacement drug vamorolone, armed with new data from a pivotal trial, in what looks like a reversal of its fortunes. With prospects for idebenone looking shaky, Santhera snapped up vamorolone from US biotech ReveraGen BioPharma in August 2020 , claiming worldwide rights to the nonhormonal steroid modulator in DMD and all ot

Drugs 104
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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Three Companies Offering Vegan Thanksgiving Alternatives

XTalks

Plant-based eating is growing drastically as more and more evidence has concluded the diet may be better for human and planetary health. Sales of plant-based meat and dairy products reached a whopping $29.4 billion last year and could increase to over $160 billion by 2030. And while turkey is the traditional meal of choice on Thanksgiving, an estimated 45 million of them will be plant-based.

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New species of green microalga identified in São Paulo

Scienmag

A group led by researchers affiliated with the Phycology Laboratory at the Federal University of São Carlos (UFSCar) in the state of São Paulo, Brazil, have discovered a new species of green microalga in a reservoir located in the northwest of the state. As a result of the discovery, microalgae of the genus Nephrocytium have been moved […].

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New Starbucks Concept Store Uses Amazon Go’s ‘Just Walk Out’ Technology

XTalks

Starbucks and Amazon Go joined forces and brought a new digital and physical retail space to Starbucks customers. The new Starbucks café will have Amazon Go available in a store located in New York City. The new store combines Starbucks Pickup with Amazon Go, utilizing the Starbucks app and the Just Walk Out technology from Amazon Go. Besides the easy check-out experience at the New York City-based Starbucks, the coffee shop will offer modernized lounge seating, including individual workspaces,

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A new snow tracking sensor

Scienmag

Roofs collapsing under heavy snow, mini-avalanches in cities, and flash floods are just some of the winter headaches that could be resolved if there were a better way to track snow cover. With that in mind, PhD student Mohamed Karim El Oufir, research assistant Anas El Alem, and Professor Karem Chokmani from Institut national de […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Biovectra to Build First mRNA Vaccine and Drug Manufacturing Plant in Canada

XTalks

Canadian pharma and biotech contract development and manufacturing organization (CDMO) Biovectra has announced plans for building one of the first state-of-the-art mRNA vaccine and biomanufacturing facilities in Canada. The $79.6 million project received funding from the province of Prince Edward Island (PEI) in Eastern Canada, where the facility will be built, and the Canadian federal government in amounts of $10 million and $39.8 million, respectively.

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Nykode Therapeutics partners with Regeneron to develop cancer and infectious disease vaccines

Pharma Times

Nykode Therapeutics, a clinical-stage biopharmaceutical company, announced that it has entered into a collaboration agreement with Regeneron.

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USDA Cautiously Optimistic About SARS-CoV-2 Spread in Wildlife Populations

BioSpace

A preprint in bioRxiv from Penn State showed SARS-CoV-2 was detected in 33% (94) of the 283 white-tailed deer tested in Iowa between November 23, 2020 and January 10, 2021.

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For a fungus, the right “accessories” can make or break a relationship with a plant

Scienmag

For a fungus, the right “accessories” can make or break a relationship with a plant Credit: APS For a fungus, the right “accessories” can make or break a relationship with a plant Plants interact with a diversity of organisms over the course of their lifetime, but even very similar microbes can cause opposite reactions. Two […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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LMC Manna, IACT Health join in integrated research network

Outsourcing Pharma

The alliance is aimed at expanding service to pharmaceutical firms and other partners, and advancing treatment options for patients across North America.

Research 115
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COVID-19: Dire Predictions from WHO and Good News for Older Patients

BioSpace

Although vaccines and effective therapeutics are powerful tools in preventing and treating COVID-19, we’re not done battling the disease just yet. For those stories and more, read on.

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Understanding Eraser Enzymes

Scienmag

University of Delaware biochemist Jeff Mugridge is trying to figure out how so-called mRNA eraser enzymes work in our cells, why those erasers can sometimes misbehave and lead to cancer, and how science can pave the way for possible solutions to this problem. Credit: Photo by Evan Krape University of Delaware biochemist Jeff Mugridge is trying to […].

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CVS, Walgreens and Walmart Fueled Opioid Crisis, Jury Finds

NY Times

This is the first jury verdict in an opioid case. The decision embraced a key legal argument that judges in other opioid cases had recently rejected.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Neurobiologists reveal how value decisions are coded into our brains

Scienmag

In 2019 University of California San Diego researchers discovered the area of the brain where “value decisions” are made. Credit: UC San Diego In 2019 University of California San Diego researchers discovered the area of the brain where “value decisions” are made. An area within the cerebrum known as the retrosplenial cortex (RSC), they found, […].

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CVS, Walgreens and Walmart Perpetuated Opioid Crisis, Jury Finds

NY Times

This is the first jury verdict in an opioids case. The decision embraced a key legal argument that judges in other opioids cases had recently rejected.

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New chip hides wireless messages in plain sight

Scienmag

Emerging 5G wireless systems are designed to support high-bandwidth and low-latency networks connecting everything from autonomous robots to self-driving cars. But these large and complex communication networks could also pose new security concerns. Credit: Illustration by Ella Maru Studio/Princeton University Emerging 5G wireless systems are designed to support high-bandwidth and low-latency networks connecting everything from […].

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Merck and Dragonfly, Together Again

BioSpace

Merck opted to license its second TriNKET immunotherapy candidate from Dragonfly Therapeutics. The option came one year after Merck licensed its first immunotherapy candidate.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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When bees get a taste for dead things

Scienmag

A little-known species of tropical bee has evolved an extra tooth for biting flesh and a gut that more closely resembles that of vultures rather than other bees. Credit: Quinn McFrederick/UCR A little-known species of tropical bee has evolved an extra tooth for biting flesh and a gut that more closely resembles that of vultures […].

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Allorion Debuts with $40 Million to Enhance and Discover Precision Targets

BioSpace

The precision medicine company is developing mutant selective and isoform-specific drugs in non-conventional ways for well-known targets in the oncology and autoimmune spaces.

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Cooled RFA relieves pain after knee replacement

Scienmag

CHICAGO – A minimally invasive ablation procedure offers long-term relief for patients who experience chronic and debilitating pain after knee replacement surgery, according to a study being presented next week at the annual meeting of the Radiological Society of North America (RSNA). Credit: RSNA and researcher, Felix Gonzalez, M.D. CHICAGO – A minimally invasive ablation […].

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AML Study Placed Under Partial Hold Following Patient Death

BioSpace

Shares of Kura Oncology have plunged nearly 30% in premarket trading after the FDA placed a partial clinical hold on the company’s Phase Ib leukemia study following the report of a patient's death.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.