Sun.May 09, 2021

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Flagship Pioneering Announces Launch of mRNA Cousin eRNA with Laronde

BioSpace

Over the past year, the world at large has become more familiar with mRNA technology thanks to vaccines developed against COVID-19. Now the world will be introduced to a new type of RNA-based medicine called Endless RNA, or eRNA for short.

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Sharks in protected area attract illegal fishers

Scienmag

Credit: Claire Collins Thousands of sharks have been illegally caught in a Marine Protected Area (MPA) in the Indian Ocean, new research shows. The MPA was created in 2010 around the Chagos Archipelago, also known as the British Indian Ocean Territory (BIOT), banning all fishing there. The new study examined information on illegal fishing in […].

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BioNTech Secures Manufacturing Capacity in Asia for mRNA Vaccine and Therapeutics

BioSpace

BioNTech will open a state-of-the-art manufacturing facility in Singapore to support a global supply of mRNA-based vaccines and therapeutics.

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Could wider use of gene reserves protect rare species?

Scienmag

Credit: Melissa Minter, University of York UK landowners and conservationists welcome wider-spread use of Gene Conservation Units (GCUs) to help protect some of the rarest plants and insects, research at the University of York has shown. In particular the Great Yellow Bumblebee and the Mountain Ringlet Butterfly, which are at risk of further population decline, […].

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Researchers Concerned Over Long Covid Effects on Communities of Color

BioSpace

Researchers are now concerned that the same health inequalities that have made certain racial and ethnic groups experience higher infection and death rates also drive disparities in treatment for long Covid.

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Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia

JAMA Internal Medicine

This cross-sectional study evaluates the degree of anticoagulant use among nursing home residents with advanced dementia and atrial fibrillation at the end of life.

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Smartphone breath alcohol testing devices vary widely in accuracy

Scienmag

Some failed to detect users were over legal driving limit more than half the time, Penn medicine research finds PHILADELPHIA– Alcohol-impaired driving kills 29 people a day and costs $121 billion a year in the U.S. After years of progress in reducing alcohol-impaired driving fatalities, efforts began to stall in 2009, and fatalities started increasing […].

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Abingworth's $582 Million Co-Development Fund Will Propel Late-Stage Trials

BioSpace

London-based venture capital fund Abingworth closed on a new Clinical Co-Development Fund now at $582 million. The fund's original target was just at $350 million.

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Research shows for the first time that protein complexes ‘inflammasomes’ are linked to obesity-related colon cancer

Scienmag

New research presented at this year’s European Congress on Obesity (held online, 10-13 May) finds evidence that structures called inflammasomes (a part of the innate immune system that helps to regulate inflammation) could play an important role in the development of obesity-associated colon cancer. The study is by Dr Victoria Catalán and Professor Gema Frühbeck, […].

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Trends and Characteristics of Retracted Articles in the Biomedical Literature, 1971 to 2020

JAMA Internal Medicine

This cross-sectional study describes trends and characteristics of retracted articles in the biomedical literature from 1971 to August 2020.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Worldwide network develops SARS-CoV-2 protocols for research laboratories

Scienmag

80% of all SARS-CoV-2 proteins produced in the laboratory — protocols available for worldwide research – Goethe University Frankfurt, Germany, forms the hub of research network from 17 countries Credit: Uwe Dettmar for Goethe-University Frankfurt, Germany FRANKFURT. When the SARS-CoV-2 virus mutates, this initially only means that there is a change in its genetic blueprint. […].

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New patent expiration for Abbvie Inc drug TECHNIVIE

Drug Patent Watch

Annual Drug Patent Expirations for TECHNIVIE Technivie is a drug marketed by Abbvie Inc and is included in one NDA. There are nine patents protecting this drug. Drug patent litigation…. The post New patent expiration for Abbvie Inc drug TECHNIVIE appeared first on DrugPatentWatch - Make Better Decisions.

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Cricket bats should be made from bamboo not willow, Cambridge study finds

Scienmag

Credit: Ben Tinkler-Davies Bamboo cricket bats are stronger, offer a better ‘sweet spot’ and deliver more energy to the ball than those made from traditional willow, tests conducted by the University of Cambridge show. Bamboo could, the study argues, help cricket to expand faster in poorer parts of the world and make the sport more […].

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New patent for Zogenix Inc drug FINTEPLA

Drug Patent Watch

Annual Drug Patent Expirations for FINTEPLA Fintepla is a drug marketed by Zogenix Inc and is included in one NDA. It is available from one supplier. There are ten patents…. The post New patent for Zogenix Inc drug FINTEPLA appeared first on DrugPatentWatch - Make Better Decisions.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Future-proofing mental health — Experts set out research roadmap to prioritise key areas

Scienmag

A group of UK academics are calling for targets for mental health in order to meet the healthcare challenges of the next decade. Published today in Journal of Mental Health researchers set out four overarching goals that will speed up implementation of mental health research and give a clear direction for researchers and funders to […].

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Cosmo Pharmaceuticals announces a change in its board of directors

BioTech 365

Cosmo Pharmaceuticals N.V. / Key word(s): Miscellaneous 10-May-2021 / 06:00 GMT/BST Release of an ad hoc announcement pursuant to Art. 53 KR The issuer is solely responsible for the content of this announcement. * retirement of Dr.

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New Strep A human challenge model paves the way to test vaccines against the deadly bacteria

Scienmag

Researchers have successfully developed a new Strep A human challenge model, paving the way to test vaccines against the common deadly bacteria that causes sore throats, scarlet fever and skin sores. The collaborative research effort, led by the Murdoch Children’s Research Institute (MCRI) and published in The Lancet Microbe, found the model, which deliberately infected […].

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Telix Commences Phase III Clinical Trial of Prostate Cancer Therapy

BioTech 365

Telix Commences Phase III Clinical Trial of Prostate Cancer Therapy Telix Commences Phase III Clinical Trial of Prostate Cancer Therapy MELBOURNE, Australia, May 09, 2021 (GLOBE NEWSWIRE) — Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces it has … Continue reading →

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Higher BMI in childhood may help protect women against breast cancer in later life, both before and after the menopause

Scienmag

A study of more than 173,000 women in Denmark, presented at the European Congress on Obesity (ECO) held online this year, suggests that girls with a higher body mass index (BMI) during childhood are less likely than their peers with a lower BMI to develop breast cancer as adults, both before and after the menopause. […].

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Clinical Catch-Up: May 3-7

BioSpace

It was a busy week for clinical trial news. Here’s a look.

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Higher BMI, body fat, and larger waist and hips pose similar risk for

Scienmag

10 common cancers in study of over 400,000 UK adults Obesity increases the risk of developing 10 of the most common cancers, regardless of how it is measured, according to a study of more than 400,000 adults in the UK, being presented at The European Congress on Obesity (ECO) held online this year, with central […].

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Which pharmaceutical drugs have the most drug patents in South Africa?

Drug Patent Watch

This chart shows the drugs with the most patents in South Africa. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is…. The post Which pharmaceutical drugs have the most drug patents in South Africa? appeared first on DrugPatentWatch - Make Better Decisions.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Combining BMI with body shape better predictor of cancer risk, suggests

Scienmag

UK study in over 440,000 adults New research being presented at The European Congress on Obesity (ECO) held online this year, suggests that a measure of body shape should be used alongside body mass index (BMI) to help determine the risk of obesity-related cancers. BMI is a simple way of measuring body fat from the […].

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Body mass index during childhood linked with risk of anorexia nervosa and bulimia nervosa in later life

Scienmag

New research being presented at the European Congress on Obesity (ECO) held online this year, suggests that among girls a low body mass index (BMI) during childhood indicates a higher risk of developing anorexia nervosa as young adults, whereas a high BMI or overweight in childhood indicates a higher risk of bulimia nervosa. “By examining […].

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Molecular tweezers that attack antibiotic resistant bacteria developed by Ben-Gurion U.

Scienmag

Credit: Dani Machlis/BGU BEER-SHEVA, Israel May 10, 2021 – Researchers from Ben-Gurion University (BGU), together with American and German colleagues, have developed new “molecular tweezers” to combat antibiotic-resistant bacteria. Their recently announced findings were published in Cell Chemical Biology. For years, medical professionals have struggled with bacterial infections becoming increasingly resistant to antibiotics.