Bio Pharma Dive
MARCH 7, 2023
As many as a third of FDA-approved drugs target GPCRs in some fashion, with uses ranging from treating cancer to pain. But biotech startups say there is still room to develop more.
Pharmaceutical Technology
MARCH 7, 2023
Clene has presented updated trial results for its Visionary MS Phase II clinical trial for its lead pipeline candidate, CNM-Au8. The trial is investigating CNM-Au8 as a treatment for patients with relapsing forms of multiple sclerosis (MS) with chronic optic neuropathy. The agent has a first-in-class mechanism of action within the MS portfolio, as it is a first drinkable treatment based on a nanocrystalline gold suspension that has reached late-stage development for MS.
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Bio Pharma Dive
MARCH 7, 2023
Rapport Therapeutics aims to find new so-called receptor-associated proteins that could serve as targets for neurological disease medicines. Its most advanced drug is already in early-stage human testing.
Pharmaceutical Technology
MARCH 7, 2023
The recently closed Amazon-One Medical acquisition focuses on a “longitudinal relationship” with individual members and has nothing to do with patient data, said One Medical’s CEO Amir Dan Rubin, amidst data privacy concerns surrounding the deal, at a recent panel. On 6 March, at the Wall Street Journal (WSJ) Health Forum, Rubin said the deal should not invite any data privacy concerns given its structure.
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Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud
Bio Pharma Dive
MARCH 7, 2023
The agency is considering three-year follow-up data in its review of Roctavian, pushing back the potential U.S. arrival of BioMarin’s drug once again.
AuroBlog - Aurous Healthcare Clinical Trials blog
MARCH 7, 2023
Exercise should be the primary treatment for depression and other common mental health conditions, according to University of South Australia (UniSA) researchers. The most comprehensive review of research to date shows that mild to moderate symptoms of depression, anxiety, and psychological distress can be alleviated with physical activity. According to their investigation, exercise is 1.
Clinical Research Informer brings together the best content for clinical researchers from the widest variety of industry thought leaders.
Pharmaceutical Technology
MARCH 7, 2023
Due to a growing body of research, the connection between mental health and perimenopause is becoming clearer, namely its impact on mood and the onset of depression and anxiety. However, despite focused efforts in scientific research, this connection is still largely unexplored in the pharmaceutical space. Perimenopause refers to the stage of menopausal transition when an irregularity in the menstrual cycle symptoms may arise before the last menstrual bleed.
Bio Pharma Dive
MARCH 7, 2023
Ampersand Biomedicines claims to be developing a way to make medicines that act only at the site of disease and spare healthy tissue.
Rethinking Clinical Trials
MARCH 7, 2023
In the March 16 session of IMPACT Grand Rounds, the NIA IMPACT Collaboratory will host Dr. Eleanor Murray, who will present on the topic of causal inference in pragmatic trials. From the announcement : Join us for IMPACT Grand Rounds on Thursday, March 16 at 12pm ET with Dr. Murray who will be presenting on the “Causal Inference in Pragmatic Trials.
Bio Pharma Dive
MARCH 7, 2023
The proposal — part of a 2024 budget set to be released Thursday — would further reduce what Medicare pays for prescription drugs and raise taxes on Americans earning over $400,000.
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White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations
AuroBlog - Aurous Healthcare Clinical Trials blog
MARCH 7, 2023
The ministry of health and family welfare (MoHFW) will soon allow import of drugs into India through Gangavaram Port at Visakhapatnam, in Andhra Pradesh, an all-weather deep-water port owned by Adani Ports and Special Economic Zone (APSEZ).
NPR Health - Shots
MARCH 7, 2023
"We are putting out a clear call to all of our shops: Do not allow people to enter the store without taking off their face mask," the mayor said. A flurry of questions ensued.
STAT News
MARCH 7, 2023
The diversity of medical school classes has barely budged in recent decades, even with the ability to consider an applicant’s race as one factor in admissions. Now, many medical school leaders fear a looming U.S. Supreme Court decision to restrict or ban race-conscious admissions policies could lead to precipitous declines, imperiling efforts to fight the nation’s stark racial and ethnic health disparities.
NPR Health - Shots
MARCH 7, 2023
The lawsuit filed on behalf of five patients who said their lives were put at risk and two physicians asks a state judge to clarify exceptions for medical emergencies under Texas law.
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When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.
Medical Xpress
MARCH 7, 2023
Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes). Large-scale genome-wide association studies (GWASs) have revealed that variations in the genes present on the fatty acid desaturase (FADS) locus are linked to an increased risk of BD.
NPR Health - Shots
MARCH 7, 2023
Participants in the federal food program might want to reevaluate their eligibility level for SNAP — and consider other assistance programs — as a pandemic-era supplement ends this month.
Medical Xpress
MARCH 7, 2023
An artificial intelligence (AI) tool can accurately identify normal and abnormal chest X-rays in a clinical setting, according to a study published in Radiology.
NPR Health - Shots
MARCH 7, 2023
California Gov. Gavin Newsom said that the state would halt business with Walgreens after the pharmacy giant agreed to stop distributing mifepristone in some red states amid legal pressure. (Image credit: Michael M.
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This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.
Medical Xpress
MARCH 7, 2023
Tap water scald burns exact high personal and financial costs every year in the U.S., finds an audit of relevant national data, published online in the journal Injury Prevention.
STAT News
MARCH 7, 2023
LONDON — Victoria Gray had come to Nashville, Tenn., from her home in Mississippi for what was supposed to be a routine checkup. But when a pain crisis struck — an agonizing emergency of sickle cell disease in which Gray’s misshapen red blood cells caught in her blood vessels — the visit became a days-long hospital stay. It was in the midst of this attack that her doctor told her about a clinical trial for a new kind of treatment, one where CRISPR would be used to alt
Medical Xpress
MARCH 7, 2023
Extra virgin olive oil may have positive effects on individuals with mild cognitive impairment, according to a recently completed study by Amal Kaddoumi in Auburn University's Harrison College of Pharmacy. Her findings, recently published in the journal Nutrients, suggest compounds found in olive oil impact brain health and improve the blood-brain barrier.
STAT News
MARCH 7, 2023
WASHINGTON — It’s hard to shop for health insurance. It’s harder still when there’s few options to help. Some Americans who can’t rely on a federal program or their employers’ HR department turn to brokers who are trained to help them navigate the complex web of deductibles, formularies, and subsidies. But in 2021 in Hartford, Bridgeport, and New Haven, Connecticut — as in many poorer areas in the U.S.
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As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.
Medical Xpress
MARCH 7, 2023
Published today in the Journal of Child Psychology and Psychiatry, a new study by Dr. Nikhil Chaudhary, an evolutionary anthropologist at the University of Cambridge, and Dr. Annie Swanepoel, a child psychiatrist, calls for new research into child mental health in hunter-gatherer societies. They explore the possibility that some common aspects of hunter-gatherer childhoods could help families in economically developed countries.
STAT News
MARCH 7, 2023
BOSTON — FDA Commissioner Robert Califf said on Monday that it “bothers” him that Novo Nordisk, which makes an obesity medication, funded the development of obesity coursework for medical schools. But he also said he saw it as an example of a drug company filling the void left by health systems that aren’t teaching doctors and trainees how to use new medicines.
Medical Xpress
MARCH 7, 2023
A new University of Chicago study examining Medicare claims found older adults living near fracking sites in Pennsylvania were more likely to be hospitalized for cardiovascular diseases than those who lived in nearby New York state, where fracking is banned. The research was published in The Lancet Planetary Health.
STAT News
MARCH 7, 2023
Best Buy isn’t the first name that comes to mind when people think of health care. But a new partnership between the electronics retailer and Atrium Health, part of the nonprofit health system Advocate Health, is a sign of how big tech and retail companies are getting in on the booming hospital-at-home market. Best Buy first dove into the health care space with its 2021 acquisition of Current Health, a remote patient monitoring platform that major hospital systems across the country rely
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Medical Xpress
MARCH 7, 2023
Researchers at the University of Houston are using glow-in-the-dark materials to enhance and improve rapid COVID-19 home tests. If you've taken an at-home COVID-19 or pregnancy test, then you've taken what is scientifically called a lateral flow assay (LFA) test, a diagnostic tool widely used because of its rapid results, low cost and ease of operation.
STAT News
MARCH 7, 2023
After months of anticipation, the manufacturer of a controversial drug for premature births has agreed to withdraw its treatment, capping an unusual battle with the U.S. Food and Drug Administration over its authority to have medicines removed from the market. The drug in question, called Makena, was approved more than a decade ago and quickly generated a firestorm over its cost.
Medical Xpress
MARCH 7, 2023
Researchers from Children's Hospital of Philadelphia (CHOP) have found that opioids were responsible for more than half of all fatal poisonings in children ages 5 and younger between 2005 and 2018, more than double the proportion of fatal poisonings caused by opioids in 2005. Additionally, over-the-counter drugs still contribute to fatal poisonings in this age group despite increased regulation.
Drug Discovery World
MARCH 7, 2023
For International Women’s Day, DDW’s Diana Spencer celebrates some of the women in leadership making an impact on the drug discovery and life sciences sector. The life sciences sector has traditionally outperformed others when it comes to attracting women to its workforce. In its ‘Women in Business 2022’ report, Grant Thornton reported that at 39%, the healthcare industry had the highest proportion of women in senior management out of the 15 industries surveyed. 1 However, this progress seems t
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The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.
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