Vaxcyte has signed a new agreement with Lonza to manufacture pneumococcal conjugate vaccines. Credit: Mufid Majnun on Unsplash.

Vaxcyte has signed a new commercial agreement with Lonza for the global manufacture of broad-spectrum pneumococcal conjugate vaccines (PCVs).

Building on an existing collaboration, the new deal will enable the commercialisation of Vaxcyte’s PCV candidates, VAX-24 and VAX-31, for both paediatric and adult populations globally.

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This agreement supports Vaxcyte’s strategy to leverage Lonza’s existing infrastructure for clinical development and the upcoming US launch of VAX-24 for adults.

Lonza will offer Vaxcyte a custom-built manufacturing suite as part of its Ibex Dedicate Biopark at its site in Visp, Switzerland.

The suite will be used to produce essential components for Vaxcyte’s PCV franchise.

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Starting with VAX-24, which is advancing towards late-stage clinical trials, Vaxcyte’s manufacturing facility will help address the long-term global market needs for both adults and children.

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The manufacturing suite’s design is almost finished and equipment installation is set to commence in 2024.

Lonza will create 300 new jobs at peak production.

Lonza biologics president Jean-Christophe Hyvert stated: “Having supported the early-stage clinical development of Vaxcyte’s PCV programmes, we are pleased to continue our long-standing collaboration by supporting the late-stage clinical manufacturing utilising our unique IbexDedicate offering, with the capability to provide commercial supply of their products.”

In 2022 to 2023, Vaxcyte achieved significant advancements in its VAX-24 clinical programme, including two positive Phase II results in adults and the commencement of a Phase II study in infants.

Vaxcyte CEO and co-founder Grant Pickering stated: “Following the successful completion of our VAX-24 Phase II adult studies, and as we prepare for Phase III clinical studies, we are excited to expand our relationship with Lonza, a pre-eminent contract development and manufacturing organisation, and put into motion the key steps required to establish large-scale and long-term commercial manufacturing capacity for our PCV candidates.”