Sat.Mar 20, 2021

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Supplements may protect those with low vitamin D levels from severe COVID-19

Scienmag

Study finds more than half of patients with low vitamin D do not receive supplements WASHINGTON–Patients with low vitamin D levels who are hospitalized for COVID-19 may have a lower risk of dying or requiring mechanical ventilation if they receive vitamin D supplementation of at least 1,000 units weekly, according to a study presented virtually […].

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Pressure will mount to unblock clinical trial bottlenecks

The Pharma Data

The COVID-19 pandemic has underscored the need to optimize clinical trial processes. While the public-private initiative Operation Warp Speed has won public attention for its ability to speed vaccine development and distribution, “it has also focused new attention on common bottlenecks in the clinical trial process,” said C.J. Anderson, president of CCT Research, a clinical research network.

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Tubeless automated insulin delivery system improves blood glucose outcomes

Scienmag

Study finds Omnipod® 5 simplifies diabetes management in type 1 diabetes WASHINGTON–People with type 1 diabetes can improve their blood sugar control while reducing time with low blood sugar, or hypoglycemia, using Insulet Corporation’s Omnipod 5 Automated Insulin Delivery System compared to their standard insulin therapy. Results from an industry-sponsored study of the latest Omnipod, […].

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Global decentralized studies will become a standard clinical trial design approach

The Pharma Data

After a year of unprecedented disruption in the clinical research industry, 2021 is set to be another transformative year for sponsors and contract research organizations (CROs), according to John Reites, president of Thread, a technology and service provider focusing on decentralized clinical research. “Studies will embrace decentralized trial approaches as design options earlier in the clinical trial planning process,” Reites said.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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New patent expiration for AKORN drug XOPENEX

Drug Patent Watch

Annual Drug Patent Expirations for XOPENEX Xopenex is a drug marketed by Akorn and Sunovion and is included in two NDAs. It is available from two suppliers. There are three…. The post New patent expiration for AKORN drug XOPENEX appeared first on DrugPatentWatch - Make Better Decisions.

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Radiomics will gain ground in drug development and clinical trials

The Pharma Data

Precision imaging analytics technology known as radiomics will see increased adoption in 2021 and will be incorporated into drug development strategies and clinical trials management, according to Rose Higgins, CEO of HealthMyne. “These AI-powered analytics will enable drug developers to gain deeper insights from medical images than previously capable, driving accelerated therapy development, greater personalization of treatment and the discovery of new biomarkers that will enhance clinical deci

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Digital therapeutics will increasingly complement drugs

The Pharma Data

After smartphones had been around several years, a handful of influential digital-savvy physicians began to boast that they prescribed more apps than drugs. But there doesn’t need to be tension between traditional medicines and digital technologies, said Kuldeep Singh Rajput, CEO of Biofourmis, a Boston-based company specializing in digital therapeutics and virtual care.

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Common drugs for type 2 diabetes and obesity do not increase breast cancer risk

Scienmag

Findings relieve concerns arising from clinical trials of liraglutide WASHINGTON–Commonly used medications for type 2 diabetes and obesity called glucagon like peptide-1 receptor agonists (GLP-1 RAs), are not associated with an increased risk of breast cancer, despite previous studies that suggested a possible link, according to a study presented virtually at ENDO 2021, the Endocrine […].

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5000i – Faster Scale-up of Fermentation Processes

The Pharma Data

The InPro 5000 sensor from METTLER TOLEDO enables precise and reliable. inline measurement of dissolved CO2 throughout an entire cultivation period at. variable gas transfer from liquid to gas phase. Kluyver Center, Delft, Netherlands. The Kluyver Center for Genomics of Industrial Fermentation in Delft, Holland, is a consortium of several different Universities and Research Centres.

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Combination thyroid hormone therapies treat hypothyroidism as well as levothyroxine

Scienmag

Treatment should be individualized for common thyroid condition, researchers say WASHINGTON–Treatment of hypothyroidism, which results from an underactive thyroid gland, should be individualized and consideration should be given to alternatives to the first-line therapy, including desiccated thyroid extract and combination therapy to replace the body’s two main thyroid hormones, thyroxine (T4) and triiodothyronine (T3).

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Life science companies will turn to NLP to process mountains of text-based data

The Pharma Data

Natural language processing (NLP) has long held potential for the life sciences field, given the industry’s reliance on text-based data in the form of clinical records, scientific papers, pharmaceutical companies’ call center transcriptions and so forth. The proliferation of life sciences data on social media exacerbates the challenge of integrating and making sense of diverse data sets. .

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‘Hunger hormone’ ghrelin affects monetary decision making

Scienmag

High ghrelin levels in healthy females predict more impulsive choices, researchers say WASHINGTON–Higher levels of the stomach-derived hormone ghrelin, which stimulates appetite, predict a greater preference for smaller immediate monetary rewards over larger delayed financial rewards, a new study finds. The study results will be presented at ENDO 2021, the Endocrine Society’s annual meeting.

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COVID-19 will continue to surprise

The Pharma Data

For all of the brainpower and data models researchers have used to model the COVID-19, the pandemic continues to surprise experts. The unprecedented nature of the pandemic makes it challenging to anticipate what impact the virus will have next year. “I don’t think there is enough information at this point to do long term estimates,” said Kasey Fu, director of epidemiology at GlobalData.

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Core One Labs Files Application to List its Common Shares on NASDAQ

BioTech 365

Core One Labs Files Application to List its Common Shares on NASDAQ Core One Labs Files Application to List its Common Shares on NASDAQ VANCOUVER, British Columbia, March 20, 2021 (GLOBE NEWSWIRE) — Core One Labs Inc.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Which pharmaceutical drugs have the most drug patents in Bulgaria?

Drug Patent Watch

This chart shows the drugs with the most patents in Bulgaria. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.…. The post Which pharmaceutical drugs have the most drug patents in Bulgaria? appeared first on DrugPatentWatch - Make Better Decisions.

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Chiasma Presents New Positive Data for MYCAPSSA from Phase 3 Trial MPOWERED™ for the Maintenance Treatment of Acromegaly at ENDO 2021

BioTech 365

Chiasma Presents New Positive Data for MYCAPSSA from Phase 3 Trial MPOWERED™ for the Maintenance Treatment of Acromegaly at ENDO 2021 Chiasma Presents New Positive Data for MYCAPSSA from Phase 3 Trial MPOWERED™ for the Maintenance Treatment of Acromegaly at … Continue reading →

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Brochure: Dynabeads manual and automated SARS-CoV-2 enrichment

The Pharma Data

INTRODUCTION. Coronaviruses are RNA viruses and include common human coronaviruses, severe acute respiratory syndrome-CoV (SARS-CoV), Middle East respiratory syndrome-CoV (MERS-CoV) and SARS-CoV-2 ( 1 ). Although the large majority of common cold infections caused by coronaviruses do not have any significant clinical sequelae, the more recently identified coronaviruses have caused major public health outbreaks ( 2 , 3 ).

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BridgeBio Pharma Announces Proof-of-Concept Data of Encaleret in ADH1 at the Endocrine Society’s 2021 Annual Meeting

BioTech 365

BridgeBio Pharma Announces Proof-of-Concept Data of Encaleret in ADH1 at the Endocrine Society’s 2021 Annual Meeting BridgeBio Pharma Announces Proof-of-Concept Data of Encaleret in ADH1 at the Endocrine Society’s 2021 Annual Meeting – Normalization of Blood Calcium and Urine Calcium … Continue reading →

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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White button mushrooms could slow progression of prostate cancer

Scienmag

Mouse study suggests mushrooms may suppress androgen receptor activity WASHINGTON–The chemicals present in white button mushrooms may slow the progression of prostate cancer, according to a mouse study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting. “Androgens, a type of male sex hormone, promote the growth of prostate cancer cells by binding to […].

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Theratechnologies Announces New Data Demonstrating Tesamorelin’s Positive Effect on Immune Response Linked to Liver Inflammation

BioTech 365

Theratechnologies Announces New Data Demonstrating Tesamorelin’s Positive Effect on Immune Response Linked to Liver Inflammation Theratechnologies Announces New Data Demonstrating Tesamorelin’s Positive Effect on Immune Response Linked to Liver Inflammation Data presented at ENDO 2021 MONTREAL, March 20, 2021 (GLOBE … Continue reading →

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Tackling the Challenges of Limited Resources During a Pandemic

The Pharma Data

As laboratories around the world tackle the challenges of screening large numbers of samples for SARS-CoV-2, the managers of these labs have turned to the use of automation to address some key concerns. Whether the scale of these labs is at the national level, processing hundreds of thousands of samples a day, through to small-scale and agile laboratories testing at an organizational level, there is a place in the workflow to accommodate automation.

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89bio Presents Additional Analysis of Phase 1b/2a NASH Study at the Annual ENDO 2021 Conference

BioTech 365

89bio Presents Additional Analysis of Phase 1b/2a NASH Study at the Annual ENDO 2021 Conference 89bio Presents Additional Analysis of Phase 1b/2a NASH Study at the Annual ENDO 2021 Conference New analysis shows BIO89-100 meaningfully reduces liver fat volume and … Continue reading →

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Developing high quality content for the pharma industry

The Pharma Data

Introduction: For a company to succeed in the ultra-competitive global biopharma landscape, it’s simply not enough to deliver exceptional products and services at a competitive price. According to the Demand Generation Benchmark Report, 2016, 47% of buyers viewed 3-5 pieces of content before engaging with a sales rep. Today’s senior-level decision makers actively seek out quality content to help them make educated purchase decisions before they will even speak with you, much less become loyal cu

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Rhythm Pharmaceuticals Presents New Data from Phase 2 Basket Study Showing Continued Weight Loss at Up to Nine Months in Patients with HET Obesity on Setmelanotide at ENDO 2021

BioTech 365

Rhythm Pharmaceuticals Presents New Data from Phase 2 Basket Study Showing Continued Weight Loss at Up to Nine Months in Patients with HET Obesity on Setmelanotide at ENDO 2021 Rhythm Pharmaceuticals Presents New Data from Phase 2 Basket Study Showing … Continue reading →

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