Sun.Feb 05, 2023

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Eggs prices drop, but the threat from avian flu isn't over yet

NPR Health - Shots

After months of eye-popping prices, egg lovers are finally seeing some relief. Wholesale prices in the Midwest fell by 58 cents at the end of January, but the days of a $1.50 a dozen may not return.

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Opinion: FDA: Base blood donation policy on science, not stigma

STAT News

As a doctor, I have dedicated my life to saving the lives of others. But as a gay doctor, I have long been unable to do one simple thing that saves lives: donate blood. For more than 30 years, policies in the United States have banned gay and bisexual men from donating blood. That could change — ending decades of discrimination — if the Food and Drug Administration’s newly announced proposal for blood donation is made permanent.

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We asked for wishes, you answered: Send leaders into space, free electricity, dignity

NPR Health - Shots

Send leaders into space for perspective, tap solar power to offer electricity for all, make "dignity" a priority — those are some of the wishes readers have for 2023.

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As many as 80K Marylanders could lose Medicaid eligibility

Medical Xpress

Maryland officials are preparing for as many as 80,000 residents who could no longer qualify for Medicaid coverage this spring, as the federal government reinstates a requirement that existed before the COVID-19 pandemic for states to verify the eligibility of recipients.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Excess Mortality Among US Physicians During the COVID-19 Pandemic

JAMA Internal Medicine

This cross-sectional study examines the death rates among active and nonactive physicians aged 45 to 84 years.

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Vitamin D found to not reduce risk of asthma attacks

Medical Xpress

Taking vitamin D supplements does not reduce the risk of asthma attacks in children or adults, according to an updated Cochrane Review.

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ASCO: Novartis’ Kisqali Prevents Breast Cancer Return in Phase III Trial

BioSpace

The Swiss pharma’s CDK4/6 inhibitor reduced risk for recurrence by 25% when added to the standard-of-care endocrine therapy, inviting comparisons to Lilly’s Verzenio.

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Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition

JAMA Internal Medicine

This prospective cohort study investigates the association between healthy lifestyle factors prior to SARS-CoV-2 infection and risk of post–COVID-19 condition.

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ASCO Highlights

BioSpace

Follow updates from the American Society of Clinical Oncology 2023 annual meeting—BioSpace will be tracking key updates here throughout the conference. All times are Eastern Standard.

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TCR Therapies: An Emerging Therapeutic Modality

Roots Analysis

Modified T-cell receptors or TCR therapies is an emerging class of adoptive therapy that employs genetically modified lymphocytes to target specific tumor markers. Structurally, TCR is a heterodimer comprising of two different polypeptide chains, namely the α-chain and β-chain. TCR therapies’ tumor-cell killing efficacy may be primarily attributed to the fact that they are pre-sensitized to cancer specific antigens; this enables such interventions to selectively target and eliminate tumor

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Antibody-Drug Conjugates, Lung Cancer Late-Breaker to Take Center Stage at ASCO

BioSpace

ADCs from BioNTech, Daiichi Sankyo and Merck are the subject of high-profile abstracts featured at the oncology meeting, along with Merck’s late-breaking Phase III non-small cell lung cancer data.

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Good Things Came in Threes for These Drug Companies: Three Judges at the Third Circuit Found for Three Drug Makers in 340B Contract Pharmacy Case

FDA Law Blog

By Faraz Siddiqui — In the Spring of 2021, the Health Resources and Services Administration (HRSA) threatened six drug companies with billions of dollars in penalties for not providing 340B discounts to covered entities that sell drugs through vast networks of contract pharmacies (more background on earlier posts ). The drug makers argued that their statutory obligation to provide discounts did not extend to multiple contract pharmacies, who they said often abused the system.

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Coherus to Offer 85% Discount for its Humira Biosimilar

BioSpace

The company's Humira biosimilar Yusimry will launch in July with a $995 list price. Mark Cuban’s online pharmacy will sell it at a list price of $569.27 plus fees.

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Deprescribing Medications Among Older Adults Through Postacute Care

JAMA Internal Medicine

This randomized clinical trial examines the safety and efficacy of reducing or stopping medications among inpatients 50 years or older.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Grail Expands Blood Test to Symptomatic Patients, Aims to Revolutionize Cancer Diagnosis

BioSpace

Grail, the blood testing company, explores the potential of its commercial blood test, Galleri, in detecting cancer symptoms.

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Drug Patent Expirations for the Week of February 5, 2023

Drug Patent Watch

NEXAVAR (sorafenib tosylate) Bayer hlthcare Patent: 8,618,141 Expiration: Feb 11, 2023 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com… The post Drug Patent Expirations for the Week of February 5, 2023 appeared first on DrugPatentWatch - Make Better Decisions.

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Pfizer’s Antibiotic Combo Clears Phase III, Shows Promise Against Multidrug Resistance

BioSpace

The company’s aztreonam-avibactam matched the cure rate of a meropenem-based regimen in patients with drug-resistant infections.

Drugs 52
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Which pharmaceutical companies have the most drug patents in Cyprus?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Cyprus. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Cyprus? appeared first on DrugPatentWatch - Make Better Decisions.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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FDA grants approval to Gilead Sciences’ breast cancer therapy

Pharmaceutical Technology

The US Food and Drug Administration (FDA) has granted approval for Gilead Sciences ’ Trodelvy (sacituzumab govitecan-hziy) to treat unresectable locally advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative (IHC 0, IHC 1+ or IHC 2+/ISH–) breast cancer adult patients. Trodelvy has been approved for HR+/HER2- breast cancer adult patients who have previously received endocrine-based therapy and a minimum of two additional systemic therapies

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