Mon.Jul 05, 2021

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As Lebanon’s Crisis Deepens, Lines for Fuel Grow, and Food and Medicine Are Scarce

NY Times

The World Bank said the financial crisis could rank among the world’s three worst since the mid-1800s. The currency has lost more than 90 percent of its value and unemployment has skyrocketed.

Medicine 123
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Queen awards the George Cross to the NHS for 73 years of service

Pharma Times

The Queen has awarded the ‘unprecedented’ honour to staff for their response to the COVID-19 pandemic

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Ancient diamonds show Earth was primed for life’s explosion at least 2.7 billion years ago

Scienmag

Credit: Credit: Michael Broadley A unique study of ancient diamonds has shown that the basic chemical composition of the Earth’s atmosphere which makes it suitable for life’s explosion of diversity was laid down at least 2.7 billion years ago. Volatile gases conserved in diamonds found in ancient rocks were present in similar proportions to those […].

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Boehringer, Lilly: Jardiance Significantly Reduced CV Death and HF-Related Hospitalization in HFpEF

BioSpace

Jardiance most recently received approval by the European Commission for the treatment of adult patients with HF with ejection fraction, based on findings from the EMPEROR-Reduced trial.

Trials 98
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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Seabird colony creates ‘halo’ of depleted fish stocks

Scienmag

Credit: Sam Weber A vast seabird colony on Ascension Island creates a “halo” in which fewer fish live, new research shows. Ascension, a UK Overseas Territory, is home to tens of thousands of seabirds – of various species – whose prey incudes flying fish. The new study, by the University of Exeter and the Ascension […].

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FDA Action Alert: ChemoCentryx, Chimerix and AstraZeneca/FibroGen

BioSpace

After the July 4 holiday, the U.S. FDA has several things on their immediate calendar, including a couple target action dates and an advisory committee hearing. Here’s a look.

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More Trending

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Over 600,000 COVID-19 tests genomically sequenced in the UK

Pharma Times

The UK is estimated to contribute around 23% of all COVID-19 sequencing uploaded to GISAID

Genome 128
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Fossil shark scales provide a glimpse of reef predator populations before human impact

Scienmag

The results indicate that shark abundance in the region declined roughly three-fold since prehistoric times Credit: ERIN DILLON, AARON O’DEA AND JORGE CEBALLOS Scientists recently made news by using fossil shark scales to reconstruct shark communities from millions of years ago. At the same time, an international team of researchers led by UC Santa Barbara […].

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Diabetes Care and Glycemic Control During the COVID-19 Pandemic in the United States

JAMA Internal Medicine

This cohort study compares rates at which patients with type 2 diabetes received diabetes-related health services prior to and during the COVID-19 pandemic.

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Science on a shoestring

Scienmag

A life in the liberal arts from beginning to end Credit: World Scientific “Long, thin, and cool as hell” was how parasitologist Thomas Platt described the new genus and species of trematode (Baracktrema obamai) he named in honor of the 44th USA president and his 5th cousin, Barack Obama. That discovery marked the end of […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Global Clinical Research Firm Parexel to Be Acquired for $8.5 Billion

BioSpace

?Upon completion of the merger, Parexel will be owned by EQT IX Fund and the private equity business within Goldman Sachs Asset Management.

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New method to identify dirt on criminals can lead to prosecution

Scienmag

Credit: Patrice De Caritat Scientists have taken the first steps in developing a new method of identifying the movements of criminals using chemical analysis of soil and dust found on equipment, clothing and cars. The locating system allows police or security services to match soil remnants found on personal items to regional soil samples, to […].

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GSK and Alector ink neurodegenerative diseases partnership

Pharma Times

Under the terms of the collaboration, Alector could receive up to $1.

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Study: constructed wetlands are best protection for agricultural runoff into waterways

Scienmag

Credit: Amy Hansen LAWRENCE — A new paper from a lead author based at the University of Kansas finds wetlands constructed along waterways are the most cost-effective way to reduce nitrate and sediment loads in large streams and rivers. Rather than focusing on individual farms, the research suggests conservation efforts using wetlands should be implemented […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Merck KGaA and BioMed X launch new joint cancer research programme

Pharma Times

New partnership will explore the role of extrachromosomal DNA in cancer

DNA 122
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EMA backs active substance scale-up at Janssen’s COVID-19 vaccine site in the Netherlands

BioPharma Reporter

The committee for human medicines (CHMP) of the European Medicines Agency (EMA) has approved a scale-up of the active substance manufacturing process at a Janssen Biologics BV site in the Netherlands.

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Spaces still available in the 2021 Marketer of the Year competition

Pharma Times

Entries for the 2021 competition are well underway and PharmaTimes are calling on pharma marketers in a variety of roles to step forward and enter.

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AGC Biologics to acquire cell and gene therapy manufacturing facility in Longmont, Colorado

BioPharma Reporter

CDMO AGC Biologics will purchase a cell and gene therapy commercial manufacturing facility in Longmont, Colorado, from Novartis Gene Therapies.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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FDA Expands Approval for Keytruda in Locally Advanced Cutaneous SCC

BioSpace

The expanded approval was made based on positive data from a second interim analysis of the Phase II KEYNOTE-629 trial.

Trials 102
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How fish got their spines

Scienmag

Scientists from Konstanz unravel the genetic mechanisms controlling fin spine formation across fish lineages Credit: Joost Woltering In the movie “A Fish Called Wanda”, the villain Otto effortlessly gobbles up all the occupants of Ken`s fish tank. Reality, however, is more daunting. At least one unfortunate fan who re-enacted this scene was hospitalized with a […].

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Comparison of Spending on Common Generic Drugs by Medicare vs Costco Members

JAMA Internal Medicine

This cross-sectional study uses 2017 and 2018 Medicare Part D clams to compare the amount Medicare pays for common generic prescriptions in Part D with prices available to patients without insurance at Costco.

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Being clean and hygienic need not impair childhood immunity

Scienmag

Peer-reviewed | opinion | people The theory that modern society is too clean, leading to defective immune systems in children, should be swept under the carpet, according to a new study by researchers at UCL and the London School of Hygiene & Tropical Medicine. In medicine, the ‘hygiene hypothesis’ states that early childhood exposure to […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Effect of Antibiotic-Prescribing Feedback to High-Volume Physicians on Number of Prescriptions

JAMA Internal Medicine

This randomized clinical trial evaluates peer-comparison audit and feedback to primary care physicians with a high volume of antibiotic prescribing to assess the effect of targeted messaging on avoiding unnecessary antibiotic initiation and long-duration prescribing.

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Infusion centers associated with substantially better outcomes than the ER for patients with acute pain events and sickle cell disease

Scienmag

Embargoed news from Annals of Internal Medicine Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, […].

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COVID-19 News: New Variants, Third Doses and More

BioSpace

Continuing studies and news about COVID-19 around the world keeps coming in. Here’s a look.

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How can ‘shark dandruff’ contribute to coral reef conservation?

Scienmag

Credit: STRI For 400 million years, shark-like fishes have prowled the oceans as predators, but now humans kill 100 million sharks per year, radically disrupting ocean food chains. Based on microscopic shark scales found on fossil- and modern coral reefs in Caribbean Panama, Smithsonian scientists reveal the changing roles of sharks during the last 7000 […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Pharma execs join DigitalEurope’s new health council

pharmaphorum

Senior figures from GlaxoSmithKline, Roche, Bayer, and Johnson & Johnson have been named to an 18-strong executive council for health at DigitalEurope – a trade association representing the tech industry. The new council has been set up to help drive the adoption of digital approaches that could help deliver personalised care, improve disease monitoring and prevention, and potentially reduce costs for health systems across Europe.

Genome 64
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Nanomaterials shape and form influences their ability to cross the blood brain barrier

Scienmag

Nanomaterials found in consumer and health-care products can pass from the bloodstream to the brain side of a blood-brain barrier model with varying ease depending on their shape – creating potential neurological impacts that could be both positive and negative, a new study reveals. Scientists found that metal-based nanomaterials such as silver and zinc oxide […].

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Private equity firms play ‘pass the Parexel’ with $8.5bn handover deal

pharmaphorum

Four years after being taken private, Parexel has been sold again, with Goldman Sachs’ private equity arm and EQT paying $8.5 billion to claim ownership of the contract research organisation. The handover comes four years after Pamplona Capital Management bought the company for around $5 billion, and just a few weeks after lab tech company Thermo Fisher Scientific agreed to acquire another CRO – PPD – in a deal valued at $17.4 billion.

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Hunting and hidden deaths led to 30% reduction in WI wolf population

Scienmag

MADISON, Wis. — About 100 additional wolves died over the winter in Wisconsin as a result of the delisting of grey wolves under the Endangered Species Act, alongside the 218 wolves killed by licensed hunters during Wisconsin’s first public wolf hunt, according to new research. The combined loss of 313 to 323 wolves represents a […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.