Sun.Oct 25, 2020

Bayer Acquires AskBio for Up to $4 Billion to Expand Gene Therapy Platform

BioSpace

Bayer is paying $2 billion upfront for AskBio's AAV-based gene therapy pipeline of treatments for Pompe disease, among others, and could pay an additional $2 billion in potential milestones

Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion for Symptomatic Hyponatremia

JAMA Internal Medicine

This randomized clinical trial compares the risk of overcorrection with use of rapid intermittent bolus and slow continuous infusion with hypertonic saline in patients with symptomatic severe hyponatremia

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Targeted inhibitor of mutated KRAS gene shows promise in lung, bowel, & other solid tumors

Scienmag

Gene 63

FORMA Therapeutics’ Olutasidenib Shows Promising Activity Against IDH1-Mutated AML

BioSpace

Treatment with FORMA Therapeutics’ investigational agent olutasidenib has shown promising efficacy and safety in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) and mutations in isocitrate dehydrogenase 1 (IDH1m

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1 in 12 parents say their teen has attended a demonstration about racism or police reform

Scienmag

The majority of parents support teen’s involvement with demonstrations; Black parents more likely to discuss racism and police brutality in-depth with teens, new national poll suggests. Credit: C.S.

FibroGen Provides More Support for Roxadustat in Anemia Associated with Kidney Disease

BioSpace

FibroGen presented data from two pooled analyses from its roxadustat global Phase III development program this weekend at the American Society of Nephrology Kidney Week 2020 Reimagined conference

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New patent expiration for LILLY drug CIALIS

Drug Patent Watch

Annual Drug Patent Expirations for CIALIS Cialis is a drug marketed by Lilly and is included in one NDA. It is available from seven suppliers. There is one patent protecting…. The post New patent expiration for LILLY drug CIALIS appeared first on DrugPatentWatch - Make Better Decisions.

Inhibitor of KRAS gene mutation shows promise in lung, bowel and other solid tumors

Scienmag

Latest results from KRYSTAL-1 early clinical trial of adagrasib (MRTX849) Credit: Pasi A. Jänne New results from early clinical trials of a drug that targets a cancer-causing mutation in the KRAS gene have shown that it can shrink tumours and is well-tolerated by patients.

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AstraZeneca's COVID-19 Vaccine Boosts Immune Response in Older, Younger Adults

BioSpace

Days after the U.S. FDA greenlit the restart of AstraZeneca’s Phase III COVID-19 vaccine trial, the company said the preventative medication boosts immune responses in older and younger adults against the novel coronavirus

Oncotarget: Survival after resection of brain metastases: A matched cohort analysis

Scienmag

The cover for issue 32 of Oncotarget features Figure 2, ‘This figure depicts overall survival and local in-brain recurrence-free survival in the study’s subgroups,’ by Hussein, et al. Credit: Correspondence to – Bawarjan Schatlo – bawarjan.schatlo@med.uni-goettingen.de

Spectrum Pharmaceuticals Sees Delay from FDA on Eflapegrastim BLA

BioSpace

"We are actively working with the FDA to find a way to expedite the plant inspection," said Joe Turgeon, president and CEO of Spectrum Pharmaceuticals. The manufacturing facility is ready for inspection and we are eager to assist the FDA in completing their assessment as soon as possible

People with type 2 diabetes need not avoid eating potatoes based on glycemic index

Scienmag

New study findings show that people with type 2 diabetes can better maintain overnight glycemic control when high Glycemic Index (GI) potatoes are included in an evening meal versus low GI basmati rice People with type 2 Diabetes (T2D) are frequently told to avoid eating potatoes, and other high Glycemic Index (GI) foods, because of […]. Agriculture Diabetes Diet/Body Weight Food/Food Science Medicine/Health

GBT Presents Data at 15th Annual Scientific Conference on Sickle Cell and Thalassemia

The Pharma Data

Real-world effectiveness data on Oxbryta ® (voxelotor) in the treatment of sickle cell disease featured as oral presentation. SOUTH SAN FRANCISCO, Calif., 26, 2020 (GLOBE NEWSWIRE) — Global Blood Therapeutics, Inc.

Calamine lotion for chickenpox skin itchiness

Druggist

Calamine lotion for chickenpox is usually considered the first choice in the management of itchiness caused by varicella-zoster virus infection. Calamine lotion is cheap and widely available. In this post, I will review the use of calamine lotion for chickenpox.

Clinical Catch-Up: October 19-23 | BioSpace

The Pharma Data

It was another busy week for clinical trial updates and news. Here’s a look. COVID-19-Related. The U.S. Army Medical Research and Development (USAMRDC ) initiated a Phase I clinical trial of its novel vaccine against COVID-19.

Novartis' Most Advanced Kidney Compound Shows Promise in C3G

BioSpace

Novartis released promising interim Phase II data of iptacopan in C3 glomerulopathy (C3G). The analysis was presented at the virtual American Society of Nephrology (ASN) 2020 Annual Meeting

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PTC Therapeutics Announces Initiation of a Registration-Directed Clinical Trial to Evaluate Vatiquinone in Mitochondrial Epilepsy

The Pharma Data

. SOUTH PLAINFIELD, N.J. , 26, 2020 /PRNewswire/ — PTC Therapeutics , Inc.

Aridis CEO Confident Inhaled Antibody Formulation Will Play a Key Role in Controlling COVID-19

BioSpace

Only a fraction of intravenous antibody treatments will make their way to the lungs of COVID-19 patients, which is where the infection is primarily located. Aridis Chief Executive Officer Vu Truong believes his company has a better solution – an inhaled antibody

Santen Announces U.S. FDA Filing Acceptance of New Drug Application (NDA) for Cyclosporine Topical Ophthalmic Emulsion, 0.1% for the Treatment of Severe Vernal Keratoconjunctivitis in Patients Ages 4-18

The Pharma Data

. EMERYVILLE, Calif. , 26, 2020 /PRNewswire/ — Santen, Inc. the U.S. subsidiary of Santen Pharmaceutical Co., hereinafter, Santen), a global company focused exclusively on ophthalmology, today announced that the U.S.

Hospitalizations for Chronic Disease and Acute Conditions in the Time of COVID-19

JAMA Internal Medicine

This study examines the frequency of hospitalization for all non–COVID-19-related conditions in a health system at the epicenter of the COVID-19 pandemic

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BioXcel Therapeutics Receives FDA Clearance of IND for Phase 2 Trial with BXCL501 for the Treatment of Agitation Associated with DeliriumFifth potential indication for BXCL501, an orally dissolving thin film

The Pharma Data

NEW HAVEN, Conn., 26, 2020 (GLOBE NEWSWIRE) — BioXcel Therapeutics, Inc. (“BTI”

Kid influencers are promoting junk food brands on YouTube — garnering more than a billion views

Scienmag

Little-known but common form of product placement boosts children’s exposure to unhealthy food, warrants stronger regulations Kids with wildly popular YouTube channels are frequently promoting unhealthy food and drinks in their videos, warn researchers at NYU School of Global Public Health and NYU Grossman School of Medicine in a new study published in the journal […].

SQI Diagnostics Updates Clinical Progress on Novel COVID-19 Tests Under Development for U.S. FDA Regulatory Submission

The Pharma Data

Company Confirms COVID-19 Antibody Home Test and Two Severity Triage Tests can be Submitted to U.S. FDA Under Emergency Use Authorization. TORONTO , Oct. 26, 2020 /PRNewswire/ – SQI Diagnostics Inc.

Liver cancer diagnoses and deaths impacted by geography and household income

Scienmag

An analysis of information from a large U.S. cancer database indicates that patients with liver cancer from rural regions and lower income households often have more advanced cancer at the time of diagnosis and face a higher risk of death compared with other patients. The findings are published early online in CANCER, a peer-reviewed journal […]. Cancer cancer Death/Dying Demography Diagnostics Liver Medicine/Health Mortality/Longevity Poverty/Wealth Public Health Socioeconomics

FDA Grants 510(k) Clearance for Abiomed’s Innovative Cardiopulmonary Support Technology

The Pharma Data

26, 2020 11:55 UTC. DANVERS, Mass.–( –( BUSINESS WIRE )– The United States Food and Drug Administration (FDA) has granted Abiomed (NASDAQ: ABMD) a 510(k) clearance for an all-in-one, compact cardiopulmonary bypass system called the Abiomed Breethe OXY-1 System.

Next generation BRAF inhibitor cancer drug shows promise in early patient trial

Scienmag

A new drug designed to work on cancers with an altered BRAF gene has shown promise in an early patient trial presented at the 32nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. The BRAF gene is involved in telling healthy cells when to grow and form new cells, […]. Medicine & Health cancer Clinical Trials Dermatology Gastroenterology Genes Genetics Medicine/Health Neurobiology

Moderna Announces Supply Agreement with the Ministry of Public Health to Supply Qatar with mRNA Vaccine Against COVID-19 (mRNA-1273)

The Pharma Data

26, 2020 11:00 UTC. CAMBRIDGE, Mass.–(

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Globalized economy making water, energy and land insecurity worse: Study

Scienmag

The first large-scale study of the risks that countries face from dependence on water, energy and land resources has found that globalisation may be decreasing, rather than increasing, the security of global supply chains. Countries meet their needs for goods and services through domestic production and international trade. As a result, countries place pressures on […].

AstraZeneca Resumes U.S. COVID-19 Vaccine Trial

The Pharma Data

The FDA has given AstraZeneca the all-clear to restart its late-stage U.S. vaccine trial after wrapping up its safety review. Source link. Research

The effects of social determinants of health on kidney transplant candidates

Scienmag

Highlights Social determinants of health are associated with patient-reported outcomes in adults who are eligible to undergo kidney transplantation evaluations. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. Washington, DC (October 25, 2020) — Certain social determinants of health predict patient-reported outcomes in potential kidney transplant […]. Medicine & Health Medicine/Health

India Study of Convalescent Plasma Shows ‘Limited Effectiveness’ for COVID-19 Patients

The Pharma Data

An Indian trial evaluating convalescent plasma as a COVID-19 treatment has found that the therapy failed to reduce progression to severe COVID-19 or death, leaving the Indian government skeptical about its viability, though medical experts say the treatment may still hold promise. Source link.

Indian and Pakistani women diagnosed with more aggressive breast cancer at younger age

Scienmag

Culturally relevant strategies are necessary to improve preventive health care in this rapidly growing population, Rutgers researchers say Indian and Pakistani women are diagnosed with breast cancer, including more aggressive forms of the disease, at a younger age, according to Rutgers researchers. South Asians are the fastest-growing major ethnic group in the United States with […]. Medicine & Health Breast Cancer Medicine/Health

CureVac Touts Positive Preclinical Data for COVID-19 Vaccine | 2020-10-26

The Pharma Data

German drugmaker CureVac said preclinical studies of its COVID-19 vaccine candidate, CVnCoV, showed the vaccination prompted a successful immune response.

Clinical Catch-Up: October 19-23

BioSpace

It was another busy week for clinical trial updates and news. Here’s a look