Thu.Jan 06, 2022

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Lilly pours more money into genetic treatments for neurological diseases

Bio Pharma Dive

For $50 million, Lilly has secured rights to a technology that's meant to transport nucleic acid therapies in a way that's more targeted and better tolerated than other methods.

Genetics 300
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B-cell lymphoma clinical trials now open on the TrialWire Platform

Pharma Mirror

ADELAIDE, AUS – TrialWire(TM) is pleased to announce new B-cell lymphoma clinical studies are now available on the TrialWire Platform. More than 6 million people have used TrialWire over the past few years to find clinical trials that are right for them at clinics and specialist centers near them. The studies on TrialWire are available in Australia, New Zealand, and the U.S.

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Sanofi cuts ties with Sangamo, sharpening focus on 'off-the-shelf' cell therapy

Bio Pharma Dive

The French pharma cited a "change in strategic direction" for ending a long-running pact focused on genetic medicines for blood diseases, led by a sickle cell treatment in early testing.

Genetics 278
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Digital health innovation in 2022: Anticipating healthcare trends ahead of the J.P. Morgan week

pharmaphorum

We spoke with Tanja Dowe, ahead of the annual J.P. Morgan Health Care Conference 2022, about radical innovation in healthcare, including the potential of digital solutions to diagnose disease earlier, using digital therapeutics or preventive digital solutions more efficiently, and making use of technologies that result in accelerated drug discovery and development.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Novartis turns to Alnylam in research deal aimed at liver failure

Bio Pharma Dive

The Swiss pharma is well familiar with Alnylam's RNA-based technology, which underpins Novartis' newly approved cholesterol drug Leqvio.

RNA 276
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Finally: A comprehensive diagnostic guide to a well-established boxwood disease

Scienmag

For more than 150 years, Volutella blight has been one of the most common diseases of the loved and iconic boxwood plant as well as other plants in the family, including pachysandra and sarcococca. Despite its presence on every continent except Antarctica, the disease can be hard to identify. To help with diagnosis, a group […].

Medicine 109

More Trending

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Sosei Heptares and Verily to collaborate on immune-mediated disease treatments

Pharma Times

The companies share the goal of furthering knowledge around GPCR biology in immune cells in order to better understand a range of immune system disorders.

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Shingles is new focus for Pfizer and BioNTech in mRNA vaccine development partnership

BioPharma Reporter

Pfizer and BioNTech, in what will be the third mRNA vaccine collaboration between the two companies, are teaming up on the development of a potential first mRNA-based vaccine for the prevention of shingles.

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PCR not needed following lateral flow test under new guidelines

Pharma Times

Testing rules for COVID-19 are set to be eased for those who test positive on a lateral flow test but are asymptomatic.

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Danone Partners with Cold Stone Creamery for Plant-Based Dessert

XTalks

Danone North America is partnering with Cold Stone Creamery to offer a new plant-based dessert: The Silk Chocolate Almondmilk Frozen Dessert. Along with the flavor launch, Cold Stone Creamery is introducing a new menu item called Don’t Cry Over Spilled Silk Creation, which features this latest flavor as well as banana, peanut butter and roasted almonds.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Another mRNA company gets snapped up as Merck buys Exelead

pharmaphorum

The latest pharma company to make a move for an mRNA specialist is Germany’s Merck KGaA, which has offered a $780 million cash buyout to US biotech Exelead. Unlike other recent deals however the takeover isn’t focused on adding a pipeline of mRNA candidates, as Indianapolis-based Exelead is a contract development and manufacturing organisation (CDMO) provide derives to other drugmakers.

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Mass production of revolutionary computer memory moves closer with ULTRARAMâ„¢ on silicon wafers for the first time

Scienmag

A pioneering type of patented computer memory known as ULTRARAM™ has been demonstrated on silicon wafers in what is a major step towards its large-scale manufacture. Credit: Manus Hayne, Lancaster University A pioneering type of patented computer memory known as ULTRARAM™ has been demonstrated on silicon wafers in what is a major step towards its […].

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White House seeks out community digital health examples

pharmaphorum

The Biden administration has launched a fact-finding mission to try to find ways to deploy digital health technologies effectively in community settings, in order to boost “individual wellness and health equity.” The request for information – which appeared in the Federal Register yesterday – was filed by the White House Office of Science and Technology Policy (OSTP) and is aimed particularly at community-based programmes in populations that are currently “underserved” by

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Cities boosted rain, sent storms to the suburbs during Europe’s deadly summer floods

Scienmag

When it comes to extreme weather, climate change usually gets all the attention. But according to a study from The University of Texas at Austin and two universities in China, the unique effects of cities – which can intensify storms and influence where rain falls – need to be accounted for as well. Credit: Martin […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Covid Treatments Including Paxlovid Are Rationed as Cases Spike

NY Times

Scarce supplies and surging Covid cases have caused health officials, hospitals, doctors and patients to scramble for pills and infusions.

Doctors 87
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Organic light emitting diodes operated by 1.5 V battery

Scienmag

Various properties of organic light-emitting diodes (OLEDs) have been optimized, including current to photon conversion efficiency. An external quantum efficiency exceeding 20%, with internal quantum efficiency of 100%, has been achieved owing to the development of thermally activated delayed fluorescent and phosphorescent materials that manage the spin of excited states.

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Clover Biopharmaceuticals starts construction of new R&D center in Shanghai

BioPharma Reporter

Clover Biopharmaceuticals, a clinical-stage biotech developing novel vaccines and biologic therapeutic candidates, has started construction on a new R&D Center in Zhangjiang Biotech and Pharmaceutical Industrial Base in Shanghai.

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Dog brains can distinguish between languages

Scienmag

Dog brains can detect speech, and show different activity patterns to a familiar and an unfamiliar language, a new brain imaging study by researchers from the Department of Ethology, Eötvös Loránd University (Hungary) finds. This is the first demonstration that a non-human brain can differentiate two languages. This work has been published in NeuroImage.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Otsuka dips its toe in psychedelic waters, backing Mindset Pharma

pharmaphorum

Despite the growing interest in developing medicines based on psychedelic compounds, big pharma has seemed a bit wary of getting involved, leaving the task to small start-ups. Now, Japan’s Otsuka Pharmaceutical has become one of the first to gather a position in the sector via a small deal with Mindset Pharma that will provide funding to take candidates though early-stage clinical testing.

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Risk of overactive bladder associated with medications for dementia

Scienmag

A study from the University of Houston College of Pharmacy, and published in the Journal of the American Geriatrics Society, has evaluated the risk of overactive bladder (OAB) as a side effect of cholinesterase inhibitor (ChEI) drugs taken for dementia and Alzheimer’s disease. The research was based on the dissertation work of the study’s first author Prajakta Masurkar.

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Charles River Laboratories to Present at J.P. Morgan Healthcare Conference

BioTech 365

Charles River Laboratories to Present at J.P. Morgan Healthcare Conference Charles River Laboratories to Present at J.P. Morgan Healthcare Conference WILMINGTON, Mass.–(BUSINESS WIRE)–$CRL #CRL–Charles River Laboratories International, Inc.

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Unlocking the secrets of a critical schistosomiasis drug

Scienmag

Independent teams from Texas Biomedical Research Institute and the Medical College of Wisconsin have published two papers in Science Translational Medicine identifying how the only approved drug to treat schistosomiasis, a widespread parasitic worm infection, works on the molecular level. Credit: Texas Biomed Independent teams from Texas Biomedical Research Institute and the Medical College of […].

Drugs 85
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Amgen pledges $1.9bn to alliance with AI specialist Generate

pharmaphorum

Fresh from a sizeable funding round that raised $370 million, artificial intelligence-based drug discovery firm Generate Biomedicines has just signed its first major partnering deal with Amgen. The machine learning specialist – founded by venture capital firm Flagship Pioneering in 2018 – is getting $50 million upfront to kick off the alliance, with another £370 million in the offing for up to five programmes.

Protein 59
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Nematicity is a new piece in a phase diagram puzzle

Scienmag

Although twisted sheets of double bilayer graphene have been studied extensively the past few years, there are still pieces missing in the puzzle that is its phase diagram—the different undisturbed, ground states of the system. Writing in Nature Physics, Carmen Rubio-Verdú and colleagues have found a new puzzle piece: an electronic nematic phase. Credit: Carmen […].

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C.S. Lewis & Jesus

Pharma Packaging Solutions

Our theme for 2022 is simple but bold, obvious but too often overlooked. It’s “Jesus 365.” Last Sunday we revisited the story of Jesus’ parents leaving him behind in Jerusalem, losing him for 3 days! It really isn’t a story about safe parenting but a story about God’s calling and our unawareness of God’s absence.

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Scientists reduce all-solid-state battery resistance by heating

Scienmag

All-solid-state batteries are now one step closer to becoming the powerhouse of next-generation electronics as researchers from Tokyo Tech, AIST, and Yamagata University introduce a strategy to restore their low electrical resistance. They also explore the underlying reduction mechanism, paving the way for a more fundamental understanding of the workings of all-solid-state lithium batteries.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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New patent for Anacor Pharms drug EUCRISA

Drug Patent Watch

Annual Drug Patent Expirations for EUCRISA Eucrisa is a drug marketed by Anacor Pharms Inc and is included in one NDA. It is available from one supplier. There are four…. The post New patent for Anacor Pharms drug EUCRISA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Select heart surgery patients may not need opioid pain meds when discharged

Scienmag

CHICAGO (December 16, 2021) — Many patients who undergo heart surgery may be able to safely and effectively control postoperative pain without opioids after hospital discharge, according to research published online today in The Annals of Thoracic Surgery. “In some cases, patients assume that after surgery, especially a big operation like cardiac surgery, that they will […].

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New patent for Intra-cellular drug CAPLYTA

Drug Patent Watch

Annual Drug Patent Expirations for CAPLYTA Caplyta is a drug marketed by Intra-cellular and is included in one NDA. There are nine patents protecting this drug. CAPLYTA drug price trends.…. The post New patent for Intra-cellular drug CAPLYTA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Racialized women frequently excluded from developing medical guidance: Study

Scienmag

A study of all clinical practice guidelines published in national general medical journals in Australia, Canada, the United Kingdom, and the United States over a period of eight years – including the pandemic period – has found that the panels developing recommendations are mostly made up of white men and frequently exclude racialized women. Credit: […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.