Wed.Oct 27, 2021

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Merck agrees to license COVID-19 pill widely through pact with patent group

Bio Pharma Dive

The deal with the Medicines Patent Pool is meant to increase access in lower-income countries to molnupiravir, an experimental drug that could become the first oral treatment for COVID-19.

Licensing 321
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About your DTC messaging…

World of DTC Marketing

SUMMARY : DTC message development and use is the most essential action to get patients interested in your product, but it can’t be based on unrealistic patient behavior modifications. Yesterday I received a call from a physician who is a thought leader in the diabetes area. He had read my BLOG post from yesterday and wanted to add something that he thinks DTC marketers need to hear. “Don’t promise results that most patients will never see.” As we talked, he mentioned a di

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Takeda reels in a cell therapy research partner with 'build-to-buy' deal

Bio Pharma Dive

The Japanese drugmaker is acquiring GammaDelta Therapeutics, a partner since 2017, and its research on allogeneic cell therapy for cancer.

Research 328
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Merck takes further steps to expand access to oral COVID pill

pharmaphorum

Merck & Co has signed a licensing deal with the UN-backed Medicines Patent Pool (MPP) that could pave the way for generic companies to manufacture its much-anticipated oral antiviral for COVID-19. The agreement would provide royalty-free licenses to companies manufacturing molnupiravir – originally developed by Ridgeback Biotherapeutics – for distribution in 105 low- and middle-income countries around the world.

Licensing 143
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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Priority review for Novartis CAR-T cell therapy Kymriah

Pharma Times

Novartis is eyeing approval for Kymriah to treat adult patients with relapsed or refractory follicular lymphoma

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Bayer, One Drop launch AI tool for heart disease prevention

pharmaphorum

Bayer’s two-year-old digital health collaboration with One Drop has borne its first fruit, an artificial intelligence-powered software module for preventing cardiovascular disease (CVD). The German pharmaceutical company has been working with New York-based One Drop on digital health products that span multiple therapeutic areas, including oncology and women’s health as well as CVD in the alliance , which was expanded last year in a $98 million deal.

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Fluvoxamine Helps Lower Risk of Hospitalization From Covid, Study Finds

NY Times

Scientists say the results of the latest research examining the inflammation-fighting qualities of fluvoxamine, capping similar smaller studies, could lead to new treatment guidelines.

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Positive Results in Hand, AbbVie Eyes Potential Approval for Parkinson’s Treatment

BioSpace

AbbVie’s experimental subcutaneous Parkinson’s disease drug ABBV-951 hit the mark in a 12-week Phase III study in patients with an advanced form of the disease.

Drugs 105
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From Restaurant to Retail: Red Lobster’s Famous Biscuits

XTalks

In the age of convenience, restaurants and foodservice operators that don’t offer takeout and/or delivery, especially during the ongoing COVID-19 pandemic, will likely fall by the wayside. But some take it a step further by launching their most popular products in retail — the latest of which is Red Lobster. Earlier this week, the seafood chain announced it would be launching a frozen, ready-to-bake version of its famous Cheddar Bay Biscuits exclusively in Walmart stores.

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10 Tips On How To Get Started With Agile Marketing

Pharma Marketing Network

What is Agile Marketing Exactly? Agile marketing is the application of agile values and principles to manage the way a marketing team gets work done. At its core, an agile approach values flexibility, iteration, and speed. It enables you to quickly learn what does and does not work, so you can incrementally improve the results of your marketing efforts.*. * Source: AHA!

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Multi-algorithm approach helps deliver personalized medicine for cancer patients

Scienmag

Today, machine learning, artificial intelligence, and algorithmic advancements made by research scientists and engineers are driving more targeted medical therapies through the power of prediction. The ability to rapidly analyze large amounts of complex data has clinicians closer to providing individualized treatments for patients, with an aim to create better outcomes through more proactive, personalized […].

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Novartis Under New DOJ Scrutiny Over Potential Kickback Allegations

BioSpace

Novartis is the subject of a DOJ inquiry over the company’s marketing and pricing of Entresto over the past five years, receiving a Civil Investigative Demand from the government.

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On the generation and propagation of internal solitary waves in the southern Andaman Sea: A numerical study

Scienmag

This study is led by Prof. Cai (South China Sea Institute of Oceanology, Chinese Academy of Sciences). The two-dimensional Massachusetts Institute of Technology general circulation model is applied to investigate the dynamics of ISWs in the southern Andaman Sea. From west to east, there are three main ridges along the section of the Great Channel, […].

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How to Decide Which Covid Booster Shot to Get

NY Times

Health officials approved mix-and-match Covid booster shots, but didn’t say whether it’s better to switch vaccines or stick with your original shot.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Hazardous levels of alcohol consumption identified in African hunter-gatherer group

Scienmag

The Mbendjele BaYaka are an Indigenous Congolese hunter-gatherer population, one of a number of “Pygmy” hunter-gatherer populations living in the rainforests of Central Africa. Credit: N. Chaudhary The Mbendjele BaYaka are an Indigenous Congolese hunter-gatherer population, one of a number of “Pygmy” hunter-gatherer populations living in the rainforests of Central Africa.

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FDA Sends Warning Letter to Former Sesen Bio Trial Investigator

BioSpace

The letter was related to a 2021 FDA inspection connected to Sesen’s Biologics License Application for Vicineum for the treatment of BCG-unresponsive non-muscle invasive bladder cancer.

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Cancer cells change shape, how they move to invade different types of tissue, OSU research shows

Scienmag

CORVALLIS, Ore. – Oregon State University research has shed new light on the way malignant cells change their shape and migration techniques to invade different types of tissue. Credit: Bo Sun, OSU CORVALLIS, Ore. – Oregon State University research has shed new light on the way malignant cells change their shape and migration techniques to […].

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Merck Will Share Formula for its Covid Pill With Poor Countries

NY Times

The company announced a licensing deal that will allow the drug, molnupiravir, to be made and sold cheaply in 105 developing nations.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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To convert heat into electricity: Scientists developed an efficient generator

Scienmag

Researchers from Peter the Great St. Petersburg Polytechnic University (SPbPU) in collaboration with an industrial partner elaborated thermoelectric generator of new generation, which is ten times more efficient than its analogues currently available on the market. The final product will be implemented by an industrial partner at the end of 2021. The project is conducted within […].

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Sturgeon urged to speed COVID booster jab rollout as vulnerable groups left waiting

Pharma Times

Opposition leaders have emphasised that more than 100,000 people eligible for a third dose have not yet received it

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Development of precision focused ultrasound surgery technology destructing only the desired tissues

Scienmag

Development of precision focused ultrasound surgery technology destructing only the desired tissuesThere are ongoing efforts to use various ultrasonic effects with non-invasive properties to replace existing surgical procedures. The focused ultrasound-based bio-tissue destruction technology, which can mechanically fractionate the surrounding bio-tissue using a powerful bubble (cavitation) generated at a short time of approximately 1/100th of […].

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Rafael Pharmaceuticals’ Cancer Metabolism Drug Fails Phase III Assessment

BioSpace

Despite these challenges, Raphael remains dedicated to developing the field of cancer metabolism-based therapeutics.

Drugs 111
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Immunotherapy for intractable mutant cancer using a statin, hyperlipidemia drug

Scienmag

Third-generation cancer immunotherapy, a method of removing cancer using the body’s immune system, has shown remarkable clinical benefits in recent years, giving hopes to many researchers and patients. Cancer immunotherapy generates memory immunity to cancer, and the anticancer effect lasts without causing harm to normal cells. Therefore, the treatment has good outcomes with few side […].

Drugs 87
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Stallergenes Greer and Aptar Pharma to develop immunotherapy treatment device

Pharma Times

The development of the device is being carried out by Aptar Pharma’s Digital Health group

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Model could help archeologists unearth new Pleistocene sites in Cyprus, suggesting that more historic hunter-gatherer activity on Eastern Mediterranean islands than previously suspected

Scienmag

Model could help archeologists unearth new Pleistocene sites in Cyprus, suggesting that more historic hunter-gatherer activity on Eastern Mediterranean islands than previously suspected Credit: Moutsiou et al. et al., 2021, PLOS ONE, CC-BY 4.0 ([link] Model could help archeologists unearth new Pleistocene sites in Cyprus, suggesting that more historic hunter-gatherer activity on Eastern Mediterranean islands […].

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Early diagnosis key to future Alzheimer’s treatments

pharmaphorum

The approval of Biogen’s Alzheimer’s treatment could herald a new generation of therapies, but before that can happen, more investment and better diagnostics may be needed, explains Ben Hargreaves. This year has been marked by one of the biggest developments in the search for new treatments for Alzheimer’s disease, after the US FDA approval of Biogen’s Aduhelm (aducanumab) in June.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Mining shift workers at significant risk of sleep loss and sleep disorders

Scienmag

Fly-in fly-out (FIFO) shift workers are losing out on valuable sleep due to the design of rosters, individual lifestyle behaviours and the risk of potential prevalence of sleep disorders. Credit: Adobe Stock Fly-in fly-out (FIFO) shift workers are losing out on valuable sleep due to the design of rosters, individual lifestyle behaviours and the risk […].

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Bespoke Consortium Born to Bring Gene Therapy to Rare Diseases

BioSpace

Collaboration is key to faster breakthroughs. The NIH, FDA, and 15 private organizations have announced they are joining forces for the sake of the 30 million Americans suffering from a rare disease.

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Vascular disease in COVID-19 is not caused by viral infection of blood vessels

Scienmag

The SARS-CoV-2 virus does not infect blood vessels, despite the high risk of blood clots to COVID-19 patients, University of Queensland researchers have found. Credit: Please credit Institute for Molecular Bioscience, The University of Queensland. The SARS-CoV-2 virus does not infect blood vessels, despite the high risk of blood clots to COVID-19 patients, University of […].

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Should I Stay or Should I Go? Deciding if it’s the Right Time to Job Search

BioSpace

If you’ve been getting the itch to job search but you aren’t sure if you should, here are some reasons to possibly leave a job that might help you decide if you should stay or if you should go.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.