Thu.Nov 04, 2021

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Novartis to sell long-held stake in Roche for nearly $21B

Bio Pharma Dive

Novartis, which paid around $5 billion for its shares two decades ago, says it will gain about $14 billion from its sale and use the proceeds to further its current strategy.

Sales 152
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Pangolin trafficking: iceberg tip of Nigeria’s illegal trade revealed

Scienmag

Since the first reported pangolin seizure in Nigeria in 2010, the country has seen an explosion in the black market for the world’s most trafficked mammal – becoming Africa’s hub for the criminal export of pangolin products to East Asia. Credit: Charles Emogor Since the first reported pangolin seizure in Nigeria in 2010, the country […].

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Moderna cuts vaccine sales, delivery targets for 2021

Bio Pharma Dive

The biotech now expects to deliver between 700 million and 800 million doses this year, down from a previous forecast of 800 million to 1 billion.

Sales 169
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Pfizer to Seek EUA for COVID-19 Antiviral with 89% Efficacy

BioSpace

Pfizer plans to seek Emergency Use Authorization for an antiviral COVID-19 treatment following an interim analysis of Phase II/III data that show statistically and clinically meaningful results.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Merck wins UK authorization to sell first COVID-19 pill

Bio Pharma Dive

Molnupiravir, as the drug is known, is also under review by the FDA and other regulators. Merck expects billions in sales as countries seek to stockpile the oral treatment.

Sales 130
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Novartis finally sells Roche stake, for almost $21 billion

pharmaphorum

After more than 20 years, Novartis has finally decided to sell its substantial share in fellow Swiss pharma group Roche for $20.7 billion, a decent return on its original $5 billion investment. The agreement will see Novartis lose its one-third voting share stake in Roche, after agreeing to sell 53.3 million Roche bearer shares at their average price over 20 days prior to 2 November, when the deal was agreed.

Sales 105

More Trending

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Study shows HPV jab almost 90% effective at preventing cervical cancer

pharmaphorum

Routine vaccination with human papillomavirus vaccines have resulted in an 87% reduction in cervical cancer cases in England, and could even see the need for smear tests phased out in future, according to a new study. The jabs with have been offered by the NHS to girls between the ages of 12 and 13 since 2008, with more than 10 million doses administered since then, and from September 2019 was also offered to boys in the same age group.

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FDA Approves AbbVie’s Vuity as the First Eyedrop for Presbyopia

XTalks

As people get older, many often experience reading problems due to blurriness in their near vision in a condition called presbyopia. Now, instead of reaching for reading glasses, AbbVie’s eyedrop formulation Vuity could offer help in correcting far-sightedness as the US Food and Drug Administration (FDA) granted approval to it late last week. Vuity is a 1.25 percent pilocarpine HCL ophthalmic solution made by AbbVie-owned Allergan.

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Talaris therapy ends need for immune drugs in transplant patients

pharmaphorum

Two kidney transplant patients who received a stem cell therapy developed by Talaris Therapeutics were able to come off all immunosuppressant drugs within a year, without any evidence of graft rejection. The first findings from Talaris’ phase 3 trial of the cell therapy – called FCR001 – suggest it may be possible to eliminate the need entirely for patients to take what may be dozens of tablets daily after organ transplants , according to the US biotech.

Drugs 98
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How COVID-19 Gave Rise to Food Delivery Robots

XTalks

Food delivery robots are no longer the stuff of science fiction. The knee-high robots — capable of transporting around four large pizzas — are now making their way around college campuses and large cities in the US, UK and Canada. While they were in the works prior to the COVID-19 pandemic, demand for contactless delivery caused a boom in the number of food delivery robots navigating the streets.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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UK first to authorise Merck/Ridgeback’s COVID pill molnupiravir

pharmaphorum

Merck & Co and Ridgeback’s oral antiviral molnupiravir has been approved in its first market – the UK – as a treatment for people with mild to moderate COVID-19 who are at increased risk of developing severe disease. The Medicines and Healthcare products Regulatory Agency (MHRA) said today that molnupiravir, now given the trade name Lagevrio, is safe and effective at reducing the risk of hospitalisation and death in these patients.

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U.S. Government Cancels Contract with Embattled Emergent BioSolutions

BioSpace

The U.S. government canceled a contract with Maryland-based Emergent BioSolutions, which earlier in the year ruined about 15 million doses of the Johnson & Johnson COVID-19 vaccine.

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Coca-Cola’s Gunning for Gatorade’s Market Share with BodyArmor Buyout

XTalks

The Coca-Cola Company announced that it has acquired full ownership of BodyArmor for $5.6 billion in cash. The company initially owned a 15 percent stake in BodyArmor but has now acquired the remaining 85 percent. This acquisition is the largest purchase ever made by Coca-Cola in its 129-year history. BodyArmor’s line of sports performance and hydration drinks will be added to the company’s portfolio in hopes of growing significantly in the market.

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How to Reduce Your Chance of Medication Errors

Triage Cancer

Medication errors, which occur in hospitals, care facilities, and at home, can lead to serious health consequences, including death. Therefore, it’s critical that you learn how to reduce your chance of medication errors. Medication issues in hospitals and healthcare facilities. Collectively, patients in hospitals and healthcare facilities take a lot of medications.

Nurses 97
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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Amgen Breaks Ground on “Digitally Advanced” Smart Facility in Ohio

BioSpace

Amgen plans on investing $365 million in the site, including the introduction of 400 new job openings through the operations of its pharmaceutical packaging and assembly facility.

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Physicists discover novel quantum effect in bilayer graphene

Scienmag

Theorists at The University of Texas at Dallas, along with colleagues in Germany, have for the first time observed a rare phenomenon called the quantum anomalous Hall effect in a very simple material. Previous experiments have detected it only in complex or delicate materials. Credit: University of Texas at Dallas Theorists at The University of […].

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Guardant Health and Royal Marsden NHS Foundation Trust announce partnership

Pharma Times

Partnership will establish an in-house liquid biopsy testing service, using Guardant Health’s proprietary digital sequencing platform

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Janssen on driving R&D innovation with data science

pharmaphorum

The amount of patient data has skyrocketed, providing opportunities to gain a deeper understanding of diseases that are particularly complex or areas with a high level of unmet need, according to Janssen’s Najat Khan. She discussed the implications of this direction of travel for pharma, and some of the changes she’s seen in data science and technology in healthcare, in a session at the recent BIO-Europe with pharmaphorum’s founder Paul Tunnah.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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SARS-CoV-2 variant detected in dogs and cats with suspected myocarditis

Scienmag

A new study in the Veterinary Record reveals that pets can be infected with the alpha variant of SARS-CoV-2, which was first detected in southeast England and is commonly known as the UK variant or B.1.1.7. This variant rapidly outcompeted pre-existing variants in England due to its increased transmissibility and infectivity. Credit: Dr. Ferasin A new study in […].

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Researchers find HPV vaccine cuts cervical cancer by 87%

Pharma Times

The research paper, published in the Lancet and funded by Cancer Research UK, considered all cervical cancers diagnosed in England among women aged 20-64 between January 2006 and June 2019

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Ardelyx Prepares for Battle with FDA Over Rejected CKD Drug

BioSpace

Ardelyx, Inc. is lacing up the gloves and preparing to wade into the ring with the U.S. Food and Drug Administration to dispute the July rejection of its chronic kidney disease drug, tenapanor.

Drugs 102
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Repurposing carbon dioxide may be key to net-zero emissions

Scienmag

While only a mere 4% of the atmosphere, carbon dioxide plays a vital role in sustaining life on our planet. However, if this delicate balance is disrupted, excess carbon dioxide can pose a formidable threat to our environment and the living beings that reside within. Credit: Texas A&M University College of Engineering While only a mere […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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bluebird bio Completes Oncology Spin-Off Business, Establishes New Nest

BioSpace

bluebird bio has completed the spin-off of its oncology programs into the new business entity, 2seventy bio, Inc, which will begin trading on the Nasdaq this morning under the ticker symbol “TSVT.

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Side-polished SMS based RI sensor employing perfluorinated POF

Scienmag

In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2021.200041 , Xuezhi Zhang, Boyue Yang, Junfeng Jiang, Kun Liu, Xiaojun Fan, Zhaozhu Liu, Min Peng, Guanlong Chen and Tiegen Liu from Tianjin University, Tianjin, China discuss a side-polished SMS based RI sensor employing perfluorinated POF. Credit: OEA In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2021.200041 , Xuezhi Zhang, Boyue […].

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UK approval for MSD/Ridgeback’s COVID-19 antiviral med

Pharma Times

The antiviral medicine will be marketed with the trademark name Lagevrio in the UK

Medicine 121
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Hunting for human obesity genes in fat fruit flies

Scienmag

Fruit flies provide an effective platform for screening new obesity genes, and fat flies implicate a neuronal signaling pathway in weight gain, according to a new study publishing November 4th in the open-access journal PLOS Biology by Sadaf Farooqi and Andrea Brand of the University of Cambridge, UK, and colleagues. Credit: Neha Agrawal and Andrea […].

Gene 85
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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Alphabet Introduces New AI Drug Discovery Company

BioSpace

?Isomorphic Laboratories has expressed plans to foray into drug discovery and development by tapping into the technology of its sister company DeepMind.

Drugs 96
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Scientists join Riverdance to investigate extreme demands of elite dance

Scienmag

Credit: Riverdance, Abhann Productions, Jack Hartin Study by University of Chichester examines the physiological demands of professional live dancing Heartrate monitors are being fitted to Riverdance’s Irish dance cast for its 25th anniversary tour First-of-its-kind investigation led by dance scientist who was part of Riverdance’s original 90s show SCIENTISTS have launched a pioneering […].

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With Positive Results in Fabry Disease, Sangamo Heading for Phase III

BioSpace

?Sangamo Therapeutics announced positive preliminary findings from its ongoing Phase I/II STAAR clinical trial in Fabry disease.

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Sweat-collecting patch inspired by cactus spines

Scienmag

A sweat-collecting patch has been developed using the principle based on how the cactus spines attract water. Credit: POSTECH A sweat-collecting patch has been developed using the principle based on how the cactus spines attract water. Sweat is an effective body fluid for analyzing bioanalytes in the body without collecting blood. The sweat sensor can […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.