Mon.Jan 10, 2022

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Pfizer expands into gene editing with Beam research deal

Bio Pharma Dive

Pfizer's work with mRNA vaccines led it explore other applications of the technology, resulting in a multi-year partnership with the high-profile biotech Beam Therapeutics on gene editing treatments for rare diseases.

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Pharma is in acquisition mode but small biotechs hurting for money

World of DTC Marketing

Pharma companies are flush with cash and looking to make deals, but there are still a lot of small biotech companies that don’t have enough money to launch their products entirely. It seems that pharma is only interested in drugs that have the potential to sell hundreds of millions as opposed to small products that may only sell to a limited audience.

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Allogene cleared by FDA to resume 'off the shelf' cancer cell therapy trials

Bio Pharma Dive

A "chromosomal abnormality" that led regulators to halt Allogene's trials was judged to be unrelated to its technology, a finding with important implications for the field of donor-derived cell therapies.

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How Effective Are Drugs in Treating Communication Disorders?

Pharma Mirror

Speaking, hearing, and comprehending is how most of us communicate with the outside world, and being unable to do so — or even to do so with difficulty — can be a significant impediment to dealing with others. In particular, communications disorders can be a major challenge to school-age children, who might struggle to reach their full potential or even get the most out of their schooling.

Drugs 130
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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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BioMarin plans return to FDA with updated data on hemophilia gene therapy

Bio Pharma Dive

Two-year results from a Phase 3 study of Roctavian show treatment prevented bleeding, potentially giving BioMarin the data it needs to resubmit an application for approval.

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Synairgen announces global strategic partnership with Ashfield Engage

Pharma Mirror

Southampton, UK: Synairgen plc (LSE: SNG), the respiratory company developing SNG001 (inhaled interferon-beta or IFN-beta) for the treatment of COVID-19 as potentially the first host-targeted, broad-spectrum antiviral treatment delivered directly into the lungs, today announces a partnership with global experts in strategic engagement and commercialisation, Ashfield Engage.

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More Trending

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Stand Up to Cancer research initiative targets pancreatic cancer

Outsourcing Pharma

Joining with a noted research foundation, the group is aiming for earlier detection and treatment of the disease, which hits nearly 500K people annually.

Research 137
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JPM22: Pfizer's big bet on mRNA, Biogen 'proven wrong' on Aduhelm price and the next cell therapies

Bio Pharma Dive

The healthcare conference's first day brought a trio of mRNA deals from Pfizer, a rare admission from Biogen's CEO and new focus on what's next in cell therapy.

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Veganuary 2022: History and Significance of the Vegan Movement

XTalks

Combining the words “vegan” and “January,” Veganuary is an annual challenge encouraging people around the world to switch to a vegan diet and lifestyle for the month. This entails abstaining from animal products including food, clothing and cosmetics. And while it may seem like a daunting task to many, a record 500,000 people signed up for Veganuary in 2021.

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Leveraging print and digital communications for patient-centric clinical trials

Bio Pharma Dive

The demand for communicating and reaching trial participants where they live in the most convenient and effective fashion is growing daily and having a dynamic print solution can help make that happen.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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How a potent antifibrotic peptide works and why it could reverse scarring in multiple organs

Scienmag

A research team at the Medical University of South Carolina (MUSC) led by Carol Feghali-Bostwick, Ph.D., reports in the Journal of Clinical Investigation (JCI) Insight that the E4 peptide reverses fibrosis, or scarring, in human and mouse tissues by activating an antifibrotic pathway that is common to all organ systems. Credit: Sarah Pack, Medical University of […].

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The Pandemic isn't over; neither is the new era of healthcare logistics

Bio Pharma Dive

We have to focus on maintaining a sustainable, collaborative supply chain that delivers for everyone on this hard road ahead.

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KTU students’ success in the Silicon Valley competition: Created a transparent protective face mask

Scienmag

A team of students from Kaunas University of Technology (KTU) and start-up Assero have introduced an innovative see-through mask. The mask prototype won international recognition, as it took the second place in the Silicon Valley Innovation Competition in the Best Overall Innovation category. Credit: KTU A team of students from Kaunas University of Technology (KTU) […].

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PCMA Business Forum

Drug Channels

PCMA Business Forum. February 28 – March 1, 2022 JW Marriott Grande Lakes | Orlando, FL Register Today! www.pcma.com/businessforum. The PCMA Business Forum is PCMA's largest business networking and educational conference. PCMA’s PBM Members send a large number of executives from relevant business units including pharma and trade relations, specialty pharmacy, clinical and patient care services, and the c-suite.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Researchers Switch Off Gene to Switch On Ultraviolet in Butterfly Wings

Scienmag

[Note: High-resolution images, illustrations and animations related to this research available for download at this link. Caption and credit information provided.] Credit: Vincent Ficarrotta and Arnaud Martin/ The George Washington University [Note: High-resolution images, illustrations and animations related to this research available for download at this link.

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AstraZeneca and Neurimmune to develop investigational human monoclonal antibody NI006

BioPharma Reporter

Alexion, AstraZenecaâs Rare Disease group, has entered into an exclusive global collaboration and licence agreement with Neurimmune AG for NI006, an investigational human monoclonal antibody currently in Phase Ib development for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM).

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OU-led research uses artificial intelligence to guide the search for the next SARS-COV-2

Scienmag

Daniel Becker, an assistant professor of biology in the University of Oklahoma’s Dodge Family College of Arts and Sciences, has been leading a proactive modeling study over the last year and a half to identify bat species that are likely to carry betacoronaviruses, including but not limited to SARS-like viruses. Credit: Brock and Sherri Fenton. […].

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The NICE recommends Rinvoq for psoriatic arthritis patients

Pharma Times

The chronic, inflammatory disease affects an estimated 24 in every 10,000 people.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Scientists uncover new information about cellular death process, previously thought to be irreversible

Scienmag

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis — the process of cell death that is usually caused by infections and results in excess inflammation in the body — and shows that process, long thought to be irreversible once initiated, can in fact be halted […].

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Bayer and Mammoth Biosciences collaborate on novel gene editing tech

BioPharma Reporter

Bayer AG and Mammoth Biosciences, Inc., have announced a strategic collaboration and option agreement for the use of Mammothâs CRISPR systems to develop in vivo gene-editing therapies.

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Manifolds in commonly used atomic fingerprints lead to failure in machine-learning four-body interactions

Scienmag

Atomic environment fingerprints, or structural descriptors, are used to describe the chemical environment around a reference atom. Encoding information such as bond-lengths to neighboring atoms or coordination numbers, these fingerprints are used, for example, as inputs in machine learning approaches or to eliminate redundant structures in structural searches Credit: @UniBasel Stefan Goedecker Atomic environment fingerprints, […].

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Pregnant women urged to receive COVID-19 booster amid surging cases

Pharma Times

Since April 2021, around 84,000 pregnant women have received at least one COVID-19 vaccination.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Study shows climate change will lead to increase in kidney stones

Scienmag

Philadelphia, January 10, 2022—Rising temperatures due to climate change will lead to an increase in cases of kidney stones over the next seven decades, even if measures are put in place to reduce greenhouse gas emissions, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). Based on data from South Carolina, […].

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Amgen grabs EU approval for pathfinder KRAS drug Lumykras

pharmaphorum

Amgen now has regulatory approval on both sides of the Atlantic for Lumykras, the culmination of many years of effort to bring a drug to market that inhibits KRAS – a cancer target that for a long time was considered “undruggable” The European Commission has approved Lumykras (sotorasib) as a monotherapy for adults with advanced non-small-cell lung cancer (NSCLC) with KRAS G12C mutation and who have progressed after at least one earlier line of systemic therapy – a use cleared last M

Drugs 59
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A crowning achievement in understanding head development

Scienmag

Cranial neural crest cells, or CNCCs, contribute to many more body parts than their humble name suggests. These remarkable stem cells not only form most of the skull and facial skeleton in all vertebrates ranging from fish to humans, but also can generate everything from gills to the cornea. To understand this versatility, scientists from […].

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New patent for Allergan drug LASTACAFT

Drug Patent Watch

Annual Drug Patent Expirations for LASTACAFT Lastacaft is a drug marketed by Allergan and is included in one NDA. It is available from one supplier. There are two patents protecting…. The post New patent for Allergan drug LASTACAFT appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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New approach can help identify young children most at risk for obesity

Scienmag

UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help clinicians identify young children most at risk of developing obesity. Credit: Penn State Center for Medical Genomics UNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help clinicians identify […].

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New patent for Novartis drug KISQALI

Drug Patent Watch

Annual Drug Patent Expirations for KISQALI Kisqali is a drug marketed by Novartis and is included in two NDAs. It is available from one supplier. There are eight patents protecting…. The post New patent for Novartis drug KISQALI appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Daniele Cortecchia wins a Starting grant from the European Research Council (ERC) for innovative research on new photoluminescent materials

Scienmag

Genoa (Italy), 10 January 2022 – Materials with thicknesses of just a few nanometres, possessing predetermined, adjustable optical properties that can be used in LED devices or in photonic platforms as more efficient, higher-performance labs on chips: this is the final objective for the project submitted to the ERC, European Research Council, by Daniele Cortecchia, […].

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New patent for Genus Lifesciences drug LEVOLET

Drug Patent Watch

Annual Drug Patent Expirations for LEVOLET Levolet is a drug marketed by Genus Lifesciences and is included in one NDA. The generic ingredient in LEVOLET is levothyroxine sodium. Additional details…. The post New patent for Genus Lifesciences drug LEVOLET appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.