Tue.Nov 03, 2020

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The meeting that could change Alzheimer's treatment

Bio Pharma Dive

On Friday, a panel of experts and FDA staff will weigh in on a closely watched Alzheimer's drug from Biogen. Their feedback could affect how the disease is treated for years to come.

Drugs 363
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American health is in for a “world of hurt”

World of DTC Marketing

Cardiovascular disease deaths in the US have increased by nearly 17% since 2010, and are among the reasons that life expectancy in the U.S. is lower than in other high-income countries. The U.S. has also seen reversals in health improvements since 2010, partly due to increasing rates of obesity, high blood pressure, and high blood sugar. . We can’t ignore the poor shape of Americans.

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Bristol Myers bet pays off as psoriasis drug beats Amgen rival in study

Bio Pharma Dive

While full data were not disclosed, the trial's outcome signals competition for Amgen's Otezla, which Celgene was forced to divest last year as a result of its acquisition by Bristol Myers.

Drugs 342
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Ring 20: Could the rare disease get left behind by next-generation gene sequencing?

pharmaphorum

Ring Chromosome 20 Syndrome, or (R)20, is an ultra-rare form of epilepsy with a devastating impact – yet despite huge leaps forward in gene sequencing in recent years, diagnoses are going down instead of up. We spoke to Allison Watson, co-founder of Ring 20 Research and Support, about raising awareness, building the evidence base, and the importance of helping people through a pandemic despite limited funding.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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In 2020 election, an uncertain fate for drug price controls

Bio Pharma Dive

Three election scenarios could lead to different outcomes for the long-running effort to rein in drug costs. Here's how some analysts think each could play out.

Drugs 286
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RUDN University chemists developed new magnetic and luminescent lanthanide-siloxane-based compounds

Scienmag

Credit: RUDN University A team of chemists from RUDN University synthesized new organosilicon compounds containing terbium and europium ions. These complexes have an unusual cage-like crystal structure that contains four metal ions. The team was the first to study the magnetic and photophysical properties of such compounds and to observe their magnetic phase transition and […].

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New patent for Aerie Pharms drug RHOPRESSA

Drug Patent Watch

Annual Drug Patent Expirations for RHOPRESSA Rhopressa is a drug marketed by Aerie Pharms Inc and is included in one NDA. It is available from one supplier. There are nine…. The post New patent for Aerie Pharms drug RHOPRESSA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98
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Cancer is a legal issue: Vote.

Triage Cancer

In case you weren’t aware, today is election day. There are many issues on ballots all over the country that will impact the cancer community. While much of election law is well established, we are coming across confusing and sometimes incorrect information online. Because people are already feeling unprecedented levels of stress these days, we wanted to share some accurate and practical information about voting today.

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A material that “bruises”like the skin?

Scienmag

Development of a next-generation mechano-sensitive material where parts requiring repair can be distinguished by color. 850% improved sensitivity compared to existing materials. Credit: Korea Institue of Science and Technology(KIST) Human skin bruises when the tissue and muscle in the area suffer trauma or become damaged due to an application of blunt force.

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How COVID-19 is Catalyzing a Better, More Efficient Biopharma Environment

BioSpace

The COVID-19 pandemic changed the biopharma industry and the world irrevocably. The challenges will reverberate even after the pandemic ends, according to panelists at the Cell and Gene Meeting on the Mesa in mid-October.

Gene 102
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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Cornea appears to resist infection from novel coronavirus

Scienmag

Other viruses, such as Zika and herpes simplex, do replicate in corneal tissue Credit: Washington University School of Medicine New findings from researchers at Washington University School of Medicine in St. Louis suggest the eye’s cornea can resist infection from the novel coronavirus. Although the herpes simplex virus can infect the cornea and spread to […].

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AI Can Detect COVID-19 by Analyzing Coughs and More Related Research

BioSpace

Researchers are generating an unprecedented amount of data around COVID-19, with seemingly new and important studies coming out every day. Here’s a look at some of this week’s COVID-19 research news.

Research 102
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Venous origin of brain blood-vessel malformations

Scienmag

Credit: Fabrizio Orsenigo In the condition known as cavernoma, lesions arise in a cluster of blood vessels in the brain, spinal cord or retina. Researchers from Uppsala University can now show, at molecular level, that these changes originate in vein cells. This new knowledge of the condition creates potential for developing better therapies for patients. […].

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Novo Nordisk’s Saxenda bags NICE recommendation

Pharma Times

Obesity management treatment recommended following confidential discount

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Does my cough sound like COVID? There could be an app for that

pharmaphorum

It could be possible to detect whether someone has COVID-19 or not, just from the sound of their coughing. That’s the conclusion of testing of an artificial intelligence (AI) algorithm developed by the Massachusetts Institute of Technology (MIT), which was able to detect around 98% of cases of COVID-19 from a forced cough delivered down a cell phone – confirmed by coronavirus testing.

Scientist 109
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Nestlé Acquires Meal Delivery Service Freshly for $950 Million

XTalks

Since the onset of the pandemic, many consumers have turned to subscription-based meal delivery services for the convenience factor and to avoid frequent trips to grocery stores. Nestlé recognized the growth of these services as a result of the broadening eat-at-home market and acquired meal delivery company Freshly last Friday for $950 million. While the acquisition is the most significant, it is not the first business transaction between the two companies.

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Controversy Surrounds Biogen and Eisai’s Alzheimer’s Drug Aducanumab

BioSpace

Biogen and Tokyo-based development partner Eisai are embroiled in controversy surrounding their investigational Alzheimer’s drug, aducanumab.

Drugs 115
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EDQM publishes document to support COVID-19 recombinant viral vectored vaccine development

BioPharma Reporter

The European Directorate for the Quality of Medicines and Healthcare (EDQM) has published a text on analytical strategy options for the control of COVID-19 recombinant viral vectored vaccines.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Secrets behind “Game of Thrones” unveiled by data science and network theory

Scienmag

Credit: University of Cambridge What are the secrets behind one of the most successful fantasy series of all time? How has a story as complex as “Game of Thrones” enthralled the world and how does it compare to other narratives? Researchers from five universities across the UK and Ireland came together to unravel “A Song […].

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Prevail and Alector Both Declare Victory in Year-Long Legal Battle

BioSpace

Both sides claim to be pleased with arbitration results in dispute over Prevail CEO's alleged breach of contract from time with Allector.

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Gentoo penguins are four species, not one, say scientists

Scienmag

Credit: Gemma Clucas Gentoo penguins should be reclassified as four separate species, say scientists at the Milner Centre for Evolution at the University of Bath, after analysing the genetic and physical differences between populations around the southern hemisphere. The researchers say that counting them as four separate species will aid in their conservation because it […].

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Oxford-AstraZeneca's Phase III COVID-19 Vaccine Data Could be Available by December

BioSpace

The Oxford and AstraZeneca co-developed COVID-19 vaccine could be one of the first vaccines submitted for regulatory approval, alongside Pfizer and BioNTech’s vaccine candidate BNT162b2.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Transparent soil-like substances provide window on soil ecology

Scienmag

Transparent soil substitutes can be used to study the interactions of bacteria and fungi in the soil, which may enable scientists to learn more about how soil microbes contribute to a healthy ecosystem Credit: Sharma et al. (CC BY 4.0) By using two different transparent soil substitutes, scientists have shown that soil bacteria rely on […].

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EMA begins evaluation of filgotinib for ulcerative colitis

Pharma Times

Gilead and Galapagos’ application for oral JAK1 inhibitor validated by agency

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Industrial-strength brine, meet your kryptonite

Scienmag

Boron nitride coating is key ingredient in hypersaline desalination technology Credit: Kuichang Zuo/Rice University HOUSTON – (Nov. 3, 2020) – A thin coating of the 2D nanomaterial hexagonal boron nitride is the key ingredient in a cost-effective technology developed by Rice University engineers for desalinating industrial-strength brine.

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Emerging Biotech Enhances CNS Focus Through a Strategic Acquisition

BioSpace

On October 30, the company announced the acquisition of long-time collaborator Oscine Corp.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Implantable device can monitor and treat heart disease

Scienmag

Researchers report rubbery bioelectronic cardiac patch Credit: University of Houston Pacemakers and other implantable cardiac devices used to monitor and treat arrhythmias and other heart problems have generally had one of two drawbacks – they are made with rigid materials that can’t move to accommodate a beating heart, or they are made from soft materials […].

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FDA Awards Fast Track Designation to Multiple Non-COVID-19 Candidates

BioSpace

While the world has largely been focused on the development of vaccines and therapeutics for COVID-19, the U.S. FDA has remained busy lining up potential approvals of medications for other diseases and illnesses.

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Supersonic winds, rocky rains forecasted on lava planet

Scienmag

‘Rocky’ weather could change the surface and atmosphere over time on exoplanet K2-141b Credit: Julie Roussy, McGill Graphic Design and Getty Images Among the most extreme planets discovered beyond the edges of our solar system are lava planets: fiery hot worlds that circle so close to their host star that some regions are likely oceans […].

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Intouch EVP to Speak at Re:Imagine Pharma Marketing Conference

Intouch Solutions

Get a sneak peek at our soon-to-be-released whitepaper, “The Now and the Next in Pharma Marketing: Research and Insights to Innovate in a New Normal" at the virtual Re:Imagine Pharma Marketing conference! The post Intouch EVP to Speak at Re:Imagine Pharma Marketing Conference appeared first on Intouch Solutions.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.