Thu.Feb 11, 2021

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In surprise finding, Roche arthritis drug cuts risk of COVID-19 death in large UK study

Bio Pharma Dive

U.K. researchers running the sprawling RECOVERY trial showed that adding Actemra to standard treatment can save lives, a powerfully positive result in a long-running debate about the drug's utility in COVID-19.

Drugs 294
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The other COVID-19 health crisis in Oncology

World of DTC Marketing

SUMMARY : COVID-19 has caused substantial increases in the number of avoidable cancer deaths due to diagnostic and treatment delays. People who need healthcare are avoiding it because of COVID-related concerns, and in some cases, it costs them their lives. Where are healthcare companies? Recent data has revealed that the increase in the COVID-19 positivity rate correlates to an increase in mortality from non-coronavirus-related diseases, including cancer.

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A new startup gets Takeda's backing to take complex genetic medicines 'off the shelf'

Bio Pharma Dive

Ensoma Therapeutics debuts with a lucrative alliance with the Japanese pharma and an unusual way to deliver genetic medicines into the body.

Genetics 321
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Samsung Biologics, National OncoVenture, and Eutilex obtains IND Approval from FDA

Pharma Mirror

Samsung Biologics (KRX: 207940.KS) announced another successful Investigational New Drug (IND) clearance from the FDA for its client to begin clinical trials on a cancer immunotherapy, furthering the company’s track record as a premiere CDO service provider in the global market. In late 2018, National OncoVenture (NOV), a government-funded virtual oncology drug development program in Korea, approached Samsung Biologics for the development of EU101(NOV1801), an anti-4-1BB therapeutic monoclonal a

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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AstraZeneca plans for adapting vaccine to coronavirus variants, but offers longer timeline than rivals

Bio Pharma Dive

The drugmaker says between six to nine months are needed to ramp up production of an adapted shot. South Africa recently stopped using the vaccine due to its reduced potency against a common strain there.

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Early data back J&J and AC Immune’s Alzheimer’s jab

pharmaphorum

Shares in Swiss biotech AC Immune have risen sharply after it said a vaccine in development for Alzheimer’s disease (AD) hit the mark in a phase 1/2 trial. . ACI-35.030, partnered with Johnson & Johnson, is designed to stimulate the body to generate antibodies against tau protein, one of the factors though to play a role in the development of AD dementia.

Antibody 128

More Trending

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performance-io strikes multimillion-pound deal with STEM’s Rob Wood

pharmaphorum

Rob Wood has acquired a large minority stake in performance-io through a multimillion-pound deal that will see him join the specialist online performance marketing agency’s executive board. A former AstraZeneca director, Wood founded commercial and medical benchmarking firm STEM in 2007 before selling it to UDG Healthcare for £84 million in 2016. Since leaving that company he has invested in a number of disruptive technology-driven pharma service providers. performance-io ’s founder and CEO Matt

Sales 116
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Say ‘NO’ to bad contracts

Drug Patent Watch

Are you tired of having to naviagate complicated contracts to access the information you need? Let DrugPatentWatch free you from weeks of negotiating complex contracts and let you focus on…. The post Say ‘NO’ to bad contracts appeared first on DrugPatentWatch - Make Better Decisions.

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Handgun ownership associated with firearm suicide

Scienmag

Handgun ownership, not shotgun ownership, is associated with greater odds of a person having died from self-inflicted gunshot wound Credit: Raymond Clinkscale, Rutgers School of Public Health Among firearm-owning individuals who died by suicide, handgun ownership was associated with greater odds of having died by self-inflicted gunshot wound rather than by another method, according to […].

Medicine 104
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Genentech Could Regain the Blindness-Related Disease Market with New Treatment

BioSpace

After announcing topline data from two identical Phase III trials, Roche’s Genentech has doubled down on data and are now showing positive results from four studies for its newest blindness-fighting treatment.

Marketing 105
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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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WHO backs AstraZeneca COVID-19 vaccine for over 65s and where variants are present

BioPharma Reporter

While some jurisdictions have limited the use of the Oxford University / AstraZeneca COVID-19 vaccine, the WHO says it can be used even where variants are known to be in circulation and with people aged 65+.

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Generic inhaled steroid could treat early COVID-19, study finds

pharmaphorum

The generic respiratory drug budesonide could be an option to treat COVID-19, a small scale clinical study has suggested. Marketed in the past by AstraZeneca as Pulmicort, budesonide is an off-patent inhaled steroid and could be used to prevent the risk of people getting seriously ill with the disease, if taken within the first week of developing symptoms.

Trials 98
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Implant improves balance, movement and quality of life for people with inner ear disorder

Scienmag

Credit: Johns Hopkins Vestibular NeuroEngineering Laboratory Getting around without the need to concentrate on every step is something most of us can take for granted because our inner ears drive reflexes that make maintaining balance automatic. However, for about 1.8 million adults worldwide with bilateral vestibular hypofunction (BVH) — loss of the inner ears’ sense […].

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Increasing patient engagement with UK clinical trials

pharmaphorum

Pharma companies face many challenges when involving patients in the design of clinical trials – but doing so can have huge benefits further down the line, improving the sustainability and quality of research. Patient engagement can help address long-running industry issues, such as recruitment and retention, as well as reducing the need for additional trial protocol amendments.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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New study gives hope of eliminating mother-to-baby transmission of HIV

Scienmag

Credit: Karolinska Institutet. Anti-retroviral drugs are a vital tool in the prevention and treatment of HIV. A new study of pregnant women in Tanzania shows that life-long antiviral treatment also seems to prevent viral transmission from mother to baby. The results of the study, which was conducted in part by researchers at Karolinska Institutet in […].

Drugs 98
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Mitochondrial-based Therapies Offer New Ways to Tackle Acute and Chronic Conditions

BioSpace

CohBar, Inc. is pioneering mitochondrial-based therapies with a candidate in a Phase Ia/Ib clinical trial as a potential treatment for nonalcoholic steatohepatitis (NASH) and obesity, where top-line results are expected later this year.

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Portrait of young galaxy throws theory of galaxy formation on its head

Scienmag

Scientists from Cardiff University peer 12 billion years into the past to reveal distant galaxy with an unexpected appearance Credit: Cardiff University Scientists have challenged our current understanding of how galaxies form by unveiling pictures of a young galaxy in the early life of the Universe which appears surprisingly mature. The galaxy, dubbed ALESS 073.1, […].

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Ousted Eli Lilly CFO Loses $24 Million in Potential Pay

BioSpace

Josh Smiley’s termination from Eli Lilly for inappropriate communications with employees will cost more than a blow to his reputation.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Study finds even the common house sparrow is declining

Scienmag

Citizen scientists provide the research data Credit: Donald Metzner, courtesy Cornell Lab of Ornithology. Ithaca, NY–The European House Sparrow has a story to tell about survival in the modern world. In parts of its native range in Europe, House Sparrow numbers are down by nearly 60%. Their fate in the U.S. and Canada is less […].

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Molecular Templates Forges Cancer Deal with BMS Worth up to $1.3 Billion

BioSpace

Eric Poma, chief executive and scientific officer for Molecular Templates, touted the partnership with BMS and its strong oncology franchise.

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Finding the best targets to improve crop yield by following CO2 journey inside the leaf

Scienmag

Credit: Natalia Bateman, CoETP A team of scientists have measured the relative importance of the different obstacles that carbon dioxide (CO2) encounters in its voyage from the atmosphere to the interior of plant cells, where it is converted into sugars. This research leading method provides much needed information that will help to increase the yield […].

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Intranasal Approaches Have Potential As Vaccines & Therapies for COVID-19

BioSpace

With billions invested in R&D over the past year to find vaccines and therapies for the novel coronavirus, a few select life sciences companies and academic institutions are working on the hypothesis that intranasal vaccines and therapies could be key to stopping COVID-19 in its tracks, and provi.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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A new quantum switch for electronics

Scienmag

Credit: Oleg Lychkovskiy A Russian physicist and his international colleagues studied a quantum point contact (QCP) between two conductors with external oscillating fields applied to the contact. They found that, for some types of contacts, an increase in the oscillation frequency above a critical value reduced the current to zero – a promising mechanism that […].

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AZ’s next-generation COVID-19 vaccine could be ready in autumn

pharmaphorum

AstraZeneca is aiming to get a next-generation vaccine targeting emerging variants approved and into the arms of patients by the autumn, company representatives said in a press conference. Mene Pangalos, executive vice president of BioPharmaceuticals R&D, said work has already begun to tweak the shot developed with Oxford University to combat the new variants, which could be in the arms of patients by autumn.

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SwRI scientist proposes a new timeline for Mars terrains

Scienmag

Updated models predict that NASA’s Perseverance rover will encounter more ancient surfaces Credit: SwRI SAN ANTONIO — Feb. 10, 2021 — A Southwest Research Institute scientist has updated Mars chronology models to find that terrains shaped by ancient water activity on the planet’s surface may be hundreds of millions of years older than previously thought. […].

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Research Roundup: COVID-19 Brain Fog and More

BioSpace

Every week there are numerous scientific studies published. Here’s a look at some of the more interesting ones.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Common pipistrelle bats attracted to wind turbines

Scienmag

Credit: Fiona Mathews One of the most abundant bats in Europe may be attracted to wind turbines, a new study shows. The activity of common pipistrelle bats was monitored at 23 British wind farms and similar “control” locations close by without turbines. Activity was around a third higher at turbines than at control locations, and […].

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Rentschler Biopharma to build cell and gene therapy manufacturing capabilities in the UK

Pharma Times

German CDMO will build new manufacturing capabilities at CGT Catapult site

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Researchers find delirium in hospitalized patients linked to mortality, disability

Scienmag

Credit: Vanderbilt University Medical Center Delirium, a form of acute brain dysfunction, is widespread in critically ill patients in lower resourced hospitals, and the duration of delirium predicted both mortality and disability at six months after discharge, according to a study published in PLOS ONE. Working with partners in Zambia, Vanderbilt University Medical Center researchers […].

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Amicus Puts Positive Spin on Failure of its Phase III Trial for Pompe Disease

BioSpace

Amicus Therapeutics announced topline results from its Phase III PROPEL pivotal trial of AT-GAA (cipaglucosidase alfa and miglustat) for late-onset Pompe disease (LOPD). Although the results showed some positive data, it failed to hit the primary endpoint.

Trials 67
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.