Thu.Feb 17, 2022

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Yumanity cutting 60% of employees as it mulls possible sale

Bio Pharma Dive

The layoffs — which, according to Yumanity, should be completed by April — are part of a larger restructuring effort meant to reduce costs after a recent setback to the company's most advanced drug program.

Sales 325
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Lung cancer deaths decline but.

World of DTC Marketing

The mortality rate from lung cancer has dropped in recent decades—by 56% in men from 1990 to 2019 and by 32% in women from 2002 to 2019. In recent years, early detection and treatment improvements have helped boost the 3-year survival rate for lung cancer from 21% in 2004 to 31% in 2015 through 2017. The 5-year survival rate has increased by 6% for distant-stage lung cancer, 33% for a regional-stage disease, and 60% for localized disease.

Medicine 271
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FTC deadlocks on vote to launch study into PBM practices

Bio Pharma Dive

The antitrust agency won't study pharmacy benefit managers' pricing and contract practices as proposed, after a 2-2 vote by commissioners Thursday.

Pharmacy 211
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3 Exosome Services And Technologies For Skin Regeneration

Pharma Mirror

The importance of exosomes in skin cell regeneration has been extensively researched over the past few years. Functions involving the fibroblasts, forming of new blood vessels, and controlling the localized inflammatory response of the skin are all benefits of their use. Exosomes have another essential function, and that would be intercellular communication.

RNA 130
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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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J&J to explore RNA reprogramming with Remix research deal

Bio Pharma Dive

The agreement with the Cambridge-based startup is the latest to reflect growing large pharma company interest in targeting RNA with small molecules.

RNA 195
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The 4 Best Ways To Increase Productivity In Your Lab

Pharma Mirror

Although many labs are doing cutting-edge research and finding new ways to improve life in this world, they aren’t always the picture of productivity. Unfortunately, some labs are not very well organized internally and often could find ways to be more productive. Resources are often very limited so it makes sense to work on being more productive and wasting fewer resources to get the job done.

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Expect growth, innovation in digital health landscape: BCG Digital Ventures

Outsourcing Pharma

In its forward-looking report on digital health, the consulting outfit offers predictions on what changes are ahead and how they might impact the field.

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Efficacy of Ivermectin on Disease Progression in Patients With COVID-19

JAMA Internal Medicine

This randomized clinical trial assesses the efficacy of ivermectin treatment in preventing progression to severe disease among high-risk patients with COVID-19 in Malaysia.

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Deadly wildfires, noise pollution, and disruptive timing of life cycles: UN report identifies looming environmental threats

Scienmag

Wildfires are burning more severely and more often, urban noise pollution is growing into a global public health menace, and phenological mismatches – disruptions in the timing of life-cycle stages in natural systems – are causing ecological consequences. These critical environmental issues, requiring greater attention, are highlighted in the new Frontiers Report published today by […].

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Moderna’s commercial network grows

Pharma Times

Vaccine pioneers expand presence throughout Europe with a view to leveraging technology

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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An online game to crowdsource the science of letter shapes

Scienmag

A team of cognitive scientists lead by Dr. Yoolim Kim (Korea Institute at Harvard and Max Planck Institute for the Science of Human History) and Dr. Olivier Morin (Max Planck Institute for the Science of Human History and PSL University, Paris) have just launched a free gaming applet. The game, called “glyph”, allows players to […].

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Prescriptions for Hydroxychloroquine and Ivermectin and Voting Patterns in the 2020 US Presidential Election

JAMA Internal Medicine

This cross-sectional study examines whether an association exists between US county-level prescription rates of hydroxychloroquine and ivermectin and how people voted in the 2020 US presidential election.

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Yushan Yan elected to National Academy of Engineering

Scienmag

Yushan Yan, a University of Delaware engineering professor and expert in electrochemical engineering for sustainability, has been granted one of the highest professional distinctions in his field through his recent election to the National Academy of Engineering. Credit: Photo by Evan Krape, illustration by Joy Smoker Yushan Yan, a University of Delaware engineering professor and […].

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Seal of Approval: Direct-to-PCR COVID-19 test in the UK validated

Pharma Times

First direct-to-PCR test added to the CTDA register of approved UK products

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Finding friends in the Utah State Legislature

Scienmag

Do politicians act like humans? Many jokes suggest otherwise, but the question is real. Credit: Connor Davis Do politicians act like humans? Many jokes suggest otherwise, but the question is real. Groups of humans follow basic social rules: They build relationships, form alliances and exchange favors to help one another survive. In contrast, the stereotype […].

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Alvea launches shelf-stable DNA vaccine against new SARS-CoV-2 variants

BioPharma Reporter

Start-up biotech Alvea has started pre-clinical testing for its DNA vaccine: with clinical trials set to begin as soon as March.

DNA 75
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Antibiotic used on food crops affects bumblebee behavior, lab study finds

Scienmag

An antibiotic sprayed on orchard crops to combat bacterial diseases slows the cognition of bumblebees and reduces their foraging efficiency, a laboratory study finds. Proceedings of the Royal Society B published the findings by scientists at Emory University and the University of Washington. The research focused on streptomycin, an antibiotic used increasingly in U.S. agriculture […].

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GBT claims EU approval for sickle cell drug Oxbryta

pharmaphorum

Global Blood Therapeutics’ run of positive regulatory news for its oral sickle cell disease treatment Oxbryta has continued with an approval for the drug in Europe for patients aged over 12. The green light from the European Commission comes a couple of years after Oxbryta (voxelotor) was cleared by the FDA for the treatment of haemolytic anaemia caused by SCD in the over-12s, and a few weeks after an expansion of its US label to include patients aged four and above.

Drugs 59
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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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A novel evaluation framework for energy neutrality potential of wastewater treatment plants

Scienmag

Towards China nationally determined contribution to carbon neutrality 2060, it is necessary to consider wastewater treatment plants. This kind of municipal facility consumes huge amounts of energy and emit greenhouse gases to remove pollutants. The main three pathways for decarbonization of the plants include energy reduction, energy recovery, and energy renewables.

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BMS builds case for mavacamten label ahead of FDA decision

pharmaphorum

Bristol-Myers Squibb has new data backing up the value of mavacamten for obstructive hypertrophic cardiomyopathy (HCM), as it waits for a delayed verdict on its marketing application for the drug, acquired as part of its $13.1 billion takeover of MyoKardia in 2020. The phase 3 VALOR-HCM trial in adults with obstructive HCM eligible for a procedure called septal reduction therapy (SRT) met its primary endpoint, according to BMS.

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Everyone has heard of King Arthur, but 90% of medieval chivalry and heroism manuscripts have been lost

Scienmag

New research released today [17 Feb] finds that, while the Knights of the Round Table have won global fame, most medieval English heroic or chivalric stories have been lost. Meanwhile, more than three quarters of medieval stories in Icelandic and Irish survive to the present, in an unusual pattern suggesting island ‘ecosystems’ helped preserve culture. […].

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The Moral Danger of Declaring the Pandemic Over Too Soon

NY Times

There has to be a better way out of the rubble of the past two years.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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CPRIT supports work on combo cancer therapy

Scienmag

HOUSTON – (Feb. 17, 2022) – A three-pronged attack on solid cancer tumors is the goal of a Rice University study that has won the support of the Cancer Prevention and Research Institute of Texas (CPRIT). Credit: Jeff Fitlow/Rice University HOUSTON – (Feb. 17, 2022) – A three-pronged attack on solid cancer tumors is the goal of […].

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Tips for Principal Investigators During Monitoring Visits

ECRG Media's Clinical Research Podcast

Tips for Principal Investigators During Monitoring Visits Don't forget to Subscribe for new content! Merch: [link] [link] eliteclinicalgroup@gmail.com Podcast: [link] [link] eliteclinicalgroup@gmail.com Watch: » Industry News: [link] All Videos: [link] Interview Recaps: [link] Glassdoor Reviews: [link] We do: » Insider Interviews » Resume Reviews » Question and Answer » Discuss all things Clinical Research » News and Product Reviews » Education Elite Clinical Research Group or ECRG for short is

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Time and Beauty Reveal the Physics of Human Perceptions

Scienmag

Durhham, NC – Adrian Bejan, the J.A. Jones Distinguished Professor of Mechanical Engineering at Duke University, has published a new book titled “Time and Beauty: Why Time Flies and Beauty Never Dies.” This is Bejan’s fourth book written for a general audience that uses his concept of constructal law—the tendency of all systems to evolve […].

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Tips for Principal Investigators During Monitoring Visits

ECRG Media's Clinical Research Podcast

Tips for Principal Investigators During Monitoring Visits Don't forget to Subscribe for new content! Merch: [link] [link] eliteclinicalgroup@gmail.com Podcast: [link] [link] eliteclinicalgroup@gmail.com Watch: » Industry News: [link] All Videos: [link] Interview Recaps: [link] Glassdoor Reviews: [link] We do: » Insider Interviews » Resume Reviews » Question and Answer » Discuss all things Clinical Research » News and Product Reviews » Education.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Core strength could help dogs avoid knee injuries

Scienmag

Agility dogs lacking core strength from routine physical exercise and those participating in activities like flyball may be more susceptible to one of the most common canine knee injuries. That knee injury is a cranial cruciate ligament rupture, which is equivalent to an anterior cruciate ligament (ACL) tear in humans. According to a research survey […].

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New patent for Aveo Pharms drug FOTIVDA

Drug Patent Watch

Annual Drug Patent Expirations for FOTIVDA Fotivda is a drug marketed by Aveo Pharms and is included in one NDA. It is available from one supplier. There are two patents…. The post New patent for Aveo Pharms drug FOTIVDA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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CNIO researchers design a drug screening platform compatible with patient biopsies to fight metastasis

Scienmag

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments. This, in addition to the fact that there are no specific curative treatments for this type of metastasis, makes this disease a […].

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Food and Beverage Super Bowl Ads + Valentine’s Day Food Offerings – Xtalks Food Podcast Ep. 48

XTalks

Food and beverage brands start building buzz for their Super Bowl ads weeks in advance, and this year was no exception. In this episode of the Xtalks Food Podcast, Sydney talks about some of the food and beverage ads that premiered during Super Bowl LVI. Many fans watch the game solely for the commercials, and the use of celebrity cameos was prevalent in almost all the big game ads.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.