Fri.Apr 08, 2022

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About those online metrics

World of DTC Marketing

It’s time to stop using worthless online ad metrics. Click-through rates are the most used KPI in marketing, but they are useless. Click-through rates don’t correlate with any meaningful brand metrics. Billions of dollars are “optimized” based on nothing but noise. “One impression’ is one web browser making one server request for one advertisement.

Branding 199
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CellCentric Strengthens Leadership Team

Pharma Mirror

Cambridge, UK, CellCentric, aclinical stage, private biotechnology company pioneering small molecule inhibition of p300/CBP to treat cancer, today announces the appointments of Kris Frese as Director of Cancer Biology, and Andrew Hughes, who joins the Board as a Non-Executive Director. Both have stellar experience and track records in oncology research and development.

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NICE recommends Koselugo for the treatment of neurofibromatosis type 1

Pharma Times

Alexion Pharma UK, AstraZeneca’s Rare Disease group, announces the recommendation of its pivotal neurofibromatosis treatment

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Almirall announces a new research collaboration with the University of Dundee to develop an innovative and differentiated treatment approach for dermatological diseases

Pharma Mirror

BARCELONA, Spain and Dundee, UK, a global biopharmaceutical company focused on skin health, today announced a research collaboration with the University of Dundee, a top-ranked university in the UK in biological sciences, to develop a novel approach against chronic and debilitating dermatology diseases where itch, or pruritus, plays a dominant role.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Jazz adds first immuno-oncology drug via $1.3bn Werewolf deal

pharmaphorum

Jazz Pharma has bolstered its pipeline of cancer drugs through a $1.3 billion licensing agreement with Werewolf Therapeutics that adds its first immuno-oncology candidate. The Dublin-based pharma is paying $15 million upfront for global rights to Werewolf’s WTX-613, a prodrug of the cytokine interferon alfa-2b, which is still back n preclinical development and due to start its first clinical trials next year.

Drugs 105
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Intouchers Spend Afternoon in Service to Displaced Ukrainians

Intouch Solutions

Philanthropy at Intouch has always been a big deal. From raising funds for animal-related charities to helping the folks at our local Ronald McDonald House , to granting a young boy’s wish to visit Disney World, even to shaving our heads to support a good cause … we take giving back seriously. Since 2019, we’ve been partnering with Heart to Heart International to spread the giving further than outside our own doors — helping to provide support for those working on the fro

More Trending

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UK patients granted early access for radioligand therapy in advanced prostate cancer

Pharma Times

Patients with the life-threatening disease are set to benefit from the Early Access to Medicines Scheme

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Study shows important change in B-cells in women with PPD

Scienmag

CHAPEL HILL, NC – A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it. PPD affects 1 in 7 women and has negative mental health consequences for both mother and child. […].

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Four Solutions Manufacturers Should Consider For Retail and Specialty-lite Products

Drug Channels

Today’s guest post comes from Michael Carr, CoAssist Group Vice President at AssistRx. Michael discusses patient support challenges that are unique to specialty-lite pharmaceuticals. He goes on to describe four new categories of patient solutions and pharmacy models specific to this growing market segment. To learn more about CoAssist and AssistRx specialty therapy initiation and patient support services, click here to schedule a meeting with AssistRx at the Asembia Specialty Pharmacy Summit on

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Study finds US insiders to China news sold stock in early stages of pandemic

Scienmag

A new study of stock sales by U.S. executives with corporate ties to China indicates that corporate insiders sold stock in their companies during the earliest stages of the coronavirus outbreak in China, weeks before the virus spread to other countries and was recognized as a pandemic. The worldwide spread of COVID-19 eventually caused stock […].

Sales 90
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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Medical Informatics: a bridge between two worlds

pharmaphorum

With more than 6,000 different diseases comprising the rare disease (RD) landscape, connecting patients and practitioners with the expertise needed to achieve the correct diagnosis can be a significant barrier to treatment. . As the severity, progress and treatment potential of RD varies from patient to patient, each condition needs to be addressed differently using specialist expertise.

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First integrated laser on lithium niobate chip

Scienmag

For all the recent advances in integrated lithium niobate photonic circuits — from frequency combs to frequency converters and modulators — one big component has remained frustratingly difficult to integrate: lasers. Credit: (Credit: Second Bay Studios/Harvard SEAS) For all the recent advances in integrated lithium niobate photonic circuits — from frequency combs to frequency converters […].

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Happify says study backs value of its wellbeing app in psoriasis

pharmaphorum

People with psoriasis who used an app developed by digital health company Happify reported reduced anxiety and improvements in mental wellbeing in a real-world study involving more than two hundred subjects. It’s well recognised that people with psoriasis can develop depression or anxiety, particularly in moderate or severe cases where a sizeable part of the body can have skin lesions.

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Air pollution responsible for 180,000 excess deaths in tropical cities

Scienmag

The international team of scientists aimed to address data gaps in air quality for 46* future megacities in Africa, Asia and the Middle East using space-based observations from instruments onboard NASA and European Space Agency (ESA) satellites for 2005 to 2018. Published today in Science Advances, the study reveals rapid degradation in air quality and […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Health Innovators – Amy Bucher

pharmaphorum

pharmaphorum editor in chief Jonah Comstock takes on the Health Innovators series with a conversation with Amy Bucher, vice president of behavioural design at Lirio and author of “Engaged: Designing for Behavior Change”. Beyond patient engagement and patient activation is the idea of behaviour science and designing for effective behaviour change. Amy has spent her career engaging with these ideas and exploring their applications in the healthcare space.

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How T cell-derived interleukin-22 promotes antibacterial defense of colonic crypts

Scienmag

BIRMINGHAM, Ala. – Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea. Such pathogens pose significant risks to human health and cause infant death in developing countries. Credit: UAB BIRMINGHAM, Ala. – Intestinal epithelial […].

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Phase 3 CROWN Trial of Pfizer’s LORBRENA® (lorlatinib) Confirm Prolonged Progression-Free Survival in First-Line ALK-Positive Advanced Lung Cancer

The Pharma Data

Pfizer Inc. (NYSE: PFE) announced updated results from the Phase 3 CROWN trial, which evaluated LORBRENA® (lorlatinib, available in Europe under the brand name LORVIQUA) versus XALKORI® (crizotinib) in people with previously untreated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC). This analysis reported after a median follow-up of three years, LORBRENA continued to demonstrate meaningful improvement in progression-free survival (PFS) assessed by blinded in

Trials 52
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Double-stranded RNA induces bone loss during gum disease

Scienmag

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone. Credit: Masaki Inada, Tokyo University of Agriculture and Technology Tokyo University of Agriculture and […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Fighting viruses is as easy as breathing

The Pharma Data

The average person will take more than 600 million breaths over the course of their life. Every breath stretches the lungs’ tissues with each inhale and relaxes them with each exhale. The mere motions of breathing are known to influence vital functions of the lungs, including their development in babies, the production of air-exchange-enhancing fluid on their inner surfaces, and maintenance of healthy tissue structure.

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CRISPR gene editing reveals biological mechanism behind common blood disorder

Scienmag

UNSW researchers have used CRISPR gene editing – a type of ‘molecular scissors’ – to understand how deletions in one area of the genome can affect the expression of nearby genes. The work, led by UNSW Associate Professor Kate Quinlan and Professor Merlin Crossley, together with collaborators from the US, will help researchers investigate new […].

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New patent expiration for Tersera drug ZOLADEX

Drug Patent Watch

Annual Drug Patent Expirations for ZOLADEX Zoladex is a drug marketed by Tersera and is included in two NDAs. It is available from two suppliers. There are two patents protecting…. The post New patent expiration for Tersera drug ZOLADEX appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Innovative therapy that “tricks” and destroys cancer cells advances to clinical trial

Scienmag

Milwaukee, April 8, 2022 – A novel therapy studied at the Medical College of Wisconsin (MCW) Cancer Center has led to a clinical trial for the treatment of glioblastoma, a rare and aggressive form of brain cancer, yet the most common primary brain tumor in adults. Credit: The Medical College of Wisconsin and Imaging Biometrics […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Kit Kat Flavors Expand with Limited-Edition Blueberry Muffin

XTalks

The Hershey Company recently unveiled a limited-edition Kit Kat flavor inspired by a classic baked good. The new Blueberry Muffin Kit Kat features the classic Kit Kat wafers at the center of a blueberry muffin-flavored exterior with graham cookie pieces folded in. . Kit Kat Blueberry Muffin . “Our product creators have such passion for deciding which flavor Kit Kat should take on next and making sure it delivers for our fans,” said Dan Williard, brand manager of Kit Kat, in a press release.

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Educational attainment, lifestyle risk factors associated with all-cause mortality

Scienmag

What The Study Did: Researchers assessed the association between educational attainment, lifestyle risk factors and all-cause mortality among 415,000 U.S. adults. Authors: Charlotte Probst, Ph.D., of the Centre for Addiction and Mental Health in Toronto, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link [link] (doi:10.1001/jamahealthforum.2022.0401) […].

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CMS decision on Aduhelm is in, and it’s bad news for Biogen

pharmaphorum

The US Centres for Medicare and Medicaid Services (CMS) has firmed up its draft decision to limit reimbursement of Biogen’s Alzheimer’s disease therapy Aduhelm to a few thousand patients enrolled in clinical trials. The final verdict from the CMS dashes any remaining hopes that Biogen may have held that it would be able to build a market for Aduhelm (aducanumab) in the six million people with Alzheimer’s in the US, many of whom rely on Medicare to reimburse their therapies.

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Commercial research expands aboard the International Space Station

Scienmag

The International Space Station has spent more than two decades in low-Earth orbit serving as Earth’s orbiting laboratory. Groundbreaking research aboard the station in its unique microgravity environment has led to benefits back on the ground and paved the way for future deep space missions. Credit: NASA The International Space Station has spent more than two decades in low-Earth […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Which pharmaceutical companies have the most drug patents in Luxembourg?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Luxembourg. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is…. The post Which pharmaceutical companies have the most drug patents in Luxembourg? appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Interdisciplinary team studies challenges and prospects of lithium-CO2 dioxide batteries

Scienmag

The lithium-carbon dioxide battery is an emerging energy storage and conversion device. Although development of these batteries is still in its infancy, scientists need a thorough understanding of the critical problems that must be overcome for these batteries to achieve their potential as new energy storage devices. An interdisciplinary research team has undertaken the study […].

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NICE verdict on Trodelvy threatens unequal access to drug in UK

pharmaphorum

In draft guidance, NICE has said it cannot recommend Gilead Sciences’ Trodelvy in triple-negative breast cancer (TNBC), setting up a disparity in access to the drug via the NHS in the UK. The health technology assessment (HTA) agency said that while Trodelvy (sacituzumab govitecan) increases the time people have before their disease worsens and how long they live, “it is too expensive to be considered a cost-effective use of NHS resources.” While the decision is still open for

Drugs 59
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Fighting viruses is as easy as breathing

Scienmag

The average person will take more than 600 million breaths over the course of their life. Every breath stretches the lungs’ tissues with each inhale and relaxes them with each exhale. The mere motions of breathing are known to influence vital functions of the lungs, including their development in babies, the production of air-exchange-enhancing fluid […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.