Fri.Jul 01, 2022

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Magazine-How delays derailed Covid-19 vaccination in Africa

Pharmaceutical Technology

The latest issue of Pharma Technology Focus is out now. Read it for free on all devices. Some months after the first Covid-19 vaccines became available, the World Health Organization (WHO) set a target of vaccinating 70% of each country’s population by the end of June 2022. Global trends indicate that initially, a slow supply did not allow African countries, in particular, to stay on pace to meet this target, and now vaccination rates have even begun to slow down.

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Celldex, continuing comeback, adds to early promise for skin disease drug

Bio Pharma Dive

New study results show the medicine appears as effective, or stronger, than standard care for chronic urticarias, a common condition that drugs from Regeneron and Novartis have struggled to treat.

Drugs 141
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Pfizer seeks approval from US FDA for Covid-19 treatment

Pharmaceutical Technology

Pfizer has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) seeking approval for Paxlovid (nirmatrelvir tablets and ritonavir tablets) to treat Covid-19 patients at increased disease progression risk. An inhibitor of SARS-CoV-2 main protease (Mpro), Paxlovid is intended to be given orally. Due to the oral form, the therapy can be prescribed in the early infection stage to avert severe illness.

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New patent for Teva Pharm drug AIRDUO RESPICLICK

Drug Patent Watch

Annual Drug Patent Expirations for AIRDUO+RESPICLICK Airduo Respiclick is a drug marketed by Teva Pharm and is included in one NDA. It is available from four suppliers. There are sixteen…. The post New patent for Teva Pharm drug AIRDUO RESPICLICK appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98
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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Blueprint Medicines announces financing partnerships for $1.25bn

Pharmaceutical Technology

Blueprint Medicines has entered strategic financing partnerships for up to $1.25bn with life sciences-focused investors Sixth Street and Royalty Pharma. The company noted that the deal will bring substantial non-dilutive, low-cost capital to boost innovation and growth. The funding will offer capital to extend Blueprint’s varied pipeline toward marketing as well as to continue seeking strategic and synergistic business development prospects.

Medicine 147
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New patent for Ibsa Inst drug LICART

Drug Patent Watch

Annual Drug Patent Expirations for LICART Licart is a drug marketed by Ibsa Inst Bio and is included in one NDA. The generic ingredient in LICART is diclofenac epolamine. Additional…. The post New patent for Ibsa Inst drug LICART appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98

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New patent for Teva Pharm drug ARMONAIR RESPICLICK

Drug Patent Watch

Annual Drug Patent Expirations for ARMONAIR+RESPICLICK Armonair Respiclick is a drug marketed by Teva Pharm and is included in one NDA. It is available from one supplier. There are thirteen…. The post New patent for Teva Pharm drug ARMONAIR RESPICLICK appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98
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Liver injuries prompt clinical hold on Sanofi BTK drug

pharmaphorum

One of the main assets of Sanofi’s $3.7 billion buyout of Principia Biopharma has run into trouble, after the FDA placed it on partial clinical hold while a safety signal is investigated. The regulator is requiring Sanofi to stop dosing some patients in phase 3 trials of the BTK inhibitor tolebrutinib (SAR442168) in multiple sclerosis and myasthenia gravis, following reports of drug-induced liver damage in some subjects.

Drugs 98
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New patent for NOVO drug WEGOVY

Drug Patent Watch

Annual Drug Patent Expirations for WEGOVY Wegovy is a drug marketed by Novo and is included in one NDA. It is available from two suppliers. There are four patents protecting…. The post New patent for NOVO drug WEGOVY appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98
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New antibody detection method for coronavirus that does not require a blood sample

Scienmag

Tokyo, Japan – Despite significant and stunning advances in vaccine technology, the COVID-19 global pandemic is not over. A key challenge in limiting the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is identifying infected individuals. Now, investigators from Japan have developed a new antibody-based method for the rapid and reliable detection of SARS-CoV-2 […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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New patent for Teva Pharm drug ARMONAIR DIGIHALER

Drug Patent Watch

Annual Drug Patent Expirations for ARMONAIR+DIGIHALER Armonair Digihaler is a drug marketed by Teva Pharm and is included in one NDA. It is available from one supplier. There are twenty…. The post New patent for Teva Pharm drug ARMONAIR DIGIHALER appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98
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More is better: Epitaxial multilayer MoS2 wafers with promises in high-performance transistors

Scienmag

Two-dimensional (2D) semiconductors, such as MoS2, enable the unprecedented possibilities to solve the bottleneck of transistor scaling and to build novel logic circuits with faster speed, lower power consumption, flexibility and transparency, benefiting from their ultra-thin thickness, dangling-bond-free flat surface and excellent gate controllability.

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New patent for Teva Branded drug PROAIR RESPICLICK

Drug Patent Watch

Annual Drug Patent Expirations for PROAIR+RESPICLICK Proair Respiclick is a drug marketed by Teva Branded Pharm and is included in one NDA. It is available from two suppliers. There are…. The post New patent for Teva Branded drug PROAIR RESPICLICK appeared first on DrugPatentWatch - Make Better Decisions.

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Advocating a new paradigm for electron simulations

Scienmag

Although most fundamental mathematical equations that describe electronic structures are long known, they are too complex to be solved in practice. This has hampered progress in physics, chemistry and the material sciences. Thanks to modern high-performance computing clusters and the establishment of the simulation method density functional theory (DFT), researchers were able to change this […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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New patent for Teva Pharm drug AIRDUO DIGIHALER

Drug Patent Watch

Annual Drug Patent Expirations for AIRDUO+DIGIHALER Airduo Digihaler is a drug marketed by Teva Pharm and is included in one NDA. It is available from four suppliers. There are twenty-three…. The post New patent for Teva Pharm drug AIRDUO DIGIHALER appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 97
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Keeping the energy in the room

Scienmag

(Santa Barbara, Calif.) — It may seem like technology advances year after year, as if by magic. But behind every incremental improvement and breakthrough revolution is a team of scientists and engineers hard at work. UC Santa Barbara Professor Ben Mazin is developing precision optical sensors for telescopes and observatories. In a paper published in […].

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New patent expiration for NOVO drug SAXENDA

Drug Patent Watch

Annual Drug Patent Expirations for SAXENDA Saxenda is a drug marketed by Novo and is included in one NDA. It is available from two suppliers. There are twenty-three patents protecting…. The post New patent expiration for NOVO drug SAXENDA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 96
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Ovarian cancer in the fatty omentum: Metabolic enzyme’s key role in tumor metastasis

Scienmag

(LOS ANGELES) – July 1, 2022 – In their recent publication in Cell Reports, a team of scientists, led by Xiling Shen, Ph.D., Chief Scientific Officer at the Terasaki Institute for Biomedical Innovation (TIBI), has demonstrated the pivotal role of an enzyme, glucose-6-phosphate dehydrogenase (G6PD), in facilitating ovarian cancer (OC) growth and metastasis in the […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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New patent for Hope Pharms drug NITHIODOTE

Drug Patent Watch

Annual Drug Patent Expirations for NITHIODOTE Nithiodote is a drug marketed by Hope Pharms and is included in one NDA. It is available from one supplier. There are four patents…. The post New patent for Hope Pharms drug NITHIODOTE appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 96
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What are whale sharks up to?

Scienmag

The largest fish in the ocean is a globe-trotter that can occasionally be found basking in the coastal waters of the Panamanian Pacific. However, little more is known about the habits of the whale shark (Rhincodon typus) in the region. By satellite-tracking the whereabouts of 30 of them, scientists from the Smithsonian Tropical Research Institute (STRI), the […].

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New patent for Hope Pharms drug SODIUM THIOSULFATE

Drug Patent Watch

Annual Drug Patent Expirations for SODIUM+THIOSULFATE Sodium Thiosulfate is a drug marketed by Us Army and Hope Pharms and is included in two NDAs. It is available from one supplier.…. The post New patent for Hope Pharms drug SODIUM THIOSULFATE appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 95
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The “forever chemical”, per and polyfluoroalkyl substances (PFAS), as an emerging threat to soil health

Scienmag

Soils are impacted globally by several anthropogenic factors, including chemical pollutants. Among those, perfluoroalkyl and polyfluoroalkyl substances (PFAS) are of concern due to their high environmental persistence, which are therefore also called “forever chemicals” in public discourse. However, their effects on soil structure and function were largely ignored.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Sanofi’s Xenpozyme approved by European Commission

Pharma Times

Xenpozyme is a treatment for ASMD and the condition’s only current enzyme replacement therapy

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Engineers design motorless sailplanes for Mars exploration

Scienmag

Eight active spacecraft, including three operated by NASA, orbit Mars, gathering imagery of the planet’s surface at a resolution of about 1 foot per pixel. Three rovers traverse the ground, mapping small areas of the planet with greater precision. But what lies in the hundreds of kilometers between the rovers and the orbiters – including […].

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Recommendation for Novartis’ chronic myeloid leukaemia STAMP inhibitor

Pharma Times

Chronic myeloid leukaemia therapy Scemblix receives NICE final draft recommendation in Britain

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UTSW researchers develop rapid COVID-19 test to identify variants in hours

Scienmag

*Click here to watch “The hunt for COVID-19 variants” video Credit: UT Southwestern Medical Center *Click here to watch “The hunt for COVID-19 variants” video Last year, pathologist Jeffrey SoRelle, M.D., and colleagues developed CoVarScan, a rapid COVID-19 test that detects the signatures of eight hotspots on the SARS-CoV-2 virus.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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What Is Delta-8, and Why Is It So Popular?

NY Times

This popular cannabis product claims to be milder than regular marijuana. But is it legal? And is it safe?

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New GSA Bulletin articles published ahead of print in June

Scienmag

Boulder, Colo., USA: The Geological Society of America regularly publishes articles online ahead of print. GSA Bulletin topics studied this month include the nature and dynamics of China and Tibet; hawaiites in the Cima volcanic field, California; and the dynamic floor of Yellowstone Lake. You can find these articles at [link]. Crustal growth/reworking and […].

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New patent for Teva Branded drug PROAIR DIGIHALER

Drug Patent Watch

Annual Drug Patent Expirations for PROAIR+DIGIHALER Proair Digihaler is a drug marketed by Teva Branded Pharm and is included in one NDA. It is available from two suppliers. There are…. The post New patent for Teva Branded drug PROAIR DIGIHALER appeared first on DrugPatentWatch - Make Better Decisions.

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Prestigious NSF funding will enable UTSA professor to further demystify body’s metabolic processes

Scienmag

Chemistry professor Aimin Liu has been awarded a three-year, $495,000 Accomplishment-Based Renewal (ABR) grant from the National Science Foundation (NSF) to advance his research on the body’s metabolic processes using an innovative method that will improve the understanding of amino acids. Credit: The University of Texas at San Antonio Chemistry professor Aimin Liu has been awarded a three-year, $495,000 Accomplishment-Based Renewal (ABR) grant […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.