Mon.Feb 14, 2022

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How the biotech downturn is already affecting drug startups

Bio Pharma Dive

At an industry conference Monday, a group of venture investors noted changes in how long biotechs are taking to raise money, and a shifting outlook among investors who specialize in shepherding young companies to an IPO.

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3 Steps to More Sustainable Medical Labs

Pharma Mirror

The concept of sustainability is gaining more traction in society with each passing day. Human activities pose numerous risks to the environment, so many industries and sectors are looking to become more sustainable. Can medical labs switch to greener practices without affecting the quality and accuracy of their output? The answer is a resounding yes.

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EMA follows FDA in scrutinizing safety of certain immune drugs

Bio Pharma Dive

The European regulator began a safety review of so-called Janus kinase inhibitors from Pfizer, AbbVie, Eli Lilly and Galapagos, citing worrisome data from a study of Pfizer's drug Xeljanz.

Drugs 246
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NHS said to be central to Moderna interest in UK facility

pharmaphorum

Moderna is reportedly in late-stage negotiations with the UK government that could result in a new research and manufacturing facility being set up in the biotech ‘golden triangle’ between London, Oxford and Cambridge. The development has been prompted by a desire on the behalf of the US biotech to collaborate with the NHS, according to a report in the Financial Times, which cites people familiar with the matter.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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The key to target and biomarker discovery

Bio Pharma Dive

The secret's in the biological context: how to accelerate biological discovery and validation.

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Why was R&D productivity up in 2021?

pharmaphorum

A recent report has found that R&D productivity rose vertiginously during 2021, but how much of this was organic and how much can be attributed to the pandemic? In this feature, Ben Hargreaves looks at all of the factors involved and how the increased return can be maintained. The pharma industry has had a difficult time solving the issue of achieving greater productivity without significantly increasing the cost it takes to discover and commercialise new products.

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Lichens are in danger of losing the evolutionary race with climate change

Scienmag

Algae are more than just the green scum that shows up on aquarium walls. The tiny plants, when teamed up with a fungus, can form a composite structure called lichen. Lichens grow everywhere, from tundras in the Arctic to the bark of the tree in your yard, and they do everything from creating oxygen to […].

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Sajid Javid takes nationwide healthcare road trip

Pharma Times

UK health secretary navigates the NHS roadmap as he plans to reform the UK’s healthcare ecosystem

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Big data analytics help teaching staff improve university students’ performance

Scienmag

Juan Pedro Cerro, a member of faculty at the Universitat Oberta de Catalunya (UOC) and researcher at Edul@b, has demonstrated the effectiveness of big data when applied to education. What is known as learning analytics can be used to improve teaching as well as the academic results of university students. Cerro, a computer engineer, developed the DIANA application (an […].

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Women in Wales at higher risk of heart disease misdiagnosis

Pharma Times

Heart conditions among women in Wales are not being diagnosed due to systemic failures

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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$7.5 million effort seeks to prevent lunar traffic jams

Scienmag

The moon is top of mind for many national space programs and private companies, with some planning to send humans back to the lunar surface as early as 2025. Credit: University of Arizona The moon is top of mind for many national space programs and private companies, with some planning to send humans back to […].

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Tech, talent, and partnerships elevate data management: ICON

Outsourcing Pharma

In this second of a two-part series, experts from the clinical research organization share thoughts on how data management technology, personnel, and partnerships have evolved.

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For female yellowthroats, there’s more than one way to spot a winning mate

Scienmag

For female common yellowthroats, beauty isn’t just skin – or features – deep. New research provides evidence that large or showy physical features of males attract females because they signal high-quality male genes, such as those linked with robust immunity or stress resistance. Credit: Conor Taff For female common yellowthroats, beauty isn’t just skin – or features […].

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Collaboration to advance development of cancer therapies

Outsourcing Pharma

Cullinan Oncology has formed a strategic partnership with the Icahn School of Medicine at Mount Sinai to research and develop targeted therapies for cancer.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Study reveals likely link between mitochondrial dysfunction and age-dependent cognitive disorders

Scienmag

The mitochondrial electron transport chain, which is required for generating energy during cellular processes, also produces reactive oxygen species (ROS) that attack tissue and cause oxidative damage. This damage can cause mitochondrial dysfunction and even lead to cell death. Since our brain uses more oxygen than other organs, it is more vulnerable to this ROS […].

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New patent expiration for King Pharms drug LEVOXYL

Drug Patent Watch

Annual Drug Patent Expirations for LEVOXYL Levoxyl is a drug marketed by King Pharms and is included in one NDA. It is available from one supplier. There are three patents…. The post New patent expiration for King Pharms drug LEVOXYL appeared first on DrugPatentWatch - Make Better Decisions.

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The promise of PD-1 inhibition in relapsed cervical cancer

Scienmag

The promise of PD-1 inhibition in relapsed cervical cancer Credit: VHIO. The promise of PD-1 inhibition in relapsed cervical cancer Published in the New England Journal of Medicine, results of the phase III EMPOWER trial show improved survival with the PD-1 blocking antibody cemiplimab in recurrent cervical cancer. Overall survival was strikingly longer with […].

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New patent for Abbvie Inc drug RINVOQ

Drug Patent Watch

Annual Drug Patent Expirations for RINVOQ Rinvoq is a drug marketed by Abbvie Inc and is included in one NDA. It is available from one supplier. There are ten patents…. The post New patent for Abbvie Inc drug RINVOQ appeared first on DrugPatentWatch - Make Better Decisions.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Decline of vultures and rise of dogs carries disease risks

Scienmag

In the yards behind the slaughterhouses—also called abattoirs—of Ethiopia, an ecological shift is unfolding that has echoes of similar crises all over the world. Species with a clear and effective ecological role are in serious decline, and the less-specialized but more aggressive species that have moved in to take their place are not only less […].

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New patent for Neos Theraps drug COTEMPLA XR-ODT

Drug Patent Watch

Annual Drug Patent Expirations for COTEMPLA+XR-ODT Cotempla Xr-odt is a drug marketed by Neos Theraps Inc and is included in one NDA. It is available from one supplier. There are…. The post New patent for Neos Theraps drug COTEMPLA XR-ODT appeared first on DrugPatentWatch - Make Better Decisions.

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Yale Cancer Center led research shows new drug combination effective for patients with advanced ovarian cancer

Scienmag

A new study led by researchers at Yale Cancer Center and the University of Maryland Comprehensive Cancer Center shows ixabepilone plus bevacizumab (IXA+BEV) is a well-tolerated, effective combination for treatment of platinum/taxane-resistant ovarian cancer compared to ixabepilone (IXA) alone. The data shows it also may significantly extend both progression free survival and overall survival.

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Biogen and Xbrane in deal on rheumatoid arthritis targeting biosimilar

BioPharma Reporter

Biogen Inc and Xbrane Biopharma AB have entered into a commercialization and licensing agreement on Xcimzane, a preclinical monoclonal antibody that is a proposed biosimilar referencing CIMZIA.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Compressing gene libraries to expand accessibility, research opportunities

Scienmag

In image compression, a large file that could be cumbersome to store or share loses a small amount of visual information. This “lossiness” largely preserves the image while vastly reducing its file size — and serves as the inspiration for a new research direction in genomics, according to Justin Pritchard, assistant professor of biomedical engineering. […].

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Collegium agrees $604m buyout of pain specialist BDSI

pharmaphorum

Collegium Pharma has expanded its pain franchise though a deal to acquire BioDelivery Sciences International (BDSI), which has three FDA-approved drugs and a new migraine therapy due to launch in the coming weeks. Collegium – which sells opioid analgesics under the Xtampza (oxycodone) and Nucynta (tapentadol) brands – has agreed to pay $5.60 per share in cash for BDSI, valuing the company at around $604 million.

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Oregon State research uncovers key insight for restoration of globally important kelp forests

Scienmag

CORVALLIS, Ore. – Restoration efforts for kelp forests may be most effective in areas where the bedrock seafloor is highly contoured, research by Oregon State University suggests. Credit: Photo provided by Zachary Randell. CORVALLIS, Ore. – Restoration efforts for kelp forests may be most effective in areas where the bedrock seafloor is highly contoured, research […].

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Vaccines upstart Curevo has designs on blockbuster GSK franchise

pharmaphorum

Seattle, US vaccine startup Curevo has raised $60 million in first-round financing that it says will be used to run head-to-head trials of its experimental shingles vaccines CRV-101 and GlaxoSmithKline’s market-leading Shingrix. The cash will fund a phase 2b trial in 678 people aged over 50 that will compare CRV?101’s immunogenicity and safety profile relative to Shingrix , according to Curevo.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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U of T researchers find trove of proteins that may influence cystic fibrosis

Scienmag

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies. Credit: Photo by John McGraw Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in […].

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Seismic Therapeutic pledges new era of immunology drug development with machine learning

BioPharma Reporter

Seismic Therapeutic, Inc., a biotechnology company advancing machine learning for immunology drug development, has announced its launch and $101m in Series A financing.

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Solar-powered system offers a route to inexpensive desalination

Scienmag

An estimated two-thirds of humanity is affected by shortages of water, and many such areas in the developing world also face a lack of dependable electricity. Widespread research efforts have thus focused on ways to desalinate seawater or brackish water using just solar heat. Many such efforts have run into problems with fouling of equipment […].

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Fujifilm launches strategic investment fund for high impact biotech

BioPharma Reporter

Fujifilm Corporation has launched a new global life sciences strategic investment fund: starting off with 7BÂ ($60m) targeting early-stage biotech companies.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.