Thu.Apr 15, 2021

Merck, in latest COVID-19 setback, scraps one drug and pins hopes on another

Bio Pharma Dive

The decision to end development of a medicine acquired in a $425 million deal last November is another disappointment for Merck's coronavirus effort, which once involved multiple drugs and vaccines

The internet enables misinformation on COVID

World of DTC Marketing

QUICK READ: Some deaths will occur during the COVID-19 vaccination rollout, but these deaths would have happened for other reasons and are unrelated to the vaccine.

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Thermo Fisher to buy research contractor PPD in $17B deal

Bio Pharma Dive

The deal values PPD at $47.50 a share, or about 24% over the company's closing price on April 13 — the day before The Wall Street Journal reported word of the planned acquisition

Moderna to take mRNA flu and HIV vaccines into Phase 1 trials this year

BioPharma Reporter

Moderna will take mRNA flu and HIV vaccines into Phase 1 trials this year, as well as beginning a pivotal Phase 3 study for its cytomegalovirus (CMV) vaccine candidate. Bio Developments

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GSK stops studies testing closely watched cancer immunotherapy

Bio Pharma Dive

The British pharma will halt enrollment in two studies testing feladilimab alongside Merck's Keytruda, dealing another blow to the company's cancer drug pipeline

Drugs 169

HIV has been had

Scienmag

Credit: Department of Medicinal Chemistry, TMDU Tokyo, Japan – A team of scientists led by the Institute of Biomaterials and Bioengineering at Tokyo Medical and Dental University (TMDU) have created novel molecules that prevent human immunodeficiency virus (HIV) particles from attacking immune cells.

Vaccines Won’t Protect Millions of Patients With Weakened Immune Systems

NY Times

Many cannot produce enough infection-fighting cells to fend off the coronavirus. But researchers are testing one therapy that may help: monoclonal antibodies.

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Thermo Fisher Scientific snaps up PPD in $17.4b acquisition deal

Outsourcing Pharma

The science service and technologies firm plans to bring the CRO under its Laboratory Products and Services Segment umbrella after the deal is completed. Markets & Regulations

AXA partners Microsoft on ‘all-in-one’ digital health platform

Pharma Phorum

European insurance giant AXA has stepped up an alliance with Microsoft to develop an international digital health platform on the back of successful pilots in Germany and Italy last year. .

Pacira Takes ASA to Court in Defense of Non-Opioid Painkiller

BioSpace

With its only approved drug product on the line, Pacira Biosciences is fighting back against what it's calling “misrepresentation of the clinical effectiveness” of its non-opioid pain reliever Exparel

Ten reasons why the coronavirus is airborne

Scienmag

New assessment: Recognizing the virus is predominantly spread through air would save lives There is consistent, strong evidence that the SARS-CoV-2 virus, which causes COVID-19, is predominantly transmitted through the air, according to a new assessment published today in the medical journal Lancet. Therefore, public health measures that fail to treat the virus as predominantly […].

Monkey-Human Hybrid Research Offers Promise, but Sparks Ethical Debate

BioSpace

According to the researchers, who published their findings online in Cell, certain experiments can't be conducted in humans, making nearly human hybrids a possible solution to this investigational barrier

Triangular-shaped spikes key to coronavirus transmission, finds new study

Scienmag

Credit: This image appeared in the research paper published in Physics of Fluids. COVID-19 needs no introduction. Last year, the disease, which is caused by the virus SARS-CoV-2, reached every continent across the globe.

Citing Variants, Eli Lilly Asks FDA To Revoke EUA for Single Antibody Therapy

BioSpace

The reason for the request was the monotherapy antibody therapy is less effective against the COVID-19 variants, such as have risen from the U.K., South Africa and Brazil, as well as the growing B.1.427/B.1.429 California variant

A new treatment for rare muscular disease

Scienmag

UC researchers present findings that could give patients with Pompe disease a better quality of life Credit: University of Cincinnati Rare diseases are sometimes the most difficult to treat because of a lack of research and fewer participants to study.

Vaccines Won’t Protect Millions of Patients With Crippled Immune Systems

NY Times

Many cannot produce enough infection-fighting cells to fend off the coronavirus. But researchers are testing one therapy that may help: monoclonal antibodies.

AI pinpoints local pollution hotspots using satellite images

Scienmag

Technique could help find sources of heavy air pollution and allow researchers to better study its effects on human health and make more socially just policy decisions Credit: Tongshu Zheng, Duke University DURHAM, N.C.

Vaccines – Let’s Spread the Word

Imperical Blog

World Immunization Week is April 24-30. This year’s theme is #VaccinesWork to bring us closer. Could the timing be any better? The COVID-19 pandemic and the race for vaccines and treatments brought the topic of immunization into the living rooms of citizens across the world.

Thirdhand smoke exposure linked to fabric type, heat, and humidity

Scienmag

UC Riverside-led team developed simple, rapid method to assess contaminants in household fabrics Credit: University Communications, UC Riverside. RIVERSIDE, Calif.

Research Roundup: UK Variant Not as Lethal as Originally Reported and More

BioSpace

Every week there are numerous scientific studies published. Here’s a look at some of the more interesting ones

While species come and go, their ecosystems persist over millions of years

Scienmag

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World Immunization Week

Imperical Blog

World Immunization Week is April 24-30. This year’s theme is #VaccinesWork to bring us closer. Could the timing be any better? The COVID-19 pandemic and the race for vaccines and treatments brought the topic of immunization into the living rooms of citizens across the world.

Measuring neutron star squeezability

Scienmag

NICER collaboration, NASA astronaut reveal size of most massive neutron star, highlight Space Station science Credit: NASA / Walt Feimer A team of scientists used a telescope on the International Space Station to measure the size of PSR J0740+6620 (J0740, for short), the most massive known neutron star.

Vaccines – Let’s Spread the Word

Imperical Blog

World Immunization Week is April 24-30. This year’s theme is #VaccinesWork to bring us closer. Could the timing be any better? The COVID-19 pandemic and the race for vaccines and treatments brought the topic of immunization into the living rooms of citizens across the world.

From smoky skies to a green horizon: Scientists convert fire-risk wood waste into biofuel

Scienmag

A simplified new process transforms wood waste from agriculture and forest management into ethanol Credit: Berkeley Lab Reliance on petroleum fuels and raging wildfires: Two separate, large-scale challenges that could be addressed by one scientific breakthrough.

Sproutly Completes Financing

BioTech 365

Sproutly Completes Financing Sproutly Completes Financing NOT FOR DISSEMINATION IN THE US OR THROUGH US NEWSWIRE SERVICES VANCOUVER, British Columbia–(BUSINESS WIRE)–Sproutly Canada, Inc.

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Bearded dragon embryos become females either through sex chromosomes or hot temperatures

Scienmag

Ancient cellular processes are likely involved in temperature-dependent sex reversals Credit: Whiteley SL et al.,

 New Data for Genentech’s Ocrevus (ocrelizumab) Reinforce Significant Benefit on Slowing Disease Progression in Relapsing and Primary Progressive Multiple Sclerosis

BioTech 365

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Oxygen migration enables ferroelectricity on nanoscale

Scienmag

Credit: University of Groningen Hafnium-based thin films, with a thickness of only a few nanometres, show an unconventional form of ferroelectricity. This allows the construction of nanometre-sized memories or logic devices. However, it was not clear how ferroelectricity could occur at this scale.

Children’s Hospital Los Angeles Receives $6.1 Million in Research Funding to Study Treatment of Anxiety in Children and Adolescents

BioTech 365

Children’s Hospital Los Angeles Receives $6.1 Million in Research Funding to Study Treatment of Anxiety in Children and Adolescents Children’s Hospital Los Angeles Receives $6.1

Environmental protection could benefit from ‘micro’ as well as ‘macro’ thinking

Scienmag

Credit: Luke Holman Scientists at the University of Southampton have conducted a study that highlights the importance of studying a full range of organisms when measuring the impact of environmental change – from tiny bacteria, to mighty whales.

Pfizer Invites Shareholders to Attend Virtual-Only 2021 Annual Meeting of Shareholders on April 22

BioTech 365

Pfizer Invites Shareholders to Attend Virtual-Only 2021 Annual Meeting of Shareholders on April 22 Pfizer Invites Shareholders to Attend Virtual-Only 2021 Annual Meeting of Shareholders on April 22 NEW YORK–(BUSINESS WIRE)–Pfizer Inc.

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The architect of genome folding

Scienmag

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos Credit: MPI of Immunobiology and Epigenetics, F. Zenk The DNA molecule is not naked in the nucleus.

Veracyte Announces Retirement of CFO and Preliminary First Quarter 2021 Financial Results

BioTech 365

Veracyte Announces Retirement of CFO and Preliminary First Quarter 2021 Financial Results Veracyte Announces Retirement of CFO and Preliminary First Quarter 2021 Financial Results Keith Kennedy will retire following Q1 earnings release and 10-Q; Jane Alley appointed as acting CFO; … Continue reading → Business Wire

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Potential impact of pass/fail USMLE Step 1 scoring on radiology residency applications

Scienmag

Precision BioSciences Reacquires Global Rights to its Allogeneic CAR T Programs

BioTech 365

Precision BioSciences Reacquires Global Rights to its Allogeneic CAR T Programs Precision BioSciences Reacquires Global Rights to its Allogeneic CAR T Programs – Precision Reacquires from Servier its Global Development and Commercialization Rights and Control of All Partnered CAR T … Continue reading → Business Wire

Novak Djokovic now has a tiny new snail species named after him

Scienmag

Credit: Jozef Grego Do freshwater snails make good tennis players? One of them certainly has the name for it. Enter Travunijana djokovici, a new species of aquatic snail named after famous Serbian ten­nis player Novak Djokovic.

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