Tue.Mar 01, 2022

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'We have to make a stand': Biotech leaders vow to break ties with Russia over Ukraine war

Bio Pharma Dive

Biotech CEOs Paul Hastings and Jeremy Levin explained the goals behind a letter supported by more than 400 executives and investors that calls for drugmakers to stop working with Russian companies.

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 The US accounts for more than 40% of all health spending.

World of DTC Marketing

The United States accounts for more than 40% of global health spending. Hea Healthcarending made up 5% of total U.S. GDP in 1960. In 020, spending hit almost 20% of total U.S. GDP. It’s a significant issue, but healhealthcare companies are determined to record profits. Americans aren’t using more health care than people in other nations that spend less.

Drugs 154
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FDA rejects Gilead's closely watched HIV drug

Bio Pharma Dive

According to Gilead, the agency has concerns about the interaction between an injectable solution of the drug, called lenacapavir, and the vials in which it's contained.

Drugs 183
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Supermarkets Again Dash Past CVS and Walgreens in 2022’s Part D Pharmacy Networks

Drug Channels

The Centers for Medicare & Medicaid Services (CMS) has recently released its 2022 data on enrollment in Medicare Part D prescription drug plans (PDPs). Our exclusive analysis of these numbers finds that for 2022, an astounding 99% of seniors are enrolled in the wonderland of PDPs with preferred pharmacy networks. Below, we use the new enrollment data to examine the major pharmacy chains’ position within the 27 major Part D plans that have preferred networks.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Tiny tire particles inhibit growth of organisms in freshwater, coastal estuaries, studies find

Scienmag

CORVALLIS, Ore. – Small particles from tires inhibited the growth and caused adverse behavioral changes in organisms found in freshwater and coastal estuary ecosystems, two new research papers from Oregon State University scientists found. Credit: Saskia Madlener. CORVALLIS, Ore. – Small particles from tires inhibited the growth and caused adverse behavioral changes in organisms found […].

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Primary care sites: A new avenue for clinical research

pharmaphorum

The primary care setting offers huge potential for commercial research. This was, and still is being, demonstrated through the UK’s COVID-19 vaccine research successes. But primary care site protocols can’t just be cut and pasted from hospitals. Primary care sites require their own approach, but they can have great benefits for clinical trial recruitment, access to hard-to-reach patients, and more.

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Rafael Pharmaceuticals reports progress with rare cancer drug

Outsourcing Pharma

The company (which specializes in developing therapies for rare cancers) currently is working on a number of candidates, including its lead drug CPI-613.

Drugs 98
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Tonga volcano to have smaller cooling impact on climate change than first thought

Scienmag

A fresh analysis of the possible cooling effect of the sulfur dioxide injected into the atmosphere by the Hunga Tonga-Hunga Ha’apai volcano in January 2022 has concluded that the impact will be much smaller than initially thought—but the researchers responsible add some major caveats to this conclusion. Credit: National Satellite Meteorological Center of China A […].

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Brain Training: BioMed X Institute collaborates with Boehringer Ingelheim

Pharma Times

Sensor development project marks the fifth joint research effort between BioMed X with Boehringer Ingelheim

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Noble False Widow Spider captures bats in the attic

Scienmag

Scientists from the Ryan Institute in NUI Galway have published the first record of a Noble False Widow spider feeding on a protected species of Pipistrelle bats in the UK. Credit: NUI Galway Scientists from the Ryan Institute in NUI Galway have published the first record of a Noble False Widow spider feeding on a […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Researchers: New data adds to body of evidence for efficacy of LBPs in oncology setting

BioPharma Reporter

The authors of clinical data published in Nature Medicine this week said the findings indicate the use of a live biotherapeutic (LBP) with immunotherapy medicine can improve survival in patients with metastatic kidney cancer.

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Sustainable groundwater use could be answer to Africa’s water issues

Scienmag

Tapping into groundwater can help communities in Africa diversify their water supply and strengthen their drought defenses, according to a study led by The University of Texas at Austin. Credit: Credit: Jackson School of Geosciences/ The University of Texas at Austin. Tapping into groundwater can help communities in Africa diversify their water supply and strengthen […].

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Supermarkets Again Dash Part CVS and Walgreens in 2022’s Part D Pharmacy Networks

Drug Channels

The Centers for Medicare & Medicaid Services (CMS) has recently released its 2022 data on enrollment in Medicare Part D prescription drug plans (PDPs). Our exclusive analysis of these numbers finds that for 2022, an astounding 99% of seniors are enrolled in the wonderland of PDPs with preferred pharmacy networks. Below, we use the new enrollment data to examine the major pharmacy chains’ position within the 27 major Part D plans that have preferred networks.

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Mammoths, meet the metaverse

Scienmag

Los Angeles, CA (March 2, 2022) — Fearsome dire wolves and saber-toothed cats no longer prowl around La Brea Tar Pits, but thanks to new research, anyone can bring these extinct animals back to life through augmented reality (AR). Dr. Matt Davis and colleagues at the Natural History Museum of Los Angeles County and La […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Janssen, Legend CAR-T therapy CARVYKTI gets FDA nod

pharmaphorum

The US Food and Drug Administration (FDA) has approved a new cell-based therapy for blood cancer, developed by Janssen and China’s Legend Biotech to treat multiple myeloma. CARVYKTI (ciltacabtagene autoleucel), formerly known as cilta-cel, is chimeric antigen receptor T-cell (CAR-T) therapy indicated for the treatment of adults with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and

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Self-sustained divertor oscillation mechanism identified in fusion plasma experiment

Scienmag

To harness the forces that power the Sun to produce substantial clean energy on Earth, researchers heat fuel to such a high temperature that atoms melt into electrons and nuclei to form a hot, gaseous soup called plasma. Roughly 20 times the temperature of the Sun’s core at 200 million°C, the plasma can rip through any […].

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Intranasal Therapeutics and Drug Delivery Systems: The Perfect Alternative to Conventional Route of Administration

Roots Analysis

The intranasal route of administration is widely accepted as effective and non-invasive option for the local and systemic delivery of several types of active pharmaceutical ingredients (API). Majority of such formulations are designed to treat chronic obstructive pulmonary disorders (COPD), asthma and other respiratory diseases. Interestingly, over the past few years, drug developers focused on non-respiratory diseases have also shifted their attention towards intranasal drug formulations.

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Mutations in SARS-CoV-2 spike protein receptor-binding domains may result in escape variants resistant to therapeutics and vaccines

Scienmag

The SARS-CoV-2 virus is continuously evolving and structural changes to the virus may impact the efficacy of antibody therapies and vaccines. A study publishing February 17th in PLOS Pathogens by Anshumali Mittal at the University of Pittsburgh, USA and colleagues describes the structural and functional landscape of neutralizing antibodies against SARS-CoV-2 spike protein and discuss […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Affinivax Reacquires Rights from Astellas for ASP3772, a Novel 24-valent Streptococcus pneumoniae Vaccine Candidate from Affinivax’s MAPS™ Platform

The Pharma Data

Affinivax, Inc. (“Affinivax”) and Astellas Pharma Inc. (“Astellas”) today announced that they have entered into an agreement whereby Affinivax has reacquired the exclusive worldwide rights to ASP3772, a novel vaccine candidate targeting Streptococcus pneumoniae. In conjunction with the rights reacquisition by Affinivax, ASP3772 will be renamed AFX3772.

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Did rapid spin delay 2017 collapse of merged neutron stars into black hole?

Scienmag

When two neutron stars spiral into one another and merge to form a black hole — an event recorded in 2017 by gravitational wave detectors and telescopes worldwide — does it immediately become a black hole? Or does it take a while to spin down before gravitationally collapsing past the event horizon into a black […].

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AbbVie Acquires Syndesi Therapeutics, Strengthening Neuroscience Portfolio

The Pharma Data

– Expands AbbVie’s neuroscience portfolio, adding first-in-class modulators of the synaptic vesicle protein 2A, including lead molecule SDI-118 currently in Phase 1b studies – Novel mechanism will be evaluated for the potential to mitigate synaptic dysfunction associated with cognitive deficits across a range of neuropsychiatric and neurodegenerative disorders.

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Face masks play a crucial role, new COVID research confirms

Scienmag

An international research team from universities including Chalmers University of Technology, Sweden, the University of Padua and the University of Udine in Italy, and the University of Vienna, Austria, has developed a new theoretical model to better assess the risks of spreading viruses such as Covid-19 – with and without a face mask. The results […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Boehringer Ingelheim and Lifebit announce partnership to capture transformational value of health data

The Pharma Data

Boehringer Ingelheim partners with Lifebit Biotech, Ltd. to build a scalable data, analytics, and infrastructure platform This collaboration aims at capturing translational disease insights from large external healthcare biobanks and maximizing value of data for drug discovery and precision medicine. The leading research-driven biopharmaceutical company Boehringer Ingelheim and precision medicine software company Lifebit Biotech, Ltd.

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Protein protects brain cells most impacted by glaucoma

Scienmag

AUGUSTA, Ga. (March 1, 2022) — A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report. Credit: Michael Holahan, Augusta University AUGUSTA, Ga. (March 1, 2022) — A ubiquitous protein called sigma 1 receptor, […].

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Diversity Takes Center Stage at SCOPE 22

Imperical Blog

Diversity in clinical trial participation emerged as one of the most important and impassioned topics presented and discussed during the SCOPE 22 Summit in Orlando, Florida. Covid, and its wide-ranging impact, served… The post Diversity Takes Center Stage at SCOPE 22 appeared first on Imperial Clinical Research Services Blog; Trending Topics.

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British Columbians worried pandemic will never end, and climate change is only adding to the fear

Scienmag

If you’re feeling like the pandemic is never-ending, you’re not alone. Sixty-four per cent of British Columbians are worried the COVID-19 pandemic will be around for years to come, with concerns about climate change adding fuel to the fire. The latest results from a national mental health survey led by UBC researchers, in partnership with […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Best Pediatric Pharma Franchise Company

Creogenic Pharma

Are You a. Retailer ? Distributor ? Doctor ? M.R. ? Wholesaler ? Get Started with. India's. No. 1*. Pharma. Franchise Company. Submit. Lowest Price. 250+ Products. Best Service. Best Quality. Best Pediatric Pharma Franchise Company. In today’s scenario of Pharmaceutical Industry, a wide number of PCD Pharma companies are present. A few companies in this vast industry offer Pediatric Products to their customer.

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Genome refolding contributes to cancer therapy resistance, Penn study finds

Scienmag

PHILADELPHIA – While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer. Their findings were published this month in Molecular Cell. […].

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Are Apple’s healthcare ambitions too broad?

pharmaphorum

Apple pledged to make a giant impact in the healthcare industry, but Susan Lang, founder and CEO of XIL Health, says its focus on changing healthcare as a whole is an issue. . Total healthcare spending in the US increased substantially in 2020 and accounted for 19.7% of the nation’s gross domestic product. Before the pandemic, digital transformation within the health industry was progressing, but COVID accelerated digital adoption in almost every sector.

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Targeting the brain’s energy metabolism may hold the key for treating Parkinson’s disease

Scienmag

Nicotinamide riboside (NR) is a member of the vitamin B3 family, which can be found in foods like fruits, vegetables, meat, and milk. It is also used as a nutritional supplement to boost cellular levels of NAD (nicotinamide adenine dinucleotide). Credit: Eivind Senneset Nicotinamide riboside (NR) is a member of the vitamin B3 family, which can be […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.