Mon.Nov 29, 2021

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Heart attacks struck Sek Kathiresan's family. He's devoted his life to stopping them.

Bio Pharma Dive

After several family members had early heart attacks, Kathiresan vowed to understand why they happen. His research journey has changed medical practice and led to a new biotech startup, Verve Therapeutics, that seeks to prevent them.

Research 321
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Medscape vs. Doximity

World of DTC Marketing

SUMMARY: When it comes to reaching health care professionals, there is only one choice as far as I am concerned, and that’s Medscape. Working with them has always been a pleasure, and we can always “list match” targeted physicians. Health care professionals are going digital, and if you want to reach them, the options are growing. Lately, there has been a lot of talk about Doximity, but as the data below indicates, Medscape has much more traffic.

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Blueprint, taking aim at larger drugmakers, becomes a biotech buyer

Bio Pharma Dive

A $250 million acquisition of startup Lengo Therapeutics has given Blueprint a lung cancer drug that could compete with medicines from Takeda and J&J.

Medicine 316
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Late cancer diagnoses rise as NHS struggles with COVID-19

Pharma Times

Analyses provided by UK cancer charity Macmillan has provided insights into the repercussions experienced by patients waiting to receive treatment during the COVID-19 pandemic.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Vaccine makers move quickly to confront omicron threat

Bio Pharma Dive

Several companies, including Pfizer and Moderna, are already at work adapting their coronavirus shots to the newly identified variant, which experts worry could more readily evade vaccine protection.

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Gain Therapeutics presents hopeful data for Parkinson’s, Gaucher treatment

Outsourcing Pharma

The biotech firm has presented data from a study that could offer hope to patients with Parkinsonâs, Gaucher, Alzheimerâs and other neurodegenerative conditions.

Research 115

More Trending

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Genetic testing offers powerful weapon for detecting breast cancer: Sema4

Outsourcing Pharma

A leader from the health tech solutions company explains how progress in genetic testing has helped advance the detection and prevention of breast cancer.

Genetics 115
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Speed, flexibility and innovation: Rethinking the way biopharma industry operates

BioPharma Reporter

A new report reveals that âspeed-to-marketâ has jumped up from a lower-ranking business driver before the pandemic to the top priority today for biopharma companies, overtaking cost-based considerations by a healthy margin.

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Total UK cases of Omicron rise to nine

Pharma Times

An additional six cases of the Omicron variant have now been detected in Scotland, bringing the UK total so far to nine.

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Omicron Variant has Vaccine Makers Moving Fast and More COVID News

BioSpace

Omicron has caused the U.S. to install travel bans against several South African countries while vaccine makers rush to test their vaccines against it. For that news and more, continue reading.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Report suggests UK’s national vaccine facility is on the block

pharmaphorum

The UK’s Vaccines Manufacturing and Innovation Centre (VMIC) – unveiled with fanfare by the government in 2018 – is rumoured to be up for sale. The facility at the Harwell Science and Innovation Campus in Oxford has received £215 million in public money since it was announced, and several companies have submitted bids for the VMIC, according to the Financial Times, which said it heard the news from “people briefed on the situation.” It says the interested parties include UK biotech O

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Pfizer COVID-19 Vaccine is Effective Long Term in Adolescents 12 to 15

XTalks

Pfizer and vaccine partner BioNTech shared positive long-term data last week that shows their COVID-19 vaccine remains effective for at least four months in adolescents 12 to 15 years of age. The vaccine also maintained a good safety profile with no serious side effects. The top line results could set the stage for approval of the vaccine for this age group.

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Helix web tool guides prostate cancer genetic testing

pharmaphorum

A web-based digital tool called Helix could help clinicians identify patients with prostate cancer who would benefit from genetic testing and counselling, according to researchers in the US. The use of genetic testing has become the standard of care for men with prostate cancer in the US, as it can help direct the most appropriate therapy, but identifying those who can benefit can be a challenge, according to the researchers behind the web tool.

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Gene-Based Therapy for Rare Skin Disease Succeeds in Phase III

BioSpace

Results from its GEM-3 trial on VYJUVEK demonstrated statistical significance in its ability to promote complete wound healing within six months compared to a placebo.

Gene 100
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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Development of Omicron-specific vaccines is under way

BioPharma Reporter

Moderna, BioNTech and Johnson & Johnson have all started developing Omicron-specific vaccines: among a wider response plan to the SARS-CoV-2 variant.

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Sigilon Uncovers Possible Reason Behind Hemophilia A Trial Hold

BioSpace

Sigilon Therapeutics announced it may have discovered the reason why its experimental cell therapy treatment for severe hemophilia A was placed on clinical hold by the FDA.

Trials 95
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Science at the cusp: NASA rocket to study mysterious area above the North Pole

Scienmag

Strange things happen in Earth’s atmosphere at high latitudes. Around local noon, when the Sun is at its highest point, a funnel-shaped gap in our planet’s magnetic field passes overhead. Earth’s magnetic field shields us from the solar wind, the stream of charged particles spewing off the Sun. The gap in that field, called the […].

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How Scientists Turned Frog Embryos into Living, Self-Replicating Robots

BioSpace

?Scientists who built xenobots have discovered that the very same organisms they made in 2020 have the ability to create new versions of themselves by banding together.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Scientists fling model stars at a virtual black hole to see who survives

Scienmag

Credit: Credit: NASA’s Goddard Space Flight Center/Taeho Ryu (MPA) DOI [link] Article Title Tidal Disruptions of Main-sequence Stars. I. Observable Quantities and Their Dependence on Stellar and Black Hole Mass Article Publication Date 25-Nov-2021.

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Promising Signals Emerge from Two Phase II Cancer Studies

BioSpace

Two biopharma companies developing therapeutics in the oncology space begin the week with strong signals in Phase II.

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New study shows the largest comet ever observed was active at near-record distance

Scienmag

A new study by University of Maryland astronomers shows that comet Bernardinelli-Bernstein (BB), the largest comet ever discovered, was active long before previously thought, meaning the ice within it is vaporizing and forming an envelope of dust and vapor known as a coma. Only one active comet has been observed farther from the sun, and […].

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Early Research on Omicron, Plus More COVID-19 News

BioSpace

The whole world is watching the news about Omicron, but it’s obvious that it will be a week or two before enough is known about the new variant of concern.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Strong winds power electric fields in the upper atmosphere, NASA’s ICON finds

Scienmag

What happens on Earth doesn’t stay on Earth. Credit: Credits: NASA’s Conceptual Animation Lab What happens on Earth doesn’t stay on Earth. Using observations from NASA’s ICON mission, scientists presented the first direct measurements of Earth’s long-theorized dynamo on the edge of space: a wind-driven electrical generator that spans the globe 60-plus miles above our heads. […].

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Pharmaceutical Manufacturing And Packaging Congress 2022 Connects Pharma Leaders

pharmaphorum

Pharmaceutical Manufacturing & Packaging Congress (PHARMAP 2022) covers the current state of the pharmaceutical manufacturing and packaging industry. The Congress gathers pharmaceutical companies, CMOs and CDMOs, governmental bodies together with pharmaceutical equipment providers and service companies. It will take place on June, 20-21, 2022 in Berlin, Germany.

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Ultra-processed foods increase the risk of a second heart attack or stroke

Scienmag

Ultra-processed foods are a major public health concern for their potential adverse effects on health. Now a study by the Department of Epidemiology and Prevention of the I.R.C.C.S. Neuromed in Pozzilli (Italy) explores the health effects of a large dietary share of ultra-processed food on people already suffering from cardiovascular diseases. The findings indicate a […].

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RayzeBio-Partnered Startup Focused on Bringing Radiopharmaceuticals to China

BioSpace

Ablaze has aligned itself with RayzeBio, giving Ablaze a solid start with an in-licensing agreement to bring Rayze's products to the greater China market.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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New algorithm efficiently diagnoses shale fracture results from fiber-optic data

Scienmag

The oil industry put fiber-optic sensing cables downhole to better understand why hydraulic fracturing doesn’t free trapped oil at expected rates in shale reservoirs, but the massive streams of information received are hard to analyze. Now a team of researchers from Texas A&M University and the Colorado School of Mines has created an algorithm to […].

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UK accelerates COVID booster plans in response to Omicron

pharmaphorum

The UK looks set to extend its COVID-19 booster vaccination programme to all over-18s, as the number of cases of the new Omicron variant of SARS-CoV-2 has reached double figures. The gap between second doses and boosters is also being reduced from six to three months in an attempt to get as much protection in the population as possible ahead of the winter holiday season, in an attempt to get ahead of a potential Omicron wave.

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Telehealth-delivered diet and exercise program eased knee pain and triggered weight loss

Scienmag

New research investigating the benefits of telehealth-delivered exercise and diet programs has found 80 per cent of participants experienced improvement in pain and an average of 10 per cent in loss of body weight, with one man shedding 39 kilograms. Credit: PEAK Consulting New research investigating the benefits of telehealth-delivered exercise and diet programs has […].

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Antiviral Covid-19 Pills Are Coming. Will There Be Enough Tests?

NY Times

The pills must be given early in the course of infection, which means access to timely, accurate test results will be crucial.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.