Mon.Apr 25, 2022

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Nkarta gives first look at two 'natural killer' cell therapies for blood cancer

Bio Pharma Dive

The results build on early evidence that NK cell treatments may become viable medicines for leukemia and lymphoma, while it's still unclear whether they're as effective, or last as long, as T cell therapies.

Medicine 269
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Cardiologists say information on wearables isn’t always useful.

World of DTC Marketing

Gadget firms — starting with Apple and now Fitbit, which Google owns — are selling wearable devices that check heartbeat rhythms and alert users when something is out of sync, according to KHN.com. Although the gadgets are a technical achievement, some cardiologists say the information the devices produce isn’t always helpful. Notifications from the devices aren’t definitive diagnoses.

Doctors 231
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Connect to the conversation: Pediatric mental health

Bio Pharma Dive

More children than ever are experiencing mental health issues, so what can parents and loved ones do to help address these issues and prevent them before they start?

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Digital interventions cut heart failure mortality, study shows

pharmaphorum

An analysis of 10 clinical trials of digital health interventions targeted at patients recently hospitalised for acute heart failure has found they improve outcomes compared to standard care. The meta-analysis by researchers in the US pooled the results of the studies to assess the impact of digital approaches like telemedicine, use of monitoring sensors, Internet-based interventions, smartphone apps, or text messaging/email interactions on all-cause mortality.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Roche stumbles in latest setback for an emerging group of breast cancer drugs

Bio Pharma Dive

The Phase 2 failure marks the second negative result in two months for a closely watched group of medicines, known as SERDs, that are being developed by several large pharmaceutical companies.

Medicine 152
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Partnering to advance digital therapeutics offerings

pharmaphorum

Aaron Gani, founder and CEO of BehaVR, and Krys Zaluski, director of business development, digital health at Sumitomo Dainippon Pharma, discuss their groundbreaking partnership to develop and commercialise digital therapeutics (DTx) products. . BehaVR and Sumitomo signed a potential $140 million deal to create virtual reality (VR) therapies to treat social anxiety disorder, generalised anxiety disorder, and major depressive disorder.

More Trending

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Healome Therapeutics to accelerate development for ocular disease

Pharma Times

Studies have demonstrated that Healome’s formulations have anti-fibrotic activity and are augmented when combined with other therapeutics

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The first scientific expedition to Panama’s unexplored Cordillera de Coiba sets sail

Scienmag

Last year, Panama expanded the Cordillera de Coiba marine protected area from 17,223 to 67,908 square kilometers (6,650 to 26,219 square miles). On April 27th, an international scientific expedition made up of researchers and students from the Smithsonian Tropical Research Institute (STRI), MigraMar, the International Maritime University of Panama (UMIP), the University of Costa Rica and […].

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Overcoming the 4 leading barriers to cardiovascular disease patient recruitment

Clairnes

The post Overcoming the 4 leading barriers to cardiovascular disease patient recruitment appeared first on Clinical Trial Recruitment & Management Services.

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Meat consumption must fall by at least 75 percent

Scienmag

Every EU citizen consumes around 80 kilograms of meat per year. But every juicy steak, every delicious sausage has a price that we do not pay at the counter, because livestock farming damages the climate and the environment. Ruminants for instance produce methane, which accelerates global warming. Animals also convert only a portion of the […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Novartis UK announces new charity partnerships supporting social mobility

Pharma Times

Novartis will provide vital volunteering projects, career plans for young people and financial support to local charities

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Nature inspired strong, lightweight material for planes, buildings and bone implants

Scienmag

Material coming from a Princeton research lab is full of holes — but that’s a good thing. Designed to mimic bone, wood and other natural materials, the porous objects are lighter than traditional products and can be strategically inserted into structures to provide higher stiffness in areas with high demand. Credit: Paulino et al. Material […].

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Roche’s oral SERD giredestrant fails breast cancer trial

pharmaphorum

Roche revealed in its first-quarter results statement that giredestrant missed the mark in the phase 2 acelERA trial in advanced breast cancer, in what appears to be another blow to the emerging oral selective oestrogen receptor degrader (SERD) class. The Swiss pharma said in its update that the acelERA trial comparing giredestrant to physician’s choice of endocrine therapy for previously-treated hormone receptor (HR)-positive, HER2-negative breast cancer did not meet its primary endpoint

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Smooth movements are achieved by the stable basal ganglia activity

Scienmag

Smooth movements require coordinated control of muscles. Even a simple reaching movement involves coordinated movements of his/her shoulder, arm, wrist and fingers, which are controlled by temporally precise commands from the motor cortices in the cerebrum. In a recently published paper in Nature Communications, Atsushi Nambu and his research group at the National Institute for […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Informa Connect’s Patient Support Services Congress

Drug Channels

Informa Connect’s Patient Support Services Congress. Hybrid Event | June 14-16 in Philadelphia, PA www.informaconnect.com/patientsupport. Exclusive Offer – Be sure to use your exclusive promo PSS22DC to save 10% off* of your registration. A proven industry staple, Patient Support Services Congress is back June 14-16, 2022 and ready to arm industry with next-generation approaches to patient services for optimal program performance.

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2 out of 3 women with depression or anxiety say they’ve reached their “breaking point,” yet more than half wait a year before seeking treatment

Scienmag

Two out of three women diagnosed with depression or anxiety say they have reached or are approaching their breaking point regarding their mental health, according to the GeneSight® Mental Health Monitor, a new nationwide survey from Myriad Genetics, Inc. (NASDAQ: MYGN). Credit: GeneSight Mental Health Monitor Two out of three women diagnosed with depression or […].

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New patent for Zogenix Inc drug FINTEPLA

Drug Patent Watch

Annual Drug Patent Expirations for FINTEPLA Fintepla is a drug marketed by Zogenix Inc and is included in one NDA. It is available from one supplier. There are eleven patents…. The post New patent for Zogenix Inc drug FINTEPLA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Crew-4 astronauts head to space station to conduct microgravity science

Scienmag

NASA’s SpaceX Crew-4 mission is scheduled to launch to the International Space Station on Saturday, April 23, from NASA’s Kennedy Space Center in Florida. This?launch?carries three NASA astronauts – Kjell Lindgren, Robert Hines, and Jessica Watkins – and ESA (European Space Agency) astronaut Samantha Cristoforetti. This spaceflight is the first for Hines and Watkins and the second for Lindgren and Cristoforetti.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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iPSC Manufacturing Summit

pharmaphorum

With iPSCs exhibiting game-changing potential in the bid to develop an off-the-shelf therapy, the brand-new iPSC Manufacturing Summit is the only summit dedicated to solving the manufacturing, quality and analytical challenges hindering your iPSC-derived treatments from reaching patients. This forum will unite the exclusive community advancing the production of high-quality and consistent iPSC products, with in depth case studies aimed to develop optimal differentiation, cryopreservation, and an

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New research harnesses the power of movement

Scienmag

Harvesting energy from the day-to-day movements of the human body and turning it into useful electrical energy, is the focus of a new piece of research involving a Northumbria University Professor. Credit: Northumbria University Harvesting energy from the day-to-day movements of the human body and turning it into useful electrical energy, is the focus of […].

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Gerber Launches Its First Line of Plant-Based Baby Food

XTalks

Leading baby food brand Gerber announced the launch of its first plant-based baby food line, Plant-tastic. The line features a full range of organic plant-based toddler foods, from pouches to snacks to bowls. Created to offer a richer source of plant protein, the products are made with nutrient-dense beans, whole grains and veggies. . The new range features products such as the Banana Berry Veggie Smash Pouch, Lil’ Crunchies White Bean Hummus Toddler Snacks and the Mediterranean Medley Harvest B

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Study: Economic burden of PTSD `staggering’

Scienmag

A new study finds that the national economic burden of PTSD goes beyond direct health care expenses and exceeds the costs of other common mental health conditions, such as anxiety and depression. Credit: Mike Harris A new study finds that the national economic burden of PTSD goes beyond direct health care expenses and exceeds the […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Next Generation RNA Therapeutics Summit

pharmaphorum

Are you looking to solve challenges with current RNA therapeutics, such as the degradation of RNA by RNAses, the difficulty of RNA crossing the cell membrane by diffusion and the immunogenicity elicited by exogenous RNA? Next generation RNA therapeutics can help! The Next Generation RNA Therapeutics Summit comes to Boston on May 24-26 to unite experts to discuss how novel modalities from self-replicating to circular RNAs have the potential to overcome key challenges faced by current generations.

RNA 52
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First-of-its-kind study compares domestic violence programs, finds promising results

Scienmag

AMES, IA – A new study from Iowa State University found men convicted of domestic violence were charged with significantly fewer violent and nonviolent charges one year after completing a treatment program developed in Iowa compared to a model used in most other states. Survey data from victims still in contact with the men provided […].

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HPAPI Summit hones in on pharmaceutical manufacturing risk

Outsourcing Pharma

The 2022 edition of the Highly Potent Active Pharmaceutical Ingredients Summit (June 28 to 30 in Boston) will take on a range of topics, including safety.

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Top thought leaders tackle health care inequities in population health management

Scienmag

Continuing telehealth care delivery beyond the COVID-19 pandemic will benefit publicly insured children if they are ensured equitable access to telehealth services. This study finding is part of a Special Issue on “Reducing Health Disparities in Underserved Populations” in the peer-reviewed journal Population Health Management. Click here to read the issue now.

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Catalent acquires New Jersey cell therapy development and manufacturing facility

BioPharma Reporter

Catalent has acquired a commercial-scale cell therapy manufacturing facility in Princeton, New Jersey, from Erytech Pharma for $44.5m.

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Newly discovered protein in fungus bypasses plant defenses

Scienmag

Pullman, Wash., April 25, 2022—A protein that allows the fungus which causes white mold stem rot in more than 600 plant species to overcome plant defenses has been identified by a team of U.S. Department of Agriculture Agricultural Research Service and Washington State University scientists. Credit: ARS-USDA Pullman, Wash., April 25, 2022—A protein that allows […].

Protein 84
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Drug Patent Expirations for the Week of April 24, 2022

Drug Patent Watch

CERDELGA (eliglustat tartrate) Genzyme corp Patent: 7,253,185 Expiration: Apr 29, 2022 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com…. The post Drug Patent Expirations for the Week of April 24, 2022 appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 40
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Controlling heat flow in a solid by switching crystal structure dimensionality

Scienmag

Just as how an electrical switch regulates the flow of electric current, thermal switches can control the flow of heat. These switches serve as thermal control devices and are useful for thermal management applications. For example, they can be used in industries to reduce waste heat, resulting in cost and energy savings. These switches require […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.