Rethinking Clinical Trials

JULY 3, 2025

Dr. Natalia Morone, principal investigator for OPTIMUM Trust in their clinicians, positive interactions with study staff, and opportunities for social connection can improve recruitment, retention, and engagement with research participants, according to focus groups of participants in the OPTIMUM trial. These factors can be especially important for first-time research participants and for groups that are historically underrepresented in clinical trials.

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Scienmag

JULY 3, 2025

A groundbreaking advancement in stem cell technology promises to redefine the scope and efficacy of regenerative medicine, potentially revolutionizing treatments for a multitude of chronic and acute conditions. Researchers from Hiroshima University, Keio University, Tokyo Women’s Medical University, and the University of Utah have engineered a sophisticated method to cultivate mesenchymal stem cells (MSCs) as intricately aligned sheets.

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pharmaphorum

JULY 3, 2025

Dizal gets US approval for an oral therapy for EGFR exon 20-mutated NSCLC, offering some patients an alternative to J&J's intravenous Rybrevant

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Drugs 89

Scienmag

JULY 3, 2025

In recent years, the landscape of multiple myeloma treatment has witnessed transformative advances, notably with the emergence of chimeric antigen receptor T-cell (CAR-T) therapies targeting the B-cell maturation antigen (BCMA). A groundbreaking study published in Nature Communications by Atanackovic et al. delves deeply into the intricate immune correlates associated with two FDA-approved anti-BCMA CAR-T products: idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel).

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Speaker: Brian Richardson, Brian Richardson, Founder and CEO of Richardson Consulting Group

Let’s face it—most ethics and compliance training programs aren’t winning awards for engagement. But that doesn’t mean they can’t be effective, captivating, and maybe even enjoyable! Join learning design expert Brian Richardson for a dynamic session on how to breathe new life into your ethics and compliance training. We'll explore innovative strategies to bring traditionally dry topics to life, making them resonate with learners and drive tangible change.

Compliance

Advarra

JULY 3, 2025

10 areas that may impact your organization The third revision (R3) of the ICH E6 Guideline for Good Clinical Practice represents a significant modernization of global clinical research standards. Designed to better manage risk, patient safety, and data integrity in clinical trials, the updated guideline is expected to be adopted by regulatory authorities worldwide.

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Scienmag

JULY 3, 2025

The rapid advancement of single-cell RNA sequencing (scRNA-seq) technology has revolutionized biological research, offering unprecedented resolution to examine gene expression patterns at the level of individual cells. This extraordinary capability has facilitated extraordinary insights into cellular heterogeneity across diverse tissues and organisms, driving progress in fields such as immunology, oncology, and developmental biology.

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Scienmag

JULY 3, 2025

In the unfolding landscape of mental health research, an intriguing and critical study has emerged that delves deeply into the psychiatric aftermath of spinal cord injury (SCI), with a targeted focus on post-traumatic stress disorder (PTSD). A recent retrospective multivariate analysis conducted by Jiang, Sun, Xie, and their colleagues meticulously examines the risk factors and intervention strategies for PTSD in patients recovering from spinal cord injuries, a demographic often overlooked in ps

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The Pharma Data

JULY 3, 2025

Medimaps Group Launches Next-Generation TBS Osteo Software Across Europe to Revolutionize Osteoporosis Detection Medimaps Group S.A., a Swiss-based global leader in AI-powered bone health solutions, has announced the European launch of its next-generation TBS Osteo Advanced software, following its recent debut in the United States. With clearance under the EU’s Medical Device Regulation (MDR), the rollout marks a significant step forward in transforming osteoporosis detection and enhancing bone

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Scienmag

JULY 3, 2025

In recent years, the quest to improve outcomes for glioblastoma (GB) patients has fueled intense research into novel therapeutic avenues, among which vaccination therapy has garnered considerable attention. Glioblastoma, an aggressive and invariably fatal primary brain tumor, presents formidable challenges due to its rapid progression and resistance to conventional treatments.

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The Pharma Data

JULY 3, 2025

Novocure to Present Final PANOVA-3 Data Highlighting Pain and Quality of Life Benefits of TTFields Therapy in Pancreatic Cancer at ESMO GI 2025 Novocure (NASDAQ: NVCR) announced that it will present final secondary endpoint results from its pivotal Phase 3 PANOVA-3 clinical trial evaluating Tumor Treating Fields (TTFields) therapy in patients with unresectable locally advanced pancreatic adenocarcinoma.

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Enhancing Transparency & Efficiency Throughout the Trial Lifecycle for AI Readiness

Trials

Scienmag

JULY 3, 2025

A groundbreaking study published in the prestigious journal Genes & Diseases has unveiled a pivotal role for the gene XPR1 in the progression of ovarian cancer, illuminating new molecular pathways that could revolutionize therapeutic strategies against this formidable malignancy. Scientists at Chongqing Medical University have identified XPR1 as a key regulator of autophagy—a cellular degradation and recycling process—and as a modulator of major histocompatibility complex class I (MHC-I) exp

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pharmaphorum

JULY 3, 2025

Novartis hopes of bringing Cosentyx to patients with giant cell arteritis seem to be over after the drug missed all the endpoints in a phase 3 trial.

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Scienmag

JULY 3, 2025

In a landmark study conducted over sixteen years, researchers at the University of Hong Kong’s Department of Psychiatry have shed new light on the safety profile of lithium treatment for bipolar disorder, reaffirming its therapeutic efficacy amidst prevailing concerns about potential thyroid and kidney dysfunction. Lithium, long regarded as the gold standard mood stabiliser, has persistently faced underutilisation in clinical practice due to fears of adverse effects, yet this comprehensive analy

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The Pharma Data

JULY 3, 2025

CroíValve Awarded €12.5M in Horizon Europe EIC Accelerator Funding to Advance Novel Treatment for Tricuspid Regurgitation CroíValve, a Dublin-based medical device company committed to transforming the treatment of tricuspid regurgitation (TR), has secured a major funding boost through the European Innovation Council (EIC) Accelerator Programme, a flagship initiative under Horizon Europe.

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Speaker: Amie Phillips Pablo, VP, Corporate Compliance & Privacy Officer at Novo Nordisk

In today’s complex healthcare environment, navigating third-party relationships has become even more challenging—whether it’s vendor relationships, employee activities, or patient-facing interactions. Left unmanaged, these conflicts can compromise trust, regulatory compliance, and even organizational reputation. So, how can healthcare teams stay ahead?

Compliance

Scienmag

JULY 3, 2025

In a groundbreaking study poised to redefine our understanding of alcohol-induced liver injury, researchers have identified a novel cellular mechanism linking binge drinking to severe hepatic inflammation. Published in Nature Communications , the study unravels how excessive alcohol consumption triggers a molecular cascade within Kupffer cells—specialized macrophages residing in the liver—leading to robust inflammatory responses.

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STAT News

JULY 3, 2025

Last fall, a group of experts advising the U.S. Food and Drug Administration debated for two days on how to regulate generative artificial intelligence tools in medicine. One report presented at the meeting showed that a generative AI tool supposedly used by 40% of the radiology practices in the U.S. produced clinically significant errors in one of every 21 reports.

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Scienmag

JULY 3, 2025

In the relentless pursuit to decipher the molecular underpinnings of bladder cancer, a groundbreaking study has unveiled a pivotal role of the transcription factor TCF3 in orchestrating tumor progression through a novel ferroptosis-dependent pathway. Researchers led by Yang WF and colleagues have illuminated how TCF3 exacerbates bladder cancer development by modulating the TMBIM6-Ca²⁺ axis, intricately linking transcriptional regulation with iron-dependent cell death mechanisms.

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Worldwide Clinical Trials

JULY 3, 2025

Approximately two in 10 patients with hematologic malignancies are estimated to be eligible and able to receive cell therapy. However, the FDA’s recent decision to remove the Risk Evaluation and Mitigation Strategy (REMS) requirements for certain approved Chimeric Antigen Receptor T-cell (CAR T) therapies could dramatically shift these numbers, making life-saving treatments more accessible to those in need.

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Life Science

Scienmag

JULY 3, 2025

In the realm of adolescent mental health, treatment resistant depression (TRD) presents a daunting challenge. Affecting approximately 20% of youths who suffer from depressive disorders, TRD remains unresponsive to conventional antidepressant therapies, leaving clinicians and families seeking new avenues of care. Recent advances in neuromodulation have spotlighted repetitive transcranial magnetic stimulation (rTMS) as a promising intervention for adults with resistant depression, yet its applicat

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Pharmaceutical Commerce

JULY 3, 2025

Bruce Leuchter, CEO, Neurvati, discusses why patient engagement is essential to understanding rare diseases and driving the development of breakthrough therapies.

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Development 52

Scienmag

JULY 3, 2025

In a groundbreaking new study published in the International Journal of Obesity, researchers have unveiled compelling evidence linking dynapenic obesity to the accelerated progression of cardiometabolic multimorbidity (CMM). This work propels our understanding of how the combined burden of muscle weakness and excess adiposity converges to exacerbate cardiometabolic diseases (CMD), which include critical conditions such as type 2 diabetes, hypertension, and cardiovascular disease.

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STAT News

JULY 3, 2025

Over 660 million pilgrims gathered at the Maha Kumbh Mela in Prayagraj, India, this past February, and I’m now seeing the downstream consequences in my California clinic. This year, I’ve treated several Americans who returned ill after ritual bathing in India’s sacred river. Their diagnoses have ranged from typhoid fever and multidrug-resistant E. coli to persistent giardiasis and polymicrobial gastroenteritis.

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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Scienmag

JULY 3, 2025

In a groundbreaking study published in Nature Communications , researchers led by Wang, Cheng, Lim, and colleagues have uncovered critical insights into the role of EHMT2 in the regulation of genomic imprinting associated with Prader-Willi syndrome (PWS). This work, leveraging cutting-edge genomic and epigenetic techniques, elucidates a novel molecular pathway that underpins the pathological imprinting defects characteristic of this complex neurodevelopmental disorder.

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STAT News

JULY 3, 2025

There’s been much discussion and debate about the cuts to Medicaid eligibility that Congress just passed and, in particular, what they may mean for current Medicaid recipients. A key piece of evidence in this debate has been results from the Oregon Health Insurance Experiment (OHIE ), a randomized trial, which I helped lead, examining the impact of covering low-income uninsured adults with Medicaid for one to two years.

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Trials 139

Scienmag

JULY 3, 2025

In a groundbreaking study that could reshape our understanding of metabolic health and obesity, researchers have elucidated the critical role of adipose-resident c-kit + progenitors in brown adipocyte formation and the dynamics of adipose tissue maintenance. This advance offers promising insight into how the body’s fat tissue adapts and remodels itself, revealing a nuanced cellular mechanism that may open new therapeutic avenues for metabolic diseases.

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Regulation Gene Therapy Research RNA 59

pharmaphorum

JULY 3, 2025

Colorectal cancer patients could soon have access via the NHS to a targeted oral drug that can give them more precious time with their loved ones

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Drugs 66

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Medicine

Scienmag

JULY 3, 2025

In recent years, the concept of sustainable travel has gained remarkable momentum, particularly within the scientific community, where concerns about carbon footprints and environmental impact are ever-increasing. A compelling case study recently emerged from the experience of a pediatric researcher attending the European Academy of Paediatrics Society (EAPS) Congress in Vienna.

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Drug Discovery World podcast

JULY 3, 2025

This is the latest episode of the free DDW narrated podcast, titled “UK Spotlight: Innovation and discovery”, which covers three articles written for DDW Volume 24 – Issue 4, Fall 2023. They are called: “ Where is the drug discovery expertise happening in the UK? ”, “ From the top: Dr Martin Main, Medicines Discovery Catapult ”, and “ Meet the Researcher: Molly Stevens, Oxford University and Imperial ”.

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Medicine Drugs Research 52

Scienmag

JULY 3, 2025

In the wake of the devastating Kahramanmaraş earthquakes that struck Turkey and Syria on February 6, 2023, researchers have uncovered intriguing neurological changes in survivors diagnosed with post-traumatic stress disorder (PTSD). As the first anniversary of these catastrophic events approaches, a groundbreaking study sheds light on how traumatic exposure correlates with distinct structural alterations in critical brain regions responsible for memory and emotional processing—the hippocampus an

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The Pharma Data

JULY 3, 2025

Biosynth Unveils Expanded GMP Bioconjugation Facility in Berlin to Advance Next-Generation Therapeutics Biosynth, a global leader in providing essential raw materials and services for the life sciences and diagnostics industries, has officially inaugurated a major expansion of its GMP bioconjugation facility in Berlin. This strategic enhancement of its existing site marks a significant milestone in the company’s mission to support the development and production of advanced therapeutic and diagno

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