Wed.Apr 28, 2021

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BioMarin partners with Allen Institute to develop gene therapies for the brain

Bio Pharma Dive

Far along in testing for a hemophilia treatment, BioMarin is expanding its gene therapy research into diseases of the central nervous system and aims to use some of the institute's technology.

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Using PK Modeling and Simulation to Plan Studies for Pediatric Patient Populations

Camargo

Conducting a clinical study in a pediatric patient population requires careful planning, as providing a benefit to a child without causing harm is a weighty responsibility. The first tasks in striking this balance are dose selection and dosing interval determination, and this blog post offers an overview on how PK modeling and simulation can be applied to optimize the safety and efficacy of a product for pediatric populations in clinical trials.

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Wall Street fears Amgen's tough first quarter is just the start

Bio Pharma Dive

Product sales fell by 5% in the first quarter, keeping the pressure high for Amgen to deliver on expectations for its KRAS cancer drug Lumakras.

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CPhI post-pandemic executive pharma survey: COVID-19 driving manufacturing and CDMOs driving growth

Pharma Mirror

Ahead of CPhI Discover (17th-28th May, 2021) – global pharma’s largest ever virtual gathering – the CPhI executive post-pandemic pharma survey[i] predicts that pandemic supply chain issues have further cemented a push for repatriated manufacturing globally. The findings suggest that over the next five years, governments and companies will gradually look to reduce complexity and increase regional self-reliance.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Pfizer buys infectious disease biotech Amplyx

Bio Pharma Dive

The deal is another sign of Pfizer's interest in infectious disease beyond COVID-19, following the pharma's participation in an industry investment fund.

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AavantiBio and Catalent Announce Partnership to Support Development and Manufacturing of Gene Therapies for Rare Genetic Diseases

Pharma Mirror

AavantiBio, a gene therapy company focused on transforming the lives of patients with rare genetic diseases, and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products, today announced a partnership to support the development and manufacturing of AavantiBio’s gene therapies, including its lead program in Friedreich’s Ataxia (FA).

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CPhI Japan celebrates return, as cell & gene therapies and digital innovation highlighted

Pharma Mirror

Tokyo 27th April 2021: CPhI Japan, the first large pharma event to trade in 2021, played host to 7214 attendees at the exhibition and a further 7204 virtual users from across the globe. The event, a key marker for the strength of the regional industry, has rebounded quickly with some 216 exhibitors searching for pharma partners. In fact, such has been the demand, CPhI Japan Connect – the event’s digital platform for international audiences – will remain open until the end of May.

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The role of data science and text mining in the search for new therapies

pharmaphorum

Today, most drug discovery programmes begin with the identification and validation of disease modifying biological targets. The primary way to uncover these targets is through searching and reviewing published scientific literature. Eric Gilbert explores how data science techniques like text mining are speeding up research into areas such as pancreatic cancer.

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Wasps are valuable for ecosystems, economy and human health (just like bees)

Scienmag

Credit: Professor Seirian Sumner, UCL Wasps deserve to be just as highly valued as other insects, like bees, due to their roles as predators, pollinators, and more, according to a new review paper led by UCL and University of East Anglia researchers. The study, published in Biological Reviews, compiles evidence from over 500 academic papers […].

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Stop Food Waste Day 2021: How Consumers and Corporations Can Do Their Part

XTalks

Stop Food Waste Day occurs each year on April 28 to educate, raise awareness and fight against food waste globally. Launched in 2017 by the US division of global foodservice leader Compass Group , consumers and corporations across over 30 Compass countries work together to educate and encourage change when it comes to food waste. Exacerbated by the COVID-19 pandemic, the food waste epidemic continues to worsen.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Introducing the 2020-21 HBA Honorable Mentor and STAR Awardees

Pharma Marketing Network

Introducing the recipient of the 2020-21 HBA Honorable Mentor Award, Dr. Rod MacKenzie , Chief Development Officer and EVP, Pfizer and the recipient of the 2020-21 HBA STAR Award, Susan Torroella , Chief Operating Officer, ArmadaHealth. What is the Honorable Mentor Award? The Honorable Mentor award recognizes a man who demonstrates a long-term commitment to advancing women in the workforce, is dedicated to developing, mentoring and promoting women in the industry, and is supportive of the overal

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NYU Environmental Studies Professor Sonali Shukla McDermid named Carnegie Fellow

Scienmag

Credit: Mathew McDermid New York University’s Sonali Shukla McDermid has been named an Andrew Carnegie Fellow, one of 26 selected to the 2021 class for a program that provides support for scholars in the social sciences and humanities, the Carnegie Corporation of New York announced today. Fellows will each be supported by $200,000 “to fund […].

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How Europe Sealed a Pfizer Vaccine Deal With Texts and Calls

NY Times

The European Union is about to sign a deal for 1.8 billion doses of the Pfizer-BioNTech vaccine after a dispute with AstraZeneca derailed its vaccination campaign. Here’s how it came about.

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Researchers use a nanoscale synthetic antiferromagnet to toggle nonlinear spin dynamics

Scienmag

UC Riverside-led work could lead to better computer technologies Credit: Barsukov lab, UC Riverside. RIVERSIDE, Calif. — Researchers at the University of California, Riverside, have used a nanoscale synthetic antiferromagnet to control the interaction between magnons — research that could lead to faster and more energy-efficient computers.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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3 Ways to Pivot Your Current Job Instead of Looking for a New One

BioSpace

After you’ve been in a role for a decent amount of time it can feel like you have learned all that there is to learn. But that’s not to say that you’ve learned all you can from the company and the people that work there.

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Legendary licenses

Scienmag

Sandia tech transfer expert garners national award Credit: Photo courtesy of Sandia National Laboratories ALBUQUERQUE, N.M. — Licensing expert Bob Westervelt, who has worked to transfer Sandia National Laboratories technologies in the medical, solar and hydrogen production fields, received the 2021 Outstanding Technology Transfer Professional Award from the Federal Laboratory Consortium.

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Over a quarter of UK adults have received both COVID-19 vaccine doses

Pharma Times

UK government has also offered a first vaccine dose to all individuals in cohorts one to nine

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Many children with cardiomyopathy have a genetic mutation but few are screened

Scienmag

Routine genetic screening for all children with cardiomyopathy could make a powerful difference in outcomes and even survival Credit: Douglas Levere/University at Buffalo BUFFALO, N.Y. — A national, University at Buffalo-led study on genes in pediatric cardiomyopathy demonstrates strong evidence for routine genetic screening in children with the disease.

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Four Biotechs Rake in Over $350 Million for Rare Diseases, Cancers and More

BioSpace

Ohio-based Forge Biologics secured $120 million in a Series B financing round to support the clinical development of its gene therapy program for rare diseases, including the typically fatal Krabbe disease.

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Social media and science show how ship’s plastic cargo dispersed from Florida to Norway

Scienmag

Credit: Tracey Williams, Lost at Sea Project A ship’s container lost overboard in the North Atlantic has resulted in printer cartridges washing up everywhere from the coast of Florida to northern Norway, a new study has shown. It has also resulted in the items weathering to form microplastics that are contaminated with a range of […].

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The future of clinical trials: Are DCTs fast becoming the new norm?

BioPharma Reporter

As COVID-19 response initiatives and vaccine rollouts begin to bring the pandemic under control, we consider what changes to clinical trials will be made permanent.

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Flies grow bigger up north: Insect size a promising new proxy for palaeoclimate

Scienmag

Credit: Viktor Baranov MUNICH — Scientists use many proxies to reconstruct Earth’s ancient climates. Pollen, diatoms, geochemical isotopes, and fossils, for example, all contribute to piecing together past-climate puzzles. The ubiquity and wide geographic range of insects–like the nonbiting midge (Order Diptera, Family Chironomidae), a type of fly–have made them a useful tool to reconstruct […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Oxford Immunotec’s COVID-19 test to be used in ‘mix and match’ UK vaccine trial

Pharma Times

Test will be used for T cell testing in study, which is evaluating different combinations of COVID-19 vaccines

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Touched by light: Photoexcited stannyl anions are great for producing organotin compounds

Scienmag

Credit: Yuki Nagashima Scientists at Tokyo Institute of Technology developed a new strategy for producing a wide range of organotin compounds, which are the building blocks of many organic synthesis methods. Their approach is based on the photoexcitation of stannyl anions, which alters their electronic state and increases their selectivity and reactivity to form useful […].

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RPS makes new recommendations for pharmacist independent prescribers

Pharma Times

RPS wants to see increased use of pharmacist independent prescribers in the UK

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New algorithm makes it easier for computers to solve decision making problems

Scienmag

New approach to solving multiagent decision making problems with an agent-by-agent optimization leads to reduced computational complexity Credit: IEEE/CAA Journal of Automatica Sinica Computer scientists often encounter problems relevant to real-life scenarios. For instance, “multiagent problems,” a category characterized by multi-stage decision-making by multiple decision makers or “agents,” has relevant applications in search-and-rescue missions, firefighting, […]

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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COVID-19 Brief: Atea Initiates Phase III for Investigational Antiviral, BioNTech Tests Vaccine in.

BioSpace

The battle against COVID-19 rages on, and other therapeutics are making their way through the clinic, including monoclonal antibody treatments and antivirals. BioSpace takes a look at some of the ongoing efforts to stem the rate of infection from the virus.

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KICT’s solution for monitoring massive infrastructures

Scienmag

A trailblazer for developing a new paradigm for structural monitoring Credit: Korea Institute of Civil Engineering and Building Technology (KICT) The Korea Institute of Civil Engineering and Building Technology (KICT) has announced the development of an effective structural monitoring technique to monitor massive infrastructures, such as long-span bridge.

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Health Care in the U.S., as Seen From Abroad

NY Times

We asked eight people around the world what they thought. It didn’t go well.

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Study finds green spaces linked to lower racial disparity in COVID infection rates

Scienmag

A new study is the first to examine the relationship between the supply of green spaces and reduced disparity in infectious disease rates. Credit: Photos courtesy Bin Jiang, Yi Lu and William Sullivan CHAMPAIGN, Ill. — A higher ratio of green spaces at the county level is associated with a lower racial disparity in coronavirus […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.