Tue.Jun 29, 2021

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Pfizer's neuroscience spinout scores in schizophrenia

Bio Pharma Dive

Cerevel Therapeutics on Tuesday revealed positive results from an early-stage study of one of its drugs, doubling the price of the company's stock.

Drugs 294
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Innate Pharma’s ANKET NK Engager Platform Eradicates Tumors Safely and Efficiently

BioSpace

Innate Pharma has an alternative to T cell-based immunotherapy that has the potential to quickly and safely eradicate solid and metastatic tumors in the body.

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Sanofi dives deeper into mRNA in search for next-generation vaccines

Bio Pharma Dive

The French pharma plans to invest nearly $500 million annually on a new "center of excellence" meant to speed the development of mRNA vaccines, which have come of age during the pandemic.

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BioMarin resubmits haemophilia A gene therapy to the EMA

Pharma Times

Company initially withdrew a marketing authorisation application for the gene therapy last year

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Gilead, Foresite back biotech developer of COVID-19 pill in latest SPAC deal

Bio Pharma Dive

A merger with Foresite Capital's blank-check company makes Pardes Biosciences the latest well-funded drugmaker pursuing development of an oral coronavirus antiviral.

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‘Mix and match’ COVID-19 vaccine study yields promising results

Pharma Times

Mixing different vaccines produces a strong immune response against virus, according to researchers

More Trending

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Sanofi plans €400m investment in mRNA vaccines ‘centre of excellence’

Pharma Times

Sanofi is currently collaborating with Translate Bio on a mRNA-based COVID-19 vaccine candidate

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Pumped to assist the heart with an artificial aorta

Scienmag

Credit: © 2021 EPFL / Yoan Civet. In January of this year, EPFL engineers announced in Advanced Science their concept of a novel cardiac assist device that is devoid of rigid metallic components. It consists of a soft, artificial muscle wrapped around the aorta that can constrict and dilate the vessel, ultimately enhancing the aorta’s […].

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Triscuit Allows Consumers to Track their Crackers from Farms to Their Kitchens

XTalks

Mondel?z International has announced a food transparency program that allows consumers to follow the journey of their Triscuit crackers from start to finish using their mobile phones. Consumers can follow their product’s journey from a coop of farmers’ fields to the factory where the crackers are made. This is the first consumer-centric supply chain transparency pilot project that the North American branch of the company is introducing to reinforce its commitments to the environment,

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Financial barriers to cervical cancer screening

Scienmag

Credit: Mary Ann Liebert, Inc., publishers Among low-income, uninsured, or publicly insured women ages 25-64 years who were not up to date on cervical cancer screening, 72% perceived financial barriers to screening. The most commonly reported barriers were screening appointment costs (71%) and follow-up/future treatment costs (44%), according to a study published in the peer-reviewed […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Signify Health partners on decentralized trials for children’s cancer

Outsourcing Pharma

The trial solutions firm is working with Childrenâs Oncology Group to expand in-home research and care options for investigational immune-oncology therapy.

Trials 98
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Securing decent living standards for all while reducing global energy use

Scienmag

Credit: Vogel et al. (2021), the International Energy Agency (2018), Grubler et al. (2018), IPCC (2018) Securing decent living standards for all while reducing global energy use. Fundamental changes in our economies are required to secure decent living standards for all in the struggle against climate breakdown, according to new research. Governments need to dramatically […].

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NIH starts trial of Pear, Chess apps for opioid use disorder

pharmaphorum

Patient recruitment has begun in a National Institutes of Health (NIH) trial of two digital therapeutics (DTx) for people with opioid use disorder (OUD), developed by Pear Therapeutics and Chess Health. . The CTN-0100 study is test strategies to help keep people with OUD on drug treatment, improve the chances that those stabilised with drug treatments for OUD can come off medication without relapsing, as well as to find ways to predict the risk of relapse based on patient characteristics.

Trials 84
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Air pollution from wildfires impacts ability to observe birds

Scienmag

Credit: Kari Greer/U.S. Forest Service As smoky air becomes more common during Washington’s wildfire season, many wildlife enthusiasts wonder: What happens to the birds? Few studies have looked at wildfire smoke impacts on animals, let alone birds. And as Washington and the larger West Coast continue to experience more massive wildfires and smoke-filled air, understanding […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Akili Launches Digital Ad Campaign for First FDA-Approved ADHD Video Game

XTalks

Prescription digital medicine company Akili Interactive is set to launch a digital campaign for its FDA-approved video game for the treatment of attention deficit hyperactivity disorder (ADHD). The video game is called EndeavorRx and is the first and only FDA-backed therapy delivered through a video game experience. As a digital device, Akili is also going digital with its consumer marketing campaign, which is focused on key social media while its distribution also follows a digital-first model.

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Oncotarget: mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC

Scienmag

All these preclinical data strongly suggest that the inhibition of mTORC1 and PLK1 proteins may be a promising therapeutic approach for NSCLC patients Credit: Correspondence to – Didier Decaudin – Didier.decaudin@curie.fr Oncotarget published “High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC” which reported that the aim of […].

In-Vivo 96
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How the U.S. Military Primed Windtree CEO Craig Fraser for C-Suite Success

BioSpace

Craig Fraser, CEO of Windtree Therapeutics, became a U.S. Marine at age 17, learning to perform and lead under pressure in the field before eventually leading in the C-suite.

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‘There may not be a conflict after all’ in expanding universe debate

Scienmag

New analysis by UChicago astronomer finds agreement with standard model in ongoing ‘Hubble tension’ Credit: ESA/NASA Our universe is expanding, but our two main ways to measure how fast this expansion is happening have resulted in different answers. For the past decade, astrophysicists have been gradually dividing into two camps: one that believes that the […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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ViaCyte reports positive cell replacement result for diabetes

BioPharma Reporter

The company publishes results showing positive preliminary data for its islet cell replacement therapy for type 1 diabetes.

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Blood-based biomarkers may predict HIV remission after stopping antiretroviral therapy

Scienmag

The newly identified sugar and metabolic signatures may help predict duration and probability of HIV remission after antiretroviral therapy interruption during cure-directed clinical trials Credit: The Wistar Institute PHILADELPHIA — (June 29, 2021) — New biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are critical for the development of new therapeutic strategies that […].

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ABPI launches updated Code of Practice

Pharma Times

The new Code has been updated to reflect changes in the pharma environment

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Study shows effectiveness of suppressing female fruit flies

Scienmag

Credit: Photos by Akihiko Yamamoto and Amarish Yadav, NC State University. Populations of Drosophila suzukii fruit flies – so-called “spotted-wing Drosophila” that devastate soft-skinned fruit in North America, Europe and parts of South America – could be greatly suppressed with the introduction of genetically modified D. suzukii flies that produce only males after mating, according […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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ICYMI: Promising Study Results, Funding and More

BioSpace

Life sciences news sometimes flies under the radar. So here’s a look at a few stories you may have missed.

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Microstructure found in beetle’s exoskeleton contributes to color and damage resistance

Scienmag

Credit: Virginia Tech Beetles are creatures with built-in body armor. They are tiny tanks covered with hard shells, also known as exoskeletons, protecting their soft, skeleton-less bodies inside. In addition to providing armored protection, the beetle’s exoskeleton offers functions like sensory feedback and hydration control. Notably, the exoskeletons of many beetles are also brilliantly colored […].

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Poor Results Force Biotech Firm To Halt Trials for Intranasal COVID-19 Vaccine

BioSpace

The company said it would halt activities and focus its resources and time on liver and obesity research following "disappointing" results of its intranasal COVID-19 vaccine.

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The final dance of mixed neutron star-black hole pairs

Scienmag

Credit: © Carl Knox, OzGrav – Swinburne University Gravitational wave detectors have observed a new type of cataclysmic event in the cosmos: the merger of a neutron star with a black hole. The phenomenon was detected twice in January 2020. Several hypotheses could explain the existence of such mixed pairs. Further observations will be needed […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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California Biotech Aditum Bio Launches New Spinout Company for Treatment-Resistant Depression

BioSpace

The new portfolio firm, Ancora Bio, is focused on developing a new drug to address treatment-resistant depression.

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Scientists intensify electrolysis, utilize carbon dioxide more efficiently with magnets

Scienmag

Credit: University of Illinois/Claire Benjamin For decades, researchers have been working toward mitigating excess atmospheric carbon dioxide (CO2) emissions. One promising approach captures atmospheric CO2 and then, through CO2 electrolysis, converts it into value-added chemicals and intermediates–like ethanol, ethylene, and other useful chemicals.

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EMA approves additional J&J vaccine manufacturing site

BioPharma Reporter

The agency allows fill-finish activities for Janssenâs COVID-19 vaccine to take place at Catalentâs Italian site.

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Worse outcomes observed after heart attacks during pandemic compared to previous year

Scienmag

Sophia Antipolis – 29 June 2021: Heart attacks during the COVID-19 pandemic were more likely to result in heart failure compared with heart attacks one year earlier, according to research presented today at Heart Failure 2021, an online scientific congress of the European Society of Cardiology (ESC).1 “Heart attack patients waited an average of 14 […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.