Mon.Dec 07, 2020

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Bayer strikes a deal with Atara, wading deeper into cell therapy

Bio Pharma Dive

A pact for two Atara programs continues the German pharma's efforts to use dealmaking to build a gene and cell therapy division.

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A new normal for digital health?

World of DTC Marketing

SUMMARY : According to Harvard Business Review, “digital health solutions and technology will play a crucial role in the difficult work of optimizing processes and systems for greater efficiency, financial viability, and enhanced outcomes. While this is true digital health won’t go anywhere unless there is a renewed effort on the user experience.

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Lilly to pit Loxo cancer drug against top-selling rival after strong study results

Bio Pharma Dive

Following positive data at ASH, Lilly will test a drug it acquired in last year's buyout of Loxo Oncology against Imbruvica, one of the world's best-selling cancer treatments.

Drugs 252
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Study shows why some people may become seriously ill from meningococcal bacteria

Scienmag

Credit: Francesco Righetti Researchers at Karolinska Institutet in Sweden have come one step closer toward understanding why some people become seriously ill or die from a common bacterium that leaves most people unharmed. In a study published in The Lancet Microbe, the researchers linked RNA mutations within the bacterium Neisseria meningitidis to invasive meningococcal disease, […].

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Solving supply chain volatility

Bio Pharma Dive

Supply chain management technologies help monitor shifting demand patterns and ensure life-saving medications reach people quickly and at manageable costs.

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Newly discovered fossils prove ‘Shangri-La’-like ecosystem in central Tibet

Scienmag

Credit: SU Tao Despite decades of investigation, Tibet’s ancient topography and its role in climatic and biotic evolution remain speculative due to a paucity of quantitative surface height measurements through time and space, and sparse fossil records. During the Second Tibetan Plateau Scientific Expedition in Tibet, an international research team from the Xishuangbanna Tropical Botanical […].

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FDA Likely to Report Pfizer-BioNTech COVID-19 Vaccine is Safe and Effective, Push to EUA

BioSpace

The document prepared and released by FDA staff indicates scientists from the agency plan to tell the advisory committee on Thursday that the available clinical trial data are adequate to support its safe and effective use in public immunization programs.

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Altasciences' comprehensive, integrated solution for clinical supply manufacture

Bio Pharma Dive

Integrated CRO/CDMO solutions for accelerated and more efficient early drug development programs.

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This flexible and rechargeable battery is 10 times more powerful than state of the art

Scienmag

Credit: University of California San Diego A team of researchers has developed a flexible, rechargeable silver oxide-zinc battery with a five to 10 times greater areal energy density than state of the art. The battery also is easier to manufacture; while most flexible batteries need to be manufactured in sterile conditions, under vacuum, this one […].

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Seven Ways to Innovate: Designing the R&D Center of Tomorrow

XTalks

Every space in your innovation center is important, whether it is a highly functional lab space or a welcoming and engaging lobby. The significance of laboratory space to research & development (R&D) efforts is undisputable; yet in many ways the spaces in between the principle work areas — like coffee stations, huddle spaces and elevator lobbies — can actually matter more when it comes to innovation.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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What are schools doing to feed students during COVID-19-related closures?

Scienmag

A nationwide assessment of child nutrition administrative agencies’ initial responses to meal service provision during COVID-19 pandemic-related school closures, published in the Journal of Nutrition Education and Behavior Credit: Journal of Nutrition Education and Behavior Philadelphia, December 8, 2020 – As schools across the United States are grappling with remote and hybrid learning due to […].

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Scandal Dogs China’s ‘King of Vaccines,’ Partner to AstraZeneca

NY Times

The British-Swedish drugmaker has joined with a huge Asian company to produce a Covid-19 vaccine in China, where shady reputations are common in the pharmaceutical industry.

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Wind tunnel tests will help design future Army tiltrotor aircraft

Scienmag

Army researchers will study whirl flutter behavior to determine the viability of new tiltrotor analysis tool Credit: Harlen Capen, NASA NORFOLK, Va. — After more than three years in development, a team of U.S. Army researchers and industry partners completed the construction of a testbed that will help to inform the design of future Army […].

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Calquence shows long-term efficacy and tolerability in MCL

Pharma Times

Patients with relapsed or refractory mantle cell lymphoma (MCL) treated with AstraZeneca's Calquence remained progression free for a median of 22 months

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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UK faces “V-Day” and largest ever vaccination programme

pharmaphorum

Tuesday has been dubbed “V-day” in the UK, when the first doses of Pfizer/BioNTech’s coronavirus vaccine will be distributed to the public outside of a clinical trial. Health secretary Matt Hancock reportedly came up with the wartime analogy to describe what will be the largest scale vaccination programme in the country’s history. The UK last week became the first country in the world to officially authorise the vaccine, which has so far shown an effectiveness of around 95% and minimal side effe

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UK launch for Vagirux

Pharma Times

The drug is administered intravaginally as a local oestrogen therapy for treatment of vaginal atrophy due to oestrogen deficiency.

Drugs 112
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Biotechs Developing Innovative Ways to Activate the Immune System Against COVID-19

BioSpace

BioSpace spoke with a few companies that have some ingenious ideas at different stages of preclinical and clinical development.

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Research highlights benefit of telemedicine for stroke treatment

Pharma Times

Around one in five stroke patients could go undiagnosed with the tests currently used by paramedics

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Forbion Builds On Previous Success with 5th Life Sciences Fund Worth $545 Million

BioSpace

Investors in the fund include a variety of existing and new limited partners, both groups made up of specialized institutional and corporate investors.

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Wastewater testing for COVID-19

Scienmag

Stanford engineers co-lead research designing more responsive COVID-19 wastewater testing Credit: Image credit: City of San José Environmental Services Department Accurately identifying changes in community COVID-19 infections through wastewater surveillance is moving closer to reality. A new study, published in Environmental Science & Technology, identifies a method that not only detects the virus in wastewater […].

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Want Vaccines Fast? Suspend Intellectual Property Rights

NY Times

Otherwise, there won’t be enough shots to go around, even in rich countries.

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Natural reward theory could provide new foundation for biology

Scienmag

Credit: LE Gilbert A link between evolution over short time frames (microevolution) and long time frames (macroevolution) that could open new approaches to understanding some of biology’s deepest questions is proposed by Dr Owen Gilbert of the Department of Integrative Biology at the University of Texas at Austin (USA) in a new paper, published in […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Putting a New Spin on RNA, Remix Launches with $81 Million

BioSpace

The funds will be used to support the development of the company’s REMaster technology platform. In addition, Remix will now be able to advance its pipeline of RNA processing targeted therapeutics as well.

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The world’s first DNA ‘tricorder’ in your pocket

Scienmag

Credit: CSHL Cold Spring Harbor Laboratory (CSHL) scientists developed the world’s first mobile genome sequence analyzer, a new iPhone app called iGenomics. By pairing an iPhone with a handheld DNA sequencer, users can create a mobile genetics laboratory, reminiscent of the “tricorder” featured in Star Trek. The iGenomics app runs entirely on the iOS device, […].

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How has COVID-19 impacted clinical trial data collection?

Outsourcing Pharma

A leader from data-centric CRO Quanticate shares perspective on how the pandemic has disrupted trials, and what tools and technologies can keep work going.

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Beavers may help amphibians threatened by climate change

Scienmag

VANCOUVER, Wash. – The recovery of beavers may have beneficial consequences for amphibians because beaver dams can create the unique habitats that amphibians need. That finding was reported by four WSU Vancouver scientists in a paper published in the journal Freshwater Biology. The research took place in the Gifford Pinchot National Forest of the Cascade […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.

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Year-End Deadline Has Celgene CVR Investors Holding Their Breath for FDA Approval

BioSpace

Is there still hope for Celgene shareholders who hold the $9 per share Contingent Value Rights tickets despite the cold water that seemed to dash the chances of required goals necessary for those payoffs?

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Large US study confirms COVID-19 complications: lung, kidney and cardiovascular issues

Scienmag

A large study of patients in the United States who contracted coronavirus disease 2019 (COVID-19) confirms many complications of the disease, according to new research in CMAJ (Canadian Medical Association Journal). “Understanding the full range of associated conditions can aid in prognosis, guide treatment decisions and better inform patients as to their actual risks for […].

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What Matters Most: The Trends That Will Shape Pharma Marketing in 2021

Intouch Solutions

Download the PDF If 2020 has done anything ( … and it’s done rather a lot), it’s shown us all what we’ve always known, but never wanted to look at too closely: We live with fragility every day. This year, we’ve been through a lot. We’ve all had to let go of some of. The post What Matters Most: The Trends That Will Shape Pharma Marketing in 2021 appeared first on Intouch Solutions.

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Novel form of Alzheimer’s protein found in spinal fluid indicates stage of the disease

Scienmag

Discovery could lead to better diagnostics, speed efforts to find treatment Credit: Tammie Benzinger/Knight ADRC A novel form of an Alzheimer’s protein found in the fluid that surrounds the brain and spinal cord indicates what stage of the disease a person is in, and tracks with tangles of tau protein in the brain, according to […].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.