In this Friday’s PCT Grand Rounds, Dr. Areef Ishani of the University of Minnesota will present “The Diuretic Comparison Project: A Large Pragmatic Clinical Trial.” The Grand Rounds session will be held on Friday, August 26, 2022, at 1:00 pm eastern.
The Diuretic Comparison Project is a large, national “point-of-care clinical trial” comparing the effects of 2 thiazide-type diuretics, hydrochlorothiazide and chlorthalidone, on cardiovascular outcomes in older veterans with hypertension. The study is funded by the US Department of Veterans Affairs Cooperative Studies Program.
A point-of-care trial is an operational approach to the conduct of clinical trials—whether explanatory or pragmatic—that “centers on enhancing key clinical trial operations (including patient screening, consent, randomization, and data collection) and incorporating clinical trial processes into routine care to make clinical trials more accessible to broader and more diverse populations” (Propes et al 2022).
Dr. Ishani is the director of the Minneapolis Primary Care and Specialty Care Integrated Care Community at the Minneapolis VA, director of the VA Midwest Health Care Network, and a professor of medicine at the University of Minnesota.