Sat.Oct 30, 2021 - Fri.Nov 05, 2021

A three-decade monopoly: How Amgen built a patent thicket around its top-selling drug

Bio Pharma Dive

Through high-stakes litigation, aggressive patenting practices and a bit of luck, Amgen will likely stretch Enbrel's monopoly until 2029, more than 30 years after it was approved

Drugs 277

“Game-changing” obesity drug over-promising?

World of DTC Marketing

SUMMARY: Wegovy is selling so well that it’s hard to get at pharmacies. It’s being positioned as an anti-obesity drug, but one study by Novo Nordisk has shown that people who stop taking Wegovy after a few months tend to regain much of their lost weight within a year.

Drugs 221
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Incidence of Cerebral Venous Sinus Thrombosis After Ad26.COV2.S Vaccination

JAMA Internal Medicine

This cohort study compares the sex- and age-adjusted incidence of cerebral venous sinus thrombosis before the COVID-19 pandemic with that during the first 92 days after Ad26.COV2.S vaccination

Pangolin trafficking: iceberg tip of Nigeria’s illegal trade revealed

Scienmag

Since the first reported pangolin seizure in Nigeria in 2010, the country has seen an explosion in the black market for the world’s most trafficked mammal – becoming Africa’s hub for the criminal export of pangolin products to East Asia.

An Innovative & Creative Problem Solver Approach to Selling in the Medical Device Space

Speaker: Steve Goldstein, Sales Leader

Currently in sales or involved in a business that depends on strong sales results? Join Steve Goldstein, Sales Success Coach, Motivational Speaker and Medical Device Sales Leader from Gold Selling LLC. You will absorb critical strategies to become a trusted partner in greater sales success.

Pfizer pill for COVID-19 shows dramatic benefit in major study finding

Bio Pharma Dive

The drugmaker, which last week won FDA clearance of its vaccine in younger children, plans to quickly ask the agency for emergency authorization of the drug in high-risk patients

Pharma dodges a bullet, for now

World of DTC Marketing

SUMMARY: Pharma managed to dodge a bullet by buying politicians but changes are coming. Medicare’s innovation center may be the best avenue for lowering drug costs if provisions empowering government price negotiation don’t’ make it into a sweeping domestic spending package.

More Trending

Advanced breast cancer patients denied opportunities to join clinical trials

Scienmag

Clinicians and the wider research community involved in treating advanced breast cancer (ABC) need to do more to help and encourage patients to join clinical trials, according to a patient advocate who is leading a study that shows only 14% of ABC patients in the UK have been recruited to a trial.

Moderna faces delay in plans to bring coronavirus vaccine to US teenagers, young kids

Bio Pharma Dive

The FDA wants to better understand the risk of vaccine-associated myocarditis in 12- to 17-year-olds based on real-world use overseas, which will set back Moderna’s authorization plans in the U.S.

DTC forecasts are not really that reliable

World of DTC Marketing

SUMMARY: According to eMarketer, “in 2020, spending on digital advertising in the healthcare and pharma industry will grow by 14.2% to reach $9.53 billion, making it the fastest-growing sector after computing products and consumer electronics (which will grow 18.0% this year).

How to Reduce Your Chance of Medication Errors

Triage Cancer

Medication errors, which occur in hospitals, care facilities, and at home, can lead to serious health consequences, including death. Therefore, it’s critical that you learn how to reduce your chance of medication errors. Medication issues in hospitals and healthcare facilities.

Mandatory COVID Vaccination Policy Template

The federal government is developing a rule requiring employers with more than 100 employees ensure their workers are vaccinated or produce a negative COVID test weekly before entering the workplace. So, what can your organization do to prepare? Get Paycor’s COVID Vaccination Policy Template to help communicate important details to your employees.

Drinking alcohol to stay healthy? That might not work, says new study

Scienmag

Increased mortality risk among current alcohol abstainers might largely be explained by other factors, including previous alcohol or drug problems, daily smoking, and overall poor health, according to a new study publishing November 2nd in PLOS Medicine by Ulrich John of University Medicine Greifswald, Germany, and colleagues.

Drugs 97

Democrats' drug pricing plan, while scaled back, could still squeeze pharma top-sellers

Bio Pharma Dive

Legislation backed by President Joe Biden and top Democratic lawmakers would allow for price negotiation on up to 20 older drugs, potentially impacting blockbusters from Pfizer, Bristol Myers Squibb and others

Drugs 243

New legislation is a great first step to lower drug prices

World of DTC Marketing

SUMMARY: The new, proposed, drug legislation is a first step rather than a sweeping change. It’s a collection of measures meant to bring down prices slowly and on targeted drugs, and pharma is already complaining.

Augmented Reality Test Diagnoses and Tracks Alzheimer’s for Early Intervention

BioSpace

This novel diagnostic technology uses augmented reality and a smartphone or tablet to administer cognitive and functional tests

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Giving AI penalties to get better diagnoses

Scienmag

Anyone waiting for the results of a medical test knows the anxious question:’Will my life change completely when I know?’ And the relief if you test negative. Credit: Graphic design by Therese van Wyk, University of Johannesburg. Based on Pixabay images.

Pfizer gene therapy research delayed by trial changes, safety questions

Bio Pharma Dive

Data readouts for Pfizer's hemophilia gene therapies are now expected later than previously forecast, while the company also works through modifying a trial of its Duchenne treatment

First launch for Daiichi Sankyo’s oncolytic virus Delytact in Japan

Pharma Phorum

Daiichi Sankyo has launched its oncolytic virus therapy Delytact in Japan – its first world market – as a treatment for malignant glioma, an aggressive form of brain cancer.

Pfizer to Seek EUA for COVID-19 Antiviral with 89% Efficacy

BioSpace

Pfizer plans to seek Emergency Use Authorization for an antiviral COVID-19 treatment following an interim analysis of Phase II/III data that show statistically and clinically meaningful results

97

Through the nuclear looking glass

Scienmag

About 20 years ago, Michigan State University’s B. Alex Brown had an idea to reveal insights about a fundamental but enigmatic force at work in some of the most extreme environments in the universe. Credit: Credit: Facility for Rare Isotope Beams About 20 years ago, Michigan State University’s B.

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Moderna, teaming with a startup, wades further into gene editing

Bio Pharma Dive

The biotech has identified gene editing as a natural fit for the technology it uses to deliver its vaccines and drugs. A deal with Metagenomi, a startup backed by Bayer, will further those ambitions

Pfizer’s pill cuts COVID deaths and hospitalisations by 90%

Pharma Phorum

An oral antiviral drug developed by Pfizer has been shown to dramatically cut the risk of hospitalisation or death from COVID-19 when given in the early stages of infection.

HR 94

Biotech Raises $140 Million to Advance iPSC-based Immunotherapies

BioSpace

Shoreline Biosciences secured $140 million in financing to accelerate the growth of its induced pluripotent stem cells (iPSC)-based immunotherapies and support the expansion of its manufacturing capabilities

Hunting for human obesity genes in fat fruit flies

Scienmag

Fruit flies provide an effective platform for screening new obesity genes, and fat flies implicate a neuronal signaling pathway in weight gain, according to a new study publishing November 4th in the open-access journal PLOS Biology by Sadaf Farooqi and Andrea Brand of the University of Cambridge, UK, and colleagues.

Gene 87

FDA extends review of J&J, Legend's cell therapy for multiple myeloma

Bio Pharma Dive

The three-month delay could give an advantage to Bristol Myers Squibb, which holds the first approval for a CAR-T therapy for the blood cancer

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Novartis’ ‘wild card’ drug Scemblix gets FDA nod for leukaemia

Pharma Phorum

Novartis has claimed FDA approval for one of its ‘wild card’ drugs – Scemblix – a first-in-class STAMP inhibitor for patients with previously-treated chronic myeloid leukaemia (CML).

Merck and Synthekine Strike $525 Million Cytokine Therapy Deal

BioSpace

?Under the agreement, Merck can use Synthekine's surrogate cytokine agonist platform to discover, develop, and sell new cytokine-based treatments for up to two cytokine targets

An artificial material that can sense, adapt to its environment

Scienmag

COLUMBIA, Mo. Move over, Hollywood — science fiction is getting ready to leap off the big screen and enter the real world. While recent science fiction movies have demonstrated the power of artificially intelligent computer programs, such as the fictional character J.A.R.V.I.S.

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Amylyx asks FDA to approve ALS drug, while also preparing late-stage study

Bio Pharma Dive

The biotech has officially filed for an accelerated review of its closely watched ALS drug, an outcome that seemed unlikely just a few months ago

Drugs 235

Novartis’ iptacopan hits the mark in rare kidney disease C3G

Pharma Phorum

Novartis has chalked up another successful trial for its targeted factor B inhibitor iptacopan, an orally-active drug trying to challenge antibody-based therapies for diseases associated with the complement pathway.

FDA Approval of AbbVie Eye Drop a New Moment in Presbyopia

BioSpace

The decision made VUITY the very first and only eye drop to be approved for the condition

A commonly found parasite could treat certain types of cancer, say scientists

Scienmag

Scientists have discovered that a deadly parasite, known to cause ill health in pregnant women and immunocompromised patients, could potentially be used to treat various types of tumours.

Pfizer sales of COVID-19 vaccine climb, with tens of billions more expected next year

Bio Pharma Dive

The drugmaker again increased its forecast for 2021 sales, this time to $36 billion, or about 80% of what the rest of Pfizer's business is expected to earn this year

Sales 218

Novartis finally sells Roche stake, for almost $21 billion

Pharma Phorum

After more than 20 years, Novartis has finally decided to sell its substantial share in fellow Swiss pharma group Roche for $20.7 billion, a decent return on its original $5 billion investment. The agreement will see Novartis lose its one-third voting share stake in Roche, after agreeing to sell 53.3

Merck’s Molnupiravir: When a Private-Public Partnership Bears Fruit

BioSpace

In November 2019, Emory realized this experimental drug could have significant potential in respiratory viruses such as COVID-19

Drugs 91

ACGT Scientific Advisory Council Chair Michael T. Lotze, MD, honored with Lifetime Achievement Award from Society for Immunotherapy of Cancer

Scienmag

Alliance for Cancer Gene Therapy (ACGT) Scientific Advisory Council Chair Michael T. Lotze, MD, of the University of Pittsburgh, will be honored with the 2021 Society for Immunotherapy of Cancer (SITC) Lifetime Achievement Award at the SITC 36th Annual Meeting, Nov. 10-14, in Washington D.C.