Scienmag

JULY 6, 2022

A University of Minnesota Twin Cities-led team has developed a new technique that allows scientists and engineers to, for the first time, visualize mRNA molecules in the brains of living mice.

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Scienmag

DECEMBER 10, 2020

Credit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. For this, they successfully generated reconstituted chromatin bearing histone modifications in vitro.

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Gene Expression In-Vitro Gene Scientist 52

BioTech 365

DECEMBER 4, 2020

New Research Reveals the Secret Behind a Key Cellular Process (scitechdaily.com) New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now — precisely how … Continue reading →

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BioTech 365

APRIL 12, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Understudied mutations have big impact on gene expression.An

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Scienmag

SEPTEMBER 29, 2020

By changing gene expression first, some immunotherapies may work better, models show Credit: (courtesy of Hackensack Meridian Health) September 29, 2020 – Nutley, NJ – A one-two punch of changing gene expression, then deploying immune checkpoint inhibitors, shows promise in battling one of the most treatment-resistant types of cancer in (..)

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Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. JMB: Rick Young’s publication shows that RNA binding TFs fine-tunes gene expression.

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Gene Expression Gene Genetic Disease RNA 59

Scienmag

JULY 1, 2022

In a new study, scientists use gene expression patterns, called transcriptomics, to […]. . — The fossil record tells us about ancient life through the preserved remains of body parts like bones, teeth and turtle shells.

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Gene Expression Gene Scientist 63

Scienmag

MARCH 19, 2021

Credit: Thomas Gorochowski In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.

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Scienmag

AUGUST 4, 2020

Credit: Henry Ford Health System Findings from a research study, led by scientists at Henry Ford, published in the latest issue of Nature Communications suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.

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Gene Expression Gene Scientist Research 82

The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. Notably, these mechanisms include those driven by EZH2, a chromatin-modulatory enzyme, and cMyc, a prominent cancer-causing factor.

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Scienmag

MARCH 17, 2021

An international team of scientists from the University of Turku, Finland and PennState University, USA have solved a long-standing mystery of how living organisms distinguish RNA and DNA building blocks during gene expression paving the way for the design of new antiviral drugs. All cellular […].

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Gene Expression RNA DNA Drugs 74

Drug Discovery World

MARCH 2, 2023

A new paper has solved the 20-year mystery of how epigenetic modifications act as traffic lights to control gene expression and could ultimately speed up the development of a new class of epigenetic cancer drugs. But, until now, scientists lacked an understanding of what the chemical tag does, despite many years of research.

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Gene Expression Gene DNA RNA 52

pharmaphorum

OCTOBER 12, 2021

The research by a team of National Institutes of Health (NIH) scientists found that people who took bumetanide, a generic drug usually used to treat heart failure and oedema, had a significantly lower prevalence of Alzheimer’s compared to those not taking the drug.

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Gene Expression Drugs FDA Approval Gene 111

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch.

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Scienmag

NOVEMBER 26, 2020

For the first time, researchers describe how Rho protein really stops gene expression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off.

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BioTech 365

AUGUST 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Enabling cells to talk to computers.Genetically encoded reporter proteins have been a mainstay of biotechnology research, allowing scientists to track gene expression, understand intracellular processes and debug … Continue (..)

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Gene Expression Protein Gene Scientist 40

Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

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Gene Gene Expression DNA Protein 42

pharmaphorum

NOVEMBER 12, 2021

The MOATAI-VIR algorithm, developed by scientists at Emory University and Georgia Tech, was put through its paces in a study that showed it was able to predict 24 out of 26 clinical manifestations of COVID-19, including acute respiratory distress, blood clotting issues, cytokine storms, brain fog, and loss of smell or taste. .

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Doctors Doctor Drugs Gene Expression 135

Drug Discovery World

OCTOBER 4, 2023

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. Parallel findings in humans underscored the involvement of interferon-related genes in major depressive disorder.

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Drug Discovery World

OCTOBER 6, 2023

Researchers uncover molecular pathways underlying depression Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets.

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Drug Discovery World

JULY 27, 2023

Scientists from Boston University have published evidence that the atypical antidepressant tianeptine potentially provides rapid and lasting neuropathic pain relief with a low risk of addiction.

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RNA Gene Expression Gene Medicine 52

Drug Discovery World

OCTOBER 10, 2023

Read more: First oral drug for postpartum depression approved in US The role of genetics In October, scientists discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets.

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Drugs Gene Expression Gene Immune Response 59

Drug Discovery World

JULY 10, 2023

If there’s one thing I would take from the Summer 2023 issue of Drug Discovery World , it would be that the application of technologies and processes throughout the pharmaceutical industry are changing how scientists pursue the development of therapies. There are myriad ways that this is being enabled.

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Gene Therapy Gene Scientist Gene Editing 52

pharmaphorum

OCTOBER 19, 2022

The challenge in unlocking their potential to inform drug discovery is to work out which variants regulate which genes in which cell types and whether they exert a positive or negative impact on gene expression, according to the biotech.

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Drug Discovery World

AUGUST 1, 2023

Towards the end of last year, Kite, a Gilead company, entered into an exclusive license agreement with synthetic biology company Refuge to access its gene expression platform to develop potential treatments for blood cancers. Scientists use human stem cells to create miniature 2D or 3D living systems of tissues and organs.

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Drugs Gene Expression Engineer Gene 52

The Pharma Data

SEPTEMBER 2, 2021

Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs. In fact, scientists were able to slow the metastatic growth of breast and lung tumors in this way.

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Gene Expression Scientist Antibody Research 52

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. The post bluebird seeks gene therapy trial restart after cancer scare appeared first on.

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The Pharma Data

JULY 11, 2021

Scientists at the Universities of Würzburg and Marburg have now succeeded for the first time in experimentally demonstrating that bacterial metabolites are able to increase the cytotoxic activity of certain immune cells and thus positively influence the efficiency of tumour therapies. The immune system is mentioned particularly frequently.

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Bacteria Genetics Regulation Scientist 52

The Pharma Data

FEBRUARY 22, 2021

Born in 1970, the British and American research scientist has been Director of the Department of Microbiome Research at the Max Planck Institute for Developmental Biology in Tübingen since 2016. We are very pleased to honor today a true pioneer and outstanding scientist in microbiome research.”.

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The Pharma Data

MARCH 7, 2022

Because these modifications occur not in, but on top of genes, they are called epigenetic, from the Greek epi “over” or “above” the genes. The chemical modifications that regulate gene activity are called epigenetic markers. Cas9 is the protein used in the gene editing process called CRISPR.

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Protein Gene Genome Genomics 52

Drug Discovery World

AUGUST 3, 2022

In a recent publication from scientists at the University of Bordeaux, a CPP-based nanoparticles approach was reportedly used to deliver siRNA into cancer cells of solid tumours. In a second publication by the scientists at Bordeaux, CPP-based nanoparticles were applied as a vector for an anti-miRNA (AMO). cells, such as diabetes.

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Bioavailability In-Vivo RNA In-Vitro 52

Drug Discovery World

DECEMBER 12, 2022

The study was led by scientists at the National Human Genome Research Institute (NHGRI), part of NIH, who successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). . “The

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Drugs Gene Editing Genome Genomics 52

Drug Discovery World

AUGUST 1, 2022

As a result, scientists have been unable to determine whether the cells possess distinctive attributes that HIV-cure-directed therapies may exploit. Using data produced by FIND-Seq, the scientists compared the gene expression patterns of HIV-infected memory CD4+ T cells to those of HIV-uninfected memory CD4+ T cells in the same individuals.

Gene Expression 52

Gene Expression Scientist Gene Allergies 52

Drug Discovery World

FEBRUARY 29, 2024

They are called: Sitting down with… PharmEnable , Is single-cell gene expression the next trend in next generation sequencing? and Preparing for new-era drug modalities with technology.

Gene Expression 52

Gene Expression DNA Genome Genomics 52

Drug Discovery World

FEBRUARY 29, 2024

They are called: Sitting down with… PharmEnable , Is single-cell gene expression the next trend in next generation sequencing? And Preparing for new-era drug modalities with technology.

Gene Expression 52

Gene Expression DNA Genome Genomics 52

pharmaphorum

JUNE 3, 2021

Further evidence of its potential efficacy as a drug candidate was also established based on diminished hypothalamic inflammatory gene expression. Marks is an established physician scientist with experience leading clinical research studies. About the author. Dr. Daniel L.

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Drug Discovery World

FEBRUARY 10, 2023

Magnus Persson is a physician and scientist with a background in both academia and industry, working for the likes of Sanofi on clinical trials activities and across venture capital firms in the US. He is now a founding partner of EIR Ventures, a venture capital firm investing in innovative companies across the Nordics.

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