pharmaphorum

OCTOBER 13, 2020

UK biotech e-therapeutics has a new CEO, with executive chairman and former Silence Therapeutics chief Ali Mortazavi chosen to spearhead the next stage in the company’s development into gene silencing and other areas. He said: “These big pharma companies have every type of technology available to them.

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pharmaphorum

JANUARY 6, 2021

A host of other pharma companies including Gilead, Novo Nordisk, Merck & Co are also developing potential NASH drugs. Only this morning, Novo Nordisk selected the first candidate from a project with Dicerna to find new gene-silencing drugs to treat liver-related diseases including NASH.

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Delveinsight

AUGUST 6, 2020

Gene-silencing Therapies. Silencing or modifying gene TTR aims to reduce the effect of both variant and wild-type TTR gene, thus reducing hepatic production by targeting its mRNA. The past years have witnessed a shift from off-label and symptomatic therapies to approved TTR stabilizers and gene-silencing therapies.

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pharmaphorum

DECEMBER 23, 2020

Pharma companies have also made headway in rare diseases as several pipeline projects came to fruition. In summer, Alnylam’s gene silencing drug Oxlumo, the first treatment for primary hyperoxaluria type 1 (PH1), an ultra-rare and life-threatening genetic disorder Oxlumo was approved in the European Union and the US.

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Marketing Gene Silencing Gene Drugs 81

Drug Discovery World

OCTOBER 4, 2022

This year has seen some major deals announced by big pharma companies. In May, Pfizer announced it would be acquiring the biopharmaceutical company Biohaven, which has a pipeline of therapies targeting migraines, for the sum of $11 billion. Knockout’ mice are bred in a laboratory with specific genes silenced or ‘knocked out’.

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