Study highlights role of disordered protein interactions in gene expression

Scienmag

A team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered a new piece of the puzzle of how gene expression is orchestrated. Published in the journal Science, the findings reveal a novel mechanism that coordinates the assembly of components inside cells that control gene expression. Latest News Disordered expression gene highlights interactions protein role study

Researchers speed identification of DNA regions that regulate gene expression

Scienmag

Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Biology Gene Therapy Genes Genetics Medicine/Health

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Early-life social connections influence gene expression, stress resilience

Scienmag

Strong social connections and greater maternal care early in life can influence molecular markers related to gene expression in DNA and future stress response, suggests a […]. Credit: Kay E.

Researchers identify key RNA “gatekeeper” in gene expression, pointing to possible new drug targets

Scienmag

BOSTON – An important player in the healthy development of female embryos turns out also to play a key role in regulating the behavior of chromosome loops and gene expression in both sexes, according to a new study by researchers at Massachusetts General Hospital (MGH). Latest News Drug expression gatekeeper gene identify key pointing researchers RNA targets

Researchers reveal 3D structure responsible for gene expression

Scienmag

Study marks the first time this complex has been visualized for human cells Credit: Northwestern University For the first time ever, a Northwestern University-led research team has peered inside a human cell to view a multi-subunit machine responsible for regulating gene expression.

Salt stress alters legume responses to symbiotic rhizobacteria by modulating gene expression

Scienmag

Social & Behavioral Science alters expression gene legume modulating responses rhizobacteria salt stress symbioticCrop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations.

Researchers identify RNA editing events that impact gene expression and phenotype

Scienmag

CHOP researchers find small changes in RNA due to RNA editing could have a large impact on gene expression and phenotype Philadelphia, March 9, 2021–Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, […]. Chemistry AND Physics Biochemistry Genes Genetics Medicine/Health Microbiology

The Equalizer: An engineered circuit for uniform gene expression

Scienmag

The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell. Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […]. Technology and Engineering Biology Biomedical/Environmental/Chemical Engineering Biotechnology Cell Biology Genetics

#news #biotech Researchers identify key RNA “gatekeeper” in gene expression, pointing to possible new drug targets

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Researchers identify key RNA “gatekeeper” in gene expression, pointing to possible new drug targets.An important player in the healthy development of female embryos turns out also to … Continue reading → #news

#news #biotech Algorithm maps gene expression in space

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Algorithm maps gene expression in space.As we accumulate more and more gene-sequencing information, cell-type databases are growing in both size and complexity. There is a need to … Continue reading → #news

Quantitative approach on understanding how epigenetic switches control gene expression

Scienmag

Biology GenesCredit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model.

#news #biotech Protein that manipulates gene expression inside the cell nucleus could inspire new RSV drugs, vaccines

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Protein that manipulates gene expression inside the cell nucleus could inspire new RSV drugs, vaccines.Protein that manipulates gene expression inside the cell nucleus could inspire new RSV … Continue reading → #news

New 3D maps reveal inner workings of immune cell gene expression

Scienmag

LJI scientists track down control elements that govern gene expression from a distance Credit: Alex Fung LA JOLLA–The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease.

BostonGene Announces Publication in Clinical Cancer Research Identifying the Cellular Features and Gene Expression Characteristics Underlying MRI Visibility in Prostate Cancer

BioTech 365

10x Genomics Puts Single Cell Analysis Within Reach of All With Low Throughput Gene Expression Kit

BioTech 365

10x Genomics Puts Single Cell Analysis Within Reach of All With Low Throughput Gene Expression Kit 10x Genomics Puts Single Cell Analysis Within Reach of All With Low Throughput Gene Expression Kit Along with recent release of CellPlex, product increases … Continue reading → GlobeNewswire

#news #biotech ADA: TB vaccine repurposed in Type 1 diabetes restores gene expression in key immune cells

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: ADA: TB vaccine repurposed in Type 1 diabetes restores gene expression in key immune cells.ADA: TB vaccine repurposed in Type 1 diabetes restores gene expression in key … Continue reading → #news

Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression

BioTech 365

Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression Company expands global footprint with opening … Continue reading → Business Wire

#news #biotech New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue reading → #news

#news #biotech Understudied mutations have big impact on gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Understudied mutations have big impact on gene expression.An international team of researchers led by computer scientists at the University of California San Diego have identified 163 variable … Continue reading → #news

Global Gene Expression Market Size, Share & Trends Analysis 2021-2028 by Product (DNA Chip/Microarray, Kits & Reagents), Technique (Promoter Analysis, RNA Exp.) – ResearchAndMarkets.com

BioTech 365

Global Gene Expression Market Size, Share & Trends Analysis 2021-2028 by Product (DNA Chip/Microarray, Kits & Reagents), Technique (Promoter Analysis, RNA Exp.) – ResearchAndMarkets.com Global Gene Expression Market Size, Share & Trends Analysis 2021-2028 by Product (DNA Chip/Microarray, Kits & … Continue reading → Business Wire

#news #biotech MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without changing DNA

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without changing DNA.MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without … Continue reading → #news

Study reports novel role of enzyme in plant immunity and defense gene expression

Scienmag

A recently published article in the Molecular Plant-Microbe Interactions journal provides new evidence that pathogens are hijacking the plant immune system to cause disease while providing insights into a newly discovered mechanism. A large variety of pathogens infect plants and cause different diseases, which can lead to reduced crop yields. During infection, pathogens secrete effector […].

#news #biotech Study highlights role of disordered protein interactions in gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study highlights role of disordered protein interactions in gene expression.A team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered … Continue reading → #news

#news #biotech How epigenetic switches control gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: How epigenetic switches control gene expression.Scientists at Tokyo Institute of Technology have deciphered how to quantitatively assess the effects of specific epigenetic changes on the rate of … Continue reading → #news

Key early steps in gene expression captured in real time by CSU researchers

Scienmag

Capturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function. Cellular proteins get their marching orders from genetic instructions encoded in DNA, whose sequences are first copied and made […]. Chemistry AND Physics Biochemistry Bioinformatics Biology Biomechanics/Biophysics Genetics

A startup emerges with $125M and plans to edit the epigenome

Bio Pharma Dive

Chroma Medicine's launch is the latest step in a decadeslong quest by drugmakers to capitalize on research into epigenetics, a way of controlling gene expression without altering DNA

Rocket Pharmaceuticals Announces Positive Gene Expression, Clinical Biomarker and Preliminary Functional Data from Phase 1 Trial of RP-A501 for the Treatment of Danon Disease

BioTech 365

Rocket Pharmaceuticals Announces Positive Gene Expression, Clinical Biomarker and Preliminary Functional Data from Phase 1 Trial of RP-A501 for the Treatment of Danon Disease Rocket Pharmaceuticals Announces Positive Gene Expression, Clinical Biomarker and Preliminary Functional Data from Phase 1 Trial … Continue reading → Business Wire

For the first time, researchers describe how Rho protein really stops gene expression

BioTech 365

Source : Biology Textbooks Wrong?

Gene Therapy and Pharmacokinetics

Camargo

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19.

#news #biotech The plant hormone auxin may promote disease by regulating virulence gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: The plant hormone auxin may promote disease by regulating virulence gene expression.Scientists have long known that the plant hormone auxin controls many aspects of plant growth, development, … Continue reading → #news

#news #biotech GTEx Consortium releases fresh insights into how DNA differences govern gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GTEx Consortium releases fresh insights into how DNA differences govern gene expression.Scientists from the Genotype-Tissue Expression (GTEx) project, a National Institutes of Health-funded consortium including researchers from … Continue reading → #news

Racial/ethnic variation found in nasal gene expression of key protein used by SARS-CoV-2

Scienmag

Findings suggest one factor that may contribute to disparities in COVID-19 infection New York – In a study published in JAMA today, Mount Sinai researchers report findings that shed some light on the disproportionate impact of COVID-19 on Blacks, who have experienced rates of infection and death that are much greater, in some areas twice […]. Medicine & Health Biology Genetics Medicine/Health

CARTANA launches expanded range of In Situ Sequencing kits for high throughput single cell gene expression mapping

Drug Discovery Today

Users will be able to analyse either fresh/fixed frozen or FFPE samples and rapidly create single cell gene expression maps of up to 600 genes Stockholm, May 1st, 2020 – Swedish biotechnology company CARTANA today announced the launch of a new range of In Situ Sequencing (ISS) reagent kits designed to increase the efficiency and enable ISS on virtually any tissue sample.

Combining the Powers of Single Cell Sequencing and AI in Understanding Disease Biology and Drug Development

XTalks

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. Visium Spatial Gene Expression Solution.

Epigenetic Therapeutic Targets Summit

Pharma Phorum

Join the Epigenetic Therapeutic Targets Summit – the only virtual summit dedicated to the clinical translation and optimization of therapeutic candidates targeting epigenetic mechanisms of gene expression.

Gene editing: beyond the hype

Pharma Phorum

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome.

Bioengineers learn the secrets to precisely turning on and off genes

Scienmag

Credit: Thomas Gorochowski In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.

Tune Therapeutics Debuts with $40 Million to Fine-Tune the Human Genome

BioSpace

Tune claims TEMPO can rapidly target and adjust the epigenomic machinery, controlling gene expression and dictating how the DNA will be molded

“Nuclear speckle” structures inside cells enhance gene activity, may help block cancers

Scienmag

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in partnership with a key […]. Cancer Biology cancer Cell Biology Genes Genetics

New insight into a placental gene pathway and its association with vitamin D

Scienmag

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina.

Microglial methylation “landscape” in human brain

Scienmag

Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states.

How alike are the cancer cells from a single patient?

Scienmag

To carry out these behaviors, each cancer cell uses its genes to make the needed molecules in a unique way known as its “gene expression signature.”

MicroRNAs: Biological indicators of the physiological status of animals

Scienmag

Known to be fine regulators of gene expression, microRNAs are small molecules that remain particularly stable in biofluids—blood, urine, etc.