Drug Discovery World

NOVEMBER 27, 2023

Predictable milestones and future perspectives Transposons (genetic elements) have been used to deliver a gene of interest into transcriptionally active sites of the cell line genome leading to rapid cell line development eventually resulting in high titers of the recombinant protein drug.

Production 59

Production Engineer Gene Editing Gene 59

Pharmaceutical Technology

MAY 8, 2023

Innovation S-curve for the pharmaceutical industry Zinc-finger nucleases is a key innovation area in pharmaceutical Zinc finger nucleases (ZFNs) are tools used in genetic engineering to cleave a chosen genomic sequence.

Genetics 130

Genetics DNA Genetic Engineering Antibody 130

Bioengineer

JULY 19, 2021

The researchers at the CNIO created two genetically engineered mouse models that lacked KRAS4B and expressed the KRAS4A variant only, both with and without the G12V mutation (KRAS4AG12V). Our results suggest that for therapies to be effective, the two KRAS isoforms should be targeted.” ” KRAS genes in embryonic development.

Research 52

Research Gene Genetic Engineering Genetics 52

XTalks

MARCH 28, 2024

Gene Editing and CAR T-Cell Therapy Genetic engineering technologies, such as CRISPR-Cas9, are providing newer potential avenues for cancer treatment. The integration of genomic profiling into clinical practice has allowed the possibility of more precise treatment selection.

Gene Editing 59

Gene Editing Life Science Clinical Trials Clinical Trials 59

The Pharma Data

SEPTEMBER 1, 2021

Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation. The engineered cells reduced inflammation and prevented a type of damage to bone, known as bone erosion, in a mouse model of rheumatoid arthritis. ” The new findings are published online Sept.

Drugs 52

Drugs Engineer Drug Delivery Gene 52

The Pharma Data

MARCH 29, 2022

In a preprint, the researchers at Cornell University led by Associate Professor Hector Aguilar-Carreno showed that genetically engineered mice infected with the virus causing COVID-19 and given a daily dose of the compound in a nasal spray for four days. Shapira, T., Monreal, I.A.,

Genetic Engineering 52

Genetic Engineering Research Genetics Drugs 52

Roots Analysis

FEBRUARY 15, 2022

Gene engineering based on recombination was pioneered in the mid-1990s; Currently, development of gene editing technologies has opened up the possibility of modifying genomic sequences in both eukaryotic and prokaryotic organisms. Genome Editing is a way of making changes in the DNA. Type of Genome Editing: Zinc-Finger Nuclease.

Genome 52

Genome Genomics Gene Editing DNA 52

Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry Gene splicing using nucleases is a key innovation area in the pharmaceutical industry Nucleases play a fundamental role in the field of recombinant DNA technology, or genetic engineering. Nucleases are enzymes that hydrolytically cleave the phosphodiester backbone of DNA.

Gene Splicing 130

Gene Splicing Gene Recombinant DNA Technology DNA 130

Pharmaceutical Technology

JUNE 4, 2023

AAV genomes are highly compact, with overlapping coding regions, alternate splicing schemes, and multiple transcription initiation codons. There are two main genes in the AAV genome, rep and cap, which encode nine different proteins.

Gene 262

Gene Gene Therapy Genetics DNA 262

pharmaphorum

SEPTEMBER 13, 2022

It wasn’t until 2002, when Memorial Sloane Kettering Cancer Center scientists Michel Sadelain, Renier Brentjens, and Isabelle Rivière opted to push the boundaries of research, by genetically engineering T-cells with a CAR, that the technique achieved successful results. 2012 – The 100,000 Genomics Project begins.

Genome Project 98

Genome Project Genome Genomics DNA 98

Roots Analysis

MARCH 16, 2023

The IVT mRNAs are structurally similar to natural mRNAs, these synthetic mRNAs can be used to express proteins through genetic engineering. In the last few years, researchers have become interested in using in vitro transcribed (IVT) mRNA as a drug delivery agent.

Vaccination 52

Vaccination Vaccine DNA Protein 52

pharmaphorum

SEPTEMBER 4, 2020

The treatments are developed using cutting- edge technologies such as genomic sequencing and genetic engineering, helping to account for the individual variability in both patient and disease characteristics. Tools for visualizing the service. Novel therapies require designers to be adaptive.

Medicine 59

Medicine Production Genetic Engineering Genetics 59

The Pharma Data

JANUARY 19, 2021

But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. At least five companies are using CRISPR-Cas9 systems to develop therapeutics: Caribou Biosciences, Intellia Therapeutics, CRISPR Therapeutics, ERS Genomics and Editas Medicine.

Bacteria 52

Bacteria Gene Editing Research RNA 52

Drug Discovery World

JANUARY 23, 2023

Increasing interest in CRISPR-Cas gene editing systems over recent years has delivered innovative developments in precision genome engineering technologies, holding enormous potential for applications across the healthcare sector. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.

Gene Editing 52

Gene Editing Gene Engineer DNA 52

Drug Discovery World

MARCH 13, 2023

ELISA, ELISpot), and cytotoxicity assays, single cell and whole genome sequencing, SNP analysis, and rapid sterility methods to characterise cell therapies. Genetic Engineering & Biotechnology News. Over the last two decades, developers have largely relied on analytical tools including flow cytometry, immunoassays (i.e.,

Gene Therapy 52

Gene Therapy Gene Manufacturing Development 52

Drug Discovery World

NOVEMBER 8, 2023

Bredl’s poster looks at genetically engineered macrophages to disrupt the cold tumour microenvironment, and Sobczak’s covers deciphering the structural details of the recognition mode of cancer-associated glycoproteins by siglec receptors implicated in immune suppression in cancer.

Antibody 64

Antibody Engineer Protein Scientist 64