Genetics and Genomics - Clinical Research Informer

Tome Biosciences debuts with $213M and a new way to edit the genome

Bio Pharma Dive

DECEMBER 12, 2023

Based on the work of MIT scientists, the well-funded startup is developing ways to insert large sizes of genetic material anywhere in the genome without damaging or breaking DNA.

Genome

Genome Genomics DNA Genetics

Scribe and Sanofi expand genetic therapy development deal

Pharmaceutical Technology

JULY 18, 2023

Scribe Therapeutics and Sanofi have expanded partnership to progress the development of in vivo genetic therapies to treat genomic diseases.

Genetics

Genetics In-Vivo Development Genome

Leveraging Genetic Testing for Enrolling Rare Disease Trials

Worldwide Clinical Trials

JANUARY 24, 2024

Written By: Derek Ansel, MS, CCRA, Executive Director, Therapeutic Strategy Lead, Rare Disease Given that 80% of rare diseases have a genetic etiology, genetic implications should be addressed at the onset of a clinical program to support trial enrollment. One diagnostic example that I discussed in my presentation is autism.

Genetics

Genetics Trials Clinical Trials Clinical Trials

UK agency pilots biobank to study links between genetics and drug side effects

Pharmaceutical Technology

MAY 25, 2023

The Medicines and Healthcare products Regulatory Agency (MHRA) aims to launch a pilot genetic biobank that will gather patient data to associate drug-related adverse events to their genetic makeup. The Yellow Card biobank will launch as a joint venture with the UK-government funded entity Genomics England on June 1.

Biobanking

Biobanking Genetics Genome Project Genome

Hopewell Therapeutics raises funds for genomic medicines development

Pharmaceutical Technology

JUNE 8, 2023

Biotechnology company Hopewell Therapeutics has raised $25m in seed financing to accelerate the development of next-generation lipid nanoparticles for targeted delivery of genomic medicines. Hopewell Therapeutics is engaged in discovering, synthesising and developing advanced ttLNPs to provide next-generation genomic medicines.

Genome

Genome Genomics Medicine Development

Elsevier partners with American College of Medical Genetics and Genomics to publish Genetics in Medicine

Scienmag

JULY 26, 2021

Collaboration signifies strong commitment by all stakeholders to maintain the journal’s high standards and expand its global prominence Credit: ACMG New York, July 26, 2021 – The American College of Medical Genetics and Genomics (ACMG), the only nationally recognized US medical professional organization solely dedicated to improving health (..)

Genetics

Genetics Genome Genomics Medicine

Genome Edited Foods: Understanding the New FDA Guidance

XTalks

MARCH 1, 2024

In a pivotal move for the food industry, the US Food and Drug Administration (FDA) has unveiled industry guidance for genome edited foods derived from plants. This landmark guidance aims to demystify the FDA’s risk-based approach towards both genome edited foods and all new plant varieties. What is Genome Editing?

Genome

Genome Genomics Production Marketing

New approach successfully traces genomic variants back to genetic disorders

Medical Xpress

JANUARY 5, 2023

A genotype-first approach to patient care involves selecting patients with specific genomic variants and then studying their traits and symptoms; this finding uncovered new relationships between genes and clinical conditions, broadened the traits and symptoms associated with known disorders, and offered insights into newly described disorders.

Genome

Genome Genomics Genetics Genotype

A new dawn of the genomic age: five areas set to be transformed in 2023

pharmaphorum

JANUARY 26, 2023

2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.

Genome

Genome Genomics Genome Project Genetics

$8 million awarded to landmark genetic research project

Drug Discovery World

MARCH 18, 2024

Landmark genetic research could allow doctors to accurately predict whether a patient is at risk of developing common diseases, decades before any symptoms would become evident. He’s going to accelerate personalised medicine based on an individual’s genome.

Genetics

Genetics Research Genome Genomics

Fulgent Genetics acquires therapeutics development company Fulgent Pharma

Pharmaceutical Technology

NOVEMBER 8, 2022

Fulgent Genetics has acquired clinical-stage therapeutics development firm Fulgent Pharma for a total deal price of nearly $100m. According to the deal, the purchase price, contingent on adjustments, has to be paid by Fulgent Genetics as a combination of cash on hand and its shares of common stock.

Genetics

Genetics Development Genome Genomics

SOPHiA GENETICS and AstraZeneca partner for oncology drugs development

Pharmaceutical Technology

FEBRUARY 13, 2023

SOPHiA GENETICS is expanding its collaboration with AstraZeneca to include multimodal approaches for developing cancer drugs. This collaboration aims to use the global SOPHiA DDM platform, a cloud-native platform of SOPHiA GENETICS, and multimodal algorithmic capabilities for AstraZeneca’s oncology portfolio.

Genetics

Genetics Development Drugs Genome

Kansas children’s hospital first to use world’s most advanced genomic sequencing

BioPharma Reporter

OCTOBER 10, 2023

Childrenâs Mercy Kansas City, an independent pediatric health organization, has become the first health care system to replace old genetic tests, such as rapid exome and chromosomal microarray analysis, with the worldâs most-advanced genomic sequencing technology from PacBio.

Genome

Genome Genomics Genetics Development

rAAV Genome sequencing uncovers transgene integrity and packaging impurities

Drug Discovery World

APRIL 16, 2024

The post rAAV Genome sequencing uncovers transgene integrity and packaging impurities appeared first on Drug Discovery World (DDW). A live Q&A session follows the webinar presentation.

Packaging

Packaging Packaging Genome Genomics

Why genomic healthcare data matters in the development of new therapies

Drug Discovery World

NOVEMBER 7, 2022

Genomic healthcare data is critical to identify disease risk, ancestry, traits and response to medicines and aids in the development of new targeted therapies – precision medicines. In April 2003, after its launch in October 1990, the project was completed, generating the first sequence of the human genome. The origins .

Genome

Genome Genomics Development Genetics

BU researchers find “genetic baggage” accumulates in the genomes of aging mutant animals

Scienmag

MARCH 3, 2022

EMBARGOED by PLOS GENETICS until March 3, 2022, 2 pm, ET Contact: Gina DiGravio, 617-358-7838, ginad@bu.edu (Boston)—You are probably familiar with the term that some people carry “a lot of extra baggage.”

Genome

Genome Genomics Genetics Research

Genetic diagnosis helps guide care of childhood hearing loss

Medical Xpress

JANUARY 19, 2023

Advances in understanding the many different genetic causes of childhood-onset hearing loss indicate that genomic testing could assist in treatment planning, including optimal timing of treatment.

Genetics

Genetics Genome Genomics

Researchers identify large genetic changes that contribute to dementia risk

Medical Xpress

MAY 8, 2023

Scientists at the National Institutes of Health have identified new genetic risk factors for two types of non-Alzheimer's dementia. These findings were published in Cell Genomics and detail how researchers identified large-scale DNA changes, known as structural variants, by analyzing thousands of DNA samples.

Genetics

Genetics DNA Research Genome

UK announces mass genome sequencing programme for newborns

Medical Xpress

DECEMBER 13, 2022

UK health authorities on Tuesday announced a pioneering research programme using the genomes of 100,000 new-born babies, to detect rare genetic illnesses and speed up treatment.

Genome

Genome Genomics Genetics Research

Leading innovators in genetically modified animal models for the pharmaceutical industry

Pharmaceutical Technology

FEBRUARY 15, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Genetically modified animal models. Regeneron Pharmaceuticals is one of the leading patent filers in the generation of genetically modified animal models.

Genetics

Genetics DNA Antibody Genome

Emmes and MedGenome Launch Genomics Strategic Partnership Focused on Advancing Rare Disease Research

Pharma Mirror

NOVEMBER 16, 2021

Rockville, Emmes, a global, full-service Clinical Research Organization dedicated to supporting the advancement of public health and biopharmaceutical innovation, today announced a partnership with MedGenome aimed at accelerating breakthrough treatments, powered by human genomics, for rare disease patients.

Genome

Genome Genomics Research Genetics

STAT+: ??Genomics is racing toward a $100 genome. Are we ready for it?

STAT News

JULY 27, 2022

As the cost of DNA sequencing plummets, we’re fast approaching a point when decoding a human genome could cost $100 — about as much as the average American’s weekly grocery store run. Health systems are preparing to test programs that could lead to the use of whole-genome screening in millions of newborns.

Genome

Genome Genomics DNA Genetics

To Share or Not to Share Failed Genetic Screening Results with Patients

Worldwide Clinical Trials

FEBRUARY 6, 2023

When using genetic screening to identify clinical trial volunteers, a sponsor’s obligations for further testing and disclosure of results to patients and families are unclear, especially when the results have no impact on medical management. Guidance in this area is much needed. Read the full article!

Genetics

Genetics Clinical Trials Clinical Trials Genotype

Unexplored genomic control regions yield the key to finding causes of rare disease

Medical Xpress

NOVEMBER 7, 2022

Scientists have discovered the cause of a rare condition within a part of the genome that has been largely unexplored in medical genetics.

Genome

Genome Genomics Genetics Gene

STAT+: CRISPR pioneer Feng Zhang launches new genetic delivery startup with $193 million

STAT News

FEBRUARY 16, 2023

Zhang, one of the leading scientists in the groundbreaking field of genetic editing, had reached out two days prior to discuss a new company he was working on. Akin Akinc was scouring his email spam box last summer, looking for a missing message, when he stumbled across an unexpected email from a quite recognizable name: Feng Zhang.

Genetics

Genetics DNA Genome Genomics

Study finds it's cost-effective to diagnose intellectual disabilities with whole genome sequencing

Medical Xpress

MAY 4, 2023

Researchers at Karolinska Institutet and Karolinska University Hospital have together with health economists at Linköping University analyzed costs for various methods to diagnose genetic causes of intellectual disability.

Genome

Genome Genomics Genetics Research

STAT+: England to sequence genomes of 100,000 newborns, to try to catch illness earlier

STAT News

DECEMBER 12, 2022

LONDON — England is launching a pilot program sequencing the genomes of up to 100,000 newborns to see if such a strategy can speed up the detection of genetic illnesses. The Newborn Genomes Programme will scan DNA for mutations that can cause some 200 conditions.

Genome

Genome Genomics Genetic Disease Genetics

National Academies calls for transforming use of racial and ethnic labels in genetics research

STAT News

MARCH 14, 2023

Saying genetics researchers inconsistently and inappropriately use racial and ethnic labels that fail to capture the complex patterns of human genetic variation, the National Academies of Sciences, Engineering, and Medicine issued a report Tuesday calling for a transformation in how such descriptors are used. Read the rest…

Genetics

Genetics Research Genome Genomics

Whole-genome sequencing used to track down genes behind familial glioma

Medical Xpress

MAY 2, 2023

A team of gene therapists, oncologists, genetic sequencing experts and neurosurgeons affiliated with a host of institutions in the U.S. In their study, reported in the journal Science Advances, the group sequenced the genomes of members of glioma-affected families.

Genome

Genome Genomics Gene Genetics

Novel technique opens up new possibilities in synthetic genomics

Drug Discovery World

DECEMBER 29, 2023

Known as ‘CReATiNG’ (Cloning Reprogramming and Assembling Tiled Natural Genomic DNA), the method offers a simpler and more cost-effective approach to constructing synthetic chromosomes. The thing about most synthetic genomics research is that it involves building chromosomes or genomes from scratch using chemically synthesised DNA pieces.

Genome

Genome Genomics DNA Scientist

New tool facilitates clinical interpretation of genetic information

Medical Xpress

APRIL 21, 2023

Despite the increasing use of genomic sequencing in clinical practice, interpreting rare genetic mutations, even among well-studied disease genes, remains difficult.

Genetics

Genetics Genome Genomics Gene

Investment fuels AI-driven development of breakthrough genomic medicines

pharmaphorum

OCTOBER 12, 2022

David Del Bourgo (CEO and co-founder, Whitelab Genomics) has always been passionate about introducing disruptive, innovative technologies to markets. We founded Whitelab Genomics after realising the potential to use data, data science, and AI in a more systematic way to develop genomic therapies,” Del Bourgo says.

Genome

Genome Genomics Medicine Development

Genetic links between migraine and blood sugar levels confirmed

Medical Xpress

FEBRUARY 23, 2023

In a study published in Human Genetics, QUT Professor Dale Nyholt and QUT Ph.D. researcher Rafiqul Islam, describe using large-scale genome-wide associations studies (GWAS) summary statistics to analyze hundreds of thousands of human genomes from headache and migraine sufferers and non-sufferers.

Genetics

Genetics Genome Genomics Research

Study suggests DNA sequencing could reduce infant deaths, often caused by genetic disease

STAT News

FEBRUARY 9, 2023

Researchers who believe genomics can transform human health love to recount success stories. But a new study focuses on a much more somber set of stories: those of infants who died with genetic diseases and who in some cases could have been treated, perhaps even saved. Read the rest…

Genetic Disease

Genetic Disease DNA Genetics Genome

Why early participant engagement is now a top priority in genetic disease research

pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return. Navigating the right not to know.

Genetic Disease

Genetic Disease Genetics Research Genome

Genetic causes of bone tumors discovered in 1,000-year-old Irish skeletons

Medical Xpress

DECEMBER 5, 2022

Donegal had a genetic condition called multiple osteochondromas, which causes benign bone tumors. One of the disease mutations is a new discovery, so this is the first time such information has been unlocked from ancient genomic data. Two men buried long ago in a medieval graveyard in Co.

Genetics

Genetics Genome Genomics

Opinion: Where are the guidelines for the production of animals with intentional genomic alterations?

STAT News

APRIL 17, 2023

Genetic engineering has the potential to transform how we raise animals for meat and other products, making food safer, improving animal health and welfare, and shrinking animal agriculture’s environmental footprint. Pigs that are less likely to induce allergic reactions in humans. Read the rest…

Genome

Genome Genomics Genetic Engineering Production

Scientists expand entomological research using genome editing

Scienmag

JULY 22, 2022

Genome sequencing, where scientists use laboratory methods to determine a specific organism’s genetic makeup, is becoming a common practice in insect research.

Genome

Genome Genomics Scientist Research

STAT+: Ahead of genome summit in London, questions linger about CRISPR baby scandal

STAT News

MARCH 3, 2023

Next week, hundreds of scientists from around the world will convene in London for an international summit on genome editing. That technology, which enables scientists to easily excise, alter, or replace specific sections of DNA, was awarded the 2020 Nobel Prize for Chemistry.

Genome

Genome Genomics Gene Editing Genetic Disease

Landmark study details sequencing of 64 full human genomes to better capture genetic diversity

Scienmag

FEBRUARY 25, 2021

Scott Devine, PhD 64 human genomes sequenced will serve as new reference for genetic variation and predisposition to human diseases Credit: NIH Researchers at the University of Maryland School of Medicine (UMSOM) co-authored a study, published today in the journal Science, that details the sequencing of 64 full human genomes.

Genome

Genome Genomics Genetics Medicine

Personalising whole genome sequencing doubles diagnosis of rare diseases

Drug Discovery World

NOVEMBER 7, 2022

A new study led by Medical Research Council-funded researchers from UCL has found that tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases. . Consequently, the UK has established itself at the forefront of diagnostic whole genome sequencing. Context .

Genome

Genome Genomics Genetics Genetic Disease

Inclusive new tool makes genomic research better reflect world’s diversity

Scienmag

MARCH 10, 2022

Scientists have developed a powerful, inclusive new tool for genomic research that boosts efforts to develop more precise treatments for many diseases by leveraging a better representation of the genetic diversity of people around the world.

Genome

Genome Genomics Research Scientist

STAT+: At genome-editing summit, experts worry that rule changes on embryo research in China fall short

STAT News

MARCH 6, 2023

That was the message Chinese scientists delivered Monday on the opening day of the Third International Summit on Human Genome Editing in London. Continue to STAT+ to read the full story…

Genome

Genome Genomics Gene Editing Genetics

Stanford scientist who broke genome sequencing record on what faster diagnoses mean for patients

STAT News

MARCH 22, 2023

Stanford cardiologist Euan Ashley and his research team received a Guinness World Record last year for sequencing a full human genome in just over five hours. Ashley is at the forefront of a push by researchers to make more genetic information available to patients facing major health care decisions.

Genome

Genome Genomics Scientist Genetics

Tome Biosciences debuts with $213M and a new way to edit the genome

Scribe and Sanofi expand genetic therapy development deal

Trending Sources

Leveraging Genetic Testing for Enrolling Rare Disease Trials

UK agency pilots biobank to study links between genetics and drug side effects

Hopewell Therapeutics raises funds for genomic medicines development

Elsevier partners with American College of Medical Genetics and Genomics to publish Genetics in Medicine

Genome Edited Foods: Understanding the New FDA Guidance

New approach successfully traces genomic variants back to genetic disorders

A new dawn of the genomic age: five areas set to be transformed in 2023

$8 million awarded to landmark genetic research project

Fulgent Genetics acquires therapeutics development company Fulgent Pharma

SOPHiA GENETICS and AstraZeneca partner for oncology drugs development

Kansas children’s hospital first to use world’s most advanced genomic sequencing

rAAV Genome sequencing uncovers transgene integrity and packaging impurities

Why genomic healthcare data matters in the development of new therapies

BU researchers find “genetic baggage” accumulates in the genomes of aging mutant animals

Genetic diagnosis helps guide care of childhood hearing loss

Researchers identify large genetic changes that contribute to dementia risk

UK announces mass genome sequencing programme for newborns

Leading innovators in genetically modified animal models for the pharmaceutical industry

Emmes and MedGenome Launch Genomics Strategic Partnership Focused on Advancing Rare Disease Research

STAT+: ??Genomics is racing toward a $100 genome. Are we ready for it?

To Share or Not to Share Failed Genetic Screening Results with Patients

Unexplored genomic control regions yield the key to finding causes of rare disease

STAT+: CRISPR pioneer Feng Zhang launches new genetic delivery startup with $193 million

Study finds it's cost-effective to diagnose intellectual disabilities with whole genome sequencing

STAT+: England to sequence genomes of 100,000 newborns, to try to catch illness earlier

National Academies calls for transforming use of racial and ethnic labels in genetics research

Whole-genome sequencing used to track down genes behind familial glioma

Novel technique opens up new possibilities in synthetic genomics

New tool facilitates clinical interpretation of genetic information

Investment fuels AI-driven development of breakthrough genomic medicines

Genetic links between migraine and blood sugar levels confirmed

Study suggests DNA sequencing could reduce infant deaths, often caused by genetic disease

Why early participant engagement is now a top priority in genetic disease research

Genetic causes of bone tumors discovered in 1,000-year-old Irish skeletons

Opinion: Where are the guidelines for the production of animals with intentional genomic alterations?

Scientists expand entomological research using genome editing

STAT+: Ahead of genome summit in London, questions linger about CRISPR baby scandal

Landmark study details sequencing of 64 full human genomes to better capture genetic diversity

Personalising whole genome sequencing doubles diagnosis of rare diseases

Inclusive new tool makes genomic research better reflect world’s diversity

STAT+: At genome-editing summit, experts worry that rule changes on embryo research in China fall short

Stanford scientist who broke genome sequencing record on what faster diagnoses mean for patients

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