Worldwide Clinical Trials

DECEMBER 12, 2022

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. What are the benefits and limitations to using genetic testing? It is important to consider the type of testing performed (e.g.,

Clinical Trials 130

Clinical Trials Clinical Trials Genetics Trials 130

Medical Xpress

JANUARY 5, 2023

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care. The study was published in the American Journal of Human Genetics. This approach contrasts with the typical phenotype-first approach to clinical research, which starts with clinical findings.

Genome 75

Genome Genomics Genetics Genotype 75

Scienmag

APRIL 19, 2022

New Edith Cowan University (ECU) research has identified a crucial link between arthritis and the risk of serious liver disease in people with Australia’s most common genetic condition. It […].

Genetics 75

Genetics Genotype Research 75

pharmaphorum

JANUARY 24, 2023

Ben Hargreaves finds that the vast amount of genetic data that exists today could help provide a faster, more targeted way of developing new drug candidates. The logical extension to this kind of approach is treating individual patients, with their individual genetic makeup.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

Scienmag

AUGUST 25, 2020

Credit: Iliana Baums, Penn State Coral conservation efforts could get a boost from a newly developed genotyping “chip”–the first of its kind for corals.

Genotype 94

Genotype Genetics Development Research 94

Scienmag

JANUARY 13, 2021

Credit: Delaneau Group Thousands of genetic markers have already been robustly associated with complex human traits, such as Alzheimer’s disease, cancer, obesity, or height.

Genomics 84

Genomics Genome Genotype Genetics 84

Worldwide Clinical Trials

AUGUST 14, 2024

Historically, these indications have challenged the one-size-fits-all treatment approach due to patient variability, such as genetic differences in drug metabolism and underlying health conditions. This resistance may occur due to genetic mutations, epigenetic changes, or a tumor’s microenvironment.

Genetics 195

Genetics Protein Gene Genotype 195

BioTech 365

JUNE 14, 2021

Twist Bioscience Collaborates with Regeneron for Production of Genotyping by Sequencing Panel to Enable Diverse Genome-wide Screening Twist Bioscience Collaborates with Regeneron for Production of Genotyping by Sequencing Panel to Enable Diverse Genome-wide Screening — Population Genetics Sequencing Panel Incorporates … Continue reading (..)

Genotype 40

Genotype Genome Genomics Production 40

The Pharma Data

NOVEMBER 18, 2020

Genetics Tied to Thromboembolism Risk With Inflammatory Bowel Disease. 18, 2020 — Genetic variants in some patients with inflammatory bowel disease (IBD) are associated with a significantly increased risk for developing thromboembolic disease (TED), according to a study published online Oct. Professional. WEDNESDAY, Nov.

Genetics 52

Genetics Genotype Genome Genomics 52

Scienmag

JUNE 6, 2025

The implications challenge our understanding of social mobility and the reproduction of social stratification, providing a fresh lens through which to consider the interplay of genetics, environment, and human behavior. Such insights have far-reaching implications for understanding the genetic architecture of complex social traits.

Genetics 59

Genetics Genotype Research Genome 59

Scienmag

JUNE 7, 2025

Additionally, integrating genetic risk profiles may uncover genotype-phenotype interactions influencing disease trajectory. Future studies incorporating molecular biomarkers like cerebrospinal fluid alpha-synuclein and novel PET ligands could further refine subtype characterizations. In conclusion, the work by Tang et al.

Genotype 75

Genotype Clinical Trials Clinical Trials Research 75

Medical Xpress

FEBRUARY 3, 2023

For their paper published in the journal Science, Lorenzo Talamanca, Cédric Gobet and Felix Naef analyzed data obtained for the Genotype-Tissue Expression project. A trio of bioengineering scientists at Ecole Polytechnique Fédérale de Lausanne has found age and gender differences in gene expression related to the circadian clock.

Gene Expression 76

Gene Expression Gene Genotype Scientist 76

XTalks

NOVEMBER 10, 2020

Expeditious and accurate diagnoses are necessary for patients to access healthcare services and treatment options for rare genetic diseases. Increasing the efficiency of case analysis and interpretation is essential to providing timely care for patients with genetic diseases.

Genome 98

Genome Genomics Medicine Genetic Disease 98

pharmaphorum

OCTOBER 9, 2020

The rare, X-linked genetic condition is characterised by short stature and facial, limb and genital abnormalities and was first described in 1970. Because Aarskog is an X-linked genetic condition affecting predominantly males, women have traditionally been considered asymptomatic carriers. No one would listen.”.

Research 111

Research Genetics Genotype Nurses 111

XTalks

FEBRUARY 4, 2021

Through these collaborations, cohort research dataset sharing programs allow for whole-genome sequence and genotype data to be made available for independent research. Now, if all you’ve already got is a bioresource of 20,000 people that have already been genotyped, you can choose those from that sample and focus your effort.”.

Research 98

Research Biobanking Drugs Genome 98

pharmaphorum

AUGUST 11, 2022

The participants undergo monitoring for genetic variations that could potentially negatively impact their reaction to therapies. The program is aiming to genotype roughly 150,000 participants over the next few years to demonstrate the impact personalised testing can have on a large scale. About the Author.

Genome 98

Genome Genomics Genetics Drugs 98

XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. Hannelius said this highlights the importance of genetics when developing therapies for type 1 diabetes.

Vaccine 103

Vaccine Vaccination Insulin Trials 103

Bioengineer

JANUARY 16, 2024

Another genetic change at the C797 residue in the ATP binding region of EGFR’s exon 20 has emerged as a key mechanism of resistance to osimertinib. However, when osimertinib is used first-line, the T790M mutation is usually absent before or after progression, reducing its significance with increased frontline use.

Genome 119

Genome Genomics Protein In-Vitro 119

XTalks

JANUARY 21, 2025

There, plasma is separated, and tumor DNA is identified by detecting genetic mutations, methylation patterns and fragmentation signals. Using cervical or self-collected vaginal specimens, the test works with the BD Viper LT and BD COR systems to detect individual genotypes, such as HPV 16, 18 and 31, and grouped results for other types.

FDA Approval 105

FDA Approval Manufacturing RNA Development 105

pharmaphorum

JANUARY 16, 2023

“In addition to living longer, the reason behind the higher female prevalence is thought to be related to the effects of menopause and the impact of the APOE4 genetic risk factor being greater in women,” said Professor Minihane. Their work specifically focused on the effect of HRT on women with the APOE4 genotype.

Hormones 75

Hormones Genotype Research Genetics 75

XTalks

SEPTEMBER 28, 2020

Based on the genetic biomarker(s) identified, the most effective therapy targeting the specific molecular marker can be selected. The liquid biopsy will therefore help personalize medicines for patients based on the molecular features of their disease.

Gene 105

Gene DNA Life Science Genotype 105

Roots Analysis

AUGUST 12, 2024

These diagnostic solutions are essential for detecting and monitoring diseases, identifying genetic abnormalities, and guiding personalized treatment plans. Molecular diagnostic solutions are pivotal across various medical fields, including oncological disorders, infectious diseases, genetic testing, and personalized medicine.

Genetics 40

Genetics Gene Expression RNA DNA 40

XTalks

DECEMBER 12, 2023

Moreover, combining biofluid analytes with molecular pathology (genetic biomarkers) allows for the classification and differentiation of neurodegenerative diseases. To accurately identify these genetic factors, genotyping techniques such as Sanger sequencing, next-generation sequencing (NGS) and copy number variant analysis are used.

Trials 111

Trials Clinical Trials Clinical Trials Genetics 111

The Pharma Data

SEPTEMBER 8, 2021

As manufacturer of custom oligonucleotides the company partnered in the development of molecular diagnostics and built a broad portfolio of diagnostic assays, in particular for inherited genetic as well as somatic mutation testing, quantitative assays for haematology and transplantation medicine.

Genotype 52

Genotype Reagent Genetics Research 52

Roots Analysis

APRIL 28, 2024

Factors Contributing to Kidney Diseases There are several factors which contribute to an increased risk of developing kidney diseases, including genetic causes and underlying metabolic causes ( diabetes, high blood pressure, aging and obesity ), which when combined with other factors increase the risk of developing kidney diseases.

Genetics 40

Genetics Genotype Development Research 40

Roots Analysis

AUGUST 31, 2023

Quantitative real time polymerase chain reaction ( RT PCR ) and DNA microarray technologies have been successfully used to evaluate the interactions between genes and diet, which is measured in terms of changes in the genetic expression. It is worth mentioning that more than 50 genes in a human body are associated with obesity.

Genome 40

Genome Genomics Genetics Gene 40

Scienmag

JUNE 10, 2025

Infantile Hypertrophic Cardiomyopathy: Paving the Way for an Evidence-Based Genetic Testing Paradigm In the realm of pediatric cardiology, infantile hypertrophic cardiomyopathy (HCM) stands as a particularly elusive and formidable challenge. However, the application of genetic screening in infantile HCM has been hampered by several factors.

Genetics 59

Genetics Genotype Cardiology Gene Editing 59

pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return.

Genetic Disease 97

Genetic Disease Genetics Research Genome 97

Scienmag

JUNE 21, 2025

In a groundbreaking stride toward addressing the complex challenges posed by Fanconi anemia, a genetic disorder marked by progressive bone marrow failure and cancer susceptibility, researchers have unveiled novel therapeutic agents that promise to fundamentally alter treatment landscapes.

Drugs 59

Drugs Genetics Protein DNA 59

Scienmag

JUNE 6, 2025

Genetic polymorphisms of the cytochrome P450 2C19 enzyme (CYP2C19) were also explored due to their known influence on sertraline metabolism. However, within the pediatric and adolescent subpopulation, dose-adjusted serum concentrations (C/D ratios) significantly varied across CYP2C19 genotypes, with PMs showing higher C/D values.

Drugs 92

Drugs Genetics Genotype Protein 92

Scienmag

JUNE 19, 2025

This study’s organoids retain not only the genetic makeup of the parental colorectal cancer cells but also exhibit robust self-renewal and differentiation capacities intrinsic to cancer stem cells. One of the transformative aspects of this research is its potential to inform personalized medicine approaches.

In-Vivo 59

In-Vivo Research Gene Expression Genotype 59

XTalks

APRIL 15, 2021

A 2015 study published in Nature Genetics found that the availability of human genetic data made investigational drugs twice as likely to pass pivotal trials and eventually be approved. Figure 1: The use of Mendelian randomization to validate genetic drug targets. Genuity Science Drug Target Discovery Study.

Development 98

Development Drugs Genome Genomics 98

XTalks

APRIL 24, 2023

Approximately 72 percent of rare diseases are genetic, and around 70 percent of rare genetic diseases emerge in childhood. One substantial obstacle is from the additional regulatory requirements of gene therapies containing genetically modified organisms (GMOs). Rare diseases can often be progressive, chronic and fatal.

Gene Therapy 95

Gene Therapy Gene Trials Clinical Trials 95

The Pharma Data

NOVEMBER 2, 2020

ONWARD is investigating Adial’s lead drug candidate, AD04, as a therapeutic agent for the treatment of Alcohol Use Disorder (AUD) in persons with certain target genotypes related to the serotonin transporter and receptor genes. Key ONWARD highlights include: All 25 planned investigative sites are active.

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Trials Genotype Marketing Production 52

XTalks

MARCH 3, 2021

The US Food and Drug Administration (FDA) has granted approval to Nulibry (fosdenopterin) for reducing the risk of death associated with molybdenum cofactor deficiency type A (MoCD Type A), making it the first treatment for the ultra-rare, genetic metabolic disorder. The approval was granted to BridgeBio Pharma, Inc.

FDA Approval 64

FDA Approval Genotype Clinical Trials Clinical Trials 64

The Pharma Data

OCTOBER 9, 2021

Food and Drug Administration (FDA) Antimicrobial Drugs Advisory Committee (AMDAC) voted unanimously to recommend use of maribavir (TAK-620) for the treatment of refractory cytomegalovirus (CMV) infection and disease with genotypic resistance to ganciclovir, valganciclovir, foscarnet or cidofovir in transplant recipients.

Genotype 52

Genotype Drugs Bioavailability Medicine 52

The Pharma Data

MARCH 7, 2022

The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. This is the FDA’s first low-risk determination for enforcement discretion for an IGA in an animal for food use.

Genome 52

Genome Genomics Production Marketing 52