Medical Xpress

DECEMBER 6, 2022

Non-Hispanic Black women with hormone receptor (HR)-positive/HER2-negative, lymph node-positive breast cancer had worse outcomes compared to non-Hispanic whites, Asians, and Hispanics, despite similar 21-gene recurrence scores, according to a study presented at the 2022 San Antonio Breast Cancer Symposium, held December 6-10, 2022.

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pharmaphorum

SEPTEMBER 14, 2020

Merck & Co has signed a multi-billion cancer drug development deal, which will see it investing $1 billion in partner Seattle Genetics. Seattle Genetics will receive a $600 million upfront payment and Merck will make a $1.0 million shares of Seattle Genetics common stock at a price of $200 per share.

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Drug Discovery World

SEPTEMBER 7, 2022

NICE has judged olaparib too expensive partly because of the cost of genetic testing to tailor the drug for patients. The post NICE rejects prostate cancer drug due to cost of genetic testing appeared first on Drug Discovery World (DDW). A “penalty for innovation”. Biomarker testing “should be routine”.

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The Pharma Data

SEPTEMBER 15, 2020

MSD has signed two new oncology-based deals with Seattle Genetics which together could be worth up to around $4.4 For this, MSD will put up $600 million up front and a $1 billion equity investment for five million of Seattle Genetics’ shares, while the latter will also have the option to scoop up an additional $2.6 Matt Fellows.

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BioSpace

AUGUST 31, 2021

This is an effort to eliminate severe adverse reactions by matching the birth control to the genetics and hormones of the individual.

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Drug Discovery World

DECEMBER 9, 2022

The drug capivasertib combined with hormone therapy doubled the time it took for cancer to progress in people with advanced forms of the most common type of breast cancer. . In the trial, adding capivasertib to fulvestrant hormone therapy doubled the median time to disease progression, from 3.6 Genetic alterations of the AKT pathway.

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XTalks

JUNE 20, 2022

TTR is made in the liver and is involved in carrying the thyroid hormone thyroxine (T4) and retinol (vitamin A) to the liver. Defects in the TTR transporter leads to a buildup of amyloid protein (amyloidosis) in tissues and organs, occurring mainly in the nerves in the peripheral nervous system.

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Scienmag

SEPTEMBER 13, 2021

Philadelphia, September 13, 2021—Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

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Drug Discovery World

DECEMBER 18, 2023

It is caused by GDF15, a hormone produced by the foetus. The international team from the University of Cambridge, Scotland, the USA and Sri Lanka used a combination of approaches including human genetics, new ways of measuring hormones in pregnant women’s blood, and studies in cells and mice.

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XTalks

MARCH 28, 2024

Causes and Risk Factors for Endometriosis As the exact cause of endometriosis remains unclear, many potential causes are being proposed, including retrograde menstruation (where menstrual blood flows back into the pelvic cavity instead of leaving the body), immune system disorders and hormonal imbalances.

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Pharma Packaging Solutions

JUNE 30, 2023

Hormones (such as insulin, glucagon, and growth hormone, to name a few) are produced by recombinant DNA, as are blood factors, thrombolytic agents, interferons, monoclonal antibodies, therapeutic enzymes, and more.

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Scienmag

MARCH 26, 2021

Bottom Line: Various genetic alterations in circulating tumor cells (CTCs) were associated with clinical outcomes and resistance to hormone therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

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XTalks

MARCH 7, 2024

The team talks about the differences between genetically modified organisms (GMO) and gene edited foods, as well as whether these foods could be considered organic. These foods are banned in other countries for a variety of reasons, such as the inclusion potentially unsafe dyes, hormones and preservatives.

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Scienmag

AUGUST 14, 2020

Findings have implications for seed production and crop yield and could help rewrite textbooks, translating to practical applications for plant reproduction Credit: Dr. Wangshu Mou Researchers at the University of Maryland (UMD) have discovered an entirely new role for a well-known plant molecule called ACC, providing the first clear example of ACC (..)

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pharmaphorum

AUGUST 16, 2022

AstraZeneca and Merck & Co’s PARP inhibitor Lynparza is already used to treat prostate cancer associated with a specific genetic mutation, but could see its use broadened if a new marketing application is approved by the FDA. months and 16.6 months, respectively.

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Scienmag

NOVEMBER 4, 2020

Researchers from Nara Institute of Science and Technology find that the plant hormone ethylene mediates the invasion of hosts by parasitic plants Credit: Satoko Yoshida Nara, Japan – Mutants that reveal the secrets of how plants attack?

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Drug Discovery Today

FEBRUARY 13, 2020

Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations.

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Drug Discovery World

APRIL 6, 2023

Men in England and Wales with advanced, incurable prostate cancer who have BRCA1/2 mutations in their tumours and who have seen their cancer progress despite hormone therapy will also have access to olaparib. NICE previously decided not to recommend the drug as a prostate cancer treatment due to the high cost of genetic testing.

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pharmaphorum

JANUARY 16, 2023

Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK.

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Scienmag

MARCH 11, 2021

During pregnancy, the hormone progesterone helps to […]. The study in mice — published online in the Proceedings of the National Academy of Sciences — provides novel insights for developing treatments.

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Scienmag

MAY 18, 2021

Mutations associated with autism can inhibit the release of the bonding hormone oxytocin and cause abnormal social behavior in mice Credit: Tokyo University of Science Autism spectrum disorder is a neurodevelopmental condition involving impaired social abilities, and this makes it a fascinating subject for neuroscientists like Prof.

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Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

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Roots Analysis

OCTOBER 24, 2023

This has led to their widespread production and extensive use in the treatment of various indications including hormonal imbalances, oncological disorders and respiratory disorders. Hormones: Biologic HPAPIs which are not classified as oncology drugs include hormones, narcotics and retinoids.

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The Pharma Data

JUNE 2, 2023

“These additional data on Verzenio and Jaypirca build on the evidence supporting the role each of these medicines play in improving the treatment paradigms for patients with node-positive, high risk early breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively,” said David Hyman, M.D.,

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pharmaphorum

SEPTEMBER 24, 2021

AstraZeneca and Merck & Co PARP inhibitor Lynparza is already used to treat prostate cancer associated with a specific genetic mutation, but could see the drug’s use broadened after a positive phase 3 trial.

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Olympian Clinical Research

NOVEMBER 6, 2023

While the exact cause is unknown, factors like genetics, inflammation, and hormones play a role. Here are some common triggers of HS: Hormonal Changes: Many individuals with HS report flare-ups during periods of hormonal change, such as menstruation, pregnancy, or menopause.

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XTalks

FEBRUARY 14, 2024

Moreover, these advancements have enabled healthcare providers to tailor treatments according to the genetic profile of each tumor, which has, in turn, helped enhance efficacy while minimizing adverse effects. In fact, for healthcare providers and medical device companies, these advancements are both a challenge and an opportunity.

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Trialfacts

JANUARY 28, 2024

Individuals aged 18 to 30 years who are diagnosed with Bipolar I Disorder or Bipolar II Disorder Must be currently taking lithium Must not have colour blindness Must not be using drugs for recreational purposes and be willing to refrain from using for 4 weeks before enrolment Must not be working on a shift schedule or have travelled internationally (..)

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Delveinsight

AUGUST 31, 2021

FDA’s Green Flag to Ascendis’s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency. Growth Hormone Deficiency , commonly known as dwarfism, can constitute short stature and complications with metabolism, which arise due to inadequate production of growth hormones by the pituitary gland inside the body.

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Olympian Clinical Research

DECEMBER 19, 2023

Family History: Genetics plays a significant role. Hormonal Changes: Hormonal fluctuations, especially during puberty, can influence the severity and onset of psoriasis. Hormonal Changes: Hormonal fluctuations, especially during puberty, can influence the severity and onset of psoriasis.

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The Pharma Data

OCTOBER 22, 2020

That means a woman already predisposed to have a dissection is more likely to have one during pregnancy, possibly due to hormones and changes to the body during pregnancy and postpartum. The researchers found that 19% of aortic dissections in women younger than 35 were associated with pregnancy.

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Delveinsight

SEPTEMBER 27, 2021

Furthermore, the condition carries the risk of differential diagnosis as more than 50 genetic/metabolic diseases are associated with infantile spasms, and many patients have other disorders that cause developmental delays (e.g., Early diagnosis is necessary for better treatment outcomes. cerebral palsy, Down syndrome, tuberous sclerosis, etc.)

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The Pharma Data

NOVEMBER 21, 2021

Achondroplasia is a genetic condition that causes severely short stature and disproportionate growth. People with achondroplasia have a genetic mutation that causes a certain growth regulation gene called fibroblast growth factor receptor 3 to be overly active, which prevents normal bone growth. Inheritance is autosomal dominant.[1][2]

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The Pharma Data

DECEMBER 17, 2020

This patient had a genetic mutation that ruxolitinib is known to work on. Forbes said it’s not clear if other people with type 1 diabetes also have this specific genetic mutation. Insulin is a hormone that ushers the sugars from foods into the body’s cells to be used as fuel.

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The Pharma Data

AUGUST 15, 2021

Advise patients of these risks and the need for effective non-hormonal contraception. WELIREG can render some hormonal contraceptives ineffective. This is a rare genetic disease with an estimated incidence of 10,000 people in the U.S. WELIREG can render some hormonal contraceptives ineffective.

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Delveinsight

JULY 30, 2020

The buildup in adrenal glands leads to the insufficient hormonal response, thus leading to several of the symptoms such as deficiency of steroid hormones (mainly cortisol and aldosterone), impaired cortisol secretion, and others that are harbingers of the disease. The disorder can occur at any stage of life and vary with severity.

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XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. Hannelius said this highlights the importance of genetics when developing therapies for type 1 diabetes. “It

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