Scienmag

JUNE 19, 2025

In a groundbreaking study that reshapes our understanding of the genetic determinants of serum lipid levels, a consortium of international researchers has unveiled novel genetic loci influenced by the complex interplay between genetic variants and psychosocial factors.

Genetics 59

Genetics Genomics Genome Gene 59

Scienmag

JUNE 17, 2025

At the forefront of this paradigm shift is Professor Diego di Bernardo, Genomic Medicine Program Coordinator at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and Professor of Biomedical Engineering at the University of Naples “Federico II.”

Genetics 59

Genetics Gene Therapy Gene Expression Gene 59

Scienmag

JUNE 24, 2025

In the rapidly evolving realm of psychiatric genetics, a landmark review published on June 24, 2025, in Genomic Psychiatry elucidates the intricate relationships between polygenic scores for mood disorders and clinical outcomes across major psychiatric conditions.

Genetics 52

Genetics Genomics Genome Gene 52

XTalks

DECEMBER 18, 2024

CAH is a group of rare genetic disorders affecting the adrenal glands, which produce essential hormones like cortisol, aldosterone and androgens. Trial data for both the pediatric and adult trials were published in The New England Journal of Medicine. Crenessity marks the third approved drug for Neurocrine.

Genetics 116

Genetics Hormones Trials Pharmacy 116

Scienmag

JUNE 9, 2025

A recently published study has uncovered a significant shortfall in the genetic testing of patients diagnosed with endometrial cancer—commonly referred to as womb cancer—across the UK and Ireland. Affecting approximately one in every 300 individuals, it remains underdiagnosed with a staggering 95% of carriers unaware of their genetic status.

Genetics 59

Genetics DNA Gene Genomics 59

Scienmag

JUNE 20, 2025

This unprecedented collaboration seeks to leverage deep clinical insights and cutting-edge technologies to reshape the future landscape of cardiovascular medicine, with a particular emphasis on Asian populations, whose unique clinical profiles present both challenges and opportunities rarely addressed on a global scale.

Research 88

Research Cardiology Medicine Genetics 88

Scienmag

JUNE 27, 2025

This research highlights the profound genetic heterogeneity and clinical challenges posed by HER2 mutations in NSCLC, an area that has historically seen limited exploration outside high-income countries. The disparity in treatment outcomes was stark.

Genetics 59

Genetics Genomics Genome Protein 59

Scienmag

JUNE 17, 2025

Unlocking these enzymes would enable transferring their genetic blueprints into fast-growing industrial microorganisms, like yeast, converting them into microbial factories that produce Taxol on scales far surpassing what nature offers. This comprehensive gene set promises to transform industrial drug manufacture.

Research 94

Research Genomics Genome Drugs 94

Scienmag

JULY 1, 2025

This degree of control can enhance therapeutic safety profiles and efficacy, particularly for complex diseases that necessitate finely tuned genetic interventions. From a translational perspective, the NIR-activatable CRISPR platform holds tremendous promise for treating genetic disorders, cancers, and infectious diseases.

Gene Editing 59

Gene Editing Gene Gene Therapy Genomics 59

Scienmag

JULY 4, 2025

In a groundbreaking study that promises to reshape our understanding of autism spectrum disorder (ASD), researchers have employed state-of-the-art single-cell genomic technologies to unravel the complex molecular alterations underlying dup15q syndrome—a genetic condition strongly linked to autism. Velmeshev, D.,

Gene Expression 52

Gene Expression Gene Genetics RNA 52

Scienmag

JUNE 25, 2025

In a landmark advance that promises to reshape our understanding of bipolar disorder, researchers have employed cutting-edge genomic mapping techniques to pinpoint the genetic underpinnings of this complex psychiatric condition with remarkable precision. The implications of these findings cascade beyond mere genetic associations.

Gene 59

Gene Genome Genomics Genetics 59

Drug Patent Watch

DECEMBER 9, 2024

This intersection is where pharmacognosy meets drug patents, creating a unique landscape that shapes the future of medicine. Let’s embark on a journey to uncover the secrets of nature’s medicine cabinet and the legal frameworks that protect these discoveries.

Medicine 94

Medicine Drugs Production Manufacturing 94

Scienmag

JUNE 18, 2025

Despite their importance, the fine-scale functional landscape within these regulatory sequences has remained elusive, hindering our ability to interpret the consequences of genetic variation in human disease contexts. Enhancers act as molecular switches that integrate signals and guide gene expression programs.

In-Vivo 80

In-Vivo Gene Expression Gene DNA 80

Scienmag

JUNE 7, 2025

In an era where precision medicine is rapidly transforming pediatric healthcare, a groundbreaking nationwide study has emerged, shedding light on the utility of biological treatments in children suffering from eosinophilic esophagitis (EoE). The investigation presented by Soudant et al.

Medicine 78

Medicine Immune Response Research Nurses 78

Scienmag

JULY 7, 2025

This meticulous customization framework empowers researchers and clinicians to design bespoke base editors with nucleotide and context specificity, which is particularly critical when precise genetic corrections are warranted. The team demonstrated the practical utility of these evolved BEs in two major avenues. of tested cases.

Genomics 59

Genomics Genome Genotype Engineer 59

Scienmag

JUNE 10, 2025

Despite significant advances through precision medicine and targeted therapies that have reshaped oncology, the issues of drug resistance and disease recurrence continue to plague many patients. Cancer remains a formidable adversary in global health, affecting millions annually and presenting persistent challenges to effective treatment.

Research 59

Research Clinical Trials Clinical Trials Gene Editing 59

The Pharma Data

JUNE 24, 2025

The strategic funding arrangement is designed to support the continued advancement and global commercialization of Revolution Medicines’ RAS(ON) inhibitor portfolio, including its lead candidate daraxonrasib, as the company scales its operations independently across the international oncology market.

Medicine 40

Medicine Development Drugs Protein 40

Scienmag

JUNE 6, 2025

A groundbreaking study conducted by biomedical scientists at the University of California, Riverside School of Medicine has unveiled new insights into the genetic underpinnings of iron deficiency anemia in patients with inflammatory bowel disease (IBD).

Genetics 59

Genetics Protein Gene Regulation 59

Scienmag

JULY 2, 2025

These compartments can be broadly divided into two categories: membrane-bound organelles, such as mitochondria that generate energy and the nucleus that safeguards our genetic blueprint, and membrane-less structures known as biomolecular condensates. The implications of these findings for medicine are profound.

RNA 75

RNA Protein Engineer Genetics 75

Scienmag

JUNE 7, 2025

The influence of genetic factors on neonatal outcomes has long been a subject of intense scientific scrutiny, with particular emphasis on identifying biomarkers that could predict susceptibility to severe health complications in vulnerable populations.

Genetics 59

Genetics Immune Response Medicine Research 59

Worldwide Clinical Trials

JANUARY 6, 2025

Technological advancements have fostered novel drugs and improved precision medicine, suggesting an increased trend of R&D in this direction. As part of the 4P model Prediction, Prevention, Precision, and Participation precision medicine is becoming the gold standard for effective therapeutics.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Genetics 130

Scienmag

JUNE 19, 2025

Traditionally, this involves harvesting T cells from patients, genetically modifying them outside the body, expanding these cells, and reinfusing them—a process that requires extensive infrastructure, time, and significant costs. The advantages of utilizing mRNA are profound.

In-Vivo 52

In-Vivo Engineer Manufacturing DNA 52

Scienmag

JULY 4, 2025

In recent years, the integration of artificial intelligence and biomechanics has opened transformative pathways in healthcare, particularly in musculoskeletal research and rehabilitation medicine. In sports medicine, synthetic gait models can optimize training regimens and injury prevention protocols tailored to individual biomechanics.

Research 84

Research Medicine Development Genetics 84

XTalks

DECEMBER 4, 2024

In the Asia-Pacific market, Jupiter has negotiated partnerships with companies such as Sichuan Kelun and Tianjin Pharmaceuticals, focusing on Jotrol’s integration into traditional Chinese medicine frameworks. International patents valid until 2036 further strengthen its global positioning.

Bioavailability 111

Bioavailability Genetic Disease Marketing RNA 111

Scienmag

JUNE 29, 2025

Kidney xenotransplantation, the transplantation of organs between species, particularly from genetically modified pigs to humans, has long been heralded as a promising solution to the global organ shortage crisis. However, immunological rejection remains the foremost obstacle delaying widespread clinical success.

Bioinformatics 59

Bioinformatics Genetics Immune Response Gene 59

Scienmag

JUNE 13, 2025

DOI 10.1038/s41551-025-01370-3 Media Contact Dione Chew Agency for Science, Technology and Research (A*STAR), Singapore dione_chew@hq.a-star.edu.sg

DNA 59

DNA Genomics Genome Genetics 59

Scienmag

JUNE 25, 2025

This tiny but indispensable structure, coined the “hemifusome,” was identified through cutting-edge cryo-electron tomography techniques by a collaborative team of researchers at the University of Virginia School of Medicine and the National Institutes of Health.

Scientist 75

Scientist Genetics Genetic Disease Medicine 75

Worldwide Clinical Trials

OCTOBER 14, 2024

Scientists now use cutting-edge techniques, including biological therapies that target specific immune system components and precision medicine approaches that personalize treatment plans based on a patient’s genetic profile.

Research 130

Research Clinical Trials Clinical Trials Immune Response 130

Pharma Times

JULY 15, 2025

HAE is a rare genetic disorder that causes unpredictable and painful swelling in areas such as the face, throat and abdomen. The medicine is taken orally in tablet form. Sebetralstat allows patients to treat attacks at the earliest sign of symptoms without injections, offering greater convenience and faster intervention.

DNA 81

DNA Genetics Medicine Trials 81

Scienmag

JUNE 24, 2025

Published in Translational Psychiatry , this reverse translational proof-of-concept investigation bridges experimental models and clinical practice, pushing the frontier of personalized medicine in addiction treatment. Ethical considerations were thoroughly integrated throughout the study design.

Gene Expression 52

Gene Expression Research Bioinformatics Genetics 52

Scienmag

JULY 11, 2025

Phenotypic profiling is increasingly embraced for elucidating cellular mechanisms, dissecting disease pathways, and screening genetic perturbations. Beyond drug discovery, the implications of this work extend into broader biological research realms.

Compound Screening 59

Compound Screening Research Drugs Medicine 59

Scienmag

JULY 4, 2025

Addressing these intricate challenges demands cutting-edge strategies that combine personalized medicine with advanced cardiovascular surgery. By offering a safer alternative with demonstrable success, PEARS holds promise for alleviating these burdens and improving quality of life, alongside advancing maternal-fetal medicine.

Genetics 59

Genetics Medicine Engineer Research 59

Scienmag

JUNE 20, 2025

This inclusivity empowered a comprehensive evaluation of heterogeneity, recognizing that geographic and genetic factors may modulate disease expression and severity. The researchers amassed extensive datasets from multiple clinical centers, encompassing diverse ethnic groups and geographical backgrounds.

Research 81

Research Immune Response Big Data Development 81

The Pharma Data

JUNE 24, 2025

Royalty Pharma and Revolution Medicines Forge $2 Billion Strategic Funding Pact to Accelerate Global Development of RAS Cancer Therapies Royalty Pharma plc, a prominent funder of innovation in the biopharmaceutical industry, announced a transformative agreement with Revolution Medicines, Inc.,

Medicine 40

Medicine Clinical Development Packaging Packaging 40

Scienmag

JULY 3, 2025

Notably, pharmacological blockade or genetic deletion of mGluR5 or NOX2 significantly mitigated glutamate-induced inflammatory responses, underscoring their critical roles as effectors in this pathway. Such diagnostic advancements could facilitate timely interventions to prevent progression to chronic liver disease in at-risk populations.

In-Vivo 52

In-Vivo Genetics In-Vitro Gene Expression 52

World of DTC Marketing

MAY 31, 2025

Patients face bills for infusions, imaging, hospital stays, genetic testing, and supportive therapies—all of which add up fast. Cancer Shouldn’t Come With a Bankruptcy Notice Advanced cancer generally can’t be cured, and the new medicines haven’t changed that. But they’re often launched with six-figure price tags.

Drugs 194

Drugs Nurses Doctor Doctors 194

Scienmag

JULY 3, 2025

CAR-T cell therapies, by genetically engineering patients’ own T cells to express receptors specific to BCMA—a surface protein highly expressed on malignant plasma cells—have revolutionized treatment paradigms.

FDA Approval 85

FDA Approval Genetic Engineering Engineer Production 85