Medical Xpress

MARCH 21, 2023

The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research. The disorder is caused by genetic variations that disrupt immune cell signaling through a protein called PI3K.

Genetics 84

Genetics Protein Research 84

Pharmaceutical Technology

MARCH 28, 2024

Discover how 4D Molecular Therapeutics Inc's patented variant AAV capsid proteins enhance muscle cell infectivity for gene therapy, revolutionizing treatment for genetic disorders.

Gene Therapy 130

Gene Therapy Genetics Protein Gene 130

Medical Xpress

FEBRUARY 17, 2023

Researchers at the National Institutes of Health and their colleagues have found that a toxic protein made by the body called DUX4 may be the cause of two very different rare genetic disorders.

Protein 98

Protein Genetics Research 98

Medical Xpress

APRIL 26, 2023

Researchers from Children's Hospital of Philadelphia (CHOP) and Princeton University have discovered a novel genetic disorder associated with neurodevelopmental differences. The study "Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish" is published in Science Advances today, April 26.

Genetics 101

Genetics Research Protein 101

pharmaphorum

AUGUST 5, 2021

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins. These regions are critical for optimal interactions between proteins.

Protein 126

Protein Gene Bioassay DNA 126

Pharmaceutical Technology

JUNE 4, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Transcription factors for genetically modified cells. However, not all innovations are equal and nor do they follow a constant upward trend.

Genetics 130

Genetics Gene Expression DNA Antibody 130

Scienmag

MARCH 30, 2022

Russian researchers and their international collaborators have developed a full-function bioelectronic photocell using one molecule of a fluorescent protein attached to a carbon nanotube. The […].

Protein 69

Protein Genetics Development Research 69

Scienmag

NOVEMBER 22, 2021

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact.

Protein 90

Protein Scientist Genetics Medicine 90

Scienmag

NOVEMBER 11, 2020

Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism. The Japan-based team published their results on November 11th in Nature Communications.

Protein 98

Protein Genetics RNA Development 98

Scienmag

SEPTEMBER 7, 2020

Credit: Dr Jie Zheng An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases.

Genetics 56

Genetics Protein Drugs Development 56

Outsourcing Pharma

JULY 13, 2021

The genetic exome sequence analysis partnership has created a large database linking rare protein-coding genetic variants to human health and disease.

Genetics 98

Genetics Protein Research 98

XTalks

MARCH 28, 2024

Duvyzat, a histone deacetylase (HDAC) inhibitor that works to reduce inflammation and muscle loss, is the first nonsteroidal drug approved to treat patients with all genetic variants of DMD. Progressive muscle weakness in the disease is caused by genetic mutations in the dystrophin gene that lead to a lack of functional dystrophin protein.

FDA Approval 105

FDA Approval Genetics Gene Therapy Gene 105

Scienmag

MAY 7, 2021

Credit: UPMC PITTSBURGH, May 7, 2021 – In a paper published today in Nature Communications, an international group of collaborators led by researchers at UPMC Children’s Hospital of Pittsburgh have identified a genetic cause of a rare neurological disorder marked by developmental delay and loss of coordination, or ataxia.

Genetics 95

Genetics Genetic Disease RNA Protein 95

Drug Discovery World

FEBRUARY 14, 2024

Adding automation Recombinant protein vaccines, which are obtained by conventional genetic engineering, are based on the proteins of target pathogens that can activate our immune systems. In particular, we must work to accelerate recombinant protein vaccine development. WuXi Biologics, and WuXi Vaccines.

Protein 59

Protein Vaccination Vaccine Manufacturing 59

XTalks

JUNE 20, 2022

Hereditary ATTR has an autosomal dominant pattern of inheritance and is caused by point mutations in the transthyretin ( TTR ) gene that codes for the transthyretin transport protein found in the plasma and cerebrospinal fluid.

FDA Approval 98

FDA Approval Protein Genetics RNA 98

STAT News

APRIL 10, 2023

So we were excited when we were referred to a pediatric geneticist who offered Gabrielle whole exome sequencing , which sequences all of the protein-coding regions of the genome, to determine whether there was a genetic cause. Read the rest…

Genetics 98

Genetics Genome Genomics Protein 98

Drug Discovery World

FEBRUARY 16, 2023

Challenges remain with current delivery approaches, and genetic medicines applications have been generally restricted to the liver and ex vivo settings. The post Start-up aims to advance transformative genetic medicines appeared first on Drug Discovery World (DDW).

Genetics 52

Genetics Medicine Gene Editing In-Vivo 52

Medical Xpress

DECEMBER 5, 2022

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

Protein 75

Protein Genetic Engineering Research Engineer 75

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

Genetics 105

Genetics DNA Genome Genomics 105

Drug Discovery World

JULY 24, 2023

The Defense Advanced Research Projects Agency (DARPA) has announced that Ginkgo Bioworks, which is building a platform for cell programming and biosecurity, has been awarded a four-year contract worth up to $18 million to reimagine how to manufacture complex therapeutic proteins.

Protein 52

Protein Manufacturing Gene Sequencing Production 52

BioTech 365

SEPTEMBER 7, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Genetic study of proteins is a breakthrough in drug development for complex diseases.An

Genetics 40

Genetics Protein Development Drugs 40

pharmaphorum

MARCH 26, 2021

There’s a new kid on the block among companies using artificial intelligence in drug discovery, after 1910 Genetics launched today with $26 million in financing. 1910 Genetics is named after the year in which sickle cell disease (SCD) was first discovered in the US by James Herrick.

Genetics 101

Genetics Drugs Protein Scientist 101

Medical Xpress

JANUARY 17, 2023

In addition, protein mutations in the delta variant were found to significantly reduce the effect of acquired humoral immunity to COVID-19 from prior infection or vaccination. The SARS-CoV-2 delta variant that caused the third wave of COVID-19 in mid-2021 turned out to be more contagious than earlier SARS-CoV-2 variants.

Genetics 124

Genetics Protein Research Vaccination 124

Roots Analysis

JANUARY 19, 2024

Introduction In a strategic move to accelerate the development and launch of genetic medicines, BridgeBio Pharma has successfully secured up to USD 1.25 ATTR is an inherited disease causing abnormal transthyretin protein and the accumulation of amyloid protein in various tissues, including the heart.

Genetics 40

Genetics Medicine Development Sales 40

Drug Discovery World

OCTOBER 26, 2022

A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London. . Identifying the proteins . The new method involves adding chemical tags to sugar molecules which are added to cells.

Protein 52

Protein Genetics Containment Research 52

Medical Xpress

MAY 15, 2023

Irregularities in the body's genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn't clear.

RNA 119

RNA Genetics Containment Protein 119

Scienmag

JUNE 1, 2021

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington’s disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder.

Protein 42

Protein Genetics Scientist Research 42

Drug Discovery World

AUGUST 16, 2023

A new study has shed light on the genetic messages encoded by genes within ‘triple negative’ breast cancers (TNBC), and shows they could predict response to chemotherapy. The presence of these biomarkers could be used to accelerate the development of more personalised treatments for triple negative breast cancers.

Genetics 52

Genetics Gene Hormones RNA 52

Pharmaceutical Technology

MAY 17, 2023

Antisense therapies are designed for destroying mRNA, reducing the amount of disease-causing protein. They will also have the potential to treat diseases that are caused by too little protein by increasing production, thus restoring the protein to normal levels.

Development 246

Development Protein RNA Genetics 246

Scienmag

APRIL 19, 2022

Eukaryotes (from the Greek meaning “true kernel”) have a cell nucleus that harbours most of the cell’s genetic information and includes organisms such as humans, plants and fungi. In prokaryotes, the cell’s contents, including its genetic material, are diffusely distributed. Eukaryotes typically have much larger […].

Protein 83

Protein Scientist Genetics 83

The Pharma Data

MARCH 15, 2022

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilising the protein and making it more potent. The new protein also proved to be more stable than ordinary p53 and capable of killing cancer cells.

Protein 52

Protein Research Genetics DNA 52

Medical Xpress

MARCH 21, 2023

An international study led by the Molecular Physiology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) identifies new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer's disease.

Protein 98

Protein Gene Life Science Research 98

Scienmag

APRIL 5, 2021

. – Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein’s interactions with SARS-CoV-2 genetic material.

Protein 61

Protein Vaccination Vaccine Drugs 61

Medical Xpress

DECEMBER 1, 2022

A University of Massachusetts Amherst scientist has discovered that a mutation in the misfolding protein that causes Parkinson's disease offers protection against another fatal neurodegenerative disorder—multiple system atrophy (MSA), which is caused by the same misfolding protein.

Protein 73

Protein Scientist Genetics 73

Scienmag

MARCH 9, 2022

The genome also has the code for making a capsid, the protein shell of a virus that encapsulates the genome and protects it like a nanocontainer. . — Each simple RNA virus has a genome, its “native RNA.” This genome dictates how the virus replicates in cells to eventually cause disease. Credit: Zandi lab, […].

Packaging 84

Packaging Packaging Genetics Genome 84

XTalks

DECEMBER 2, 2021

Natreve, a premium wellness company based in Vancouver, has partnered with Perfect Day to give consumers the first animal-free whey protein powder. The powder is called Mooless and it offers the same taste, texture and nutritional benefits of whey protein, just without the animal components. lactoglobulin protein.

Protein 59

Protein Marketing Production Branding 59

XTalks

JULY 26, 2021

But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. Because of their near-neutral pH and high protein and moisture content, plant-based meats are susceptible to microbial growth. Subject to Microbial Growth.

Protein 98

Protein Contamination Allergies Bacteria 98